Article
Oncology
Bryann Pardieu, Justine Pasanisi, Frank Ling, Reinaldo Dal Bello, Justine Penneroux, Angela Su, Romane Joudinaud, Laureen Chat, Hsin Chieh Wu, Matthieu Duchmann, Gaetano Sodaro, Clementine Chauvel, Florence A. Castelli, Loic Vasseur, Kim Pacchiardi, Yannis Belloucif, Marie-Charlotte Laiguillon, Eshwar Meduri, Camille Vaganay, Gabriela Alexe, Jeannig Berrou, Chaima Benaksas, Antoine Forget, Thorsten Braun, Claude Gardin, Emmanuel Raffoux, Emmanuelle Clappier, Lionel Ades, Hugues de The, Francois Fenaille, Brian J. Huntly, Kimberly Stegmaier, Herve Dombret, Nina Fenouille, Camille Lobry, Alexandre Puissant, Raphael Itzykson
Summary: By analyzing multiple AML datasets, we identified SLC7A11 as a potential gene that is essential for AML cell survival. Inhibition of SLC7A11 using genetic and chemical methods reduced the viability and clonogenic capacity of AML cell lines. Sulfasalazine, a drug with xCT inhibitory activity, showed anti-leukemic effects against primary AML samples in vitro. Inhibition of xCT affected multiple metabolic pathways, leading to depletion of glutathione pools and oxidative stress-induced cell death in leukemic cells.
Review
Pharmacology & Pharmacy
Roshan Katekar, Pragati Singh, Richa Garg, Saurabh Verma, Jiaur R. Gayen
Summary: The shift from 'one drug- one target' to 'multiple drug- multiple targets' paradigm with combination therapies has shown promising results in overcoming multiple drug resistance (MDR), particularly for taxane-based anticancer medicines. Nanoparticles such as liposomes, micelles, polymeric nanoparticles, and gold nanoparticles have been explored for delivering taxanes to reverse drug resistance. However, there is still limited research on polypharmacology and advanced nanoformulations focusing on MDR in the literature.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaolei Li, Xiao Su, Rui Liu, Yongsha Pan, Jiankai Fang, Lijuan Cao, Chao Feng, Qianwen Shang, Yongjing Chen, Changshun Shao, Yufang Shi
Summary: Pharmacological modulation of macrophage phenotype by HDAC inhibitors can reshape the tumor immune microenvironment, enhance anti-tumor immune responses, and improve the efficacy of immunotherapies in various tumors.
Article
Mathematics, Applied
J. A. Gonzalez, Z. Akhtar, D. Andrews, S. Jimenez, L. Maldonado, T. Oceguera-Becerra, I Rondon, O. Sotolongo-Costa
Summary: New combination therapies against COVID-19 have been designed using nonlinear mathematical models and data from laboratory and clinical studies.
Article
Cell Biology
Sara Petillo, Elena Sproviero, Luisa Loconte, Lorenzo Cuollo, Alessandra Zingoni, Rosa Molfetta, Cinzia Fionda, Alessandra Soriani, Cristina Cerboni, Maria Teresa Petrucci, Francesca Fazio, Rossella Paolini, Angela Santoni, Marco Cippitelli
Summary: Natural Killer (NK) cells play an important regulatory role in the development of hematological malignancies, and their suppressor activity against Multiple Myeloma (MM) cells has been confirmed in multiple studies. Dysfunctions in NK cell effector activities and changes in NK cell subset distribution have been observed in MM patients, and these are correlated with disease staging.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Vijaya Bharti, Reese Watkins, Amrendra Kumar, Rebecca L. Shattuck-Brandt, Alexis Mossing, Arjun Mittra, Chengli Shen, Allan Tsung, Alexander E. Davies, Walter Hanel, John C. Reneau, Catherine Chung, Gina M. Sizemore, Ann Richmond, Vivian L. Weiss, Anna E. Vilgelm
Summary: Inhibition of BCL-xL protein increases cell death in cancer cells treated with oncology drugs, improving therapeutic outcomes. This study reveals a crosstalk between the mitochondrial apoptotic pathway and cell cycle regulation, providing a new therapeutic target for cancers with wild-type p53.
