Article
Cell & Tissue Engineering
Mariko Tsuruda, Saori Morino-Koga, Minetaro Ogawa
Summary: Experimental findings suggest that VE-cad(+) cells from late-stage embryos can differentiate into MCs independently of HSCs in vitro, and have the potential to generate connective tissue MCs in vivo, shedding light on the differentiation mechanism of hematopoietic cells.
Review
Cell Biology
Sydney Treichel, Marie-Dominique Filippi
Summary: Hematopoietic stem cells have the ability to self-renew or differentiate into various blood cell lineages. The cell fate decisions of self-renewal or differentiation must be tightly controlled to prevent diseases like bone marrow failure or leukemia. Studies have shown that the cell cycle length plays a crucial role in hematopoietic stem cell fate. Cell cycle kinetics, divisional history, asymmetric cell divisions, metabolic and organelle activity all have an impact on hematopoietic stem cell fate decisions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biology
Leonard Herault, Mathilde Poplineau, Adrien Mazuel, Nadine Platet, Elisabeth Remy, Estelle Duprez
Summary: By analyzing 15,000 young and aged HSC transcriptomes, the study identified 15 groups of HSCs showing rare and new specific abilities that change with age. This established a new reference map of HSC differentiation and revealed a potential mechanism that delays differentiation in aged HSCs, potentially contributing to age-related hematologic diseases.
Article
Cell Biology
Yun-Qiao Li, Yandong Gong, Siyuan Hou, Tao Huang, Haizhen Wang, Di Liu, Yanli Ni, Chaojie Wang, Junliang Wang, Jun Hou, Ruichuang Yang, Jing Yan, Guangyu Zhang, Bing Liu, Yu Lan
Summary: This study reveals the spatiotemporal and functional heterogeneity of Hematopoietic stem cells (HSCs) derived from Hemogenic Endothelial Cells (HECs) during embryonic development. PK44 cells in the AGM region and yolk sac display similar developmental dynamics and functional characteristics with endothelial and hematopoietic features. They demonstrate multilineage reconstitution capacity and transcriptional differences, providing a fundamental basis for future research on HSC generation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Junjie Du, Han He, Zongcheng Li, Jian He, Zhijie Bai, Bing Liu, Yu Lan
Summary: The current study reveals transcriptional conservation of critical cell populations and molecular characteristics during HSC development between human and mouse. In humans, HSCs mature in the AGM region before colonizing the fetal liver, which contrasts with the process in mice. These findings provide a basis for future studies on mammalian HSC development and regeneration using mouse models.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Immunology
Motoko Koyama, Geoffrey R. Hill
Summary: Allogeneic stem cell transplantation is an effective therapy for hematopoietic malignancies, relying on donor T cells and NK cells for the graft-versus-leukemia effect. However, graft-versus-host disease remains a major complication, highlighting the importance of understanding alloantigen presentation to separate beneficial effects from detrimental ones. Mouse models and tools play a key role in quantifying alloantigen presentation post-alloSCT.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Runfeng Miao, Harim Chun, Xing Feng, Ana Cordeiro Gomes, Jungmin Choi, Joao P. Pereira
Summary: This study reveals that a complex homeostatic balance between hematopoietic stem cells (HSCs) and hematopoietic progenitor cells is maintained through competition for a limited amount of cell signaling molecule. When early hematopoietic progenitors fail to interact with specific cells, HSC numbers increase.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Nattaya Damkham, Surapol Issaragrisil, Chanchao Lorthongpanich
Summary: This review provides an update on the regulation of YAP and TAZ, transcriptional coactivators in the Hippo signaling pathway, in stem cell behaviors and differentiation. It highlights their roles in mechanosensing and mechanotransduction, as well as the importance of understanding how cells perceive and respond to their microenvironment for improving the efficiency and efficacy of stem cell products.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Developmental Biology
Jiahui Du, Junjun Jing, Shuo Chen, Yuan Yuan, Jifan Feng, Thach-Vu Ho, Prerna Sehgal, Jian Xu, Xinquan Jiang, Yang Chai
Summary: The research reveals that Arid1a maintains tissue homeostasis by inhibiting the Aurka-Cdk1 axis, limiting proliferation of TACs, and promoting their differentiation, while loss of Arid1a leads to reduction of the MSC population.
