期刊
TRENDS IN MICROBIOLOGY
卷 20, 期 9, 页码 419-428出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2012.06.002
关键词
tuberculosis; leprosy; T cells; innate immunity; genome wide screens; inflammation; protection
资金
- Netherlands' Organization of Scientific Research (NWO)
- Royal Netherlands' Academy of Arts and Sciences (KNAW)
- WOTRO/NACCAP
- Bill and Melinda Gates Foundation Grand Challenges in Global Health [GC6 74, GC12 82]
- EDCTP (AE-TBC project)
- Top Institute Pharma
- Netherlands Leprosy Relief Foundation
- Turing Foundation
- European Union's Seventh Framework Programme (FP7) for project NEWTBVAC
- European Union's Seventh Framework Programme (FP7) for project IDEA
- European Union's Seventh Framework Programme (FP7) for project ADITEC [280873]
Recent studies have uncovered new mechanisms by which the human immune system attempts to control infection and how pathogens elude these mechanisms. Mycobacterial infections are prime examples of chronic battle fields between host and pathogens. The study of tuberculosis and related mycobacterial infectious diseases such as leprosy have greatly aided in deciphering mechanisms of immune mediated protection and pathology in humans. Here we review recent insights into the role of newly discovered T cell subsets including Th17, Tregs and nonclassically restricted T cells in adaptive immunity to mycobacteria. The role of newly discovered innate immune mechanisms in tuberculosis and leprosy along with recent results from 'unbiased' genome-wide and functional genetic approaches, are deciphering critical host pathways in human infectious disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据