Article
Chemistry, Medicinal
SeongShick Ryu, Jung-Eun Park, Young Jin Ham, Daniel C. Lim, Nicholas P. Kwiatkowski, Do-Hee Kim, Debabrata Bhunia, Nam Doo Kim, Michael B. Yaffe, Woolim Son, Namkyoung Kim, Tae-Ik Choi, Puspanjali Swain, Cheol-Hee Kim, Jin-Young Lee, Nathanael S. Gray, Kyung S. Lee, Taebo Sim
Summary: This study successfully designed and synthesized a series of macrocyclic peptidomimetics with high selectivity and inhibitory activities against Plk1's PBD. Compound 16e showed more potent inhibitory activity than the previous PMQSpTPL. The pi-π stacking interaction between 16a and Arg516 revealed a new design strategy, and PEGylation of 16h caused delocalization and mitotic failure of Plk1. Furthermore, the number of phospho-H3-positive cells in zebrafish embryos correlated with the amount of 16a. These findings suggest that macrocyclic peptidomimetics can serve as valuable templates for potent and novel Plk1-PBD inhibitors.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Immunology
Zhenqiang Gao, Cuiting Zheng, Yaqi Xing, Xiyu Zhang, Yunfei Bai, Chen Chen, Yuanyuan Zheng, Wen Wang, Hongbing Zhang, Yan Meng
Summary: In sepsis, Plk-1 promotes the development of SIMD. Inhibition of Plk-1 improves LPS-induced myocardial injury and inflammation, and enhances the survival rate of mice. Plk-1 inhibition also impedes NF-κB signal pathway activation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Styliani Iliaki, Rudi Beyaert, Inna S. Afonina
Summary: PLK1 is a Ser/Thr kinase that plays crucial roles in cell cycle regulation, DNA damage response, apoptosis, and cancer progression. Overexpression of PLK1 is associated with poor prognosis in cancer, making it an attractive therapeutic target.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Respiratory System
Rongrong Chen, Hongfei Wang, Cuiting Zheng, Xiyu Zhang, Li Li, Shengwei Wang, Hongyu Chen, Jing Duan, Xian Zhou, Haiyong Peng, Jing Guo, Anchen Zhang, Feifei Li, Wang Wang, Yu Zhang, Jun Wang, Chen Wang, Yan Meng, Xinling Du, Hongbing Zhang
Summary: The study aimed to investigate the role of the mitotic regulator Polo-like kinase 1 (PLK1) in the development of pulmonary hypertension (PH). The results showed that hypoxia stimulated the expression of PLK1 through the induction of HIF1a and RELA. Overexpression of PLK1 was essential for the development of PH, suggesting that PLK1 could be a potential druggable target for PH.
RESPIRATORY RESEARCH
(2023)
Article
Medicine, Research & Experimental
Yue Zhou, Lei Xu, Zhangding Wang, Hongwen Liu, Xiang Zhang, Chuanjun Shu, Meng Zhang, Ting Wang, Xinyun Xu, Xiaohong Pus, Jian He, Pin Wang, Yudong Qiu, Guifang Xu, Xiaoping Zou, Yun Zhu, Lei Wang
Summary: PLK1 is identified as a mutual target derived from tumor cells and stroma in CCA, playing a crucial role in malignant proliferation of tumor cells and regulation of stroma production in CAFs. The PLK1 inhibitor (Ro3280) loaded dual-targeting drug delivery system (AA-HA-ODA) shows promising anticancer efficacy at cellular and in vivo levels.
Article
Biochemistry & Molecular Biology
Dandan Liu, Xiangmin Ding, Jian Ding, Jing Sun
Summary: This study analyzes the assemblies formed by charged polyelectrolytes via electrostatic interactions and demonstrates the superior stability of the polypeptoid/folic acid complex as compared to other polymers. By encapsulating the anticancer drug in the complex vesicles, enhanced therapeutic efficacy is achieved through receptor-mediated endocytosis. pH-responsive morphological transformations were also observed.
