Article
Cell Biology
Rabia Ramzan, Amalia M. Dolga, Susanne Michels, Petra Weber, Carsten Culmsee, Ardawan J. Rastan, Sebastian Vogt
Summary: This study investigates the effects of ATP inhibition on cytochrome c oxidase (CytOx) in isolated rat heart mitochondria. The findings suggest that inhibiting CytOx activity with ATP leads to static respiration and decreased ROS production, highlighting the importance of ATP/ADP ratio for mitochondrial function.
Article
Multidisciplinary Sciences
Luke E. Formosa, Shadi Maghool, Alice J. Sharpe, Boris Reljic, Linden Muellner-Wong, David A. Stroud, Michael T. Ryan, Megan J. Maher
Summary: COA7 is a crucial assembly factor for the biogenesis of mitochondrial complex IV. It interacts with SCO1 and SCO2 to catalyze copper relay and reduction of disulfide bonds, which are important for complex IV assembly.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Iman M. Ahmad, Alicia J. Dafferner, Ramia J. Salloom, Maher Y. Abdalla
Summary: This study explored new strategies that could lead to the development of less toxic and more effective therapies against PDAC by combining increased cellular stress and targeting autophagy.
Article
Biochemistry & Molecular Biology
Mengran Du, Chenrui Wu, Renqiang Yu, Yuqi Cheng, Zhaohua Tang, Biying Wu, Jiayuanyuan Fu, Weilin Tan, Qiang Zhou, Ziyu Zhu, Ehab Balawi, Xuekang Huang, Jun Ma, Z. B. Liao
Summary: This study investigated the expression of circRNAs and their relation with neurological dysfunction after TBI. The research found that circIgfbp2 was significantly increased in injured brain tissue and in TBI patients, and its levels were positively correlated with anxiety symptoms. Knockdown of circIgfbp2 relieved anxiety-like behaviors and sleep disturbances induced by TBI. Mechanistically, circIgfbp2 targeted miR-370-3p to regulate BACH1, and down-regulating BACH1 alleviated mitochondrial dysfunction and oxidative stress-induced synapse dysfunction. Therefore, circIgfbp2 may be a novel therapeutic target for anxiety and sleep disorders after TBI.
MOLECULAR PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Olga Fedotovskaya, Ingrid Albertsson, Gustav Nordlund, Sangjin Hong, Robert B. Gennis, Peter Brzezinski, Pia Adelroth
Summary: The study identified a supercomplex composed of cyt. bc(1) and aa(3)-type cyt. c oxidase, and demonstrated the formation and activity of this supercomplex through various experiments. The potential role of membrane-anchored cyt. cy as a component in supercomplexes was also investigated in the study.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2021)
Article
Pharmacology & Pharmacy
Jingjing Jia, Jianwen Deng, Haiqiang Jin, Jie Yang, Ding Nan, Zemou Yu, Weiwei Yu, Zhiyuan Shen, Yuxuan Lu, Ran Liu, Zhaoxia Wang, Xiaozhong Qu, Dong Qiu, Zhenzhong Yang, Yining Huang
Summary: This study used a chemical proteomics approach to identify cytochrome C oxidase 7c (Cox7c) as a key interacting target of dl-3-n-Butylphthalide (NBP). The findings suggest that NBP inhibits mitochondrial apoptosis and ROS release, increases ATP production, improves mitochondrial respiratory capacity, upregulates the HIF-1 alpha/VEGF pathway, and promotes angiogenesis. These mechanisms contribute to the neuroprotective effects of NBP and highlight the critical role of Cox7c in protecting mitochondrial function.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Wenshu Cong, Li Meng, Yuanjie Pan, Han Wang, Jiahui Zhu, Yuanyu Huang, Qingli Huang
Summary: Population aging is a global issue, and this study presents a novel approach using Pd-based single-atom nanozymes to improve mitochondrial function and attenuate aging. The nanozyme mimics enzyme activities in the mitochondrial respiratory chain and enhances mitochondrial activities and abundance. Additionally, it demonstrates excellent anti-aging and neuroprotective effects through the activation of the mitochondrial unfolded protein response (UPRmt) pathway.
