Review
Urology & Nephrology
Ruifeng Wang, Yiping Wang, David C. H. Harris, Qi Cao
Summary: Innate immune cells, including a newly discovered group of innate lymphoid cells (ILCs), play critical roles in kidney diseases by providing immunomodulatory cytokines and guiding immune responses. Understanding the function of ILCs in normal and diseased kidneys emphasizes the emerging importance of ILC-regulated immunity for future research and therapeutic interventions.
KIDNEY INTERNATIONAL
(2021)
Article
Immunology
Ruifeng Wang, Jingjing Zhang, Dandan Li, Guiling Liu, Yuqin Fu, Qing Li, Lei Zhang, Long Qian, Li Hao, Yiping Wang, David C. H. Harris, Deguang Wang, Qi Cao
Summary: This study investigated the frequency of circulating ILC subsets in various chronic kidney diseases (CKD) and found an increase in these subsets correlated with certain disease features. This suggests a possible role for ILCs in CKD.
CLINICAL IMMUNOLOGY
(2022)
Article
Microbiology
Nelly Amenyogbe, Pedro Dimitriu, Kinga K. Smolen, Eric M. Brown, Casey P. Shannon, Scott J. Tebbutt, Phillip J. Cooper, Arnaud Marchant, Tessa Goetghebuer, Monika Esser, Brett B. Finlay, Tobias R. Kollmann, William W. Mohn
Summary: This study identified differences in immune responses correlating to gut microbiomes across biogeographically diverse settings and evaluated biological plausibility using a mouse model.
Review
Immunology
Bernd Heinrich, Firouzeh Korangy
Summary: Innate lymphoid cells (ILCs) are a heterogeneous population of the innate immune system that play a crucial role in maintaining immune homeostasis. They exhibit high plasticity, allowing them to quickly respond to changes in their microenvironment. ILCs can transdifferentiate into different subsets in the tumor microenvironment, influencing the immune response and tumor therapy. This review summarizes the functional and plastic heterogeneity of ILCs in homeostasis and disease, with a focus on tumor-driven plasticity and the impact of ILC-induced inflammation on the tumor microenvironment and anti-tumor immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Zhiyu Ma, Jinsong Wang, Lei Hu, Songlin Wang
Summary: Periodontitis is an irreversible inflammatory response that occurs in periodontal tissues. Innate lymphoid cells (ILCs) have been found to play a crucial role in regulating immune responses in periodontitis. This review focuses on the intricate crosstalk between ILCs and the microenvironment in periodontal tissue homeostasis for the purpose of regulating or improving immune responses in periodontitis prevention and therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Margaux Vienne, Marion Etiennot, Bertrand Escaliere, Justine Galluso, Lionel Spinelli, Sophie Guia, Aurore Fenis, Eric Vivier, Yann M. Kerdiles
Summary: NK cells are known to have cytotoxic effects on tumor cell lines, but their specific roles in primary tumor detection and elimination remain unclear. ILC1 play an active role in inhibiting the antitumoral immune response, suggesting the need to evaluate the tumor infiltration of ILC1 and NK cells to optimize immune harnessing in cancer therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Oceane Paris, Franck J. D. Mennechet, E. J. Kremer
Summary: This study investigated the interaction between ILCs and adaptive immune response. The researchers found that ILCs uptake HAdVs, leading to phenotypic maturation and cytokine secretion. Moreover, the complex of neutralizing antibodies and host defense proteins altered the cytokine profile generated by ILCs, potentially impacting the efficacy of adenovirus-based vaccines.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Minghui Li, Zehui Wang, Wei Jiang, Yihan Lu, Jun Zhang
Summary: Group 3 innate lymphoid cells (ILC3s) are a subset of lymphocytes found in the intestinal mucosa, playing a crucial role in maintaining intestinal immune homeostasis. They secrete cytokines such as IL-22 to eliminate luminal antigens, promote tissue repair, and regulate intestinal immunity. However, dysfunction of ILC3s can contribute to the development of various gut diseases. This review focuses on recent research advances and discoveries regarding the role of ILC3s in enteric infectious diseases, intestinal inflammation, and tumors, aiming to explore potential therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ying Kong, Han-Dong Li, Dan Wang, Xiaolin Gao, Chunsheng Yang, Minshu Li, Ting Chang, Qiang Liu
Summary: The study found a correlation between the reduction of ILC2 and disease severity in neuromyelitis optica spectrum disorder (NMOSD), and expanding ILC2 could alleviate the pathological conditions.
