Rare Genetic Blood Disease Modeling in Zebrafish

Human AK2 links intracellular bioenergetic redistribution to the fate of hematopoietic progenitors

(2018) Koichi Oshima et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Liver metabolomics in a mouse model of erythropoietic protoporphyria

(2018) Pengcheng Wang et al.   BIOCHEMICAL PHARMACOLOGY

How Surrogate and Chemical Genetics in Model Organisms Can Suggest Therapies for Human Genetic Diseases

(2018) Katherine A. Strynatka et al.   GENETICS

An efficient platform for generating somatic point mutations with germline transmission in the zebrafish by CRISPR/Cas9-mediated gene editing

(2018) Yibo Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia

(2018) Nadia Danilova et al.   Scientific Reports

How Surrogate and Chemical Genetics in Model Organisms Can Suggest Therapies for Human Genetic Diseases

(2018) Katherine A. Strynatka et al.   GENETICS

The zebrafish: A fintastic model for hematopoietic development and disease

(2018) Aniket V. Gore et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Zebrafish Models of Human Disease: Gaining Insight into Human Disease at ZFIN

(2017) Yvonne M. Bradford et al.   ILAR JOURNAL

The first wave of T lymphopoiesis in zebrafish arises from aorta endothelium independent of hematopoietic stem cells

(2017) Ye Tian et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Highly efficient RNA-guided base editing in mouse embryos

(2017) Kyoungmi Kim et al.   NATURE BIOTECHNOLOGY

Programmable base editing of zebrafish genome using a modified CRISPR-Cas9 system

(2017) Yihan Zhang et al.   Nature Communications

CRISPR-Cpf1 mediates efficient homology-directed repair and temperature-controlled genome editing

(2017) Miguel A. Moreno-Mateos et al.   Nature Communications

Guidelines for morpholino use in zebrafish

(2017) Didier Y. R. Stainier et al.   PLoS Genetics

c-Myb acts in parallel and cooperatively with Cebp1 to regulate neutrophil maturation in zebrafish

(2016) H. Jin et al.   BLOOD

Microglia Colonization of Developing Zebrafish Midbrain Is Promoted by Apoptotic Neuron and Lysophosphatidylcholine

(2016) Jin Xu et al.   DEVELOPMENTAL CELL

Modeling human diseases: an education in interactions and interdisciplinary approaches

(2016) Leonard Zon   Disease Models & Mechanisms

Understanding the regulation of vertebrate hematopoiesis and blood disorders - big lessons from a small fish

(2016) Anne L. Robertson et al.   FEBS LETTERS

The contribution of mouse models to the understanding of constitutional thrombocytopenia

(2016) C. Leon et al.   HAEMATOLOGICA

Fish to Learn: Insights into Blood Development and Blood Disorders from Zebrafish Hematopoiesis

(2016) Serine Avagyan et al.   HUMAN GENE THERAPY

Cebpα is essential for the embryonic myeloid progenitor and neutrophil maintenance in zebrafish

(2016) Yimei Dai et al.   Journal of Genetics and Genomics

T Cell Immune Deficiency in zap70 Mutant Zebrafish

(2016) John C. Moore et al.   MOLECULAR AND CELLULAR BIOLOGY

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

(2016) Alexis C. Komor et al.   NATURE

The Zebrafish Model Organism Database: new support for human disease models, mutation details, gene expression phenotypes and searching

(2016) Douglas G. Howe et al.   NUCLEIC ACIDS RESEARCH

Epigenetic regulation of hematopoiesis by DNA methylation

(2016) Aniket V Gore et al.   eLife

The contribution of mouse models to the understanding of constitutional thrombocytopenia

(2016) C. Leon et al.   HAEMATOLOGICA

Homology Directed Knockin of Point Mutations in the Zebrafish tardbp and fus Genes in ALS Using the CRISPR/Cas9 System

(2016) Gary Alan Barclay Armstrong et al.   PLoS One

Antisense oligonucleotides in therapy for neurodegenerative disorders

(2015) Melvin M. Evers et al.   ADVANCED DRUG DELIVERY REVIEWS

Hematopoietic Stem Cell Arrival Triggers Dynamic Remodeling of the Perivascular Niche

(2015) Owen J. Tamplin et al.   CELL

Intron targeting-mediated and endogenous gene integrity-maintaining knockin in zebrafish using the CRISPR/Cas9 system

(2015) Jia Li et al.   CELL RESEARCH

Temporal-Spatial Resolution Fate Mapping Reveals Distinct Origins for Embryonic and Adult Microglia in Zebrafish

