Article
Radiology, Nuclear Medicine & Medical Imaging
Ryo Kurokawa, Shimpei Kato, Hiroaki Koyama, Masanori Ishida, Mariko Kurokawa, Ryohei Kuroda, Tetsuo Ushiku, Haruki Kume, Osamu Abe
Summary: This study compares the clinical and CT imaging characteristics of prostate cancer patients with high-risk and intermediate-low-risk groups, focusing on bone metastases. The high-risk group shows significantly higher age, PSA levels, and frequencies of osteolytic or mixed bone metastases. This highlights the importance of considering high-risk prostate cancer in the differential diagnosis of bone metastases.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Engineering, Biomedical
Christina Polan, Christina Brenner, Monika Herten, Gero Hilken, Florian Grabellus, Heinz-Lothar Meyer, Manuel Burggraf, Marcel Dudda, Willi Jahnen-Dechent, Christian Wedemeyer, Max Daniel Kauther
Summary: Particle-induced osteolysis is a major cause of prosthetic loosening. In this study, the influence of fetuin-A on particle-induced osteolysis was investigated using fetuin-A-deficient mice. The results showed that fetuin-A deficiency led to increased bone resorption, eroded surface areas, and osteoclast numbers. Fetuin-A deficiency also caused changes in bone metabolism parameters. These findings suggest that fetuin-A deficiency may be a risk factor for particle-induced osteolysis.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Giulia Furesi, Antonio Miguel de Jesus Domingues, Dimitra Alexopoulou, Andreas Dahl, Matthias Hackl, Johannes R. Schmidt, Stefan Kalkhof, Thomas Kurth, Hanna Taipaleenmaeki, Stefanie Conrad, Christine Hofbauer, Martina Rauner, Lorenz C. Hofbauer
Summary: Prostate cancer communicates with bone progenitor cells through extracellular vesicles, promoting vitality and proliferation of the progenitor cells while decreasing mineral deposition. Additionally, small RNAs released by prostate cancer cells may play a critical role in suppressing the activity of bone progenitor cells. These findings reveal an important communication mechanism between prostate cancer and bone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Xi Cheng, Jinrong Wei, Qi Ge, Danlei Xing, Xuefeng Zhou, Yunzhu Qian, Guoqin Jiang
Summary: The importance of optimized drug delivery systems for the treatment of cancer metastatic osteolysis was discussed in this review, introducing some novel nanotechnology and nanomaterials that offer new perspectives for scientists.
Article
Endocrinology & Metabolism
Rachel A. Davey, Michele Clarke, Suzanne B. Golub, Patricia K. Russell, Jeffrey D. Zajac
Summary: This study demonstrates that during lactation, CTR activation inhibits osteocytic osteolysis by regulating the acidity of the lacunae microenvironment. Additionally, CTR is found to be dispensable for the replacement of bone mineral within lacunae by osteocytes post-lactation.
JOURNAL OF ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Paola Maroni, Paola Bendinelli, Anita Ferraretto, Giovanni Lombardi
Summary: Bone metastases are a major issue in the progression of breast cancer, posing a significant treatment challenge. Interleukin-11 plays a key role in bone metastasis and could be a candidate for anti-metastatic therapy. Further research is needed to understand the contribution of different cytokines in breast cancer progression and develop effective therapeutic strategies.
Article
Cell Biology
Wenbo Zhao, Philip Wiedemann, Eva Maria Woelfel, Mona Neven, Stephanie Peters, Thomas Imhof, Manuel Koch, Bjoern Busse, Michael Amling, Thorsten Schinke, Timur Alexander Yorgan
Summary: Col22a1, predominantly expressed in bone, deficiency may result in trabecular osteopenia and increased osteoclast numbers.
Article
Biochemistry & Molecular Biology
Sirikanda Jantaboon, Nithidol Sakunrangsit, Parichart Toejing, Asada Leelahavanichkul, Prapaporn Pisitkun, Matthew B. Greenblatt, Sutada Lotinun
Summary: Chronic inflammation in patients with SLE contributes to skeletal disorders by stimulating osteoclast activity and causing bone loss. This study found that the loss of FcγRIIB gene alleviates bone regeneration and that LPS induction impairs fracture healing and mineralization in mice. Both local and systemic LPS burden exacerbate bone regeneration impairment, delay mineralization and skeletal repair, and induce inflammation in SLE patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Claudia Enriquez, Valeria Cancila, Renata Ferri, Roberta Sulsenti, Irene Fischetti, Matteo Milani, Paola Ostano, Ilaria Gregnanin, Maurizia Mello-Grand, Enrico Berrino, Marco Bregni, Giuseppe Renne, Claudio Tripodo, Mario P. Colombo, Elena Jachetti
Summary: The study demonstrated a tumor-stroma cross-talk that induces neuroendocrine differentiation in prostate cancer under hormone therapy via a GRP78/ SPARC/ IL6 axis, highlighting potential therapeutic targets and biomarkers for neuroendocrine prostate cancer.
