Article
Multidisciplinary Sciences
Guidantonio Malagoli Tagliazucchi, Anna J. Wiecek, Eloise Withnell, Maria Secrier
Summary: The authors develop a method to evaluate EMT transformation and trajectories in cancer transcriptomics data, characterising EMT macro-states, including a hybrid state, and EMT hallmarks. The study explores the spatial heterogeneity of EMT transformation and its interaction patterns with cytotoxic, NK cells and fibroblasts in the tumor microenvironment. It also provides a catalogue of genomic events underlying distinct evolutionary constraints on EMT transformation.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Paras Jain, Sugandha Bhatia, Erik W. Thompson, Mohit Kumar Jolly
Summary: Phenotypic heterogeneity is a hallmark of aggressive cancer behavior and a clinical challenge. This study suggests that fluctuations or noise in content duplication and partitioning of the SNAIL gene during cell division can explain spontaneous phenotypic switching and dynamic heterogeneity in PMC42-LA cells.
Article
Cell Biology
Wen Jia, Mohit Kumar Jolly, Herbert Levine
Summary: The epithelial-mesenchymal transition (EMT) is a crucial cellular process for wound healing, cancer metastasis, and embryonic development. Recent studies have shown that hybrid epithelial/mesenchymal states, possessing both epithelial and mesenchymal traits, play a significant role in cancer metastasis and resistance to therapies. NRF2 has been identified as a stabilizing factor for these hybrid states. This research incorporates a phenomenological epigenetic feedback effect into a computational model for EMT signaling and demonstrates its stabilizing effect on the hybrid state if NRF2 influences SNAIL at an epigenetic level.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hwi Gon Kim, Ye Seon Lim, Seonyeong Hwang, Hye-Yoon Kim, Yuseok Moon, Yong Jung Song, Yong-Jin Na, Sik Yoon
Summary: DEHP, a commonly used plasticizer, may be linked to the development of endometriosis by inducing cell proliferation, migration, inflammation, and stemness through the TGF-β/Smad signaling pathway, providing novel insights into the pathogenesis of endometriosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hector Esquer, Qiong Zhou, Travis Nemkov, Adedoyin D. Abraham, Sebastien Rinaldetti, Yu-Chi Chen, Xiaohu Zhang, Michael Orman, Angelo D'Alessandro, Marc Ferrer, Wells A. Messersmith, Daniel LaBarbera
Summary: The translation describes the important role of epithelial-mesenchymal transition (EMT) in promoting cancer, as well as a dual-reporter system for identifying and isolating different cell phenotypes. This tool enables the study and induction of EMT and MET processes, providing insights into mesenchymal cell plasticity.
Article
Oncology
Jing Zhang, Zhimin Hu, Calista A. Horta, Jing Yang
Summary: Epithelial-mesenchymal transition (EMT) is involved in various aspects of tumor development. The tumor microenvironment, consisting of different stroma cells and biochemical factors, influences the EMT program and tumor progression. This review explores the effects of tumor microenvironmental signals on EMT regulation, discusses the molecular mechanisms of EMT in therapy resistance, and proposes new therapeutic approaches targeting the tumor microenvironment to impact EMT and tumor progression.
SEMINARS IN CANCER BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Xiaoyan Xie, Mu Xu, Hangjing Gao, Xianjing Chen, Liangzhi Cai
Summary: This study found that exosome-derived miR21 enhanced the proliferation, migration, and invasion of EOC cells while inhibiting apoptosis. This suggests that exosomal miR21 may be a tumor promoter for ovarian cancer.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Medicine, Research & Experimental
Monika Hollenhorst, Rajender Nandigama, Saskia B. Evers, Igor Gamayun, Noran Abdel Wadood, Alaa Salah, Mario Pieper, Amanda Wyatt, Alexey Stukalov, Anna Gebhardt, Wiebke Nadolni, Wera Burow, Christian Herr, Christoph Beisswenger, Soumya Kusumakshi, Fabien Ectors, Tatjana Kichko, Lisa Huebner, Peter Reeh, Antje Munder, Sandra-Maria Wienhold, Martin Witzenrath, Robert Bals, Veit Flockerzi, Thomas Gudermann, Markus Bischoff, Peter Lipp, Susanna Zierler, Vladimir Chubanov, Andreas Pichlmair, Peter Koenig, Ulrich Boehm, Gabriela Krasteva-Christ
Summary: This study reveals that tracheal brush cells express functional taste receptors and that bitter taste signaling induces neurogenic inflammation, which mediates secretion of immune mediators and defense against bacterial infections.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Cell Biology
Charles B. Trelford, Evelyn Ng, Craig I. Campbell, Gianni M. Di Guglielmo
Summary: The study revealed that p62/SQSTM1 co-localizes with TGFO receptors in A549 NSCLC cells and regulates the Smad2 phosphorylation to affect EMT process. Silencing of p62/SQSTM1 promotes EMT marker expression, actin stress fiber formation, and cell migration.
