Article
Biochemistry & Molecular Biology
Huinan Suo, Mubashir Hussain, Hua Wang, Nuoya Zhou, Juan Tao, Hao Jiang, Jintao Zhu
Summary: The study developed an antibiotic-free hydrogel-based biomaterial for the management of chronic bacteria-infected wounds, utilizing an antimicrobial peptide as a cross-linking agent to achieve acidity-triggered release of AMP, along with high biostability and enhanced mechanical strength.
Review
Chemistry, Multidisciplinary
Yongping Liang, Jiahui He, Baolin Guo
Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.
Article
Chemistry, Physical
Soo-Bin Joo, Muhammad Gulfam, Sung-Han Jo, Yi-Jun Jo, Trung Thang Vu, Sang-Hyug Park, Yeong-Soon Gal, Kwon Taek Lim
Summary: In this study, we developed injectable hydrogels with high biocompatibility and fast absorbency. The hydrogels were engineered through a specific chemical reaction to create porous structures. By adjusting the ratio of the raw materials, hydrogels with different porosity, gelation time, mechanical strength, and swelling ratios were obtained. These hydrogels exhibited rapid swelling and a high swelling ratio, able to encapsulate and release drugs without cytotoxicity.
Article
Biochemistry & Molecular Biology
Zhen Wang, Kaiyue Li, Qianru Xu, Guoliang Fu, Haiying Li, Wenzhi Yang
Summary: A novel wound dressing that possesses antibacterial properties and accelerates skin wound repair was developed. The dressing has a three-dimensional cavity structure, good swelling and moisturizing ability, no cytotoxicity, and certain antibacterial capability. In rat skin wound healing, the dressing can reduce inflammation and accelerate wound closure.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biotechnology & Applied Microbiology
Zhiwei Peng, Huai Xue, Xiao Liu, Shuguang Wang, Guodong Liu, Xinghai Jia, Ziqiang Zhu, Moontarij Jahan Orvy, Yin Yang, Yunqing Wang, Dong Zhang, Lei Tong
Summary: Researchers have developed a tough and adhesive biomimetic hydrogel made of hyaluronic acid methacryloyl and poly(N-hydroxyethyl acrylamide). This hydrogel shows high mechanical strength and adhesiveness, and exhibits good biocompatibility and blood compatibility. This study has significant implications for wound repair.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Yangqian Hou, Yu Tian, Jiakun Tian, Jiali Shi, Hongwei Zhao, Jun Hu, Yi Zhang
Summary: Researchers have developed anti-cancer peptide/PVA double-network hydrogels for treating melanoma, which possess ideal mechanical properties and demonstrate good anti-cancer efficacy without toxicity to normal cells. These hydrogels also promote wound healing and have potential for direct treatment of malignant melanomas as well as prevention of recurrence and bacterial infection.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Nathan Lagneau, Pierre Tournier, Boris Halgand, Yves Maugars, Catherine Le Visage, Vianney Delplace
Summary: The cellular microenvironment is crucial for cell functions, thus biomaterials such as hydrogels are used to mimic the cellular microenvironment for cell encapsulation, delivery, and 3D culture. However, the effects of cell-material interactions and the ability to control the mechanical and biochemical properties of hydrogels remain to be fully understood.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Environmental
Yuxin Zhang, Can Wu, Yuanyuan Xu, Zhiyu Chen, Lei Li, Jiali Chen, Ning Ning, Yi Guo, Zeyu Yang, Xuefeng Hu, Jieyu Zhang, Yunbing Wang
Summary: In this study, advanced hydrogels with stable conductivity and effective antibacterial properties were developed by incorporating antibacterial terbium ions into the hydrogel network. The hydrogel showed tremendous antibacterial effects and biomimetic conductivity, which enabled electrical stimulation (ES) treatment for diabetic ulcers (DUs) and accelerated wound healing.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Applied
Hongjuan Weng, Weibin Jia, Min Li, Zonggang Chen
Summary: Novel NSC-OHA-based hydrogels with self-healing and injectable properties were fabricated, and the mechanical behavior and bioactivities were regulated by the addition of Ca2+ or PEG1. The hydrogels showed improved biocompatibility, hemostasis, and wound healing abilities, making them promising for medical applications.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Multidisciplinary
Shangzhi Li, Qi Dong, Xiaotong Peng, Yun Chen, Hongjun Yang, Weilin Xu, Yanteng Zhao, Pu Xiao, Yingshan Zhou
Summary: A self-healing nanocomposite hydrogel based on hyaluronic acid has been developed, which exhibits good strength, self-healing ability, and the potential to load platelet-rich plasma (PRP) for promoting skin wound healing.