Review
Immunology
Alex Kayongo, Nicole M. Robertson, Trishul Siddharthan, Moses Levi Ntayi, Josephine Caren Ndawula, Obondo J. Sande, Bernard S. Bagaya, Bruce Kirenga, Harriet Mayanja-Kizza, Moses L. Joloba, Sofia K. Forslund
Summary: Chronic Obstructive Pulmonary Disease (COPD) is a major contributor to global mortality, with three million deaths reported annually. The impact is expected to increase, with approximately five million people predicted to die from COPD-related causes each year in the next 40 years. The immune mechanisms driving disease progression, as well as the relationship between airway microbiome changes and immune activation, remain unclear.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Marek Wagner, Shigeo Koyasu
Summary: Innate lymphoid cells (ILCs), enriched in barrier tissues like skin, play a role in immune pathways despite lacking antigen receptors found on T and B cells. They are crucial in controlling melanoma and potentially benefiting patients with skin malignancies through their therapeutic potential.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Allergy
Maryam Ghaedi, Fumio Takei
Summary: Innate lymphoid cells (ILCs) mainly reside at barrier surfaces and play a regulatory role in tissue homeostasis and immunity. They are divided into 3 groups based on similar effector programs to T cells, and their development from lymphoid progenitors in adult mouse bone marrow has been extensively studied.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Agata Poniewierska-Baran, Beata Tokarz-Deptula, Wieslaw Deptula
Summary: Innate lymphoid cells (ILCs) are an important group of immune cells that play a crucial role in regulating homeostasis and protecting humans from infections and diseases. Current research is focused on understanding the biology of ILCs and their functions in the human body, particularly in disease states such as cancer, metabolic disorders, and inflammation.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Review
Immunology
Rodolfo R. Favaro, Katherine Phillips, Romane Delaunay-Danguy, Kaja Ujcic, Udo R. Markert
Summary: Members of the innate immune system, specifically innate lymphoid cells (ILCs), play important roles in the uterine environment, supporting pregnancy and placental development. These cells demonstrate immune memory, allowing them to remember previously encountered antigens and mount enhanced responses. By studying ILCs, we can gain insights into the immunological mechanisms underlying female fertility/infertility, placental development, and distinct outcomes in second pregnancies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Jongho Ham, MinYeong Lim, Dongmo Kim, Hye Young Kim
Summary: Innate lymphoid cells (ILCs) are recently discovered innate immune cells that play a role in the defense against external insults in mucosal tissues. They exhibit characteristics similar to adaptive immune cells and can potentially have memory-like properties. Studies suggest that ILCs may play a significant role in the pathogenesis of asthma.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Gregory M. Sindberg, Shannon E. Callen, Santanu Banerjee, Jingjing Meng, Vanessa L. Hale, Ramakrishna Hegde, Paul D. Cheney, Francois Villinger, Sabita Roy, Shilpa Buch
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2019)
Editorial Material
Immunology
Jack C. Yu, Hesam Khodadadi, Evila da Silva Lopes Salles, Fairouz Chibane, Jatinder Bhatia, Babak Baban
CELLULAR & MOLECULAR IMMUNOLOGY
(2020)
Article
Microbiology
Minsuk Kim, Emily Vogtmann, David A. Ahlquist, Mary E. Devens, John B. Kisiel, William R. Taylor, Bryan A. White, Vanessa Hale, Jaeyun Sung, Nicholas Chia, Rashmi Sinha, Jun Chen
Article
Medicine, Research & Experimental
De-Huang Guo, Masaki Yamamoto, Caterina M. Hernandez, Hesam Khodadadi, Babak Baban, Alexis M. Stranahan
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Multidisciplinary Sciences
Adrienne M. Antonson, Morgan Evans, Jeffrey D. Galley, Helen J. Chen, Therese A. Rajasekera, Sydney M. Lammers, Vanessa L. Hale, Michael T. Bailey, Tamar L. Gur
SCIENTIFIC REPORTS
(2020)
Editorial Material
Microbiology
L. Vanessa Hale
Summary: Vanessa L. Hale researches the role of the microbiome in disease susceptibility in animal and human health, reflecting on how two papers on gut microbes and disease susceptibility have laid the foundation for studying the drivers of gut microbial structure and change across host species in relation to evolution and disease risk.
Article
Multidisciplinary Sciences
Ryan Mrofchak, Christopher Madden, Morgan Evans, Vanessa L. Hale
Summary: Studies on urinary microbiota have shown a diverse array of microbes present in urine, with extraction methods having minimal impact on the results. The Bacteremia Kit yielded the highest DNA concentrations, making it an effective option for studying the urine microbiota.