CELLULAR SIGNALLING
(2021)
Article
Biochemistry & Molecular Biology
Tsugumasa Toma, Hiroshi Tateishi, Kensaku Kawakami, Taha F. S. Ali, Masahiro Kamo, Kazuaki Monde, Yuta Nakashima, Mikako Fujita, Masami Otsuka
Summary: Metastasis is the main cause of mortality in solid tumors, but there are no available antimetastatic drugs on the market. This study focused on a synthetic compound called HPH-15, which showed anti-EMT and anti-cell migration activities in non-small-cell lung cancer cells. HPH-15 was found to inhibit downstream TGF-beta signaling and could potentially lead to the development of new antimetastatic drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
William L. Harryman, Kendra D. Marr, Ray B. Nagle, Anne E. Cress
Summary: This article discusses the diffusion and invasion mechanisms of muscle-invasive cancers in specialized biophysical and growth factor enriched microenvironments. The study proposes that the heterogeneity of cell-cell and cell-ECM adhesion receptors is a key factor in driving aggressive tumor networks, while the tumor's phenotype heterogeneity allows it to traverse through muscle and survive. The study also identifies the existence of epithelial-mesenchymal cooperation (EMC) within the tumor invasive network, facilitating tumor escape, muscle invasion, and metastasis. Additionally, the study highlights the special characteristics of the smooth muscle microenvironment and its alteration by primary tumors that contribute to tumor escape.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Jaewang Lee, Jong-Lyel Roh
Summary: Cancers that have transitioned to a mesenchymal state are resistant to conventional therapies. This transition affects lipid metabolism and increases polyunsaturated fatty acids in cancer cells, resulting in chemo- and radio-resistance. The altered metabolism in cancer cells enables invasion and metastasis but also makes them susceptible to lipid peroxidation under oxidative stress. Ferroptosis is highly effective against mesenchymal cancer cells, and targeting the lipid peroxidase pathway can kill therapy-resistant cells. This article discusses the regulatory mechanisms of ferroptosis in cancer and its implications for effective cancer therapy.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Biochemical Research Methods
Ayalur Raghu Subbalakshmi, Sarthak Sahoo, Prakruthi Manjunatha, Shaurya Goyal, Vignesh A. Kasiviswanathan, Yeshwanth Mahesh, Soundharya Ramu, Isabelle McMullen, Jason A. A. Somarelli, Mohit Kumar Jolly
Summary: ELF3 is a factor strongly associated with an epithelial phenotype and is inhibited during EMT. It inhibits the progression of EMT and can counteract EMT induction even in the presence of EMT-inducing factors. The prognostic capacity of ELF3 is specific to cell-of-origin or lineage.
JOURNAL OF BIOLOGICAL ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Juliane Strietz, Stella S. Stepputtis, Marie Follo, Peter Bronsert, Elmar Stickeler, Jochen Maurer
Summary: Primary breast cancer stem cell (BCSC) cultures isolated from TNBC specimens have been established and shown to grow as tumor spheres under anchorage-independent culture conditions in vitro, while reliably forming tumors in mice when transplanted in limiting dilutions in vivo. Additionally, these BCSC xenograft tumors exhibit similar architecture and gene expression to the original patient tumor, suggesting a promising model for researching BCSC biology and testing new treatment options for TNBC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Xiaobo Zheng, Fuzhen Dai, Lei Feng, Hong Zou, Li Feng, Mingqing Xu
Summary: The interplay between epithelial-mesenchymal plasticity and cancer stem cells plays a crucial role in cancer progression, affecting the aggressiveness of tumor cells and their response to treatment. Understanding the dynamic nature of EMT as a hybrid state rather than a binary model is important for unraveling the complexities of cancer biology and developing targeted therapeutic interventions.