Article
Polymer Science
Emine Salva, Ahmet Enes Akdag, Saadet Alan, Sema Arisoy, Fatma Julide Akbuga
Summary: The 3D polymeric network structure of chitosan/hyaluronic acid/honey hydrogels, which imitates the extracellular matrix, promotes cell growth and differentiation and exhibits excellent wound-healing abilities. The hydrogels were characterized and their properties, such as water content, water uptake capacities, and porosity, were investigated. The addition of honey altered the interaction between chitosan and hyaluronic acid, resulting in changes in the hydrogel's properties. The honey-containing hydrogels showed decreased porosity and slightly decreased water-uptake capacity, but increased cell adhesion and proliferation. In vivo studies demonstrated that honey addition accelerated wound healing. These findings highlight the potential of honey-loaded chitosan-hyaluronic acid hydrogels in wound healing applications.
Review
Biotechnology & Applied Microbiology
Fei Fan, Sanjoy Saha, Donny Hanjaya-Putra
Summary: Hydrogels play a crucial role in wound healing by supporting a hydrated environment and promoting better healing outcomes through the incorporation of biomolecules and supporting cells. Various types of hydrogels have been developed and modified to match different stages of wound healing, with challenges related to adoption and future perspectives discussed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Applied
Punnida Nonsuwan, Preeyaporn Plaimee Phiboonchaiyanan, Namon Hirun, Pakorn Kraisit
Summary: A Pul-derivative hydrogel was developed by introducing methacrylate groups and beta-cyclodextrin to improve mechanical properties and increase curcumin solubility. The hydrogel exhibited enhanced curcumin solubility, biocompatibility, and accelerated wound healing.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Multidisciplinary
Yaodong Zhao, Bingcheng Yi, Jilin Hu, Dongjie Zhang, Guotai Li, Yun Lu, Qihui Zhou
Summary: In order to prevent microbial invasion, inhibit scar formation, and promote wound healing, a thermo-responsive and tissue-adhesive hydrogel dressing was developed. This dressing, based on N-dimethylbisacrylamide (NIPAM) and glutaraldehyde (GTA) cross-linked hyaluronic acid (HA), showed self-contraction and tissue adhesiveness, aiding wound closure via mechanical stretch. It also demonstrated hemocompatibility and cytocompatibility, accelerating wound healing. In vivo experiments using a mouse model showed that the hydrogel dressing achieved sutureless closure at the early stage of wound healing and promoted healing by reducing inflammation, promoting angiogenesis, and reducing collagen deposition.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Tong Guan, Jiayang Li, Chunying Chen, Ying Liu
Summary: This review introduces the advantages of self-assembling peptide-based hydrogels in wound treatment and emphasizes their precise control capabilities during different stages of wound healing. Furthermore, recent advancements in multifunctional self-assembling peptide-based hydrogels that can regulate and remodel the wound immune microenvironment are summarized.
Editorial Material
Chemistry, Multidisciplinary
Eun Hye Kim, Jongwon Lee, Gijung Kwak, Hochung Jang, Hyosuk Kim, Haeun Cho, Yeongji Jang, Jiwoong Choi, Sung Gil Chi, Kwangmeyung Kim, Ick Chan Kwon, Yoosoo Yang, Sun Hwa Kim
Summary: This study developed a dual-targeting drug delivery system (Pep-21) that can inhibit miR-21 activity in both cancer cells and tumor-associated macrophages (TAMs). The study found that Pep-21 treatment reduced tumor cell migration, reprogrammed immunosuppressive TAMs into immunostimulatory macrophages, and restrained tumor progression.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Analytical
Yurim Kim, Hong Yeol Yoon, Il Keun Kwon, Inchan Youn, Sungmin Han
Summary: Heart rate variability is closely related to cancer pain and can be used as a tool for assessing pain.