(2015) Jin Xu et al.   DEVELOPMENTAL CELL

Making Sense of Anti-Sense Data

(2015) Didier Y.R. Stainier et al.   DEVELOPMENTAL CELL

Morpholinos: Antisense and Sensibility

(2015) Martin Blum et al.   DEVELOPMENTAL CELL

Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish

(2015) Fatma O. Kok et al.   DEVELOPMENTAL CELL

ZFIN, The zebrafish model organism database: Updates and new directions

(2015) Leyla Ruzicka et al.   GENESIS

High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9

(2015) Gaurav K. Varshney et al.   GENOME RESEARCH

Reticular dysgenesis–associated AK2 protects hematopoietic stem and progenitor cell development from oxidative stress

(2015) Alberto Rissone et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophils in host defense: new insights from zebrafish

(2015) E. A. Harvie et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Genetic compensation induced by deleterious mutations but not gene knockdowns

(2015) Andrea Rossi et al.   NATURE

Antisense Oligonucleotide-Mediated Transcript Knockdown in Zebrafish

(2015) Andrea Pauli et al.   PLoS One

AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages

(2015) E Six et al.   Cell Death & Disease

Novel Genome-Editing Tools to Model and Correct Primary Immunodeficiencies

(2015) Lisa M. Ott de Bruin et al.   Frontiers in Immunology

Human Immunodeficiencies Related to Defective APC/T Cell Interaction

(2015) Marinos Kallikourdis et al.   Frontiers in Immunology

Precise in-frame integration of exogenous DNA mediated by CRISPR/Cas9 system in zebrafish

(2015) Yu Hisano et al.   Scientific Reports

CBF  and RUNX1 are required at 2 different steps during the development of hematopoietic stem cells in zebrafish

(2014) E. Bresciani et al.   BLOOD

Whole-exome sequencing and functional studies identify RPS29 as a novel gene mutated in multicase Diamond-Blackfan anemia families

(2014) L. Mirabello et al.   BLOOD

A transgenic zebrafish model expressingKIT-D816V recapitulates features of aggressive systemic mastocytosis

(2014) Tugce B. Balci et al.   BRITISH JOURNAL OF HAEMATOLOGY

Gene Therapy for Wiskott-Aldrich Syndrome

(2014) Marita Bosticardo et al.   CURRENT GENE THERAPY

Precise and efficient genome editing in zebrafish using the CRISPR/Cas9 system

(2014) U. Irion et al.   DEVELOPMENT

Smoc2 modulates embryonic myelopoiesis during zebrafish development

(2014) Hendrik Mommaerts et al.   DEVELOPMENTAL DYNAMICS

Zebrafish as a model for understanding the evolution of the vertebrate immune system and human primary immunodeficiency

(2014) Norimasa Iwanami   EXPERIMENTAL HEMATOLOGY

Developmental hematopoiesis: Ontogeny, genetic programming and conservation

(2014) Aldo Ciau-Uitz et al.   EXPERIMENTAL HEMATOLOGY

LincRNA-p21 Activates p21 In cis to Promote Polycomb Target Gene Expression and to Enforce the G1/S Checkpoint

(2014) Nadya Dimitrova et al.   MOLECULAR CELL

Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing

(2014) Shengdar Q Tsai et al.   NATURE BIOTECHNOLOGY

Transplantation Outcomes for Severe Combined Immunodeficiency, 2000–2009

(2014) Sung-Yun Pai et al.   NEW ENGLAND JOURNAL OF MEDICINE

Defects of protein production in erythroid cells revealed in a zebrafish Diamond–Blackfan anemia model for mutation in RPS19

(2014) Y Zhang et al.   Cell Death & Disease

Efficient generation of knock-in transgenic zebrafish carrying reporter/driver genes by CRISPR/Cas9-mediated genome engineering

(2014) Yukiko Kimura et al.   Scientific Reports

Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity

(2013) F. Ann Ran et al.   CELL

Efficient CRISPR/Cas9 genome editing with low off-target effects in zebrafish

(2013) A. Hruscha et al.   DEVELOPMENT

Gene therapy for PIDs: Progress, pitfalls and prospects

(2013) Sayandip Mukherjee et al.   GENE

Gene therapy of primary T cell immunodeficiencies

(2013) Alain Fischer et al.   GENE

A large-scale zebrafish gene knockout resource for the genome-wide study of gene function

(2013) G. K. Varshney et al.   GENOME RESEARCH

Highly efficient CRISPR/Cas9-mediated knock-in in zebrafish by homology-independent DNA repair

(2013) T. O. Auer et al.   GENOME RESEARCH

Establishing diagnostic criteria for severe combined immunodeficiency disease (SCID), leaky SCID, and Omenn syndrome: The Primary Immune Deficiency Treatment Consortium experience

