Review
Immunology
Kingston H. G. Mills
Summary: IL-17 cytokines have both protective and pathological functions in the context of infection and autoimmunity. They promote protective immunity against pathogens but can also drive inflammatory pathology. Dysregulated IL-17 responses can contribute to immunopathology, and IL-17 is implicated in various inflammatory diseases.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Roman J. Krawetz, Asmaa Affan, Catherine Leonard, Dwaraka Natha Veeramreddy, Akash Fichadiya, Liam Martin, Heinrike Schmeling
Summary: Juvenile idiopathic arthritis patients' synovial derived mesenchymal stem/progenitor cells (MPCs) have reduced self-renewal ability and chondrogenic differentiation capacity, and cannot induce cartilage regeneration. These findings may have implications for future cell therapy strategies.
SCIENTIFIC REPORTS
(2022)
Review
Rheumatology
Soren Lomholt, Malthe Jessen Pedersen, Mia Glerup, Tue Wenzel Kragstrup
Summary: This scoping review aimed to summarize the current knowledge on synovial fibroblasts and their potential involvement in the pathogenesis of juvenile idiopathic arthritis. The review identified several mechanisms and characteristics of synovial fibroblasts that may contribute to disease traits in juvenile idiopathic arthritis. However, the limited number of studies highlights the need for further research in this area.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Medicine, Research & Experimental
M. Amelie Jule, J. Kacie Hoyt, Kevin Wei, Maria Gutierrez-Arcelus, L. Maria Taylor, Julie Ng, A. James Lederer, M. Siobhan Case, H. Margaret Chang, M. Ezra Cohen, Fatma Dedeoglu, M. Melissa Hazen, S. Jonathan Hausmann, Olha Halyabar, Erin Janssen, Jeffrey Lo, S. Mindy Lo, Esra Meidan, E. Jordan Roberts, F. Mary Beth Son, P. Robert Sundel, Y. Pui Lee, Talal Chatila, A. Peter Nigrovic, A. Lauren Henderson
Summary: Oligoarticular juvenile idiopathic arthritis (oligo JIA) is characterized by Th1 polarization, particularly prominent in CD4+ T cells, while not compromising the regulatory identity of Tregs. Single-cell RNA-Seq revealed heterogeneous effector and regulatory subpopulations in synovial fluid, including IFN-induced Tregs, peripheral helper T cells, and cytotoxic CD4+ T cells.
Article
Immunology
Anna Vanni, Alessio Mazzoni, Roberto Semeraro, Manuela Capone, Patrick Maschmeyer, Giulia Lamacchia, Lorenzo Salvati, Alberto Carnasciali, Parham Farahvachi, Teresa Giani, Gabriele Simonini, Giovanni Filocamo, Micol Romano, Francesco Liotta, Mir-Farzin Mashreghi, Lorenzo Cosmi, Rolando Cimaz, Alberto Magi, Laura Maggi, Francesco Annunziato
Summary: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic condition in childhood, with T cells playing a key role in its pathogenesis. The expression of PD-1 on CD4+ and CD8+ T cells in JIA indicates their active contribution in sustaining chronic inflammation. Targeting PD-1 could be an effective therapeutic strategy for JIA.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Biology
Avijit Dutta, Chen-Yiu Hung, Tse-Ching Chen, Sung-Han Hsiao, Chia-Shiang Chang, Yung-Chang Lin, Chun-Yen Lin, Ching-Tai Huang
Summary: Adaptive transfer experiments using an influenza hemagglutinin antigen-specific mouse model suggest that viral neuraminidase-activated TGF-beta from Th1 cells guides Th17 evolution to promote protection from lung inflammation in severe influenza.
COMMUNICATIONS BIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jinmei Zhang, Angela X. Wang, Yafei Wu, Shaoping Zhang
Summary: This study aimed to assess the role of interleukin - 1 receptor antagonist (IL-1RA) in a ligature-induced periodontal (LIP) model and investigate the mechanism of IL-1RA in regulating IL-17-mediated periodontal bone loss. The results showed that IL-1RA plays a protective role in the LIP model by suppressing the expansion of IL-17+ cells and preventing a hyper-IL-17 response in the gingiva.