Article
Multidisciplinary Sciences
Hyosuk Kim, Byeong-Wook Song, Soon-Jung Park, Seong Woo Choi, Hanbyeol Moon, Ki-Chul Hwang, Sun-Woong Kang, Sung-Hwan Moon, Yoosoo Yang, Ick Chan Kwon, Sun Hwa Kim
Summary: This study proposes an extracellular vesicle (EV)-guided, nonviral, direct lineage conversion strategy to enhance the transdifferentiation of fibroblasts to induced cardiomyocyte-like cells (iCMs). The resulting iCMs show typical cardiac features and have gene expression profiles similar to cardiomyocytes. This method achieves a high conversion efficiency (>60%) and establishes a more accessible platform for generating specialized somatic cells through direct lineage conversion.
Article
Pharmacology & Pharmacy
Jeongrae Kim, Yongwhan Choi, Suah Yang, Jaewan Lee, Jiwoong Choi, Yujeong Moon, Jinseong Kim, Nayeon Shim, Hanhee Cho, Man Kyu Shim, Sangmin Jeon, Dong-Kwon Lim, Hong Yeol Yoon, Kwangmeyung Kim
Summary: By using DOX as an ICD inducer and PLGA-based nanoparticles for controlled release, continuous ICD induction and reduced cell viability can be achieved. Direct injection of DP-NPs allows DOX to remain in the tumor site for 14 days and enhances antitumor immunity, with minimal toxicities.
Article
Engineering, Biomedical
Hyosuk Kim, Hyun-Ju Park, Hyo Won Chang, Ji Hyun Back, Su Jin Lee, Yae Eun Park, Eun Hye Kim, Yeonsun Hong, Gijung Kwak, Ick Chan Kwon, Ji Eun Lee, Yoon Se Lee, Sang Yoon Kim, Yoosoo Yang, Sun Hwa Kim
Summary: The highly immunosuppressive tumor microenvironment with protumoral immune cells accelerates malignant transformation and treatment resistance. Tumor-associated macrophages (TAMs), as the predominant immune cells in tumors, play a crucial role in regulating the immunosuppressive tumor microenvironment. This study explores an exosome-guided direct reprogramming of tumor-supportive M2-polarized TAMs into tumor-attacking M1-type macrophages, potentially enhancing antitumor immunity.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Wan Su Yun, Man Kyu Shim, Seungho Lim, Sukyung Song, Jinseong Kim, Suah Yang, Hee Sook Hwang, Mi Ra Kim, Hong Yeol Yoon, Dong-Kwon Lim, In-Cheol Sun, Kwangmeyung Kim
Summary: In this study, a promising approach of using mesenchymal stem cells (MSCs) for the deep tumor delivery of gold nanorods (AuNRs) has been demonstrated. The AuNRs are modified and chemically conjugated to the MSCs, allowing deep tissue penetration and enhanced photothermal effect against colon tumor growth. This provides a potential method for effective photothermal therapy.
Article
Pharmacology & Pharmacy
Hanhee Cho, Man Kyu Shim, Yujeong Moon, Sukyung Song, Jinseong Kim, Jiwoong Choi, Jeongrae Kim, Youngjoo Lee, Jung Yeon Park, Yongju Kim, Cheol-Hee Ahn, Mi Ra Kim, Hong Yeol Yoon, Kwangmeyung Kim
Summary: This study proposes tumor-specific monomethyl auristatin E (MMAE) prodrug nanoparticles for safe and effective chemotherapy. The nanoparticles efficiently accumulate within tumor tissues and inhibit tumor cell growth by releasing MMAE. Meanwhile, these nanoparticles maintain a non-toxic inactive state in normal tissues, reducing the toxicity of MMAE.
