Article
Integrative & Complementary Medicine
Xiao Li, Wei Liu, Chong Geng, Tingting Li, Yanni Li, Yaoyu Guo, Chunhui Wang
Summary: This study demonstrated that Ginsenoside Rg3 could effectively inhibit colon cancer cell invasion and metastasis by suppressing the Notch-Hes1-EMT signaling pathway.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jianmin Hu, Jin Li, Can Dai, Jinlin Ren, Wenru Yang, Caixia He, Fei Meng, Congling Dai, Sicong Zeng
Summary: By introducing HES1-/-mutations into human embryonic stem cells and differentiating them into human intestinal organoids, the study reveals the important role of HES1 and WNT5A signaling in epithelial-mesenchymal crosstalk in the human intestinal mucosa.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
Katsutoshi Kuriyama, Yuzo Kodama, Masahiro Shiokawa, Yoshihiro Nishikawa, Saiko Marui, Takeshi Kuwada, Yuko Sogabe, Nobuyuki Kakiuchi, Teruko Tomono, Tomoaki Matsumori, Atsushi Mima, Toshihiro Morita, Tatsuki Ueda, Motoyuki Tsuda, Yuki Yamauchi, Yojiro Sakuma, Yuji Ota, Takahisa Maruno, Norimitsu Uza, Ryoichiro Kageyama, Tsutomu Chiba, Hiroshi Seno
Summary: Notch/Hes1 signaling is essential for the postnatal maturation of exocrine tissue in pancreatic progenitor cells, partially through the formation of centroacinar cells.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hikaru Handa, Nobuo Idesako, Motoyuki Itoh
Summary: Notch activation by immobilized ligands is primarily driven by actin-based cell movement, which provides mechanical force for receptor cleavage, rather than receptor cis-endocytosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cell Biology
Shengbo Chen, Hongbin Liu, Zhijun Li, Jingyi Tang, Bing Huang, Fachao Zhi, Xinmei Zhao
Summary: PBLD plays a crucial role in UC, as its deficiency leads to impaired intestinal barrier function and dysregulated immune responses, exacerbating colonic inflammation.
CELL DEATH & DISEASE
(2021)
Article
Pharmacology & Pharmacy
Yaying You, Yongtao Xiao, Ying Lu, Jun Du, Hui Cai, Wei Cai, Weihui Yan
Summary: The pathogenesis of IBD is complicated and still unclear. This study found that through the activation of NOD2 and MDP, gut inflammation can be alleviated and intestinal barrier repair can be promoted by regulating autophagy in intestinal epithelial cells, reducing intestinal barrier damage.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Yuwen Zhao, Rui Yang, Zoe Bousraou, Kiarra Richardson, Shue Wang
Summary: This study established a LNA/DNA nanobiosensor for gene expression analysis in single hMSCs during osteogenic differentiation. The results showed that Notch1-Dll4 signaling plays an important role in regulating hMSCs osteogenic differentiation. Additionally, Dll4 was identified as a molecular signature of differentiated hMSCs during osteogenic induction, and the role of Notch1-Dll4 signaling in a 3D spheroid model was elucidated.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Li Yang, Xuhui Wang, Jiawei Sun, Chunyan Liu, Guoxiang Li, Jingling Zhu, Jin Huang
Summary: Neuritin plays a crucial role in angiogenesis and may affect angiogenesis by inhibiting the Notch signaling pathway. The expression of Neuritin is decreased in lung cancer vascular tissue but is correlated with increased vascular density. Overexpression of Neuritin can suppress the Notch signaling pathway and enhance the migration and tubular formation of HUVECs.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Plant Sciences
Hui Jiang, Gao-Feng Shi, Yu-Xi Fang, You-Qian Liu, Qi Wang, Xian Zheng, Dong-Jian Zhang, Jian Zhang, Zhi-Qi Yin
Summary: AA can prevent colitis by enhancing intestinal barrier function through suppressing the Notch signaling pathway. Oral administration of AA can alleviate colitis symptoms, inhibit inflammation, promote normal cell proliferation, and increase the expression of tight junction proteins and mucus secretion in the intestinal wall.
