Impaired Clearance of Apoptotic Cells in Chronic Inflammatory Diseases: Therapeutic Implications

LC3-associated phagocytosis

(2014) Susana Romao et al.   Autophagy

Macrophages Engulfing Apoptotic Cells Produce Nonclassical Retinoids To Enhance Their Phagocytic Capacity

(2014) Z. Sarang et al.   JOURNAL OF IMMUNOLOGY

The Nuclear Receptor Nr4a1 Mediates Anti-Inflammatory Effects of Apoptotic Cells

(2014) N. Ipseiz et al.   JOURNAL OF IMMUNOLOGY

The lysosomal cathepsin protease CPL-1 plays a leading role in phagosomal degradation of apoptotic cells in Caenorhabditis elegans

(2014) Meng Xu et al.   MOLECULAR BIOLOGY OF THE CELL

Daidzein enhances efferocytosis via transglutaminase 2 and augmentation of Rac1 activity

(2014) Jia-Hau Yen et al.   MOLECULAR IMMUNOLOGY

Mfge8 promotes obesity by mediating the uptake of dietary fats and serum fatty acids

(2014) Amin Khalifeh-Soltani et al.   NATURE MEDICINE

Macrophage Plasticity in Skeletal Muscle Repair

(2014) Elena Rigamonti et al.   Biomed Research International

Milk fat globule-EGF factor 8 mediates the enhancement of apoptotic cell clearance by glucocorticoids

(2013) K Lauber et al.   CELL DEATH AND DIFFERENTIATION

Efferocytosis and Lung Disease

(2013) Alexandra L. McCubbrey et al.   CHEST

Enhanced Efferocytosis of Apoptotic Cardiomyocytes Through Myeloid-Epithelial-Reproductive Tyrosine Kinase Links Acute Inflammation Resolution to Cardiac Repair After Infarction

(2013) Elaine Wan et al.   CIRCULATION RESEARCH

Resolution phase lipid mediators of inflammation: agonists of resolution

(2013) Charles N. Serhan et al.   CURRENT OPINION IN PHARMACOLOGY

Liver X receptor modulators: a review of recently patented compounds (2009 – 2012)

(2013) Jon Loren et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity

(2013) Zaida G Ramirez-Ortiz et al.   NATURE IMMUNOLOGY

Liver X receptors: Emerging therapeutic targets for Alzheimer's disease

(2013) Rupinder K. Sodhi et al.   PHARMACOLOGICAL RESEARCH

The N-Terminus of CD14 Acts to Bind Apoptotic Cells and Confers Rapid-Tethering Capabilities on Non-Myeloid Cells

(2013) Leanne Thomas et al.   PLoS One

Autophagy genes promote apoptotic cell corpse clearance

(2012) Wei Zou et al.   Autophagy

Cell surface-expressed phosphatidylserine as therapeutic target to enhance phagocytosis of apoptotic cells

(2012) K Schutters et al.   CELL DEATH AND DIFFERENTIATION

The atypical chemokine receptor D6 controls macrophage efferocytosis and cytokine secretion during the resolution of inflammation

(2012) Ester Pashover-Schallinger et al.   FASEB JOURNAL

Liver X receptor and peroxisome proliferator-activated receptor as integrators of lipid homeostasis and immunity

(2012) Yoko Kidani et al.   IMMUNOLOGICAL REVIEWS

Annexin A2 and A5 Serve as New Ligands for C1q on Apoptotic Cells

(2012) Myriam Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

12/15-Lipoxygenase during the regulation of inflammation, immunity, and self-tolerance

(2012) Stefan Uderhardt et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Contrasting Inflammation Resolution during Atherosclerosis and Post Myocardial Infarction at the Level of Monocyte/Macrophage Phagocytic Clearance

(2012) Edward B. Thorp   Frontiers in Immunology

Retinoids produced by macrophages engulfing apoptotic cells contribute to the appearance of transglutaminase 2 in apoptotic thymocytes

(2011) Éva Garabuczi et al.   AMINO ACIDS

Autophagy enhanced phagocytosis of apoptotic cells by oridonin-treated human histocytic lymphoma U937 cells

(2011) Linghe Zang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Liver X Receptors in Atherosclerosis and Inflammation

(2011) Seung-Soon Im et al.   CIRCULATION RESEARCH

Intrarectal administration of milk fat globule epidermal growth factor-8 protein ameliorates murine experimental colitis

(2011) Shunji Ishihara   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome

(2011) Eugenia Morselli et al.   JOURNAL OF CELL BIOLOGY

Involvement of Adenosine A2A Receptors in Engulfment-Dependent Apoptotic Cell Suppression of Inflammation

(2011) K. Koroskenyi et al.   JOURNAL OF IMMUNOLOGY

Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein

(2011) Daeho Park et al.   NATURE

Differentiation and Glucocorticoid Regulated Apopto-Phagocytic Gene Expression Patterns in Human Macrophages. Role of Mertk in Enhanced Phagocytosis