ARCHIVES OF ORAL BIOLOGY
(2022)
Article
Rheumatology
Mieke Metzemaekers, Bert Malengier-Devlies, Karen Yu, Sofie Vandendriessche, Jonas Yserbyt, Patrick Matthys, Lien De Somer, Carine Wouters, Paul Proost
Summary: This study investigated the phenotypic features of neutrophils in the blood and inflamed joints of JIA patients. The results showed that neutrophils in inflamed joints of JIA patients have an activated phenotype.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Medicine, Research & Experimental
Johannes Wohlrab, Dennis Gerloff, Kathleen Gebhardt
Summary: The key players in chronic inflammatory skin diseases are cytokines belonging to the IL-17 group, IL-17 receptors and Th17 cells. Studies have shown that IL-17RA is the most abundantly expressed receptor type in various cutaneous cell types from healthy human subjects. Different IL-17 subtypes have varying effects on the expression of different receptor types, suggesting the need for further research on relevant co-stimulating factors under physiological and pathophysiological conditions.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Tsung-Ju Wu, Sunny Li-Yun Chang, Chih-Yang Lin, Chao-Yang Lai, Xiu-Yuan He, Chun-Hao Tsai, Chih-Yuan Ko, Yi-Chin Fong, Chen-Ming Su, Chih-Hsin Tang
Summary: IL-17 increases monocyte adhesion in OA synovium by reducing miR-5701 expression and enhancing VCAM-1 production. These findings improve our understanding of IL-17's impact on OA progression and provide insights for the design of more effective OA treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Shan-Chi Liu, Hung-Lun Hsieh, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsi-Chin Wu, Sunny Li-Yun Chang, Chin-Jung Hsu, Chih-Hsin Tang
Summary: Osteoarthritis is associated with upregulation of CCN2 and IL-17 expression, with CCN2 promoting IL-17 synthesis and osteoclast formation, and affecting IL-17 production by reducing miR-655 expression.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Rheumatology
Lina Al-Jaberi, Megan M. Simonds, Anne Marie C. Brescia
Summary: This study found that elevated expression of CCL24, CXCL9, and CXCL10 in synovial fluid samples was associated with the eventual need for advanced medications in patients with oligoarticular JIA, suggesting that these protein markers could potentially be used to predict disease progression and guide earlier intervention.
Article
Multidisciplinary Sciences
Anett Mazlo, Ramona Kovacs, Noemi Miltner, Marta Toth, Zoltan Vereb, Krisztina Szabo, Ildiko Bacskai, Kitti Pazmandi, Agota Apati, Tamas Biro, Krisztian Bene, Eva Rajnavolgyi, Attila Bacsi
Summary: Findings suggest that MSCl cells promote differentiation of CTLA-4 expressing DCs through the production of all-trans retinoic acid, leading to the activation and polarization of allogeneic, naive T cells by semi-matured DCs in a CTLA-4 dependent manner. Understanding the molecular mechanisms behind MSC-mediated modulation of DC differentiation may expand the clinical application of MSCs in cell-free therapies.
