Advances in the management of constipation-predominant irritable bowel syndrome: the role of linaclotide

Mo2054 Assessing Abdominal and Bowel Symptoms Using Adequate Relief Based Thresholds: Results From 2 Phase 3 Trials of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation

(2015) Michael Camilleri et al.   GASTROENTEROLOGY

Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome

(2013) Yehuda Ringel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Effects of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation or Chronic Constipation: A Meta-analysis

(2013) Elizabeth J. Videlock et al.   Clinical Gastroenterology and Hepatology

Effect of Linaclotide on Severe Abdominal Symptoms in Patients With Irritable Bowel Syndrome With Constipation

(2013) Satish S.C. Rao et al.   Clinical Gastroenterology and Hepatology

Linaclotide Inhibits Colonic Nociceptors and Relieves Abdominal Pain via Guanylate Cyclase-C and Extracellular Cyclic Guanosine 3′,5′-Monophosphate

(2013) Joel Castro et al.   GASTROENTEROLOGY

Neuroendocrine markers and psychological features in patients with irritable bowel syndrome

(2013) Cristina Stasi et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Activation of Guanylate Cyclase-C Attenuates Stretch Responses and Sensitization of Mouse Colorectal Afferents

(2013) B. Feng et al.   JOURNAL OF NEUROSCIENCE

An evaluation of the FDA Responder Endpoint for IBS-C clinical trials: analysis of data from linaclotide Phase 3 clinical trials

(2013) J. E. MacDougall et al.   NEUROGASTROENTEROLOGY AND MOTILITY

FDA and EMA end points: which outcome end points should we use in clinical trials in patients with irritable bowel syndrome?

(2013) M. Corsetti et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Intestinal recruiting and activation profiles in peripheral blood mononuclear cells in response to pathogen-associated molecular patterns stimulation in patients with IBS

(2013) O. Rodríguez-Fandiño et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Effect of linaclotide in irritable bowel syndrome with constipation (IBS-C): a systematic review and meta-analysis

(2013) D. K. Atluri et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Gastrointestinal pain: Unraveling a novel endogenous pathway through uroguanylin/guanylate cyclase-C/cGMP activation

(2013) Inmaculada Silos-Santiago et al.   PAIN

The epidemiology of irritable bowel syndrome in Denmark. A population-based survey in adults ≤50 years of age

(2013) Laura Rindom Krogsgaard et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Randomised clinical trials: linaclotide phase 3 studies in IBS-C - a prespecified further analysis based on European Medicines Agency-specified endpoints

(2012) E. M. M. Quigley et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Linaclotide for Irritable Bowel Syndrome With Constipation: A 26-Week, Randomized, Double-blind, Placebo-Controlled Trial to Evaluate Efficacy and Safety

(2012) William D Chey et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

A 12-Week, Randomized, Controlled Trial With a 4-Week Randomized Withdrawal Period to Evaluate the Efficacy and Safety of Linaclotide in Irritable Bowel Syndrome With Constipation

(2012) Satish Rao et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Irritable Bowel Syndrome: Methods, Mechanisms, and Pathophysiology. Neural and neuro-immune mechanisms of visceral hypersensitivity in irritable bowel syndrome

(2012) Bin Feng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Guanylate cyclase-C receptor activation: unexpected biology

(2012) Stuart M Brierley   CURRENT OPINION IN PHARMACOLOGY

Chronic constipation: new diagnostic and treatment approaches

(2012) Brian E. Lacy et al.   Therapeutic Advances in Gastroenterology

The Brain-Gut Axis in Abdominal Pain Syndromes

(2010) Emeran A. Mayer et al.   Annual Review of Medicine

Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit

(2010) Robert W. Busby et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Linaclotide Improves Abdominal Pain and Bowel Habits in a Phase IIb Study of Patients With Irritable Bowel Syndrome With Constipation

(2010) Jeffrey M. Johnston et al.   GASTROENTEROLOGY

Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract

(2010) Alexander P. Bryant et al.   LIFE SCIENCES

Linaclotide - a secretagogue and antihyperalgesic agent - what next?

(2010) a. e. bharucha et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Regulation and therapeutic targeting of peptide-activated receptor guanylyl cyclases

(2010) Lincoln R. Potter   PHARMACOLOGY & THERAPEUTICS

Bacterial Heat-Stable Enterotoxins: Translation of Pathogenic Peptides into Novel Targeted Diagnostics and Therapeutics

(2010) Jieru E. Lin et al.   Toxins

The Current Prevalence of Irritable Bowel Syndrome in Asia

(2010) Full-Young Chang et al.   Journal of Neurogastroenterology and Motility

An Evidence-Based Position Statement on the Management of Irritable Bowel Syndrome

(2009)   AMERICAN JOURNAL OF GASTROENTEROLOGY

Guanylate cyclase C-mediated antinociceptive effects of linaclotide in rodent models of visceral pain

(2009) h. eutamene et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Involvement of vasopressin 3 receptors in chronic psychological stress-induced visceral hyperalgesia in rats

(2008) Sylvie Bradesi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Reciprocal changes in vanilloid (TRPV1) and endocannabinoid (CB1) receptors contribute to visceral hyperalgesia in the water avoidance stressed rat

(2008) S Hong et al.   GUT