Article
Obstetrics & Gynecology
Yanqin Zhang, Xiangyu Chang, Di Wu, Mengqi Deng, Jinwei Miao, Zhaoyu Jin
Summary: Exosomal miR-214-3p can inhibit fibrosis in endometriosis by targeting CCN2, providing a potential therapeutic approach for EMs.
REPRODUCTIVE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Toyoshi Yanagihara, Kazuya Tsubouchi, Mahsa Gholiof, Sy Giin Chong, Kenneth E. Lipson, Quan Zhou, Ciaran Scallan, Chandak Upagupta, Jussi Tikkanen, Shaf Keshavjee, Kjetil Ask, Martin R. J. Kolb
Summary: Idiopathic pulmonary fibrosis is a fatal lung disease characterized by the accumulation of myofibroblasts. The study found that connective-tissue growth factor (CTGF) plays a key role in pulmonary fibrosis. Increased levels of CTGF exacerbate lung fibrosis and CTGF expression is upregulated in patients with idiopathic pulmonary fibrosis. Different cells contribute to the maintenance of the fibrotic phenotype during fibrogenesis.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Rong Liu, Min Zhu, Jiaojiao Chen, Junwei Gai, Jing Huang, Yingqun Zhou, Yakun Wan, Chuantao Tu
Summary: In this study, a novel nanobody (Nb) against human connective tissue growth factor (CTGF) was identified, which showed antifibrotic effects in vitro by regulating the biological functions of human stellate cells. This study is of great importance for the development of antifibrotic therapies for liver fibrosis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Cell Biology
You -Tien Tsai, Hsiang -Yuan Yeh, Chia -Ter Chao, Jenq-Wen Huang, Chih-Kang Chiang
Summary: This study found that the transforming growth factor-beta (TGF-beta) plays a crucial role in vascular calcification (VC). The mechanism of TGF-beta's involvement in VC was investigated using experimental models and clinical specimens. The results revealed that TGF-beta 1 can regulate the occurrence and progression of VC by modulating the miR-378a-3p/CTGF signaling pathway at specific time points.
Article
Pharmacology & Pharmacy
Xiaoqi Nie, Qianqian Yu, Long Li, Minxiao Yi, Bili Wu, Yongbiao Huang, Yonghui Zhang, Hu Han, Xianglin Yuan
Summary: Kinsenoside alleviates radiation-induced liver fibrosis by regulating the TGF-beta 1/Smad/CTGF pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Si-Min Zhang, Chuan-Yuan Wei, Qiang Wang, Lu Wang, Lu Lu, Fa-Zhi Qi
Summary: Our research showed for the first time that M2 promotes wound healing by secreting CTGF, which further mediates the proliferation and migration of fibroblasts via the AKT, ERK1/2, and STAT3 pathways.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Medicine, General & Internal
Xiaozheng Song, Yuqiang Cui, Teng Zhu
Summary: The study aimed to verify the effects of miR-19 on cardiac fibrosis and its target. The expression of miR-19 was reduced in the heart tissue and cardiac fibroblasts. Upregulating miR-19 can improve cardiac function and attenuate cardiac fibrosis by inhibiting the CTGF and MAPK pathways.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
Article
Cell Biology
Zihang Yuan, Jie Wang, Haoran Zhang, Yuanyuan Chai, Yunxia Xu, Yingying Miao, Ziqiao Yuan, Luyong Zhang, Zhenzhou Jiang, Qinwei Yu
Summary: This study found that bile acids, particularly glycocholic acid (GCA), can induce the expression of connective tissue growth factor in hepatocytes by promoting the nuclear translocation of yes-associated protein, thereby activating hepatic stellate cells and promoting the progression of liver fibrosis in cholestatic disease.
CELLULAR SIGNALLING
(2023)
Article
Multidisciplinary Sciences
Peng Wang, Zhitao Huang, Yili Peng, Hongwei Li, Tong Lin, Yingyu Zhao, Zheng Hu, Zhanmei Zhou, Weijie Zhou, Youhua Liu, Fan Fan Hou
Summary: This study identifies a circular RNA called circBNC2, which inhibits G2/M arrest of epithelial cells to prevent fibrosis in damaged kidney and liver, providing a potential target for intervention in fibrosis.
NATURE COMMUNICATIONS
(2022)
Article
Respiratory System
Dymph Klay, Joanne J. van der Vis, Suzan M. Roothaan, Tri Q. Nguyen, Jan C. Grutters, Roel Goldschmeding, Coline H. M. van Moorsel
Summary: CTGF rs6918698G is associated with spIPF and FPF, but not with CTD-ILD in a Dutch cohort. Localization of CTGF in lung tissue suggests its involvement in IPF pathogenesis.
Article
Chemistry, Medicinal
Yuecheng Jiang, Xin Lin, Yan Mao, Jianqiu Zhao, Guihua Zhang, Jiali Yu, Rong Dong, Yan Zha
Summary: The study found that acteoside (ACT) can inhibit renal fibrosis in unilateral ureteral obstruction (UUO) rats, probably by inhibiting the beta-catenin/CTGF signaling pathway.
NATURAL PRODUCT COMMUNICATIONS
(2022)
Article
Veterinary Sciences
Abdul Razaq Hirman, Lili Du, Shaohang Cheng, Heng Zheng, Linna Duo, Qianyu Zhai, Jing Xu
Summary: The study demonstrates that miR-133a-3p can inhibit scar formation in scalded mice by reducing collagen deposition, as well as suppressing the proliferation and migration of scar-derived fibroblasts (SFs). The mechanism involves downregulation of connective tissue growth factor (CTGF), a critical mediator in cell proliferation, migration and extracellular matrix (ECM) synthesis, through direct targeting by miR-133a-3p. Consequently, miR-133a-3p shows promise as a target for treating pathological scars.
EXPERIMENTAL ANIMALS
(2021)
Article
Oncology
Hongyan Li, Tingting Yang, Zhaoxia Fei
Summary: The study demonstrated that miR-26a-5p attenuated lung inflammation and apoptosis in LPS-induced ALI by targeting CTGF.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Wei Xiang, Longhui Li, Fuyan Hong, Yongcheng Zeng, Jin Zhang, Jinye Xie, Gang Shen, Jinhong Wang, Zhenzhen Fang, Weiwei Qi, Xia Yang, Guoquan Gao, Ti Zhou
Summary: N-cadherin plays a significant role in diabetic retinopathy by inducing retinal fibrosis; a new drug called PEDF has been discovered to inhibit N-cadherin cleavage and alleviate retinal fibrosis.
Article
Biophysics
Batoul Maatouk, Miran A. Jaffa, Mia Karam, Duaa Fahs, Wared Nour-Eldine, Anwarul Hasan, Ayad A. Jaffa, Rami Mhanna
Summary: DFUs lack CTGF and IGF-I, leading to poor tissue repair. AlgSulf/PCL NPs with high affinity and sustained release of CTGF and IGF-I could promote diabetic wound healing, with no cytotoxic effects observed in HaCaT cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)