Review
Biochemistry & Molecular Biology
Yu Sawada, Ayako Setoyama, Yumiko Sakuragi, Natsuko Saito-Sasaki, Haruna Yoshioka, Motonobu Nakamura
Summary: The skin is exposed to various environmental stimuli, leading to inflammatory immune responses, especially towards cutaneous fungal infections. IL-17 producing cells play a crucial role in anti-fungal action, but their actual impact remains unclear. Research focuses on the role of IL-17-producing cells in cutaneous fungal infections and characteristics of infectious fungi on the skin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Federica Raggi, Martina Bartolucci, Davide Cangelosi, Chiara Rossi, Simone Pelassa, Chiara Trincianti, Andrea Petretto, Giovanni Filocamo, Adele Civino, Alessandra Eva, Angelo Ravelli, Alessandro Consolaro, Maria Carla Bosco
Summary: This study provides the first detailed longitudinal characterization of the EV-proteome in OJIA patients and identifies a panel of deregulated EV-prots that may serve as early molecular indicators for OJIA development, with potential diagnostic and therapeutic value.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Hematology
Lawrence G. Lum, Archana Thakur, Vidya Kondadasula, Zaid Al-Kadhimi, Abhinav Deol, Elyse N. Tomaszewski, Hiroshi Yano, Dana L. Schalk, Lois Ayash, Jeffrey A. Zonder, Joseph P. Uberti, Muneer H. Abidi, Voravit Ratanatharathorn
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2016)
Article
Immunology
Meghan E. Tumis, Deepali V. Sawant, Andrea L. Szymczak-Workman, Lawrence P. Andrews, Greg M. Delgoffe, Hiroshi Yano, Amy J. Beres, Peter Vogel, Creg J. Workman, Dario A. A. Vignali
Review
Immunology
Hiroshi Yano, Lawrence P. Andrews, Creg J. Workman, Dario A. A. Vignali
Article
Immunology
Deepali Sawant, Hiroshi Yano, Maria Chikina, Qianxia Zhang, Mengting Liao, Chang Liu, Derrick J. Callahan, Zhe Sun, Tao Sun, Tracy Tabib, Arjun Pennathur, David B. Corry, James D. Luketich, Robert Lafyatis, Wei Chen, Amanda C. Poholek, Tullia C. Bruno, Creg J. Workman, Dario A. A. Vignali
Review
Immunology
Lawrence P. Andrews, Hiroshi Yano, Dario A. A. Vignali
Article
Immunology
Coco Chu, Christopher N. Parkhurst, Wen Zhang, Lei Zhou, Hiroshi Yano, Mohammad Arifuzzaman, David Artis
Summary: ILC2s up-regulate ChAT and express AChRs after infection or treatment, with ACh administration promoting cytokine production and helminth expulsion. Deficiency of ChAT in ILC2s leads to impaired immunity.
SCIENCE IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Cheng Ye, Hiroshi Yano, Creg J. Workman, Dario A. A. Vignali
Summary: IL-35, an inhibitory cytokine, plays a crucial role in regulating the balance between inflammatory and anti-inflammatory immune responses, and is essential for controlling immune-related disorders. Understanding the biological characteristics of IL-35 and its role in diseases may contribute to its potential application as a clinical biomarker or immunotherapy.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
(2021)
Article
Immunology
Lei Zhou, Wenqing Zhou, Ann M. Joseph, Coco Chu, Gregory G. Putzel, Beibei Fang, Fei Teng, Mengze Lyu, Hiroshi Yano, Katrin I. Andreasson, Eisuke Mekada, Gerard Eberl, Gregory F. Sonnenberg
Summary: Group 3 innate lymphoid cells (ILC3s) protect the intestine from TNF-induced cell death by producing heparin-binding epidermal growth factor-like growth factor (HB-EGF), thereby playing a crucial role in inflammatory bowel disease (IBD).
Article
Biochemistry & Molecular Biology
Wen Zhang, Mengze Lyu, Nicholas J. Bessman, Zili Xie, Mohammad Arifuzzaman, Hiroshi Yano, Christopher N. Parkhurst, Coco Chu, Lei Zhou, Gregory G. Putzel, Ting-Ting Li, Wen-Bing Jin, Jordan Zhou, Hongzhen Hu, Amy M. Tsou, Chun-Jun Guo, David Artis
Summary: Research has found that nociceptive neurons have a significant impact on intestinal inflammation. Disrupted nociception leads to more severe inflammation and defective tissue repair processes. This disruption also causes changes in the intestinal microbiota and dysbiosis, while certain bacteria can promote tissue protection. Additionally, abnormal nociceptor gene expression was observed in intestinal biopsies from patients with inflammatory bowel diseases.
Article
Multidisciplinary Sciences
Mohammad Arifuzzaman, Tae Hyung Won, Ting-Ting Li, Hiroshi Yano, Sreehaas Digumarthi, Andrea F. Heras, Wen Zhang, Christopher N. Parkhurst, Sanchita Kashyap, Wen-Bing Jin, Gregory Garbes Putzel, Amy M. Tsou, Coco Chu, Qianru Wei, Alex Grier, Stefan Worgall, Chun-Jun Guo, Frank C. Schroeder, David Artis
Summary: Dietary fibre, particularly inulin, alters the composition of the microbiota and levels of microbiota-derived metabolites, such as bile acids, leading to type 2 inflammation in the intestine and lungs. This study provides insights into the pathophysiology of allergic inflammation, tissue protection, and host defense.
