Article
Oncology
Mahinbanu Mammadli, Rebecca Harris, Liye Suo, Adriana May, Teresa Gentile, Adam T. Waickman, Alaji Bah, Avery August, Elmar Nurmemmedov, Mobin Karimi
Summary: Regulatory T cells play a crucial role in controlling autoimmunity and inflammation. Inhibiting the Itk signaling pathway can increase the frequency of noncanonical Tregs and reduce the incidence of acute graft-versus-host disease without affecting graft-versus-leukemia effects. Targeting Itk signaling could be a potential therapeutic strategy for autoimmune disorders.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Dermatology
Firdosh Shah, Ankit H. Bharti, Prashant S. Giri, Mitesh Dwivedi
Summary: This study found that there are defects in the numbers and functional of TRM-Tregs and antigen-specific Tregs in patients with generalized vitiligo(GV). These defects result in the inability to suppress the cytotoxic function and proliferation of CD4(+) and CD8(+) TRM cells, compromising the survival of melanocytes.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Immunology
Beatriz F. F. Corte-Real, Rebeca Arroyo Hornero, Aleksandra Dyczko, Ibrahim Hamad, Markus Kleinewietfeld
Summary: CSF2RB (CD131) may serve as a potential biomarker for autoimmune diseases in Tregs, with its overexpression potentially being linked to disease development.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Magdalena Piotrowska, Mateusz Gliwinski, Piotr Trzonkowski, Dorota Iwaszkiewicz-Grzes
Summary: Regulatory T cells (Tregs) play a critical role in the immune system by exerting suppressive functions, and disturbances in their function can lead to autoimmune dysregulation. Apart from Foxp3, other genes are involved in Tregs development and function. Epigenetic changes, specifically DNA methylation, are believed to be crucial in determining Tregs function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Claudia Curci, Angela Picerno, Nada Chaoul, Alessandra Stasi, Giuseppe De Palma, Rossana Franzin, Paola Pontrelli, Giuseppe Castellano, Giovanni B. Pertosa, Luigi Macchia, Vito Francesco Di Lorenzo, Carlo Sabba, Anna Gallone, Loreto Gesualdo, Fabio Sallustio
Summary: Studies have shown that Adult Renal Stem/Progenitor Cells (ARPCs) can regulate immune responses by inducing Tregs and DN T cell modulation, which play a crucial role in maintaining immune tolerance and preventing autoimmunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Pusen Wang, Baojie Shi, Chunguang Wang, Yuanyuan Wang, Weitao Que, Zhongyi Jiang, Xueni Liu, Qianwei Jiang, Hao Li, Zhihai Peng, Lin Zhong
Summary: This study revealed that the PANX1-IL-33 axis protects the liver from endotoxemia and injury by regulating T cells and early resolution of inflammation.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Review
Immunology
Prerana Muralidhara, Vanshika Sood, Vishnu Vinayak Ashok, Kushagra Bansal
Summary: Immunological tolerance is critical during pregnancy to protect the semi-allogeneic fetus from immune responses. Regulatory T cells (Tregs) accumulate at the placenta in the uterus during pregnancy and confer immunological tolerance at the maternal-fetal interface. Tregs play a role in supporting proper growth of the embryo during pregnancy and their dysfunction is associated with pregnancy-related complications. Tregs also have a similar role in tumor immunity by creating a tolerogenic system.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Xiaoya Li, Huihui Xu, Jing Huang, Dan Luo, Shuang Lv, Xiangchen Lu, Cheng Xiao
Summary: Regulatory T cells (Tregs) play a crucial role in promoting immune tolerance and maintaining immune system homeostasis. Dysfunction of Tregs is closely linked to rheumatoid arthritis (RA), and research on Tregs in RA has made significant progress in both basic and clinical aspects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Christine Weissenborn, Sophie von Lenthe, Nicole Hinz, Stefanie Langwisch, Mandy Busse, Anne Schumacher, Ana C. Zenclussen, Stefan Fest