Article
Chemistry, Multidisciplinary
Mitsuru Naito, Hiroyuki Chaya, Kazuko Toh, Beob Soo Kim, Kotaro Hayashi, Shigeto Fukushima, Tetsuya Nagata, Takanori Yokota, Kazunori Kataoka, Kanjiro Miyata
Summary: The researchers found that chemical modification of oligonucleotides to have higher negative charges facilitated the formation of polyion pairs between the oligonucleotide and bPEG-PLys under harsh biological conditions, leading to enhanced blood circulation of uPICs.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Physical
Maksym Odnoroh, Olivier Coutelier, Christophe Mingotaud, Mathias Destarac, Jean-Daniel Marty
Summary: Random insertion of vinylphosphonic acid (VPA) units into PEG-PAA block copolymer improves the chemical stability and properties of hybrid nanoobjects obtained from the complexation of the copolymer with metal ions.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Polymer Science
Asmariah Ahmad, Teruki Nii, Takeshi Mori, Yoshiki Katayama, Masanori Toyofuku, Akihiro Kishimura
Summary: This study develops novel nanovehicles for polymyxin-type antibiotics using a polyion complex (PICs) system. The importance of guanidine moieties in enhancing the interaction between catiomer and colistimethate sodium (CMS) is demonstrated. The ratio of guanidine residues determines the formation of micellar or vesicular PIC nanostructures. The encapsulation efficiency of CMS depends on the guanidinium modification ratio.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Chemistry, Medicinal
Jifa Zhang, Lele Zhang, Jiaxing Wang, Liang Ouyang, Yuxi Wang
Summary: PLK1 plays an important role in cellular functions and is associated with cancer prognosis and cell proliferation. Although several inhibitors have entered clinical trials, their poor specificity has hindered their development. Recent research has discovered PLK1 inhibitors with higher selectivity and improved characteristics. This review emphasizes the structure-activity relationships of these inhibitors, providing insights for the development of antitumor drugs.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Liming Peng, Christophe Mingotaud, Florence Benoit-Marquie, Jean-Daniel Marty
Summary: Iron ions, as traditional Fenton reaction catalysts, have poor stability in aqueous solutions. Researchers have developed nanocatalysts with improved stability by complexing iron ions with double-hydrophilic block copolymers. These colloidal structures are chemically stable in a pH range of 3-7 and can be used for degrading organic pollutants in wastewater.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Radostina Kalinova, Kirilka Mladenova, Svetla Petrova, Jordan Doumanov, Ivaylo Dimitrov
Summary: The synthesis of well-defined multifunctional polymers is critical for the development of complex materials in biomedical applications. In this study, a novel multi-amino-functional diblock copolymer was successfully synthesized for potential gene and drug delivery applications. The copolymer was obtained through one-step modification of an alkyne-functional polycarbonate-based precursor, resulting in a hydrophilic block copolymer with densely grafted primary amine side groups. Additionally, polyion complex micelles with tunable surface charge, decorated with cell targeting moieties, were obtained through direct mixing of the multi-amino-functional block copolymer and an oppositely charged block copolymer.
Review
Chemistry, Multidisciplinary
Yanyan Zhu, Shoupeng Cao, Meng Huo, Jan C. M. van Hest, Hailong Che
Summary: Polymersomes are highly stable vesicular nanostructures self-assembled from amphiphilic block copolymers, and have various applications in drug delivery, nanomedicine, biological nanoreactors, and artificial cells. However, polymersomes prepared with high molecular weight components typically exhibit low permeability. This review focuses on the design and strategies for fabricating permeable polymersomes, and highlights their applications and challenges in the field of biomedical utilities.
Article
Biochemical Research Methods
Jinxuan He, Zhixiang Mou, Yuchen Tian, Yiyan Zhang, Tianjun Guan, Qixian Chen, Lan Chen
Summary: A polymeric siRNA conjugate was developed to overcome biological barriers for delivering siRNA into cells, showing potential for cancer treatment and hyperparathyroidism. The conjugate exhibited efficient release of active siRNA in the cytosol, providing a promising platform for RNA interference therapeutics and biomimetic materials.
