Article
Infectious Diseases
Didem Torumkuney, Puja Nijhara, Cristiana Ossaille Beltrame, Elisama Queiroz Baisch, Ricardo Macarini Ferreira
Summary: Background: Antimicrobial resistance (AMR) is a major threat to global public health, driven by inappropriate use of antibiotics. COVID-19 may have worsened AMR due to unnecessary antibiotic prescribing. This study reviews the situation of AMR in Brazil and initiatives addressing it, aiming to identify areas where more information is needed to take action against AMR and improve patient outcomes.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Hematology
Lekha Mikkilineni, Bonnie Yates, Seth M. Steinberg, Shilpa A. Shahani, John C. Molina, Tara Palmore, Daniel W. Lee, Rosandra N. Kaplan, Crystal L. Mackall, Terry J. Fry, Juan Gea-Banacloche, Theresa Jerussi, Veronique Nussenblatt, James N. Kochenderfer, Nirali N. Shah
Summary: Infections are a common complication of CAR T-cell therapy, with the majority occurring within the first 30 days post-infusion. Different targets and diseases have varying proportions of infection incidences. Factors such as prior lines of therapy and recent infections are associated with a higher risk of infections, as revealed in multivariable analysis.
Review
Dermatology
P. P. Naik
Summary: Keloids are abnormal tissue scarring resulting from overgrowth of granulation tissue or collagen type III in injured skin, with treatment options ranging from traditional corticosteroid therapy to emerging approaches like stem cell therapy.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Review
Medicine, General & Internal
Mohsen Afarideh, Robert Borucki, Victoria P. Werth
Summary: This article summarizes the pathogenesis and treatment options for bullous pemphigoid (BP). BP primarily affects the elderly and long-term use of corticosteroids and immunosuppressants can cause significant side effects. Therefore, developing effective and side-effect-free treatment options is crucial. The review focuses on the role of eosinophils, immunoglobulins, cytokines, and complements in the development of BP, and discusses the latest advances in novel therapeutic targets. Access to medication for refractory patients is also an important consideration.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Public, Environmental & Occupational Health
V. Ragwar, M. Brown
Summary: This study evaluated the effectiveness of community case management (CCM) in Sub-Saharan Africa and identified factors that may impact its implementation. It also provided strategies for public health practitioners, stakeholders, and policymakers to implement CCM.
Review
Oncology
Xingyue Chen, Li Zhang, Ling He, Liming Zheng, Biguang Tuo
Summary: Hepatocellular carcinoma (HCC) is a global health burden and often diagnosed at an advanced stage, limiting treatment options and prognosis. K+ channels play a crucial role in HCC by regulating cell behavior and drug resistance. This review aims to explore K+ channels as both diagnostic markers and therapeutic targets for HCC, with potential for clinical treatment in advanced stages and drug-resistant cases.
Review
Pharmacology & Pharmacy
E. Swarne, M. S. Srikanth, Ayachit Shreyas, Sneha Desai, Seema Mehdi, H. V. Gangadharappa, Suman, K. L. Krishna
Summary: Cholelithiasis is a common condition with risk factors such as genetics, diet, lifestyle contributing to its development. Treatment options include surgery and non-surgical methods, but complications and high costs are concerns. Herbal treatments are gaining popularity due to their perceived safety and cost-effectiveness, warranting further research.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biology
Haina Cai, Yang Wang, Zejun Cai, Yuqing Lin, Qinghong Xu
Summary: This study explored the effect of nutrition intervention on the management of NCP patients. The results showed that nutrition intervention can improve the nutritional status and prognosis of patients.
OPEN LIFE SCIENCES
(2022)
Article
Infectious Diseases
Didem Torumkuney, Subhashri Kundu, Giap Van Vu, Hoang Anh Nguyen, Hung Van Pham, Praveen Kamble, Ngoc Truong Ha Lan, Nergis Keles
Summary: Vietnam faces challenges in antimicrobial resistance, including excessive antibiotic use, unrestricted sale of antibiotics, and lack of local guidelines. Developing standardized and inclusive local guidelines, improving the appropriateness of antibiotic prescribing, are crucial for controlling resistance development and improving patient clinical outcomes.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Zeshan Mahmud Chowdhury, Arittra Bhattacharjee, Ishtiaque Ahammad, Mohammad Uzzal Hossain, Abdullah All Jaber, Anisur Rahman, Preonath Chondrow Dev, Md Salimullah, Chaman Ara Keya
Summary: Streptococcus pneumoniae is the major etiological agent of community-acquired pneumonia and its resistance is increasing. This study identified and analyzed 28 hypothetical proteins that may play a role in the virulence or pathogenesis of the bacteria. The majority of these proteins are involved in bacterial transcription and translation.
Review
Oncology
Blessie Elizabeth Nelson, Angelina Hong, Bagi Jana
Summary: Therapy for urothelial carcinoma is expanding rapidly with emerging novel agents targeting different molecular pathways, providing alternative treatment modalities for various types of urothelial cancer, including metastatic and non-muscle invasive bladder cancer.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, Research & Experimental
Zhenwang Ma, Hao Liang, Bingcheng Hu, Shaojie Cai, Dong Yan
Summary: Parkinson's disease is a neurodegenerative disorder characterized by the loss of dopaminergic neurons, leading to motor dysfunctions and non-motor symptoms. Autophagy is an important cellular process involved in the clearance of aberrantly modified proteins and damaged organelles, and it plays a crucial role in the progression of Parkinson's disease. Recent studies have shown that miRNAs, a group of small non-coding RNA molecules, regulate autophagy and are implicated in the pathology of Parkinson's disease, suggesting that targeting autophagy-regulating miRNAs may provide new therapeutic strategies for this disease.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Review
Medicine, General & Internal
Waldemar Kryszkowski, Tomasz Boczek
Summary: Schizophrenia, a severe neuropsychiatric disease, is associated with disrupted glutamate neurotransmission, particularly involving ionotropic NMDA receptor hypofunction. Metabotropic glutamate receptors have emerged as crucial for cognitive and psychomotor function, with potential as molecular targets for novel antipsychotics.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Roya Ramezankhani, Roya Solhi, Hamidreza Aboulkheyr Es, Massoud Vosough, Moustapha Hassan
Summary: Gastric adenocarcinoma (GAC) is the third leading cause of cancer-related death worldwide, with a high mortality rate and resistance to treatment protocols due to heterogeneous molecular pathogenesis, making it crucial to discover key etiologic molecular alterations. Epigenetic modifications play a significant role in repressing or activating cancer-related genes and forming new epigenetic signatures, which can impact cancer initiation and progression. Targeting key epigenetic drivers such as MLLs, ARID1A, and EZH2 may potentially attenuate cancer progression in GAC by manipulating the 3D chromatin structure and regulating the expression of tumor suppressor genes and oncogenes.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Hematology
Svea Stratmann, Sara A. Yones, Markus Mayrhofer, Nina Norgren, Aron Skaftason, Jitong Sun, Karolina Smolinska, Jan Komorowski, Morten Krogh Herlin, Christer Sundstrom, Anna Eriksson, Martin Hoglund, Josefine Palle, Jonas Abrahamsson, Kirsi Jahnukainen, Monica Cheng Munthe-Kaas, Bernward Zeller, Katja Pokrovskaja Tamm, Lucia Cavelier, Linda Holmfeldt
Summary: AML is the leading cause of death in adult and pediatric patients, with specific differences in mutational spectrum at relapse. Key genes ARID1A and CSF1R show recurrent mutations at relapse, while new gene mutations identified may play important roles in disease progression and therapy resistance, providing possibilities for personalized medicine.