Summary: This study found that transient ablation of Tregs hindered the growth of neuroblastoma (NB), while the absence of Bregs had no effect on NB growth, providing important evidence for targeting Tregs as a potential therapy for this aggressive childhood tumor.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Immunology
Nardos Cheru, David A. Hafler, Tomokazu S. Sumida
Summary: Maintenance of peripheral tolerance by CD4(+)Foxp3(+) regulatory T cells is crucial for regulating autoreactive T cells. Dysfunction of Foxp3 leads to autoimmune diseases. Tregs not only maintain immune homeostasis, but also establish tissue microenvironment and homeostasis of non-lymphoid tissues. Tissue resident Tregs show unique profiles and interact with both immune and non-immune cells, exerting suppressive function and adopting to local microenvironment through bidirectional interactions.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Ilse Gille, Frans H. J. Claas, Geert W. Haasnoot, Mirjam H. M. Heemskerk, Sebastiaan Heidt
Summary: Solid organ transplantation is an effective treatment for end-stage diseases, but the need for immunosuppression can lead to serious side effects. CAR Treg therapy, specifically with HLA-A2 CAR Tregs, shows potential in promoting transplantation tolerance and improving graft survival.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhen-zhen Feng, Ning Luo, Ying Liu, Jian-nan Hu, Tao Ma, Yong-ming Yao
Summary: Accumulating evidence suggests the involvement of ER stress pathway in immunity, but little information has linked ER stress to Tregs. Our study demonstrated that ER stress enhances the functional activity of Tregs and revealed a critical role of the PERK branch of UPR in regulating Tregs function.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Ellis Tibbs, Rakhee Rathnam Kalari Kandy, Delong Jiao, Long Wu, Xuefang Cao
Summary: Regulatory T cells (Tregs) express Granzyme B (GzmB) and perforin, which were shown to inhibit tumor clearance. This study investigates the role of Treg-derived GzmB in tumor progression and metastasis, showing that it is important for spontaneous lung metastasis and increasing the metastatic burden.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Immunology
Fei Guo, Brandon Hancock, Alec Griffith, Hui Lin, Kaitlyn Howard, Joshua Keegan, Fan Zhang, Adam Chicoine, Laura Cahill, Julie Ng, James Lederer
Summary: This study comprehensively characterized injury-responsive Tregs in mice using multi-dimensional profiling techniques, and found that CD44(high) Tregs expand and exhibit a highly suppressive ability in response to injury, distinct from CD44(low) Tregs. Injury-induced upregulation of specific genes was observed in CD44(high) Tregs, with chemokine receptors and cell division being the most enriched functional terms in this population.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Prashant S. Giri, Ankit H. Bharti, Jyoti Kode, Rasheedunnisa Begum, Mitesh Dwivedi
Summary: This study suggests that Harmine and Kaempferol treated Tregs may control the proliferation and production of CD8+ and CD4(+) T-cells in GV patients, leading to melanocytes' survival and proliferation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Dunja Mrdjen, Anto Pavlovic, Felix J. Hartmann, Bettina Schreiner, Sebastian G. Utz, Brian P. Leung, Iva Lelios, Frank L. Heppner, Jonathan Kipnis, Doron Merkler, Melanie Greter, Burkhard Becher
Correction
Biochemistry & Molecular Biology