Article
Medicine, Research & Experimental
Qi Wu, Zhou Liu, Zhijie Gao, Yao Luo, Fubing Li, ChuanYu Yang, Tiantian Wang, Xiangyu Meng, Haijun Chen, Juanjuan Li, Yanjie Kong, Chao Dong, Si Sun, Ceshi Chen
Summary: A new mechanism for KLF5-mediated immunosuppression in the tumor microenvironment (TME) has been identified. Inhibition of the KLF5/COX2 axis can enhance the antitumor immune response and improve the efficacy of PD1 immunotherapy. A KLF5/COX2-associated immune score (KC-IS) has been developed to predict patient survival.
Article
Oncology
Shengqin Su, Gagan Chhabra, Chandra K. Singh, Mary A. Ndiaye, Nihal Ahmad
Summary: This review discusses the role of PLK1 in cancer and the advantages of combining PLK1 inhibitors with other drugs for cancer treatment. PLK1 inhibitors in combination with chemotherapy drugs and targeted small molecules have shown superior effects against cancer both in vitro and in vivo. However, further research is needed to identify the best combination targets and drug combinations.
TRANSLATIONAL ONCOLOGY
(2022)
Article
Oncology
Paul Koller, Natalia Baran, Karine Harutyunyan, Antonio Cavazos, Saradhi Mallampati, Renee L. Chin, Zhou Jiang, Xian Sun, Heng-Huan Lee, Jennifer L. Hsu, Patrick Williams, Xuelin Huang, Michael A. Curran, Mien-Chie Hung, Marina Konopleva
Summary: This study found that the combination treatment with the tyrosine kinase inhibitor dasatinib and an anti-PD-1 antibody is highly effective in a preclinical model of Philadelphia chromosome positive B-cell acute lymphoblastic leukemia. The treatment decreases tumor burden, improves efficacy, and prolongs survival. Mechanistically, it increases MHC II expression on antigen-presenting cells and promotes influx of these cells into the leukemic bone marrow. The induction of MHC II may also enhance immune memory and impair leukemic engraftment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Multidisciplinary Sciences
Crismita Dmello, Junfei Zhao, Li Chen, Andrew Gould, Brandyn Castro, Victor A. Arrieta, Daniel Y. Zhang, Kwang-Soo Kim, Deepak Kanojia, Peng Zhang, Jason Miska, Ragini Yeeravalli, Karl Habashy, Ruth Saganty, Seong Jae Kang, Jawad Fares, Connor Liu, Gavin Dunn, Elizabeth Bartom, Matthew J. Schipma, Patrick D. Hsu, Mahmoud S. Alghamri, Maciej S. Lesniak, Amy B. Heimberger, Raul Rabadan, Catalina Lee-Chang, Adam M. Sonabend
Summary: This study identifies Chek2 as the most important kinase that promotes evasion of glioma cells from immune recognition. Genetic depletion or pharmacological inhibition of Chek2 enhances antigen presentation, STING pathway activation, and PD-L1 expression, leading to survival benefits in preclinical glioma models. Analysis of human GBMs shows a negative correlation between Chek2 expression and antigen presentation/T-cell activation. These results suggest that Chek2 may be a promising target for improving response to immune checkpoint blockade therapy.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Liang Zhang, Jiawei Hong, Wei Chen, Wei Zhang, Xi Liu, Jiahua Lu, Hong Tang, Zhentao Yang, Ke Zhou, Haiyang Xie, Changku Jia, Donghai Jiang, Shusen Zheng