Article
Cell Biology
Diana Sa da Bandeira, Alastair Morris Kilpatrick, Madalena Marques, Mario Gomez-Salazar, Telma Ventura, Zaniah Nashira Gonzalez, Dorota Stefancova, Fiona Rossi, Matthieu Vermeren, Chris Sebastiaan Vink, Mariana Beltran, Neil Cowan Henderson, Bongnam Jung, Reinier van der Linden, Harmen Jan George van de Werken, Wilfred F. J. van Ijcken, Christer Betsholtz, Stuart John Forbes, Henar Cuervo, Mihaela Crisan
Summary: This study reveals the expression of PDGFRβ in distinct perivascular stromal cell layers in mice and shows that its deletion impairs hematopoiesis. The study also demonstrates that PDGFRβ(+) cells play a dual role in murine hematopoiesis, acting as support for HSPCs in the aortic niche and giving rise to a subset of HSPCs that persist into adulthood.
Article
Cell Biology
Juan Gao, Shuaibing Hou, Shengnan Yuan, Yuxia Wang, Yanan Gao, Xiaolu Sun, Weili Wang, Yajing Chu, Yuan Zhou, Xiaoming Feng, Hongbo R. Luo, Tao Cheng, Jun Shi, Weiping Yuan, Xiaomin Wang
Summary: Research shows that Rheb1-deficiency in neutrophils can remodel the bone marrow environment and induce HSC expansion, possibly by impairing their ability to secrete IL-6, affecting the production of SCF by MSCs, and promoting HSC proliferation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Laura R. Goldberg, Mark S. Dooner, Elaine Papa, Mandy Pereira, Michael Del Tatto, Yan Cheng, Sicheng Wen, Peter J. Quesenberry
Summary: It has been demonstrated that hematopoietic stem cells alter the expression of differentiation markers B220 and Gr1 with cell cycle progression, indicating changes in their differentiation potential.
STEM CELL REVIEWS AND REPORTS
(2022)
Article
Multidisciplinary Sciences
Xiaoyu Wei, Sulei Fu, Hanbo Li, Yang Liu, Shuai Wang, Weimin Feng, Yunzhi Yang, Xiawei Liu, Yan-Yun Zeng, Mengnan Cheng, Yiwei Lai, Xiaojie Qiu, Liang Wu, Nannan Zhang, Yujia Jiang, Jiangshan Xu, Xiaoshan Su, Cheng Peng, Lei Han, Wilson Pak-Kin Lou, Chuanyu Liu, Yue Yuan, Kailong Ma, Tao Yang, Xiangyu Pan, Shang Gao, Ao Chen, Miguel A. Esteban, Huanming Yang, Jian Wang, Guangyi Fan, Longqi Liu, Liang Chen, Xun Xu, Ji-Feng Fei, Ying Gu
Summary: This study used Stereo-seq technology to analyze spatial distribution and molecular features of axolotl brain during development and regeneration. The researchers identified an injury-induced ependymoglial cell cluster as a potential progenitor cell population for replenishing lost neurons. They also discovered regressed neurons and provided evidence for the involvement of resident ependymoglial cells in neurogenesis.
Review
Endocrinology & Metabolism
Greig Couasnay, Maria-Bernadette Madel, Joohyun Lim, Brendan Lee, Florent Elefteriou
Summary: The Cre/Lox system is a powerful tool for gene studies, allowing for loss-of-function and gain-of-function experiments. However, Cre transgenic lines may have off-target activity, emphasizing the importance of selecting optimal Cre lines for research purposes.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Zhao Yin, Rui Su, Lanlan Ge, Xiuyuan Wang, Juhua Yang, Guiping Huang, Chuting Li, Yanjun Liu, Keda Zhang, Lan Deng, Jia Fei
Summary: This study reveals that RalA, a small GTPase, plays a critical role in regulating the self-renewal of leukemic stem cells (LSCs) and normal hematopoietic stem cells (HSCs). RalA overexpression promotes cell cycle progression and increases the frequency of specific progenitor cells. The interaction between RalA and RAC1 is responsible for these effects, and inhibition of RalA may serve as a therapeutic approach to eradicate LSCs in chronic myeloid leukemia (CML).