Article
Immunology
Xun Lin, Stephen J. Gaudino, Kyung Ku Jang, Tej Bahadur, Ankita Singh, Anirban Banerjee, Michael Beaupre, Timothy Chu, Hoi Tong Wong, Chang-Kyung Kim, Cody Kempen, Jordan Axelrad, Huakang Huang, Saba Khalid, Vyom Shah, Onur Eskiocak, Olivia B. Parks, Artan Berisha, Jeremy P. McAleer, Misty Good, Miko Hoshino, Richard Blumberg, Agnieszka B. Bialkowska, Sarah L. Gaffen, Jay K. Kolls, Vincent W. Yang, Semir Beyaz, Ken Cadwell, Pawan Kumar
Summary: IL-17A plays a crucial role in the differentiation of secretory epithelial cells in the gut, maintaining the integrity and health of the mucosa by regulating the cross talk between intestinal cells.
Article
Agriculture, Multidisciplinary
Xuemeng Si, Zhuan Song, Ning Liu, Hai Jia, Haozhen Liu, Zhenlong Wu
Summary: This study found that alpha-ketoglutarate (alpha-KG) has preventive effects on Citrobacter rodentium-induced colitis by regulating endoplasmic reticulum stress and activating Wnt signaling to restore barrier function.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Oncology
Menghan Shi, Shuang Ren, Hao Chen, Jing Li, Caizhi Huang, Yahui Li, Yuning Han, Yong Li, Zheng Sun, Xiaoxin Chen, Zhaohui Xiong
Summary: Alcohol exposure inhibits NOTCH signaling, leading to suppression of PAX9 expression in esophageal squamous epithelial cells. This study reveals a novel mechanism of alcohol-induced esophageal injury.
JOURNAL OF PATHOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yuting Zhong, Ye Tu, Qingshan Ma, Linlin Chen, Wenzhao Zhang, Xin Lu, Shuo Yang, Zhibin Wang, Lichao Zhang
Summary: This study found that curcumin has potential therapeutic effects in ulcerative colitis by inhibiting necroptosis of intestinal epithelial cells through blocking the phosphorylation of RIP3 and MLKL. In mouse models, curcumin also inhibited inflammatory responses caused by necroptosis signaling pathway and improved colitis pathology.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Angelos Papaspyropoulos, Andriani Angelopoulou, Ioanna Mourkioti, Aikaterini Polyzou, Daniela Pankova, Konstantinos Toskas, Simone Lanfredini, Anastasia A. Pantazaki, Nefeli Lagopati, Athanassios Kotsinas, Konstantinos Evangelou, Efstathios Chronopoulos, Eric O'Neill, Vassilis Gorgoulis
Summary: The interaction between RASSF1A and HES1 affects tumor differentiation and response to drug treatment, which is crucial for clinical therapy.
Article
Biochemistry & Molecular Biology
Cristina Bauset, Lluis Lis-Lopez, Sandra Coll, Laura Gisbert-Ferrandiz, Dulce C. Macias-Ceja, Marta Seco-Cervera, Francisco Navarro, Juan Esplugues, Sara Calatayud, Dolores Ortiz-Masia, Maria D. Barrachina, Jesus Cosin-Roger
Summary: This study found that the succinate receptor SUCNR1 plays a role in both basal and stimulated inflammatory pathways in intestinal epithelial cells. It is significantly involved in inflammasome activation in Ulcerative Colitis (UC).
Article
Biochemistry & Molecular Biology
Hiroki Matsuda, Yoichi Nibe-Shirakihara, Akiko Tamura, Emi Aonuma, Satoko Arakawa, Kana Otsubo, Yasuhiro Nemoto, Takashi Nagaishi, Kiichiro Tsuchiya, Shigeomi Shimizu, Averil Ma, Mamoru Watanabe, Motohiro Uo, Ryuichi Okamoto, Shigeru Oshima
Summary: Crohn's disease is an inflammatory disease of the gut caused by a complex interplay among genetic, microbial, and environmental factors. The ingestion of nickel particles may worsen Crohn's disease by perturbing autophagic processes in the intestine.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Gastroenterology & Hepatology
Sakura Kirino, Nobuharu Tamaki, Masayuki Kurosaki, Shun Kaneko, Kento Inada, Yuki Tanaka, Shun Ishido, Koji Yamashita, Tsubasa Nobusawa, Hiroaki Matsumoto, Yuka Hayakawa, Tatsuya Kakegawa, Mayu Higuchi, Kenta Takaura, Shohei Tanaka, Chiaki Maeyashiki, Yutaka Yasui, Yuka Takahashi, Kaoru Tsuchiya, Hiroyuki Nakanishi, Ryuichi Okamoto, Namiki Izumi
Summary: The aim of this study was to establish a target value of ALT level during NA treatment as a risk marker for HCC. The results showed that patients with ALT <21 IU/L at 1 year after NA initiation had a lower risk of HCC.