Article
Cell Biology
Bin Pan, Lin Zheng, Shijie Liu, Jiawei Fang, Chao Lou, Xingyu Hu, Lin Ye, Hehuan Lai, Jiawei Gao, Yejin Zhang, Kainan Ni, Dengwei He
Summary: Knockout of miR-148a improves bone loss by targeting NRP1, suggesting its potential as a therapeutic target in osteoporosis.
CELL DEATH DISCOVERY
(2022)
Article
Cell Biology
Eliane Gouvea de Oliveira-Barros, Luiza Castello Branco, Nathalia Meireles Da Costa, Pedro Nicolau-Neto, Celia Palmero, Bruno Pontes, Rackele Ferreira do Amaral, Soniza Vieira Alves-Leon, Jorge Marcondes de Souza, Luciana Romao, Priscila Valverde Fernandes, Ivanir Martins, Christina Maeda Takiya, Luis Felipe Ribeiro Pinto, Antonio Palumbo Jr, Luiz Eurico Nasciutti
Summary: The study found that DU145 cells exhibited more malignant and invasive phenotypes when interacting with astrocytes, along with the overexpression of GLIPR1 and SPARC potentially associated with the invasion of central nervous system by prostate malignant cells. The data presented may increase knowledge about the molecular mechanisms associated with the invasion of CNS by prostate malignant cells.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Review
Genetics & Heredity
Anna Durkin, Catherine DeVile, Paul Arundel, Mary Bull, Jennifer Walsh, Nicholas J. Bishop, Emilie Hupin, Susan Parekh, Ramesh Nadarajah, Amaka C. Offiah, Alistair Calder, Joanna Brock, Duncan Baker, Meena Balasubramanian
Summary: Patients with SPARC-related osteogenesis imperfecta commonly present with delayed motor development, scoliosis, multiple fractures, and neuromuscular weakness. Some patients also exhibit abnormal brain MRI findings.
JOURNAL OF MEDICAL GENETICS
(2022)
Article
Cell Biology
Qinyu Ma, Mengmeng Liang, Yutong Wu, Ce Dou, Jianzhong Xu, Shiwu Dong, Fei Luo
Summary: The study reveals that EVs derived from prostate cancer cells deliver osteolytic signals to osteoclasts by carrying miR-152-3p, facilitating the osteolytic progression in bone metastasis.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Article
Endocrinology & Metabolism
Eva Maria Woelfel, Franziska Lademann, Haniyeh Hemmatian, Stephane Blouin, Phaedra Messmer, Lorenz C. Hofbauer, Bjoern Busse, Martina Rauner, Katharina Jaehn-Rickert, Elena Tsourdi
Summary: Hyperthyroidism causes secondary osteoporosis by promoting bone resorption. Osteocytic osteolysis and elevated tartrate-resistant acid phosphatase (TRAP) activity were observed in hyperthyroid mice. The bone microarchitecture and turnover recovered after treatment, but the osteocytic osteolysis effects were not reversed.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Immunology
Gowrishankar Muthukrishnan, Alexandra Wallimann, Javier Rangel-Moreno, Karen L. de Mesy Bentley, Maria Hildebrand, Karen Mys, H. Mark Kenney, Eric T. Sumrall, John L. Daiss, Stephan Zeiter, R. Geoff Richards, Edward M. Schwarz, T. Fintan Moriarty
Summary: The study found that engrafting human hematopoietic stem cells into NSG mice better mimicked human S. aureus bone infections. Research on infected mice showed increased numbers of human T cells during infection, clustering around Staphylococcal abscess communities, indicating activation and proliferation by S. aureus.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Yvette Zarb, Ulrike Weber-Stadlbauer, Daniel Kirschenbaum, Diana Rita Kindler, Juliet Richetto, Daniel Keller, Rosa Rademakers, Dennis W. Dickson, Andreas Pasch, Tatiana Byzova, Khayrun Nahar, Fabian F. Voigt, Fritjof Helmchen, Andreas Boss, Adriano Aguzzi, Jan Klohs, Annika Keller
Article
Biology
Andy T. Kwok, Joseph E. Moore, Samuel Rosas, Bethany A. Kerr, Rachel N. Andrews, Callistus M. Nguyen, Jingyun Lee, Cristina M. Furdui, Boyce E. Collins, Michael T. Munley, Jeffrey S. Willey
RADIATION RESEARCH
(2019)
Article
Orthopedics
Samuel Rosas, Shane Tipton, T. David Luo, Bethany A. Kerr, Johannes F. Plate, Jeffrey S. Willey, Cynthia L. Emory
Summary: Patients with a history of prior prostate cancer have a higher risk of thromboembolic events, particularly pulmonary embolisms, after total knee arthroplasty, leading to increased economic expenditure.