Carsten Krieg, Malgorzata Nowicka, Silvia Guglietta, Sabrina Schindler, Felix J. Hartmann, Lukas M. Weber, Reinhard Dummer, Mark D. Robinson, Mitchell P. Levesque, Burkhard Becher
Article
Oncology
Stefan Stefanovic, Thomas M. Deutsch, Ralph Wirtz, Andreas Hartkopf, Peter Sinn, Florian Schuetz, Christof Sohn, Michael K. Bohlmann, Marc Suetterlin, Andreas Schneeweiss, Markus Wallwiener
Article
Biochemistry & Molecular Biology
Edoardo Galli, Felix J. Hartmann, Bettina Schreiner, Florian Ingelfinger, Eirini Arvaniti, Martin Diebold, Dunja Mrdjen, Franziska van der Meer, Carsten Krieg, Faiez Al Nimer, Nicholas Sanderson, Christine Stadelmann, Mohsen Khademi, Fredrik Piehl, Manfred Claassen, Tobias Derfuss, Tomas Olsson, Burkhard Becher
Article
Cell Biology
Felix J. Hartmann, Joel Babdor, Pier Federico Gherardini, El-Ad D. Amir, Kyle Jones, Bita Sahaf, Diana M. Marquez, Peter Krutzik, Erika O'Donnell, Natalia Sigal, Holden T. Maecker, Everett Meyer, Matthew H. Spitzer, Sean C. Bendell
Review
Rheumatology
Felix J. Hartmann, Sean C. Bendall
NATURE REVIEWS RHEUMATOLOGY
(2020)
Article
Immunology
David R. Glass, Albert G. Tsai, John Paul Oliveria, Felix J. Hartmann, Samuel C. Kimmey, Ariel A. Calderon, Luciene Borges, Marla C. Glass, Lisa E. Wagar, Mark M. Davis, Sean C. Bendall
Article
Biotechnology & Applied Microbiology
Felix J. Hartmann, Dunja Mrdjen, Erin McCaffrey, David R. Glass, Noah F. Greenwald, Anusha Bharadwaj, Zumana Khair, Sanne G. S. Verberk, Alex Baranski, Reema Baskar, William Graf, David Van Valen, Jan Van den Bossche, Michael Angelo, Sean C. Bendall
Summary: This antibody-based method allows profiling of metabolic protein expression and regulation in single cells using mass spectrometry while characterizing cellular phenotype. The approach was validated using mass cytometry and applied to clinical samples, revealing tissue-restricted, metabolically repressed immune cells in human colorectal carcinoma. The combination with multiplexed ion beam imaging unveiled the spatial organization of metabolic programs in human tissues.
NATURE BIOTECHNOLOGY
(2021)
Editorial Material
Oncology
Elise Alspach, Ryan D. Chow, Shadmehr Demehri, Jennifer L. Guerriero, Shashi Gujar, Felix J. Hartmann, Beth A. Helmink, William H. Hudson, Won Jin Ho, Leyuan Ma, Barbara B. Maier, Vivien Maltez, Brian C. Miller, Amy E. Moran, Erin M. Parry, Padmini S. Pillai, Sarwish Rafiq, Miguel Reina-Campos, Pamela C. Rosato, Nils-Petter Rudqvist, Megan K. Ruhland, Idit Sagiv-Barfi, Avinash Das Sahu, Robert M. Samstein, Christian M. Schuerch, Debattama R. Sen, Daniela S. Thommen, Yochai Wolf, Roberta Zappasodi
Summary: This commentary outlines the lessons emerged from the inaugural symposium of Arthur L. Irving Family Foundation Cancer Immunology Symposium, highlighting the importance of scientific and career development, and providing a framework for the field of cancer immunology.
CANCER IMMUNOLOGY RESEARCH
(2021)
Article
Cell Biology
Xenia Geeraerts, Juan Fernandez-Garcia, Felix J. Hartmann, Kyra E. de Goede, Liesbet Martens, Yvon Elkrim, Ayla Debraekeleer, Benoit Stijlemans, Anke Vandekeere, Gianmarco Rinaldi, Riet De Rycke, Melanie Planque, Dorien Broekaert, Elisa Meinster, Emile Clappaert, Pauline Bardet, Aleksandar Murgaski, Conny Gysemans, Frank Aboubakar Nana, Yvan Saeys, Sean C. Bendall, Damya Laoui, Jan Van den Bossche, Sarah-Maria Fendt, Jo A. Van Ginderachter
Summary: Macrophages in the tumor microenvironment can be divided into pro-inflammatory and reparative subsets, each with distinct metabolic characteristics. Lactate serves as an additional carbon source for macrophages, supporting oxidative metabolism in certain subsets while decreasing metabolic activity in others. This study reveals the metabolic intricacies of different macrophage subsets and identifies lactate as a metabolic and functional regulator of macrophages.