Article
Multidisciplinary Sciences
David Minich, Christopher Madden, Morgan V. Evans, Gregory A. Ballash, Daniel J. Barr, Keith P. Poulsen, Patricia M. Dennis, Vanessa L. Hale
Summary: Significant differences in gut microbiota were observed among deer from different sources, genders, and CWD status, with CWD-positive deer showing higher abundances of specific microbial taxa. Variations by source and gender may be influenced by diet, while differences in CWD status could be linked to CWD pathogenesis.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Andreia G. Arruda, Loic Deblais, Vanessa L. Hale, Christopher Madden, Monique Pairis-Garcia, Vishal Srivastava, Dipak Kathayat, Anand Kumar, Gireesh Rajashekara
Summary: This study investigated the differences in fecal and upper respiratory tract microbiota composition for groups of sows of different health status and from different farms. The results suggest that the farm of origin can affect microbial diversity and composition, and the health status of sows may impact the nasal microbiota composition.
Article
Environmental Sciences
Kay Bernard, Angela Davis, Ian M. Simpson, Vanessa L. Hale, Jiyoung Lee, Ryan J. Winston
Summary: This study aimed to detect the presence of SARS-CoV-2 in stormwater using RT-ddPCR, finding the virus in the majority of samples tested. The research also discovered that rainfall characteristics impact virus gene concentrations and different cities have varying levels of SARS-CoV-2 gene in stormwater.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Multidisciplinary Sciences
Ryan Mrofchak, Christopher Madden, Morgan V. Evans, William C. Kisseberth, Deepika Dhawan, Deborah W. Knapp, Vanessa L. Hale
Summary: This pilot study compared the urine and fecal microbiota of dogs with urothelial carcinoma (UC) and healthy controls. The results showed that dogs with UC had decreased microbial diversity and altered microbial composition in urine, but not in fecal samples. This study further supports the value of using dogs as a model for studying bladder cancer and urine microbiota.
Article
Virology
Patricia A. A. Boley, Patricia M. M. Dennis, Julia N. N. Faraone, Jiayu Xu, Mingde Liu, Xiaoyu Niu, Stormy Gibson, Vanessa Hale, Qiuhong Wang, Shan-Lu Liu, Linda J. Saif, Scott P. Kenney
Summary: Coronaviruses can cross species barriers and infect animals and humans. A sensitive and specific ELISA was developed to detect antibodies to SARS-CoV-2. The study found antibodies to SARS-CoV-2 in deer populations in Ohio, highlighting the need for surveillance programs to monitor susceptible wildlife species globally.
Article
Agriculture, Dairy & Animal Science
Margot Ehrlich, Christopher Madden, Dillon S. Mcbride, Jacqueline M. Nolting, Devra Huey, Scott Kenney, Qiuhong Wang, Linda J. Saif, Anastasia Vlasova, Patricia Dennis, Dusty Lombardi, Stormy Gibson, Alexis Mclaine, Sarah Lauterbach, Page Yaxley, Jenessa A. Winston, Dubraska Diaz-Campos, Risa Pesapane, Mark Flint, Jaylene Flint, Randy Junge, Seth A. Faith, Andrew S. Bowman, Vanessa L. Hale
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged as a global pandemic in late 2019, with a zoonotic spillover event identified as the presumed origin. Reports of SARS-CoV-2 infections in multiple animal species raised concerns about potential viral mutations and the development of new reservoir hosts. This study aimed to surveil for SARS-CoV-2 in various animal species in Ohio between May 2020 and August 2021 to understand transmission between animals and humans.
Article
Microbiology
Tessa H. C. Wilde, Rajni Kant Shukla, Christopher Madden, Yael Vodovotz, Amit Sharma, W. Scott Mcgraw, Vanessa L. Hale
Summary: It is essential to understand the infection and transmission risks of viruses in non-human primates, which can also infect humans. This study sought to find a field-friendly method for preserving viral RNA in primate fecal samples. The researchers found that DNA/RNA Shield was the most effective buffer for preserving SIV RNA over time in fecal samples.
Article
Microbiology
David Minich, Christopher Madden, Mauricio A. Navarro, Leo Glowacki, Kristen French-Kim, Willow Chan, Morgan Evans, Kilmer Soares, Ryan Mrofchak, Rushil Madan, Gregory A. Ballash, Krista LaPerle, Subhadeep Paul, Yael Vodovotz, Francisco A. Uzal, Margaret Martinez, Jennifer Hausmann, Randall E. Junge, Vanessa L. Hale
Summary: This study examines the gut microbiota in two lorikeet flocks with enteritis and identifies dysbiosis as a potential factor that contributes to susceptibility to enteritis. The findings provide insights into the permissive gut microbiota features for clostridial colonization and the host factors that shape responses to infection.