Article
Multidisciplinary Sciences
Katja J. Jarick, Patrycja M. Topczewska, Manuel O. Jakob, Hiroshi Yano, Mohammad Arifuzzaman, Xuemei Gao, Sotiria Boulekou, Vladislava Stokic-Trtica, Pierre S. Leclere, Alexandra Preusser, Zoe A. Rompe, Anton Stamm, Amy M. Tsou, Coco Chu, Frederik R. Heinrich, Gabriela M. Guerra, Pawel Durek, Andranik Ivanov, Dieter Beule, Sofia Helfrich, Claudia U. Duerr, Anja A. Kuehl, Christina Stehle, Chiara Romagnani, Mir-Farzin Mashreghi, Andreas Diefenbach, David Artis, Christoph S. N. Klose
Summary: This article investigates the role of innate lymphoid cells (ILCs) in protective immunity. Using a mouse model specific to ILCs, researchers found that ILC2s have non-redundant functions during steady state and disease, and they interact with adaptive immune cells to organize the immune system.
Article
Multidisciplinary Sciences
Amy M. Tsou, Hiroshi Yano, Christopher N. Parkhurst, Tanel Mahlakoiv, Coco Chu, Wen Zhang, Zhengxiang He, Katja J. Jarick, Connie Zhong, Gregory G. Putzel, Mai Hatazaki, Ivo C. Lorenz, David Andrew, Paul Balderes, Christoph S. N. Klose, Sergio A. Lira, David Artis
Summary: Emerging studies have found that cooperation between neurons and immune cells plays a crucial role in regulating antimicrobial immunity, inflammation, and tissue homeostasis. Specifically, neuropeptide-mediated regulation of non-redundant functions of innate lymphoid cells (ILC2s) has been identified as an evolutionarily conserved mechanism that integrates immunity and tissue protection.
Article
Multidisciplinary Sciences
Michael A. Wheeler, Iain C. Clark, Hong-Gyun Lee, Zhaorong Li, Mathias Linnerbauer, Joseph M. Rone, Manon Blain, Camilo Faust Akl, Gavin Piester, Federico Giovannoni, Marc Charabati, Joon-Hyuk Lee, Yoon-Chul Kye, Joshua Choi, Liliana M. Sanmarco, Lena Srun, Elizabeth N. Chung, Lucas E. Flausino, Brian M. Andersen, Veit Rothhammer, Hiroshi Yano, Tomer Illouz, Stephanie E. J. Zandee, Carolin Daniel, David Artis, Marco Prinz, Adam R. Abate, Vijay K. Kuchroo, Jack P. Antel, Alexandre Prat, Francisco J. Quintana
Summary: Cell-cell interactions in the central nervous system play important roles in neurologic diseases. However, little is known about the specific molecular pathways involved, and methods for their systematic identification are limited. In this study, the authors developed a forward genetic screening platform that combines CRISPR-Cas9 perturbations, cell coculture in picoliter droplets, and microfluidic-based fluorescence-activated droplet sorting to identify mechanisms of cell-cell communication. They used SPEAC-seq, in combination with in vivo genetic perturbations, to identify microglia-produced amphiregulin as a suppressor of disease-promoting astrocyte responses in multiple sclerosis preclinical models and clinical samples. Thus, SPEAC-seq enables the high-throughput systematic identification of cell-cell communication mechanisms.
Article
Biochemistry & Molecular Biology
Abigail E. Overacre-Delgoffe, Maria Chikina, Rebekah E. Dadey, Hiroshi Yano, Erin A. Brunazzi, Gulidanna Shayan, William Horne, Jessica M. Moskovitz, Jay K. Kolls, Cindy Sander, Yongli Shuai, Daniel P. Normolle, John M. Kirkwood, Robert L. Ferris, Greg M. Delgoffe, Tullia C. Bruno, Creg J. Workman, Dario A. A. Vignali