Article
Chemistry, Physical
Xianghan Zhang, Sumei Zhao, Zhiqing Gao, Jialin Zhou, Yuqiong Xia, Jie Tian, Changhong Shi, Zhongliang Wang
Summary: Cancer phototheranostics using mitochondria-targeted NIR cyanines encapsulated in liposomal bilayers showed promising results in balancing hydrophilicity and hydrophobicity, as well as improving tumor cell uptake through a bioorthogonal-mediated targeting strategy. The CyBI7-LPB probe exhibited excellent tumor targeting and anti-tumor therapy outcomes in experimental settings.
Article
Engineering, Environmental
Zhuang Hu, Ruihan Li, Xinyue Cui, Changjun Hu, Zilin Chen
Summary: This study reports the development of a tridentate molecular probe called PROTAC-Cy7, which integrates a warhead that binds to MCL-1, the E3 ligase ligand pomalidomide, and a heptamethine cyanine linker into the same scaffold. Bovine serum albumin nanoparticles (NPs) were used to manufacture water-insoluble PROTAC-Cy7. These NPs demonstrated tumor targeting and efficient degradation of MCL-1 through specific binding to MCL-1 receptors. Moreover, PROTAC-Cy7@BSA NPs showed excellent performance in near-infrared-II (NIR-II) noninvasive biomedical vascular imaging and tumor resection guided by intraoperative real-time imaging, as well as synergistic Chemo-Phototherapy with high tumor suppression.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Long He, Lin-Hui He, Huan-Hua Lai, Shuai Xu, Jiao-Liang Wang, Jun-Chao Xu, Ling Shi, Lin Yuan
Summary: We propose a practical strategy to design heavy-atom-free phototherapy agents (CSQs) with both PDT and PTT under NIR wavelength excitation by replacing the indole salt of xanthene Changsha (CS) with quinoline salt.
CHEMICAL COMMUNICATIONS
(2023)
Article
Materials Science, Multidisciplinary
Denghui Shang, Qilin Yu, Wei Liu, Shouting Zhang, Yi Li, Jing Chen, Zhen Zhang, Xiaoquan Lu
Summary: This study developed a nanomissile targeting mitochondria to activate the apoptotic pathway in cancer cells, enhancing tumor treatment effects. The nanomissile can selectively deliver to mitochondria, exhibiting high cytotoxicity to human lung tumor cells. It represents a viable strategy for cancer therapy with real-time visualization and efficient treatment for tumor sites in vivo.
SCIENCE CHINA-MATERIALS
(2022)
Article
Biophysics
Yuyan Yan, Yafei Hou, Huijun Zhang, Wenqing Gao, Renlu Han, Jiancheng Yu, Long Xu, Keqi Tang
Summary: mMC composite enhances the therapeutic effects of CDT, PDT, and PTT simultaneously. CeO2 and MnO2 play different roles in enhancing CDT and PDT/PTT effects, while MnO2 can also alleviate hypoxia and deplete GSH.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Nanoscience & Nanotechnology
Shanshan Liu, Ruixiang Song, Xiaosong Li, Feifan Zhou
Summary: Nanomaterials play a crucial role in the treatment of malignant tumors, offering unique properties that make them ideal for synergistic treatment strategies. By utilizing nanoplatform-mediated phototherapies in combination with other therapies, such as photochemotherapy, photoradiotherapy, and photoimmunotherapy, challenges in the current treatment of malignant tumors can be better addressed.
Article
Nanoscience & Nanotechnology
Chuanhui Song, Jianchuan Ran, Zheng Wei, Yufeng Wang, Sheng Chen, Lin Lin, Guorong Zhang, Yu Cai, Wei Han
Summary: In this study, novel organic photosensitizer Y8 synthesized nanoparticles (Y8 NPs) were found to effectively induce antitumor immunity through photodynamic and photothermal therapy in metastatic tumor-bearing murine models. The Y8 NPs showed practical photodynamic and photothermal effects with 808 nm laser irradiation, and excellent imaging effects in the near-infrared-II region. This research offers a promising therapeutic strategy for synergetic phototherapy and immunotherapy in tumor treatment.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Biotechnology & Applied Microbiology
Zeng Zeng, Chao Fang, Ying Zhang, Cong-Xian Chen, Yi-Feng Zhang, Kun Zhang
Summary: Mitochondria are essential organelles in cells that produce ATP and regulate apoptotic pathways in cancer cells. Nanocarriers combined with mitochondria have shown great potential in various cancer treatments, promoting efficient cancer therapies. This review discusses how mitochondria-targeted nanocarriers can enhance cancer treatment in different modalities and their challenges and prospects in clinical cancer treatment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Xiao Chen, Xiaopeng Ma, Gui Yang, Guan Huang, Haibing Dai, Nian Liu, Jianbo Yu
Summary: In this study, a type of squaraine capable of killing tumors through both photothermal and photodynamic effects was developed by optimizing squaraine structure with selenium modulation and formulating it into nanoparticles. These nanoparticles showed strong absorption of infrared light, negligible fluorescence, good photothermal conversion (66.6%), and strong photodynamic effects even after several irradiation cycles. In addition, the nanoparticles could be tracked through their strong optoacoustic signal. In mice, the nanoparticles effectively accumulated in tumors and eliminated them upon irradiation, without causing adverse effects. This work demonstrates the potential of selenium modulation of squaraine for precise cancer diagnosis and treatment through synergistic photothermal and photodynamic effects.