(2013) William T. Shearer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Modelling of human Wiskott-Aldrich syndrome protein mutants in zebrafish larvae using in vivo live imaging

(2013) R. A. Jones et al.   JOURNAL OF CELL SCIENCE

Targeting oncogene expression to endothelial cells induces proliferation of the myelo-erythroid lineage by repressing the notch pathway

(2013) E Alghisi et al.   LEUKEMIA

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

Efficient genome editing in zebrafish using a CRISPR-Cas system

(2013) Woong Y Hwang et al.   NATURE BIOTECHNOLOGY

Rare-disease genetics in the era of next-generation sequencing: discovery to translation

(2013) Kym M. Boycott et al.   NATURE REVIEWS GENETICS

Heritable and Precise Zebrafish Genome Editing Using a CRISPR-Cas System

(2013) Woong Y. Hwang et al.   PLoS One

Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system

(2013) Li-En Jao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leukocyte adhesion deficiencies

(2012) Suhair Hanna et al.   Annals of the New York Academy of Sciences

The Synaptic Proteins β-Neurexin and Neuroligin Synergize With Extracellular Matrix-Binding Vascular Endothelial Growth Factor A During Zebrafish Vascular Development

(2012) Alberto Rissone et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Runx1 regulates embryonic myeloid fate choice in zebrafish through a negative feedback loop inhibiting Pu.1 expression

(2012) H. Jin et al.   BLOOD

Incidence of neoplasia in Diamond Blackfan anemia: a report from the Diamond Blackfan Anemia Registry

(2012) A. Vlachos et al.   BLOOD

Neutrophils Exert Protection in the Early Tuberculous Granuloma by Oxidative Killing of Mycobacteria Phagocytosed from Infected Macrophages

(2012) Chao-Tsung Yang et al.   Cell Host & Microbe

Animal Models of Human Granulocyte Diseases

(2012) Alejandro A. Schäffer et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Frameshift mutation in p53 regulatorRPL26is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia

(2012) Hanna T. Gazda et al.   HUMAN MUTATION

Intravital Imaging of Thymopoiesis Reveals Dynamic Lympho-Epithelial Interactions

(2012) Isabell Hess et al.   IMMUNITY

Hooked! Modeling human disease in zebrafish

(2012) Cristina Santoriello et al.   JOURNAL OF CLINICAL INVESTIGATION

Foamy Virus Vector-mediated Gene Correction of a Mouse Model of Wiskott–Aldrich Syndrome

(2012) Toru Uchiyama et al.   MOLECULAR THERAPY

In vivo genome editing using a high-efficiency TALEN system

(2012) Victoria M. Bedell et al.   NATURE

Targeting nuclear RNA for in vivo correction of myotonic dystrophy

(2012) Thurman M. Wheeler et al.   NATURE

Stem Cell Factor Receptor/c-Kit: From Basic Science to Clinical Implications

(2012) Johan Lennartsson et al.   PHYSIOLOGICAL REVIEWS

Double-Strand Break End Resection and Repair Pathway Choice

(2011) Lorraine S. Symington et al.   Annual Review of Genetics

Ribosomal protein gene deletions in Diamond-Blackfan anemia

(2011) J. E. Farrar et al.   BLOOD

Dual Roles for Rac2 in Neutrophil Motility and Active Retention in Zebrafish Hematopoietic Tissue

(2011) Qing Deng et al.   DEVELOPMENTAL CELL

The gata1/pu.1 lineage fate paradigm varies between blood populations and is modulated by tif1γ

(2011) Rui Monteiro et al.   EMBO JOURNAL

Live Imaging of Disseminated Candidiasis in Zebrafish Reveals Role of Phagocyte Oxidase in Limiting Filamentous Growth

(2011) Kimberly M. Brothers et al.   EUKARYOTIC CELL

Hematopoietic defects in rps29 mutant zebrafish depend upon p53 activation

(2011) Alison M. Taylor et al.   EXPERIMENTAL HEMATOLOGY

Lentiviral-mediated gene therapy leads to improvement of B-cell functionality in a murine model of Wiskott-Aldrich syndrome

(2011) Marita Bosticardo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Heritable gene targeting in zebrafish using customized TALENs