Article
Chemistry, Multidisciplinary
Jangwook Lee, Kwangmeyung Kim, Ick Chan Kwon, Kuen Yong Lee
Summary: A new anticancer strategy exploiting abnormal cancer cell metabolism is reported. An antiglycolytic amphiphilic polymer is synthesized and regulates glucose metabolism to inhibit tumor growth. This strategy highlights the necessity for safe and effective cancer treatment without conventional drugs.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Karina Negron, Gijung Kwak, Heng Wang, Haolin Li, Yi-Ting Huang, Shun-Wen Chen, Betty Tyler, Charles G. G. Eberhart, Justin Hanes, Jung Soo Suk
Summary: Introduces drug delivery nanoparticles (NPs) made from safe materials for intracranial administration. Coating the PLGA NPs with F127 poloxamers enhances their distribution in rat brains, including orthotopically-established brain tumors. Additionally, lyophilized F127/PLGA NPs and osmotically-driven enlargement of brain tissue porosity further enhance particle dissemination and prolonged drug release.
Article
Chemistry, Physical
Ashita Nair, Kaila Javius-Jones, Jason Bugno, Michael J. Poellmann, Narsimha Mamidi, In-San Kim, Ick Chan Kwon, Heejoo Hong, Seungpyo Hong
Summary: Nanoscale drug delivery systems combining natural exosomes and synthetic dendrimers have been developed to improve the selectivity and reduce the toxicity of cancer treatment. These hybrid nanoparticles exhibit advantageous biological properties and have shown enhanced delivery and downregulation of gene and protein targets in cancer cells.
CHEMISTRY OF MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Andre-Rene Blaudszun, Woo Jun Kim, Wooram Um, Hong Yeol Yoon, Man Kyu Shim, Kwangmeyung Kim
Summary: This study proposes a combinational photodynamic and cancer immunotherapy using adoptive transfer of photosensitizer-loaded cytotoxic T cells. The loaded T cells efficiently produce reactive oxygen species under visible light irradiation and significantly inhibit tumor growth in a murine lymphoma model.
Article
Cell Biology
Gijung Kwak, Olesia Gololobova, Neeraj Sharma, Colin Caine, Marina Mazur, Kathleen Mulka, Natalie E. West, George M. Solomon, Garry R. Cutting, Kenneth W. Witwer, Steven M. Rowe, Michael Paulaitis, George Aslanidi, Jung Soo Suk
Summary: Clinical implementation of inhaled gene therapy using adeno-associated virus (AAV) vector has been challenging due to difficulty in transducing lung airway cells. However, by combining AAV serotype 6 (AAV6) with extracellular vesicles (EVs), researchers have discovered a method that greatly enhances gene expression in respiratory cells, offering a safe and effective treatment strategy.
JOURNAL OF EXTRACELLULAR VESICLES
(2023)
Article
Materials Science, Biomaterials
Divya Rao, Gijung Kwak, Heng Wang, Charles G. G. Eberhart, Justin Hanes, Jung Soo Suk
Summary: We introduce a new gene delivery platform based on bioreducible polymer, which can achieve widespread transgene expression in multiple brain regions with therapeutic relevance through intracranial convection-enhanced delivery. Compared to nonbiodegradable nanoparticles, our bioreducible nanoparticles significantly enhance gene delivery efficacy both in vitro and in vivo by releasing gene payloads preferentially inside cells. Surprisingly, our platform exhibits competitive gene delivery efficacy in a neuron-rich brain region compared to a viral vector that has shown positive outcomes in previous and current clinical investigations. Therefore, our platform may serve as an attractive alternative for intracranial gene therapy of neurological disorders.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Pharmacology & Pharmacy
Gijung Kwak, Daiheon Lee, Jung Soo Suk
Summary: Thanks to comprehensive preclinical studies, novel delivery strategies are bringing us closer to the clinical translation of lung gene therapy by overcoming biological barriers. However, careful interpretation and validation of preclinical findings are needed for meaningful therapeutic outcomes in humans. Tailored and relevant strategies should be selected and implemented based on specific therapeutic applications and goals.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Materials Science, Biomaterials
Sanghyo Park, Hyungkyu Park, Chaewon Park, Wan Su Yun, Soonjae Hwang, Hong Yeol Yoon, Ick Chan Kwon, Kwangmeyung Kim, Jaehong Key
Summary: A simple method was developed to enhance the delivery efficiency of doxorubicin in a lung metastasis model by manipulating the size, shape, loading content, and biodegradability of the drug delivery system. The system exhibited high drug release and delivered doxorubicin to lung cancer cells with minimal off-target effects, showing comparable anticancer efficacy to the free drug.
BIOMATERIALS SCIENCE
(2022)