Article
Biochemistry & Molecular Biology
Eli Varon, Gaddi Blumrosen, Moshe Sinvani, Elina Haimov, Shlomi Polani, Michal Natan, Irit Shoval, Avi Jacob, Ayelet Atkins, David Zitoun, Orit Shefi
Summary: Combining photodynamic therapy and photothermal therapy is a promising approach for cancer treatment. This study demonstrates that the use of gold nanoparticles conjugated with a photosensitizer can achieve dual photodynamic/photothermal therapy with high treatment efficacy against neuroblastoma cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Tianguang Liu, Yanli Chen, Huizhe Wang, Mengyuan Cui, Jiaqi Zhang, Wancun Zhang, Peng Wang
Summary: This study developed a series of new phototherapy agents by introducing carboxyl or sulfonic groups into the indole ring or branch chain of asymmetrical heptamethine cyanine. The encapsulated BSS-Et nanoparticles exhibited robust photostability, efficient reactive oxygen species generation, and excellent photothermal conversion efficiency under laser irradiation. These nanoparticles showed passive tumor-targeting properties and effectively eliminated tumors through photodynamic therapy and photothermal therapy synergistic therapy without recurrence.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Haijing Qu, Longmeng Li, Han Chen, Menghuan Tang, Wei Cheng, Tzu-yin Lin, Lingyan Li, Bin Li, Xiangdong Xue
Summary: In this study, researchers developed nanoparticles with strong photo/immune therapeutic effects by integrating a photosensitizer and a Toll-like receptor 7/8 agonist. These nanoparticles can directly inhibit tumor growth, promote the immune response, and reverse the suppressive tumor immune microenvironment. They have the potential to enhance the effectiveness of immunotherapy and phototherapy in cancer treatment.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Materials Science, Multidisciplinary
Linlin Zhao, Meijia Chang, Zheng He, Yunying Zhao, Jing Wang, Yan Lu
Summary: Phototherapy is a noninvasive and effective therapeutic method for tumors, and the combination of photothermal and photodynamic therapy is expected to achieve better results. In this study, a NIR light-responsive nanoplatform (UTNPs) was developed using a photoactive oligomer (UF-TTOEH-2Cl), and a folic acid-functionalized block copolymer (FA-PEG-PBLA(10)) was utilized as the polymer matrix. The UTNPs showed high photothermal conversion efficiency (42%) and singlet oxygen quantum yield (17.2%) under 880 nm laser irradiation. In vitro experiments demonstrated the efficient PDT/PTT synergistic therapy of tumors using HeLa and SiHa cells as models.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yanan Li, Jing Cui, Chenlong Li, Caiting Deng, Guowei Deng, Hui Zhang, Feifei An
Summary: Photoimmunotherapy is an emerging treatment modality that combines various processes to fight against cancer and boost immune response. However, single-modality therapy may not completely eradicate tumors, and the recurrence of tumors remains a challenge. Therefore, combining photoimmunotherapy with other immunotherapies can greatly enhance efficacy and reduce adverse effects. This review summarizes the recent advances in constructing multifunctional nano-biomaterials for combination photoimmunotherapy and analyzes the opportunities, challenges, future trends, and prospects in this field.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Ziliang Zheng, Xuejiao Chen, Yanchun Ma, Rong Dai, Shutong Wu, Tong Wang, Jun Xing, Jinnan Gao, Ruiping Zhang
Summary: This study presents an intelligent nanofactory for tumor theranostics based on a dual H2O2-amplification strategy. The nanofactory can activate the NIR-II FL signal in the tumor microenvironment by releasing Cu ions and increase the H2O2 level through both external supply and internal promotion, leading to enhanced tumor starvation therapy and chemodynamic therapy efficacy.