HEPATOLOGY RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Eiko Saito, Kazuo Ohtsuka, Ami Kawamoto, Toshimitsu Fujii, Kento Takenaka, Shuji Hibiya, Hiromichi Shimizu, Masakazu Nagahori, Shohei Tomii, Ryuichi Okamoto
Summary: A 50-year-old man presented with abdominal pain and diarrhea persisting for 8 months, after being treated for myocarditis with ulceration in the gastrointestinal tract. Biopsy confirmed CMV gastrocolitis and antiviral therapy was given. Improvement was observed after discontinuation of eplerenone.
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Kento Takenaka, Yoshio Kitazume, Ami Kawamoto, Toshimitsu Fujii, Yumi Udagawa, Ryosuke Wanatabe, Hiromichi Shimizu, Shuji Hibiya, Masakazu Nagahori, Kazuo Ohtsuka, Hiroyuki Sato, Akihiro Hirakawa, Mamoru Watanabe, Ryuichi Okamoto
Summary: This study investigates the use of LRG as a biomarker for evaluating transmural activity in patients with Crohn's disease (CD). The results show a positive correlation between LRG levels and MRE scores, indicating that LRG is a highly accurate biomarker for detecting transmural activity in CD patients. Furthermore, high LRG levels are associated with increased risks of CD-related hospitalization, surgery, and clinical relapse.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Ryuichi Okamoto, Tomohiro Mizutani, Hiromichi Shimizu
Summary: This article discusses the importance of mucosal healing in patients with IBD and introduces current factor-based or cell-based treatment options. It also explores the future prospects of regenerative medicine in the treatment of IBD.
Article
Gastroenterology & Hepatology
Shun Kaneko, Yasuhiro Asahina, Mina Nakagawa, Miyako Murakawa, Yasunari Miyazaki, Takahiro Asakage, Shohei Fukuda, Takeshi Namiki, Yoshihito Kano, Masashi Nagata, Jun Tsuchiya, Masato Miyoshi, Fukiko Kitahata-Kawai, Sayuri Nitta, Yasuhiro Itsui, Sei Kakinuma, Ryuichi Okamoto
Summary: This study aimed to identify factors associated with immune-related liver injury (irLI) and investigate its impact on overall survival (OS) in patients treated with immune checkpoint inhibitors (ICIs). The results showed that treatment with anti-cytotoxic T-lymphocyte-associated protein-4 agents and baseline grade 1 aspartate aminotransferase/alanine aminotransferase elevation were independent predictive factors for grade >= 2 irLI. Treatment with anti-cytotoxic T-lymphocyte-associated protein-4 was the only independent predictive factor for grade >= 3 irLI. Patients who experienced any immune-related adverse events (irAEs) had a significantly longer median OS, and those with grade >= 2 irLI also had a significantly longer median OS. However, there was no significant difference in median OS between patients with grade >= 3 irLI and others.
HEPATOLOGY RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Kento Takenaka, Ami Kawamoto, Yoshio Kitazume, Toshimitsu Fujii, Yumi Udagawa, Hiromichi Shimizu, Shuji Hibiya, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe, Ryuichi Okamoto
Summary: This study aimed to explore the association between serum concentrations of biologics and transmural healing in patients with Crohn's disease. The results showed that patients who achieved transmural healing had a lower risk of hospitalization and surgery. Additionally, the concentration levels of drugs were found to be related to transmural healing.