Summary: This study found that DBF4 was upregulated in hepatocellular carcinoma (HCC) and was an independent prognostic factor for patient survival. The study also revealed that p65 increased DBF4 expression by directly binding to its promoter. DBF4 complexed with CDC7 and bound to the coiled coil domain of STAT3, promoting HCC cell proliferation and tumorigenesis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Oncology
Medina Mamtimin, Akif Pinarci, Chao Han, Attila Braun, Hans-Joachim Anders, Thomas Gudermann, Elmina Mammadova-Bach
Summary: Extracellular DNA in liquid biopsies can be used as a marker for individual diagnosis and prognosis in cancer patients. Various immune cells, including neutrophils, can release DNA into the extracellular environment, promoting tumor progression and metastasis. This review summarizes the mechanisms of extracellular trap formation by different cell types and analyzes their role in cancer. Potential inhibitors of extracellular trap formation are also discussed, offering new therapeutic strategies for cancer prevention and treatment.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Ying Liang, Lingling Wang, Peijun Ma, Dongen Ju, Minggao Zhao, Yun Shi
Summary: Epigenetic mechanisms can lead to abnormal gene expression and affect immune cell behavior and the immunogenicity of tumors. Combining epigenetic therapy with immunotherapy can enhance anti-tumor immune responses and improve treatment outcomes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Fei Wu, Minglei Wang, Tao Zhong, Changyan Xiao, Xiaozheng Chen, Yiheng Huang, Meng Wu, Jinming Yu, Dawei Chen
Summary: This study identifies CDC20 as the most significantly overexpressed E3 ligase in prostate cancer, which negatively regulates pyroptosis signaling by targeting GSDME for ubiquitination-mediated proteolysis. Knockdown of CDC20 increases GSDME abundance and induces a transition from apoptosis to pyroptosis. Depletion of CDC20 enhances anti-tumor immunity and improves the efficacy of anti-PD1-based immunotherapy in murine models of prostate cancer. These findings provide insights into the upstream regulation of GSDME-mediated pyroptosis and highlight novel molecular pathways for enhancing the effectiveness of anti-PD1-based immunotherapy.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yao-An Shen, Chi-Long Chen, Yi-Hsuan Huang, Emily Elizabeth Evans, Chun-Chia Cheng, Ya-Jie Chuang, Cissy Zhang, Anne Le
Summary: Targeting glutamine catabolism for cancer therapy has gained research attention, with focus on inhibiting catalytic enzymes like GLS. However, resistance to treatments targeting glutaminolysis has been observed, leading to the development of combination therapies as a potential solution.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2021)
Article
Oncology
Carmen Ghilardi, Catarina Moreira-Barbosa, Laura Brunelli, Paola Ostano, Nicolo Panini, Monica Lupi, Alessia Anastasia, Fabio Fiordaliso, Monica Salio, Laura Formenti, Massimo Russo, Edoardo Arrigoni, Ferdinando Chiaradonna, Giovanna Chiorino, Giulio Draetta, Joseph R. Marszalek, Christopher P. Vellano, Roberta Pastorelli, MariaRosa Bani, Alessandra Decio, Raffaella Giavazzi
Summary: Inhibition of OXPHOS can control the progression of ovarian cancer, and high expression of PGC1α/β is correlated with this benefit, providing a potential biomarker for patient selection in this therapy.