Article
Oncology
C. Mueller, V Kiver, E-F Solomayer, G. Wagenpfeil, C. Neeb, J. U. Blohmer, A. Abramian, N. Maass, F. Schuetz, C. Kolberg-Liedtke, D. J. Ralser, A-C Rambow
Summary: This study presents real-world data on the treatment of HR+/HER2- ABC patients with CDK4/6 inhibitors in four certified German university breast cancer centers. The results support the efficacy and safety of CDK4/6 inhibitors as shown in randomized controlled trials (RCTs). However, the median progression-free survival (PFS) in real-world data was lower than that in RCTs, which may be due to the inclusion of patients with more advanced disease.
Article
Oncology
Paul Munson, Juraj Adamik, Felix J. Hartmann, Patricia M. B. Favaro, Daniel Ho, Sean C. Bendall, Alexis J. Combes, Matthew F. Krummel, Karen Zhang, Robin K. Kelley, Lisa H. Butterfield
Summary: Hepatocellular cancer tumors express a-Fetoprotein (AFP), which inhibits dendritic cell differentiation and maturation, and blocks oxidative phosphorylation. Tumor-derived AFP increases glycolytic capacity and glucose dependence of dendritic cells, leading to increased glucose uptake and lactate secretion. Furthermore, AFP bound with polyunsaturated fatty acids (PUFAs) skews dendritic cell metabolism and promotes immune suppression.
Article
Multidisciplinary Sciences
Makeda L. Robinson, David R. Glass, Veronica Duran, Olga Lucia Agudelo Rojas, Ana Maria Sanz, Monika Consuegra, Malaya Kumar Sahoo, Felix J. Hartmann, Marc Bosse, Rosa Margarita Gelvez, Nathalia Bueno, Benjamin A. Pinsky, Jose G. Montoya, Holden Maecker, Maria Isabel Estupinan Cardenas, Luis Angel Villar Centeno, Elsa Marina Rojas Garrido, Fernando Rosso, Sean C. Bendall, Shirit Einav
Summary: Approximately 5 million dengue virus-infected patients progress to severe dengue (SD) infection annually. This study reveals uncoordinated immune responses in SD patients and provides insights into SD pathogenesis in humans with potential implications for prediction and treatment.
Article
Multidisciplinary Sciences
Juraj Adamik, Paul V. Munson, Deena M. Maurer, Felix J. Hartmann, Sean C. Bendall, Rafael J. Arguello, Lisa H. Butterfield
Summary: This study analyzed the transcriptomic and immune-metabolic profiles of dendritic cells (DCs) from patients with late-stage melanoma. The results suggest that the metabolic profile of DCs is associated with the immunostimulatory potential of cancer vaccines.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Shelley E. Ackerman, Cecelia I. Pearson, Joshua D. Gregorio, Joseph C. Gonzalez, Justin A. Kenkel, Felix J. Hartmann, Angela Luo, Po Y. Ho, Heidi LeBlanc, Lisa K. Blum, Samuel C. Kimmey, Andrew Luo, Murray L. Nguyen, Jason C. Paik, Lauren Y. Sheu, Benjamin Ackerman, Arthur Lee, Hai Li, Jennifer Melrose, Richard P. Laura, Vishnu C. Ramani, Karla A. Henning, David Y. Jackson, Brian S. Safina, Grant Yonehiro, Bruce H. Devens, Yaron Carmi, Steven J. Chapin, Sean C. Bendall, Marcin Kowanetz, David Dornan, Edgar G. Engleman, Michael N. Alonso
Summary: Alonso and colleagues have developed immune-stimulating antibody conjugates that can specifically deliver TLR7/8 agonists to tumors, inducing durable antitumor immunity.