JOURNAL OF KNEE SURGERY
(2021)
Article
Biophysics
Parham Ghassemi, Xiang Ren, Brittni M. Foster, Bethany A. Kerr, Masoud Agah
BIOSENSORS & BIOELECTRONICS
(2020)
Article
Biochemistry & Molecular Biology
Taylor C. Peak, Gati K. Panigrahi, Prakash P. Praharaj, Yixin Su, Lihong Shi, Jacqueline Chyr, Jose Rivera-Chavez, Laura Flores-Bocanegra, Ravi Singh, Donald J. Vander Griend, Nicholas H. Oberlies, Bethany A. Kerr, Ashok Hemal, Rhonda L. Bitting, Gagan Deep
MOLECULAR CARCINOGENESIS
(2020)
Article
Chemistry, Analytical
Kruthika Kikkeri, Bethany A. Kerr, Andrea S. Bertke, Jeannine S. Strobl, Masoud Agah
JOURNAL OF SEPARATION SCIENCE
(2020)
Article
Chemistry, Analytical
Parham Ghassemi, Koran S. Harris, Xiang Ren, Brittni M. Foster, Carl D. Langefeld, Bethany A. Kerr, Masoud Agah
SENSORS AND ACTUATORS B-CHEMICAL
(2020)
Article
Medicine, Research & Experimental
Alexander H. Jinnah, Patrick Whitlock, Jeffrey S. Willey, Kerry Danelson, Bethany A. Kerr, Omer A. Hassan, Cynthia L. Emory, Thomas L. Smith, Daniel N. Bracey
Summary: The study suggests that decellularized and oxidized porcine xenograft is biocompatible and at least equivalent to demineralized bone matrix in treating a critical defect in a rat femur model.
XENOTRANSPLANTATION
(2021)
Article
Multidisciplinary Sciences
Koran S. Harris, Lihong Shi, Brittni M. Foster, Mary E. Mobley, Phyllis L. Elliott, Conner J. Song, Kounosuke Watabe, Carl D. Langefeld, Bethany A. Kerr
Summary: CD117 expression may promote prostate cancer metastasis and invasion, with patients showing decreased survival rates with CD117 expression. CD117+ cells exhibit increased proliferation and migration.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Bethany A. Kerr, Lihong Shi, Alexander H. Jinnah, Koran S. Harris, Jeffrey S. Willey, Donald P. Lennon, Arnold Caplan, Tatiana Byzova
Summary: Identification of patient mutations driving skeletal development disorders has contributed to our understanding of bone development. Kindlin-3 deficiency affects differentiation of bone marrow mesenchymal stem cells towards the chondrogenic lineage, and its expression correlates with RUNX2 during chondrogenesis.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Andy T. Kwok, Nequesha S. Mohamed, Johannes F. Plate, Raghunatha R. Yammani, Samuel Rosas, Ted A. Bateman, Eric Livingston, Joseph E. Moore, Bethany A. Kerr, Jingyun Lee, Cristina M. Furdui, Li Tan, Mary L. Bouxsein, Virginia L. Ferguson, Louis S. Stodieck, David C. Zawieja, Michael D. Delp, Xiao W. Mao, Jeffrey S. Willey
Summary: Reduced weight-bearing from spaceflight or hind limb unloading induced arthritic changes in cartilage and menisci, but exercise promoted recovery.
SCIENTIFIC REPORTS
(2021)
Article
Dermatology
Luyang Xiong, Michael McCoy, Rakhilya Murtazina, Eugene A. Podrez, Tatiana V. Byzova
Summary: TLR2 plays an important role in skin wound healing, with endothelial cells depending on it for robust angiogenesis while hair follicle stem cells do not require TLR2 for proliferation or wound healing potential.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Cell Biology
Irina Zhevlakova, Luyang Xiong, Huan Liu, Tejasvi Dudiki, Alieta Ciocea, Eugene Podrez, Tatiana Byzova
Summary: This study demonstrates the opposite roles of Kindlin 2 and Kindlin 3 in cell survival and proliferation. The interaction between Kindlin and cytoskeletal protein paxillin is critical for regulating cell adhesion machinery.
CELL PROLIFERATION
(2022)
Article
Urology & Nephrology
Bethany A. Kerr, Koran S. Harris, Lihong Shi, Jeffrey S. Willey, David R. Soto-Pantoja, Tatiana Byzova
Summary: The development of distant metastasis in prostate cancer is primarily in the skeleton. Platelet secretion was shown to be necessary for tumor growth and the formation of the pre-metastatic niche. Thrombospondin (TSP)-1 and TGF-beta 1 released by platelets play crucial roles in angiogenesis and tumor-induced bone formation. Deleting TSP-1 and TGF-beta 1 in platelets showed increased angiogenesis and disrupted tumor-induced bone turnover, suggesting a potential target for interfering with CaP metastasis to bone.
AMERICAN JOURNAL OF CLINICAL AND EXPERIMENTAL UROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Michael G. McCoy, Daniel W. Nascimento, Manoj Veleeparambil, Rakhylia Murtazina, Detao Gao, Svyatoslav Tkachenko, Eugene Podrez, Tatiana Byzova
Summary: TLR2 plays a crucial role in endothelial cells, promoting inflammatory responses, tumor growth, and angiogenesis. Studies have shown that endothelial cells lacking TLR2 have reduced anti-inflammatory capabilities, potentially contributing to disease progression.