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Neurosciences
Sung Young Park, Sang-Ho Song, Brandon Palmateer, Akash Pal, Eric D. Petersen, Gabrielle P. Shall, Ryan M. Welchko, Keiji Ibata, Atsushi Miyawaki, George J. Augustine, Ute Hochgeschwender
JOURNAL OF NEUROSCIENCE RESEARCH
(2020)
Article
Multidisciplinary Sciences
Mikiko Fukuda, Asako Sakaue-Sawano, Chikako Shimura, Makoto Tachibana, Atsushi Miyawaki, Yoichi Shinkai
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Margarete Diaz-Cuadros, Daniel E. Wagner, Christoph Budjan, Alexis Hubaud, Oscar A. Tarazona, Sophia Donelly, Arthur Michaut, Ziad Al Tanoury, Kumiko Yoshioka-Kobayashi, Yusuke Niino, Ryoichiro Kageyama, Atsushi Miyawaki, Jonathan Touboul, Olivier Pourquie
Article
Multidisciplinary Sciences
Kumiko Yoshioka-Kobayashi, Marina Matsumiya, Yusuke Niino, Akihiro Isomura, Hiroshi Kori, Atsushi Miyawaki, Ryoichiro Kageyama
Article
Multidisciplinary Sciences
Shunji Nakano, Muneki Ikeda, Yuki Tsukada, Xianfeng Fei, Takamasa Suzuki, Yusuke Niino, Rhea Ahluwalia, Ayana Sano, Rumi Kondo, Kunio Ihara, Atsushi Miyawaki, Koichi Hashimoto, Tetsuya Higashiyama, Ikue Mori
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Biochemistry & Molecular Biology
Hiroyuki Katayama, Hiroshi Hama, Koji Nagasawa, Hiroshi Kurokawa, Mayu Sugiyama, Ryoko Ando, Masaaki Funata, Nobuyo Yoshida, Misaki Homma, Takanori Nishimura, Megumu Takahashi, Yoko Ishida, Hiroyuki Hioki, Yoshiyuki Tsujihata, Atsushi Miyawaki
Article
Chemistry, Medicinal
Nobuo Kitada, Ryohei Saito, Rika Obata, Satoshi Iwano, Kazuma Karube, Atsushi Miyawaki, Takashi Hirano, Shojiro A. Maki
Review
Biotechnology & Applied Microbiology
Satoshi Furukawa, Aiko Nagamatsu, Mitsuru Nenoi, Akira Fujimori, Shizuko Kakinuma, Takanori Katsube, Bing Wang, Chizuru Tsuruoka, Toshiyuki Shirai, Asako J. Nakamura, Asako Sakaue-Sawano, Atsushi Miyawaki, Hiroshi Harada, Minoru Kobayashi, Junya Kobayashi, Takekazu Kunieda, Tomoo Funayama, Michiyo Suzuki, Tatsuo Miyamoto, Jun Hidema, Yukari Yoshida, Akihisa Takahashi
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Multidisciplinary Sciences
Shuo Chen, Linmeng He, Arthur J. Y. Huang, Roman Boehringer, Vincent Robert, Marie E. Wintzer, Denis Polygalov, Adam Z. Weitemier, Yanqiu Tao, Mingxiao Gu, Steven J. Middleton, Kana Namiki, Hiroshi Hama, Ludivine Therreau, Vivien Chevaleyre, Hiroyuki Hioki, Atsushi Miyawaki, Rebecca A. Piskorowski, Thomas J. McHugh
Article
Surgery
Yoshiharu Kono, Takeaki Ishizawa, Norihiro Kokudo, Yugo Kuriki, Ryu J. Iwatate, Mako Kamiya, Yasuteru Urano, Akiko Kumagai, Hiroshi Kurokawa, Atsushi Miyawaki, Kiyoshi Hasegawa
WORLD JOURNAL OF SURGERY
(2020)
Article
Materials Science, Multidisciplinary
Felix Sima, Hiroyuki Kawano, Masahiko Hirano, Atsushi Miyawaki, Kotaro Obata, Daniela Serien, Koji Sugioka
ADVANCED MATERIALS TECHNOLOGIES
(2020)
Review
Multidisciplinary Sciences
Ken Takahashi, Hideyuki Takahashi, Takuya Furuichi, Masatsugu Toyota, Makoto Furutani-Seiki, Takeshi Kobayashi, Haruko Watanabe-Takano, Masahiro Shinohara, Takuro Numaga-Tomita, Asako Sakaue-Sawano, Atsushi Miyawaki, Keiji Naruse
Summary: Gravity determines the shape and functions of body tissues in plants and animals, and cellular response to gravity is an active process of mechanotransduction. Despite sharing common mechanisms, each species has its own way of sensing and responding to gravity. Understanding cellular responses to gravity is important not only for life on Earth, but also for laying the foundation for living in space in the age of Mars exploration.
Proceedings Paper
Nanoscience & Nanotechnology
Daniela Serien, Hiroyuki Kawano, Atsushi Miyawaki, Koji Sugioka
LASER-BASED MICRO- AND NANOPROCESSING XIV
(2020)
Meeting Abstract
Biophysics
Yoh Shitashima, Atsushi Miyawaki
BIOPHYSICAL JOURNAL
(2020)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)