BIOCONJUGATE CHEMISTRY
(2021)
Review
Oncology
Chuanyong Zhang, Chuangye Ni, Hao Lu
Summary: PLK2 plays an important role in the cell cycle, cell differentiation, and maintaining neural homeostasis. Dysfunction of PLK2 can lead to cell cycle disorders and developmental retardation. Additionally, PLK2 may promote cell survival or apoptosis in response to stress stimuli. However, research on the role of PLK2 in immunity to viral infection is limited compared to other family members.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hiroyuki Chaya, Mitsuru Naito, Masaru Cho, Kazuko Toh, Kotaro Hayashi, Shigeto Fukushima, Yuichi Yamasaki, Kazunori Kataoka, Kanjiro Miyata
Summary: The study investigated how the polymerization degree of lysine affected the stability of uPICs in the bloodstream. A smaller polymerization degree resulted in a decreased association constant and prolonged blood retention of free bPEG-PLys. Therefore, the lysine polymerization degree can influence the dynamic stability of uPICs.
Article
Engineering, Biomedical
Naoto Yoshinaga, Satoshi Uchida, Anjaneyulu Dirisala, Mitsuru Naito, Kyoko Koji, Kensuke Osada, Horacio Cabral, Kazunori Kataoka
Summary: The study successfully stabilized Polyplex micelles (PMs) by developing RNA oligonucleotide (OligoRNA) derivatives to bridge mRNA and polycation, improving their stability against polyion exchange reaction and ribonuclease attack. This bridging strategy provides a new approach for mRNA delivery by enhancing the efficiency of mRNA introduction in cultured cells and mouse lungs after intratracheal administration.
ADVANCED HEALTHCARE MATERIALS
(2022)
Editorial Material
Chemistry, Multidisciplinary
Nicholas A. Kotov, Deji Akinwande, C. Jeffrey Brinker, Jillian M. Buriak, Warren C. W. Chan, Xiaodong Chen, Manish Chhowalla, William Chueh, Sharon C. Glotzer, Yury Gogotsi, Mark C. Hersam, Dean Ho, Tony Hu, Ali Javey, Cherie R. Kagan, Kazunori Kataoka, Il-Doo Kim, Shuit-Tong Lee, Young Hee Lee, Luis M. Liz-Marzan, Jill E. Millstone, Paul Mulvaney, Andre E. Nel, Peter Nordlander, Wolfgang J. Parak, Reginald M. Penner, Andrey L. Rogach, Mathieu Salanne, Raymond E. Schaak, Ajay K. Sood, Molly Stevens, Vladimir Tsukruk, Andrew T. S. Wee, Ilja Voets, Tanja Weil, Paul S. Weiss
Review
Pharmacology & Pharmacy
Sabina Quader, Kazunori Kataoka, Horacio Cabral
Summary: CNS tumors are highly lethal and treatment-resistant, mainly due to the difficulty of delivering drugs to the brain tumor site. Supramolecular nanomedicines show promise in addressing this challenge and improving brain tumor targeting.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Yuto Honda, Sayaka Onodera, Hiroyasu Takemoto, Noor Faizah Che Harun, Takahiro Nomoto, Makoto Matsui, Keishiro Tomoda, Yudi Sun, Yutaka Miura, Nobuhiro Nishiyama
Summary: This study aims to develop a technology to control the activity of small interfering RNA (siRNA) in a thermo-responsive manner, even at temperatures close to body temperature. By conjugating siRNA with a thermally responsive copolymer, the activity of siRNA can be enhanced based on temperature changes. This technique offers a promising approach to selectively induce therapeutic effects of siRNA in vivo.
PHARMACEUTICAL RESEARCH
(2023)
Article
Engineering, Biomedical
Haochen Guo, Wen Xu, Takahiro Nomoto, Kaito Kanamori, Yan Ming Voon, Yuto Honda, Naoki Yamada, Hiroyasu Takemoto, Makoto Matsui, Nobuhiro Nishiyama
Summary: Cancer cells overexpress LAT1 to take up neutral amino acids, and targeting LAT1 with drug delivery systems has promising potential for cancer diagnosis and therapy. This study developed polymers with Met or Cys structures to test their affinity with LAT1. The Met-modified polymers exhibited higher cellular uptake efficiency in an LAT1-selective manner and showed tumor-selective accumulation in vivo, suggesting their potential for LAT1-targeting drug delivery systems.
Article
Engineering, Biomedical
Fawad Ur Rehman, Yang Liu, Meng Zheng, Bingyang Shi
Summary: Exosome application is a promising nanotechnology discipline for disease therapy and diagnosis. Due to their natural properties, such as efficient drug delivery and blood-brain barrier traversing ability, exosomes have gained attention in clinical translation for brain diseases treatment.
