Article
Biochemistry & Molecular Biology
Lingyan Ren, Fanchun Zeng, Jiezhong Deng, Yun Bai, Kun Chen, Long Chen, Li Sun
Summary: Bone loss is a characteristic of inflammatory bone diseases caused by aberrantly activated osteoclasts. This study revealed that inflammatory osteoclast-derived exosomes specifically target osteoblasts and promote bone formation through the lncRNA LIOCE, which stabilizes the osteogenic transcription factor Osterix.
Article
Orthopedics
Ertao Jia, Zhiling Li, Hongling Geng, Haiqiong Zhu, Yadong Wang, Feng Lin, Yubao Jiang, Jianyong Zhang
Summary: This study found that monosodium urate (MSU) crystals-induced neutrophil extracellular traps (NETs) could inhibit the viability of osteoblasts and enhance the activity of osteoclasts.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Chemistry, Multidisciplinary
Chun-su Zhong, Bo Zeng, Jia-hao Qiu, Li-hui Xu, Mei-yan Zhong, Yuan-ting Huang, Rong Xu, Si-ying Liu, Qing-bing Zha, Bo Hu, Dong-yun Ou-Yang, Xian-hui He
Summary: Monosodium urate (MSU) crystals induce NLRP3-independent necrosis in gout, which can be inhibited by combined inhibitors targeting multiple signaling pathways.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Rheumatology
Ji Hye Jeong, Su Jin Choi, Soo Min Ahn, Ji Seon Oh, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo, Seokchan Hong
Summary: This study found that synovial fluid macrophages can clear MSU crystal-induced NETs, and the proportion of CD14(+) macrophages is significantly inversely correlated with levels of MPO-dsDNA complex in the synovial fluid of gout patients. Additionally, synovial fluid CD14(+) macrophages cultured with NETs did not show a significant induction in pro- and anti-inflammatory cytokines.
ARTHRITIS RESEARCH & THERAPY
(2021)
Review
Medicine, General & Internal
Guijiang Huang, Qianhao Zhao, Wenhu Li, Jianlin Jiao, Xin Zhao, Dan Feng, Wei Tang
Summary: Osteoporosis is a systemic bone disease with unclear pathogenesis and molecular mechanisms. Extracellular vesicles, particularly exosomes, play a crucial role in intercellular communication in the bone microenvironment. Exosome therapy for osteoporosis is emerging as a research hotspot.
Article
Rheumatology
Michael Toprover, Michael Mechlin, Theodore Fields, Cheongeun Oh, Fabio Becce, Michael H. Pillinger
Summary: This study used dual-energy CT to compare gout patients and controls, finding higher prevalence of monosodium urate deposition in the spinal cord of gout patients. Gout patients also experienced more severe back pain.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2022)
Article
Cell Biology
Huijeong Ahn, Gilyoung Lee, Geun-Shik Lee
Summary: Studies have shown that lower temperatures enhance the formation of MSU crystals and activation of the NLRP3 inflammasome, resulting in increased secretion of IL-1β. These findings suggest that hyperthermia therapy may reduce gout flaring.
Review
Immunology
Haibo Tan, Zhiling Li, Shan Zhang, Jianyong Zhang, Ertao Jia
Summary: The self-limiting nature of the inflammatory flare is a feature of gout. The effects of neutrophil extracellular traps (NETs) on gout have remarkably attracted researchers' attention. Aggregated NETs promote the resolution of gouty inflammation, but recent studies have shown that levels of NETs are not associated with disease activity and inflammation in human gout.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Maria Sotniczuk, Anna Nowakowska-Plaza, Jakub Wronski, Malgorzata Wislowska, Iwona Sudol-Szopinska
Summary: Dual-energy computed tomography (DECT) significantly increases the sensitivity of the ACR/EULAR criteria in the diagnosis of gout.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Thiago Neves Vieira, Andre L. Lopes Saraiva, Rafaela Mano Guimaraes, Joao Paulo Mesquita Luiz, Larissa Garcia Pinto, Veridiana de Melo Rodrigues Avila, Luiz Ricardo Goulart, Jair Pereira Cunha-Junior, Peter Anthony McNaughton, Thiago Mattar Cunha, Juliano Ferreira, Cassia Regina Silva
Summary: This study found that the antagonist of AT(2)R has the potential to alleviate pain and inflammation in a mouse model of acute gout attack, suggesting it could be a potential therapeutic option for managing gout arthritis.
INFLAMMOPHARMACOLOGY
(2022)
Article
Immunology
Anil K. Singh, Mahamudul Haque, Kayla O'Sullivan, Mukesh Chourasia, Madhu M. Ouseph, Salahuddin Ahmed
Summary: The study uncovers a novel post-translational mechanism of TAK1 activation by MSU crystals, suggesting the therapeutic potential of targeting TAK1 in regulating MSU-induced inflammation. MSU-induced proinflammatory cytokine production was completely inhibited by a TAK1 inhibitor in an in vivo mouse model, demonstrating the effectiveness of targeting this pathway in treating gout-related inflammation.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shijie Wen, Hiroshi Arakawa, Ikumi Tamai
Summary: This study revealed that MSU crystals can activate CD38, leading to a decrease in intracellular NAD(+) levels, thereby promoting inflammatory responses. Inhibition of CD38 can effectively suppress inflammatory responses triggered by MSU crystals, indicating that CD38 may be a potential therapeutic target for gout.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Rheumatology
Neus Quilis, Francisca Sivera, Daniel Seoane-Mato, Fernando Perez-Ruiz, Carlos Sanchez-Piedra, Federico Diaz-Gonzalez, Sagrario Bustabad-Reyes
Summary: A study of 4916 individuals estimated the prevalence of gout in Spain to be 2.4%, with a higher prevalence in men compared to women. A substantial proportion of undiagnosed cases were found, emphasizing the need for population-based approaches in estimating disease prevalence.
Article
Medicine, General & Internal
Ted R. Mikuls
Summary: A 64-year-old man presents with pain, redness, and swelling in his left foot, and is unable to bear weight on it. He has a history of similar episodes in his right big toe and right elbow, which were relieved with naproxen. He also has hypertension, type 2 diabetes, and moderate chronic kidney disease. Physical examination reveals warmth, redness, and nodules in the left first metatarsophalangeal joint.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Krzysztof Marycz, Agnieszka Smieszek, Klaudia Marcinkowska, Mateusz Sikora, Eliza Turlej, Paulina Sobierajska, Adrian Patej, Alina Bienko, Rafal J. Wiglusz
Summary: The study developed a new nanocomposite nHAp/IO@miR-21/124 and demonstrated its modulatory effects on bone cell metabolism, differentiation, and inflammation in vitro. The results suggest that this fabricated nanocomposite has the potential to impact proper bone regeneration in osteoporosis by restoring the balance between osteoblasts and osteoclasts.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)