Article
Environmental Sciences
Tao Liu, Baolian Hou, Zhiping Wang, Yanli Yang
Summary: This study reveals the mitochondrial toxicity of polystyrene microplastics, providing a basis for understanding the mechanisms behind sperm damage caused by polystyrene microplastics.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Ching-Tien Lee, Cheng-Fang Hsieh, Jiz-Yuh Wang
Summary: This study demonstrates that BPA induces neurotoxicity through various pathways, including apoptosis and autophagy defects, ultimately leading to neuronal death and degeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agriculture, Multidisciplinary
Bo Zou, Qianqian Yu, Lele Shao, Yingying Sun, Xingmin Li, Ruitong Dai
Summary: Lipid molecules play a crucial role in mitochondria-mediated apoptosis. This study reveals that the levels of mitochondrial lipids increase during early postmortem, accelerating apoptosis in beef muscle. The psoas major muscle has a higher degree of apoptosis and more severe muscle oxidation and antioxidant system damage compared to the longissimus lumborum muscle.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Chemistry, Medicinal
Lixia Dong, Jingqiu He, Li Luo, Kui Wang
Summary: Autophagy is a self-degradation system that maintains cellular homeostasis by recycling cellular components. It can interact with reactive oxygen species (ROS) to regulate cancer progression. Phytochemicals that modulate ROS and autophagy have shown promising anti-cancer effects with minimal side effects.
Article
Pharmacology & Pharmacy
Fanfan Liang, Kaina Zhang, Wenzhuo Ma, Heqin Zhan, Qiang Sun, LaiHua Xie, Zhenghang Zhao
Summary: Sorafenib disrupts autophagy and mitochondrial dynamics, leading to oxidative stress and cardiomyocyte apoptosis. Improving autophagy or inhibiting mitochondrial fission can attenuate Sorafenib-induced cardiotoxicity.
Article
Multidisciplinary Sciences
Michael B. Powner, Glen Jeffery
Summary: Systemic glucose levels can be modulated through specific solar wavelengths that affect mitochondrial metabolism. Different wavelengths of light have opposing effects on mitochondrial respiration, with longer wavelengths increasing ATP production and shorter wavelengths suppressing metabolism. This study in a bumblebee model found that manipulating mitochondrial activity with specific wavelengths of light significantly altered circulating glucose concentration. This research contributes to our understanding of how light can affect systemic metabolism.
Article
Plant Sciences
Aprajita Kumari, Vemula Chandra Kaladhar, Nidhi Yadav, Pooja Singh, Kishorekumar Reddy, Kapuganti Jagadis Gupta
Summary: The location of NO production in mitochondrial cytochrome c oxidase and its role in mitochondrial biogenesis were investigated in Arabidopsis seedlings under osmotic stress and recovery. Osmotic stress reduced growth and mitochondrial number while increasing NO production. Nitrite application stimulated NO production and mitochondrial number in a NO-deficient mutant. COX6b(-)3 and COA6-L subunits were induced during osmotic stress and mutants impaired in these subunits showed reduced NO production and mitochondrial biogenesis. The COX6b-3 and COA6-L subunits interacted with a VQ27 motif-containing protein in the presence of NO, and a vq27 mutant displayed impaired mitochondrial biogenesis.
PLANT CELL AND ENVIRONMENT
(2023)
Article
Biology
Aria Dianati-Nasab, Hamid Nasrollahi, Zahra Khoshdel, Mahboobeh Ghorbani, Sayed Mohammad Shafiee
Summary: Further research is needed to understand the mechanisms behind the impacts of radiation therapy (RT) on increased catabolism and production of bilirubin, as well as the increased activity of TIGAR-related pathways and overexpression of TIGAR and HO-1 in breast cancer patients.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2022)