Letter
Oncology
Francesca Bizzaro, Ilaria Fuso Nerini, Molly A. Taylor, Alessia Anastasia, Massimo Russo, Giovanna Damia, Federica Guffanti, Francesca Guana, Paola Ostano, Lucia Minoli, Maureen M. Hattersley, Stephanie Arnold, Antonio Ramos-Montoya, Stuart C. Williamson, Alessandro Galbiati, Jelena Urosevic, Elisabetta Leo, Ugo Cavallaro, Carmen Ghilardi, Simon T. Barry, Maria Rosa Bani, Raffaella Giavazzi
Summary: The combination therapy of PARP inhibitors and VEGF-signalling inhibitors in ovarian cancer has shown broad anti-tumor activity and prolonged survival, regardless of the tumor's homologous recombination repair status. The mechanisms of action of olaparib and cediranib act through complementary mechanisms affecting tumor cells and tumor microenvironment, respectively, suggesting no dominant common mechanistic inter-dependency driving therapeutic benefit.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Article
Oncology
Alessia Anastasia, Giulia Dellavedova, Antonio Ramos-Montoya, Neil James, Giovanna Chiorino, Massimo Russo, Hana Baakza, Joanne Wilson, Carmen Ghilardi, Elaine B. Cadogan, Raffaella Giavazzi, Maria Rosa Bani
Summary: The DNA-PK inhibitor AZD7648, when administered in combination with pegylated liposomal doxorubicin (PLD) or the PARP inhibitor olaparib, shows promising efficacy in delaying disease progression and inhibiting tumor growth and metastasis in ovarian cancer. The combination therapy enhances the therapeutic effect of PLD and olaparib, especially in BRCA-deficient patients.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Nutrition & Dietetics
Antonella Riva, Giovanna Petrangolini, Pietro Allegrini, Simone Perna, Attilio Giacosa, Gabriella Peroni, Milena Anna Faliva, Maurizio Naso, Mariangela Rondanelli
Summary: This study aimed to evaluate whether the combination of bergamot phytosome and artichoke leaf extract can be an alternative for patients with mild hypercholesterolemia who are poor responders to bergamot. The results showed that total and LDL cholesterol levels significantly decreased in the supplemented group, along with a significant reduction in waist circumference and visceral adipose tissue.
Article
Nutrition & Dietetics
Mariangela Rondanelli, Milena Anna Faliva, Gaetan Claude Barrile, Alessandro Cavioni, Francesca Mansueto, Giuseppe Mazzola, Letizia Oberto, Zaira Patelli, Martina Pirola, Alice Tartara, Antonella Riva, Giovanna Petrangolini, Gabriella Peroni
Summary: This review evaluates the ideal dietary approach to reduce bone mineral density loss and suggests a food pyramid for osteopenia/osteoporosis patients. The pyramid emphasizes daily consumption of carbohydrates, fruits, vegetables, light yogurt, skim milk, extra virgin olive oil, and calcium water. Weekly portions include fish, white meat, legumes, eggs, cheeses, and red/processed meats. The pyramid also highlights the need for personalized supplementation and identifies certain foods to be avoided. Additionally, regular aerobic and resistance exercises are recommended.
Article
Oncology
Andrea David Re Cecconi, Mara Barone, Mara Forti, Martina Lunardi, Alfredo Cagnotto, Mario Salmona, Davide Olivari, Lorena Zentilin, Andrea Resovi, Perla Persichitti, Dorina Belotti, Federica Palo, Nobuyuki Takakura, Hiroyasu Kidoya, Rosanna Piccirillo
Summary: The study aimed to assess the role of apelin in combating muscle loss during cancer cachexia. The results showed that although apelin exhibited beneficial effects against muscle atrophy in in vitro models, it failed to do so in in vivo models due to undesired apelin resistance. This study uncovering apelin resistance highlights potential issues in apelin-based therapy for cancer cachexia.
Article
Biochemistry & Molecular Biology
Katiuscia Pagano, Elisa Longhi, Henriette Molinari, Giulia Taraboletti, Laura Ragona
Summary: NMR-based approaches are crucial for understanding molecular recognition mechanisms and identifying potential inhibitors of protein-protein interactions. This study focuses on the interaction between FGF2 and FGFR and explores the inhibitory mechanisms using a small library of natural and synthetic molecules. The results provide valuable insights into the destabilization of the FGF2/FGFR complex and inhibition of FGF2-induced cell proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Pierre-Paul Axisa, Tomomi M. Yoshida, Liliana E. Lucca, Herbert G. Kasler, Matthew R. Lincoln, Giang H. Pham, Dante Del Priore, Jean-Marie Carpier, Carrie L. Lucas, Eric Verdin, Tomokazu S. Sumida, David A. Hafler
Summary: Genome-wide association studies have identified numerous susceptibility loci for autoimmune diseases, particularly in genes active in immune cells. In this study, the authors focused on a specific variant of the histone deacetylase 7 (HDAC7) gene and found that it plays a protective role in immune regulation. The findings provide insights into the functional characterization of genetic susceptibility loci and offer potential targets for therapeutic interventions.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Mariangela Rondanelli, Clara Gasparri, Simone Perna, Giovanna Petrangolini, Pietro Allegrini, Teresa Fazia, Luisa Bernardinelli, Alessandro Cavioni, Francesca Mansueto, Letizia Oberto, Zaira Patelli, Alice Tartara, Antonella Riva
Summary: This study aimed to evaluate the effects of green tea extract on adipose tissue dysfunction in overweight post-menopausal women. The results showed that a 60-day supplementation with green tea extract can improve fat oxidation and metabolic status in these women.
