hnRNPA1 enhances FOXP3 stability to promote the differentiation and functions of regulatory T cells

The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation

(2020) Jing Yang et al.   EMBO REPORTS

Mouse Double Minute 2 Homolog-Mediated Ubiquitination Facilitates Forkhead Box P3 Stability and Positively Modulates Human Regulatory T Cell Function

(2020) Aiting Wang et al.   Frontiers in Immunology

T cells transduce T-cell receptor signal strength by generating different phosphatidylinositols

(2019) William F. Hawse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRAF6 directs FOXP3 localization and facilitates regulatory T‐cell function through K63‐linked ubiquitination

(2019) Xuhao Ni et al.   EMBO JOURNAL

hnRNP A1 promotes keratinocyte cell survival post UVB radiation through PI3K/Akt/mTOR pathway

(2018) Jianguo Feng et al.   EXPERIMENTAL CELL RESEARCH

TCR Signal Strength Regulates Akt Substrate Specificity To Induce Alternate Murine Th and T Regulatory Cell Differentiation Programs

(2017) William F. Hawse et al.   JOURNAL OF IMMUNOLOGY

Emerging roles of hnRNPA1 in modulating malignant transformation

(2017) Rajat Roy et al.   Wiley Interdisciplinary Reviews-RNA

Poly(ADP-ribosyl)ation of FOXP3 protein mediated by PARP-1 regulates the function of regulatory T cells.

(2016) Xuerui Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

USP21 prevents the generation of T-helper-1-like Treg cells

(2016) Yangyang Li et al.   Nature Communications

E3 Ubiquitin Ligase Cbl-b Regulates Thymic-Derived CD4+CD25+Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination

(2015) Yixia Zhao et al.   JOURNAL OF IMMUNOLOGY

Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability

(2015) Alexandria Huynh et al.   NATURE IMMUNOLOGY

PIM1 Kinase Phosphorylates the Human Transcription Factor FOXP3 at Serine 422 to Negatively Regulate Its Activity under Inflammation

(2014) Zhiyuan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells

(2014) Julio Gomez-Rodriguez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TGF-β Activation and Function in Immunity

(2013) Mark A. Travis et al.   Annual Review of Immunology

HNRNPA1 interacts with a 5′-flanking distal element of interleukin-6 and upregulates its basal transcription

(2013) D Zheng et al.   GENES AND IMMUNITY

The Ubiquitin Ligase Stub1 Negatively Modulates Regulatory T Cell Suppressive Activity by Promoting Degradation of the Transcription Factor Foxp3

(2013) Zuojia Chen et al.   IMMUNITY

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

(2013) Hu Zeng et al.   NATURE

Induced CD4+Foxp3+ Regulatory T Cells in Immune Tolerance

(2012) Angelina M. Bilate et al.   Annual Review of Immunology

A Broad Range of Self-Reactivity Drives Thymic Regulatory T Cell Selection to Limit Responses to Self

(2012) Hyang-Mi Lee et al.   IMMUNITY

Heterogeneous nuclear ribonucleoprotein A1 in health and neurodegenerative disease: From structural insights to post-transcriptional regulatory roles

(2012) Uriya Bekenstein et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Transcription factor Foxp3 and its protein partners form a complex regulatory network

(2012) Dipayan Rudra et al.   NATURE IMMUNOLOGY

Phosphomimetic Substitution of Heterogeneous Nuclear Ribonucleoprotein A1 at Serine 199 Abolishes AKT-dependent Internal Ribosome Entry Site-transacting Factor (ITAF) Function via Effects on Strand Annealing and Results in Mammalian Target of Rapamycin Complex 1 (mTORC1) Inhibitor Sensitivity

(2011) Jheralyn Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional diversity of the hnRNPs: past, present and perspectives

(2010) Siew Ping Han et al.   BIOCHEMICAL JOURNAL

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Nuclear functions of heterogeneous nuclear ribonucleoproteins A/B

(2008) Yaowu He et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+cells

(2008) Sokol Haxhinasto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

(2008) S. Sauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

(2008) K. Wing et al.   SCIENCE