JOURNAL OF CROHNS & COLITIS
(2023)
Review
Gastroenterology & Hepatology
Mina Nakagawa, Yasuhiro Asahina, Sei Kakinuma, Ryuichi Okamoto
Summary: Hepatitis C virus infection causes chronic liver inflammation and fibrogenesis, resulting in severe liver diseases and hepatocellular carcinoma. The presence of the virus in non-hepatic tissues can also lead to pathogenic impacts on extrahepatic systems and organs. These extrahepatic manifestations have significant effects on morbidity, mortality, and quality of life.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Taisei Keitoku, Nobuharu Tamaki, Masayuki Kurosaki, Kento Inada, Sakura Kirino, Naoki Uchihara, Keito Suzuki, Yuki Tanaka, Haruka Miyamoto, Shun Ishido, Michiko Yamada, Tsubasa Nobusawa, Hiroaki Matsumoto, Mayu Higuchi, Kenta Takaura, Shohei Tanaka, Chiaki Maeyashiki, Shun Kaneko, Yutaka Yasui, Yuka Takahashi, Kaoru Tsuchiya, Hiroyuki Nakanishi, Yasuhiro Asahina, Ryuichi Okamoto, Namiki Izumi
Summary: The significance of fatty liver in patients with chronic hepatitis B receiving nucleic acid analog therapy remains unclear. This study aimed to determine if fatty liver affects the development of hepatocellular carcinoma (HCC) in patients receiving NA therapy. The results showed that fatty liver was not a significant factor for HCC development in these patients, while advanced fibrosis was found to be an important risk factor.
JOURNAL OF VIRAL HEPATITIS
(2023)
Article
Oncology
Shun Ishido, Kaoru Tsuchiya, Yoshihito Kano, Yutaka Yasui, Kenta Takaura, Naoki Uchihara, Keito Suzuki, Yuki Tanaka, Haruka Miyamoto, Michiko Yamada, Hiroaki Matsumoto, Tsubasa Nobusawa, Taisei Keitoku, Shohei Tanaka, Chiaki Maeyashiki, Nobuharu Tamaki, Yuka Takahashi, Hiroyuki Nakanishi, Urara Sakurai, Yasuhiro Asahina, Ryuichi Okamoto, Masayuki Kurosaki, Namiki Izumi
Summary: The clinical usefulness of comprehensive genomic profiling (CGP) in patients with unresectable hepatocellular carcinoma (HCC) who received multiple systemic therapies is investigated in this study. Gene alterations were detected in all nine patients, with seven being eligible for clinical trials based on CGP results. The median number of alterations per patient was four, and blood samples were used in patients with extrahepatic metastasis. These findings provide genomic information of patients with multiple systemic therapies and highlight the utility of blood samples in patients with extrahepatic metastasis. Furthermore, the study suggests that understanding the genomic status in patients treated with multiple molecular-targeted agents could lead to the development of newer systemic agents for HCC treatment.
Article
Physics, Applied
Takeya Unuma, Kosuke Ueda, Ryuichi Okamoto
Summary: We investigate how the initial energy distribution of electrons in a biased semiconductor superlattice, created by femtosecond pump pulses, affects terahertz Bloch oscillations. The emitted terahertz waveforms are well reproduced from a damped oscillation current with capacitive nature. In-plane excess energy changes the relaxation time via scattering processes, while partial use of the pump pulse spectrum reduces the temporal resolution.
APPLIED PHYSICS EXPRESS
(2023)
Article
Gastroenterology & Hepatology
Satoshi Watanabe, Nobuhiko Ogasawara, Sakurako Kobayashi, Sakura Kirino, Masami Inoue, Yui Hiraguri, Sayaka Nagata, Hiromichi Shimizu, Go Ito, Tomohiro Mizutani, Yasuhiro Nemoto, Kiichiro Tsuchiya, Ryuichi Okamoto, Mamoru Watanabe, Shiro Yui
Summary: This study focused on the role of sulfomucin in ulcerative colitis (UC) and found that sulfomucin production decreased in the inflammatory region of UC and increased in the distal colon and cecum of mice. Through organoids transplantation, sulfomucin secretion was restored in severely injured distal colon. This study provides a basis for the advancement of organoids transplantation therapy for refractory UC.
JOURNAL OF GASTROENTEROLOGY
(2023)
Correction
Gastroenterology & Hepatology
Mina Nakagawa, Yasuhiro Asahina, Sei Kakinuma, Ryuichi Okamoto
JOURNAL OF GASTROENTEROLOGY
(2023)