FRONTIERS IN ONCOLOGY
(2021)
Editorial Material
Oncology
Valery Adorno-Cruz, Golam Kibria, Xia Liu, Mary Doherty, Damian J. Junk, Dongyin Guan, Chris Hubert, Monica Venere, Erin Mulkearns-Hubert, Maksim Sinyuk, Alvaro Alvarado, Arnold I. Caplan, Jeremy Rich, Stanton L. Gerson, Justin Lathia, Huiping Liu
Article
Cell Biology
Benjamin L. Bryson, Damian J. Junk, Rocky Cipriano, Mark W. Jackson
Review
Oncology
Mary R. Doherty, Jacob M. Smigiel, Damian J. Junk, Mark W. Jackson
Article
Biochemistry & Molecular Biology
D. J. Junk, B. L. Bryson, J. M. Smigiel, N. Parameswaran, C. A. Bartel, M. W. Jackson
Article
Multidisciplinary Sciences
Mary R. Doherty, HyeonJoo Cheon, Damian J. Junk, Shaveta Vinayak, Vinay Varadan, Melinda L. Telli, James M. Ford, George R. Stark, Mark W. Jackson
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Multidisciplinary Sciences
William R. Taylor, Sara R. Fedorka, Ibtissam Gad, Ronit Shah, Hanan D. Alqahtani, Radhika Koranne, Nishanth Kuganesan, Samkeliso Dlamini, Tim Rogers, Ayad Al-Hamashi, Veronika Kholodoyych, Yusuf Barudi, Damian Junk, Maisha S. Rashid, Mark W. Jackson, L. M. Viranga Tillekeratne
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Caitlin M. O'Connor, Daniel Leonard, Danica Wiredja, Rita A. Avelar, Zhizhi Wang, Daniela Schlatzer, Benjamin Bryson, Eesha Tokala, Sarah E. Taylor, Aditya Upadhyay, Jaya Sangodkar, Anne-Claude Gingras, Jukka Westermarck, Wenqing Xu, Analisa DiFeo, David L. Brautigan, Shozeb Haider, Mark Jackson, Goutham Narla
Article
Oncology
Benjamin L. Bryson, Ilaria Tamagno, Sarah E. Taylor, Neetha Parameswaran, Noah M. Chernosky, Nikhila Balasubramaniam, Mark W. Jackson
Summary: The study demonstrates that inflammatory cytokines can induce cellular senescence and promote the formation of cancer stem cells. By combining CDK4/6 inhibition with senolytic therapy, cancer stem cells can be efficiently killed.
MOLECULAR CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Bryan M. Webb, Benjamin L. Bryson, Eduardo Williams-Medina, Jessica R. Bobbitt, Darcie D. Seachrist, Lindsey J. Anstine, Ruth A. Keri
Summary: This study reveals that inhibiting the TGF-beta/Activin-ABCG2 pathway is a potential avenue for preventing or overcoming resistance to CDK7 inhibitors.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Oncology
Melyssa S. Roberts, Lindsey J. Anstine, Viviane S. Finke, Benjamin L. Bryson, Bryan M. Webb, Kristen L. Weber-Bonk, Darcie D. Seachrist, Parth R. Majmudar, Ruth A. Keri
BREAST CANCER RESEARCH
(2020)
Article
Oncology
Mary R. Doherty, Jenny G. Parvani, Ilaria Tamagno, Damian J. Junk, Benjamin L. Bryson, Hyeon Joo Cheon, George R. Stark, Mark W. Jackson
BREAST CANCER RESEARCH
(2019)
Meeting Abstract
Oncology
Benjamin L. Bryson, Damian J. Junk, Jacob Smigiel, Neetha Parameswaran, Mary R. Doherty, Courtney A. Bartel, Mark Jackson
Meeting Abstract
Oncology
Benjamin L. Bryson, Damian J. Junk, Mark W. Jackson