(2011) Peng Huang et al.   NATURE BIOTECHNOLOGY

Targeted gene disruption in somatic zebrafish cells using engineered TALENs

(2011) Jeffry D Sander et al.   NATURE BIOTECHNOLOGY

Animal Models of Diamond Blackfan Anemia

(2011) Kelly A. McGowan et al.   SEMINARS IN HEMATOLOGY

Zebrafish Enhancer TRAP Transgenic Line Database ZETRAP 2.0

(2011) Igor Kondrychyn et al.   Zebrafish

Diamond Blackfan Anemia

(2011) S. Ball   Hematology-American Society of Hematology Education Program

Journal Info Home About the Journal Editorial Board Archive Research Topics View Some Authors Review Guidelines Subscribe to Alerts Search Article Type Publication Date ...... Go Author Info Why Submit? Fees Article Types Author Guidelines Submission Checklist Contact Editorial Office Submit Manuscript Review ARTICLE Abstract Full Text PDF 0 Write a Comment Primary immunodeficiency diseases: an update on the classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency

(2011) Waleed Al-Herz   Frontiers in Immunology

Irf8 regulates macrophage versus neutrophil fate during zebrafish primitive myelopoiesis

(2010) L. Li et al.   BLOOD

Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit

(2010) A. Gerbaulet et al.   BLOOD

Development of multilineage adult hematopoiesis in the zebrafish with a runx1 truncation mutation

(2010) R. Sood et al.   BLOOD

Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome

(2010) K. B. Walters et al.   BLOOD

Syk and Zap-70 function redundantly to promote angioblast migration

(2010) Tara L. Christie et al.   DEVELOPMENTAL BIOLOGY

Porphyrias

(2010) Hervé Puy et al.   LANCET

Blood stem cells emerge from aortic endothelium by a novel type of cell transition

(2010) Karima Kissa et al.   NATURE

Haematopoietic stem cells derive directly from aortic endothelium during development

(2010) Julien Y. Bertrand et al.   NATURE

ZAP-70: An Essential Kinase in T-cell Signaling

(2010) H. Wang et al.   Cold Spring Harbor Perspectives in Biology

Hematopoietic cell development in the zebrafish embryo

(2009) Julien Y Bertrand et al.   CURRENT OPINION IN HEMATOLOGY

Definitive hematopoietic stem/progenitor cells manifest distinct differentiation output in the zebrafish VDA and PBI

(2009) H. Jin et al.   DEVELOPMENT

Antiplatelet antibodies in WASP(−) mice correlate with evidence of increased in vivo platelet consumption

(2009) Bindumadhav M. Marathe et al.   EXPERIMENTAL HEMATOLOGY

Loss of Ribosomal Protein L11 Affects Zebrafish Embryonic Development through a p53-Dependent Apoptotic Response

(2009) Anirban Chakraborty et al.   PLoS One

A Primer for Morpholino Use in Zebrafish

(2009) Brent R. Bill et al.   Zebrafish

Carboxypeptidase A5 identifies a novel mast cell lineage in the zebrafish providing new insight into mast cell fate determination

(2008) J. T. Dobson et al.   BLOOD

Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family

(2008) N. Danilova et al.   BLOOD

Transparent Adult Zebrafish as a Tool for In Vivo Transplantation Analysis

(2008) Richard Mark White et al.   Cell Stem Cell

Erythropoietic Porphyrias: Animal Models and Update in Gene-Based Therapies

(2008) Emmanuel Richard et al.   CURRENT GENE THERAPY

Controlling morpholino experiments: don't stop making antisense

(2008) J. S. Eisen et al.   DEVELOPMENT

Many ribosomal protein mutations are associated with growth impairment and tumor predisposition in zebrafish

(2008) Kevin Lai et al.   DEVELOPMENTAL DYNAMICS

Deficiency of ribosomal protein S19 during early embryogenesis leads to reduction of erythrocytes in a zebrafish model of Diamond-Blackfan anemia

(2008) Tamayo Uechi et al.   HUMAN MOLECULAR GENETICS

RPS19 mutations in patients with Diamond-Blackfan anemia

(2008) Maria Francesca Campagnoli et al.   HUMAN MUTATION

Analysis of WASp function during the wound inflammatory response - live-imaging studies in zebrafish larvae

(2008) A. Cvejic et al.   JOURNAL OF CELL SCIENCE

Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases

(2008) Yannick Doyon et al.   NATURE BIOTECHNOLOGY

Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases

(2008) Xiangdong Meng et al.   NATURE BIOTECHNOLOGY

Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects

(2008) Kelly A McGowan et al.   NATURE GENETICS

Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness

(2008) Chantal Lagresle-Peyrou et al.   NATURE GENETICS

Reticular dysgenesis (aleukocytosis) is caused by mutations in the gene encoding mitochondrial adenylate kinase 2

(2008) Ulrich Pannicke et al.   NATURE GENETICS

High-resolution in situ hybridization to whole-mount zebrafish embryos

(2007) Christine Thisse et al.   Nature Protocols