(2011) Gábor Zahuczky et al.   PLoS One

Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells

(2011) J. Martinez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The life span-prolonging effect of Sirtuin-1 is mediated by autophagy

(2010) Eugenia Morselli et al.   Autophagy

PPAR  activation normalizes resolution of acute sterile inflammation in murine chronic granulomatous disease

(2010) R. Fernandez-Boyanapalli et al.   BLOOD

Saturated-efferocytosis generates pro-resolving CD11blow macrophages: Modulation by resolvins and glucocorticoids

(2010) Sagie Schif-Zuck et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease

(2010) C. Rose et al.   HUMAN MOLECULAR GENETICS

Clearance of apoptotic cells: implications in health and disease

(2010) Michael R. Elliott et al.   JOURNAL OF CELL BIOLOGY

Autoimmune Kidney Disease and Impaired Engulfment of Apoptotic Cells in Mice with Macrophage Peroxisome Proliferator-Activated Receptor   or Retinoid X Receptor   Deficiency

(2010) T. Roszer et al.   JOURNAL OF IMMUNOLOGY

Activation of autophagy during cell death requires the engulfment receptor Draper

(2010) Christina K. McPhee et al.   NATURE

The role of defective clearance of apoptotic cells in systemic autoimmunity

(2010) Luis E. Muñoz et al.   Nature Reviews Rheumatology

An Autophagy-Enhancing Drug Promotes Degradation of Mutant  1-Antitrypsin Z and Reduces Hepatic Fibrosis

(2010) T. Hidvegi et al.   SCIENCE

Successful Treatment With Retinoids in Patients With Lupus Nephritis

(2009) Koji Kinoshita et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

N-Acetylcysteine Inhibits RhoA and Promotes Apoptotic Cell Clearance during Intense Lung Inflammation

(2009) Changsuk Moon et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Defective Phagocytosis of Apoptotic Cells by Macrophages in Atherosclerotic Lesions of ob/ob Mice and Reversal by a Fish Oil Diet

(2009) Suzhao Li et al.   CIRCULATION RESEARCH

Induction of Transglutaminase 2 by a Liver X Receptor/Retinoic Acid Receptor α Pathway Increases the Clearance of Apoptotic Cells by Human Macrophages

(2009) Cédric Rébé et al.   CIRCULATION RESEARCH

Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR

(2009) Noelia A-Gonzalez et al.   IMMUNITY

Glucocorticoids Induce Protein S-Dependent Phagocytosis of Apoptotic Neutrophils by Human Macrophages

(2009) A. McColl et al.   JOURNAL OF IMMUNOLOGY

Transglutaminase 2 Is Needed for the Formation of an Efficient Phagocyte Portal in Macrophages Engulfing Apoptotic Cells

(2009) B. Toth et al.   JOURNAL OF IMMUNOLOGY

Dietary Soy Protein Isolate Attenuates Metabolic Syndrome in Rats via Effects on PPAR, LXR, and SREBP Signaling

(2009) Martin J. Ronis et al.   JOURNAL OF NUTRITION

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

PPAR-δ senses and orchestrates clearance of apoptotic cells to promote tolerance

(2009) Lata Mukundan et al.   NATURE MEDICINE

Apoptosis in the lung: induction, clearance and detection

(2008) P. M. Henson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Azithromycin Improves Macrophage Phagocytic Function and Expression of Mannose Receptor in Chronic Obstructive Pulmonary Disease

(2008) Sandra Hodge et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Prolactin induces MFG-E8 production in macrophages via transcription factor C/EBPβ-dependent pathway

(2008) Md. Monowar Aziz et al.   APOPTOSIS

Mertk Receptor Mutation Reduces Efferocytosis Efficiency and Promotes Apoptotic Cell Accumulation and Plaque Necrosis in Atherosclerotic Lesions of Apoe −/− Mice

(2008) Edward Thorp et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis

(2008) L. A. Truman et al.   BLOOD

Peroxisome Proliferator-Activated Receptors as Novel Targets in Lung Disease*

(2008) Maria G. Belvisi   CHEST

Thrombospondin-1 Deficiency Accelerates Atherosclerotic Plaque Maturation in ApoE −/− Mice

(2008) Rute Moura et al.   CIRCULATION RESEARCH

Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a “come-and-get-me” signal

(2008) David R. Gude et al.   FASEB JOURNAL

Requirement of Adaptor Protein GULP during Stabilin-2-mediated Cell Corpse Engulfment

(2008) Seung-Yoon Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms and consequences of macrophage apoptosis in atherosclerosis

(2008) Tracie Seimon et al.   JOURNAL OF LIPID RESEARCH

Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemia

(2008) Adelheid Kratzer et al.   JOURNAL OF LIPID RESEARCH

Phagocytosis of apoptotic cells

(2008) Simon P. Hart et al.   METHODS