Article
Oncology
Elena Fasanaro, Paola Del Bianco, Elena Groff, Antonella Riva, Giovanna Petrangolini, Fabio Busato, Paola Stritoni, Giovanni Scarzello, Lucio Loreggian, Gian Luca De Salvo
Summary: This study aimed to evaluate the role of SAMITAL in reducing the incidence of severe mucositis induced by concurrent chemo-radiotherapy. The results showed that although SAMITAL did not significantly reduce the incidence of severe mucositis, the lower rate of mucositis and significantly better quality of life suggested a potential clinical benefit, which needs further research for validation.
Article
Cell Biology
Marielle Margier, Chisaka Kuehnemann, Nicolas Hulo, Jazmin Morales, Prasanna Vadhana Ashok Kumaar, Cecile Cros, Helene Cannelle, Julie Charmetant, Eric Verdin, Matthias Canault, Alessia Grozio
Summary: It has been found that nicotinamide mononucleotide (NMN) can protect the heart from the toxic effects of doxorubicin (Doxo) and improve physical function. NMN increased tissue levels of NAD+ and its metabolites, improved survival and bodyweight loss, and prevented Doxo-induced cardiotoxicity in both acute and chronic studies. NMN also prevented Doxo-induced transcriptomic changes related to mitochondrial function, apoptosis, oxidative stress, inflammation, and p53 signaling in the heart.
Article
Biology
Chiara Arrigoni, Paola Ostano, Simone Bersini, Martina Crippa, Maria Vittoria Colombo, Mara Gilardi, Luigi Zagra, Maurizia Mello-Grand, Ilaria Gregnanin, Carmen Ghilardi, Maria Rosa Bani, Christian Candrian, Giovanna Chiorino, Matteo Moretti
Summary: Different tissues have different endothelial features. This study explores the implications of this heterogeneity in pathological responses, specifically in osteoarthritis (OA) and sarcopenia. The results show that inflammation affects bone and muscle endothelial cells differently, with increased angiogenesis in subchondral bone and impaired angiogenesis in muscle, possibly linking OA and sarcopenia.
COMMUNICATIONS BIOLOGY
(2023)
Review
Nutrition & Dietetics
Mariangela Rondanelli, Mara Nichetti, Valentina Martin, Gaetan Claude Barrile, Antonella Riva, Giovanna Petrangolini, Clara Gasparri, Simone Perna, Attilio Giacosa
Summary: The objective of this narrative review is to evaluate the bromatological composition of hazelnuts and compare the nutritional properties of raw versus roasted hazelnuts, taking into account differences among varieties and production territories. The review incorporates 27 scientific articles that measured and reported nutrient concentrations in hazelnuts. Results showed that the composition of hazelnuts is influenced by varieties and territories, and processing methods greatly affect nutrient concentrations, particularly the removal of the skin which contains high levels of antioxidants. The study emphasizes the importance of considering hazelnut skin as a valuable part of the nut due to its nutritional properties.
Review
Cell Biology
Elisa Longhi, Laura Carminati, Elena Carlessi, Dorina Belotti, Giulia Taraboletti
Summary: Thrombospondins (TSPs) play important roles in cancer by regulating the behavior of cancer cells and non-neoplastic cells, defining tumor cell responses to environmental changes, and controlling drug delivery and activity, tumor response, and therapy resistance. The specific effects of TSPs depend on the interactions between TSPs and cell types, receptors, and ligands.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)