Article
Oncology
Takahiro Nomoto, Kana Komoto, Tomoya Nagano, Takuya Ishii, Haochen Guo, Yuto Honda, Shun-ichiro Ogura, Masahiro Ishizuka, Nobuhiro Nishiyama
Summary: This study suggests that the use of a polymeric iron chelator can enhance the effectiveness of 5-ALA-induced photodynamic therapy by modulating the intratumoral iron levels. The polymeric iron chelator effectively deactivates intracellular labile iron and increases the accumulation of PpIX, improving the cytotoxicity upon photoirradiation.
Article
Polymer Science
Yasuhiro Nakagawa, Kotaro Ushidome, Keita Masuda, Kazunori Igarashi, Yu Matsumoto, Tatsuya Yamasoba, Yasutaka Anraku, Madoka Takai, Horacio Cabral
Summary: Multi-arm star-shaped block copolymers consisting of poly(furfuryl glycidol) (PFG) and poly(ethylene glycol) (PEG) were developed for drug delivery. The block copolymers showed controlled sizes and effectively loaded and released model drugs. When injected intravenously, they exhibited prolonged blood circulation, indicating their potential as long-circulating nanocarriers.
Article
Nanoscience & Nanotechnology
Debabrata Maiti, Hao Yu, Yuki Mochida, Seongyeon Won, Shinichi Yamashita, Mitsuru Naito, Kanjiro Miyata, Hyun Jin Kim
Summary: This study developed terbium-rose bengal coordination nanocrystals (T-RBNs) through solvothermal treatment for X-ray-induced photodynamic therapy (X-PDT). T-RBNs showed high ROS production efficiency and induced significant cell death in breast cancer cells under low-dose X-ray irradiation. T-RBNs have the potential to be used as a promising Sc/Ps platform for advanced cancer therapy.
ACS APPLIED BIO MATERIALS
(2023)
Editorial Material
Chemistry, Multidisciplinary
Warren C. W. Chan, Natalie Artzi, Chunying Chen, Xiaodong Chen, Dean Ho, Tony Hu, Kazunori Kataoka, Luis M. Liz-Marzan, Rahmi Oklu, Wolfgang J. Parak
Article
Biochemical Research Methods
Ashok Kumar Jangid, Sungjun Kim, Hyun Jin Kim, Kyobum Kim
Summary: Researchers have designed a biomaterial-mediated ex vivo surface engineering technique to enhance the targeting selectivity and anticancer efficacy of Natural Killer (NK) cells against liver cancer cells. By decorating the NK cell membrane with cancer recognition ligands, the modified NK cells demonstrated significant tumor cell binding and increased anticancer effects. This approach provides a novel engineering strategy for the treatment of liver cancers.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Hsi-Kai Tsou, Cheng-Hsin Wu, Long Yi Chan, Kazunori Kataoka, Nanae Itokazu, Minoru Tsuzuki, Hsuan Hu, Guan-Yu Zhuo, Keiji Itaka, Chin-Yu Lin
Summary: Large-area craniofacial defects pose a challenge for orthopaedists. In order to develop a safe and effective tissue engineering strategy, cytokines and chemokines can be utilized to attract endogenous stem cells for bone regeneration. The combination of BMP2 and TGF-beta3 mRNA nanomedicine promotes bone formation and provides an alternative cell-free tissue engineering method for craniofacial defect healing.
Article
Materials Science, Biomaterials
Yukiya Kitayama, Takuya Yamada, Kentaro Kiguchi, Aoi Yoshida, Shuhei Hayashi, Hiroaki Akasaka, Kazunori Igarashi, Yuya Nishimura, Yu Matsumoto, Ryohei Sasaki, Eri Takano, Hirobumi Sunayama, Toshifumi Takeuchi
Summary: A novel stealth radiation sensitizer based on Au-embedded molecularly imprinted polymer nanogels (Au MIP-NGs) was developed for low-dose X-ray radiation therapy. It showed good affinity and selectivity towards human serum albumin, and improved the efficiency of pancreatic cancer treatment in mouse models.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Meeting Abstract
Oncology
Hiroaki Kinoh, Sabina Quader, Horacio Cabral, Kazunori Kataoka