期刊
AMERICAN JOURNAL OF KIDNEY DISEASES
卷 55, 期 2, 页码 344-347出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.ajkd.2009.06.012
关键词
Lupus; retinoid; nephritis
Lupus nephritis is a major manifestation of systemic lupus erythematosus. Treatment with such immunosuppressive agents as corticosteroids or cyclophosphamide can decrease the progression of lupus nephritis; however, these agents have potentially severe adverse reactions. Therefore, the development of new drugs with fewer side effects is needed. Here, we report 2 patients with lupus that were treated successfully with retinoids. Initially, both patients were treated with 60 mg/d of prednisolone. However, nephrotic syndrome was not improved. Subsequently, treatment with 10 mg/d of all-trans-retinoic acid was started orally and elicited a good response, showing a decrease in proteinuria. Although additional controlled clinical studies are needed to confirm these findings, we suggest that therapy using retinoids may represent a novel approach to the treatment of patients with lupus nephritis. Am J Kidney Dis 55: 344-347. (C) 2010 by the National Kidney Foundation, Inc.
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