SimReg1 is a master switch for biosynthesis and export of simocyclinone D8 and its precursors

β-Glucuronidase as a Sensitive and Versatile Reporter in Actinomycetes

(2011) Maksym Myronovskyi et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Structures of the TetR-like Simocyclinone Efflux Pump Repressor, SimR, and the Mechanism of Ligand-Mediated Derepression

(2011) Tung B.K. Le et al.   JOURNAL OF MOLECULAR BIOLOGY

The regulation of the secondary metabolism of Streptomyces: new links and experimental advances

(2011) Gilles P. van Wezel et al.   NATURAL PRODUCT REPORTS

In Vivo and In Vitro Patterns of the Activity of Simocyclinone D8, an Angucyclinone Antibiotic from Streptomyces antibioticus

(2009) L. M. Oppegard et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Use of the native flp gene to generate in-frame unmarked mutations in Streptomyces spp.

(2009) Nathan Zelyas et al.   GENE

Anti-proliferative effects of simocyclinone D8 (SD8), a novel catalytic inhibitor of topoisomerase II

(2009) Ahad A. Sadiq et al.   INVESTIGATIONAL NEW DRUGS

Coupling of the biosynthesis and export of the DNA gyrase inhibitor simocyclinone inStreptomyces antibioticus

(2009) Tung B. K. Le et al.   MOLECULAR MICROBIOLOGY

Autoregulation of antibiotic biosynthesis by binding of the end product to an atypical response regulator

(2009) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8, Bound to DNA Gyrase

(2009) M. J. Edwards et al.   SCIENCE

Characterization of a negative regulator AveI for avermectin biosynthesis in Streptomyces avermitilis NRRL8165

(2008) Lei Chen et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Coordination of export and glycosylation of landomycins inStreptomyces cyanogenusS136

(2008) Iryna Ostash et al.   FEMS MICROBIOLOGY LETTERS

Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production inStreptomyces coelicolor

(2008) Sean O'Rourke et al.   MOLECULAR MICROBIOLOGY