Inhibition of class I HDACs abrogates the dominant effect of MLL-AF4 by activation of wild-type MLL

The MLL recombinome of acute leukemias in 2013

(2013) C Meyer et al.   LEUKEMIA

RUNX1 Is a Key Target in t(4;11) Leukemias that Contributes to Gene Activation through an AF4-MLL Complex Interaction

(2013) Adam C. Wilkinson et al.   Cell Reports

Epigenetics and blood disorders

(2012) Bastian Scholz et al.   BRITISH JOURNAL OF HAEMATOLOGY

Inhibitors of Histone Deacetylases

(2011) Kelly Huber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Connectivity mapping identifies HDAC inhibitors for the treatment of t(4;11)-positive infant acute lymphoblastic leukemia

(2011) D J P M Stumpel et al.   LEUKEMIA

The PHD3 Domain of MLL Acts as a CYP33-Regulated Switch between MLL-Mediated Activation and Repression,

(2010) Sangho Park et al.   BIOCHEMISTRY

The AF4{middle dot}MLL fusion protein is capable of inducing ALL in mice without requirement of MLL{middle dot}AF4

(2010) A. Bursen et al.   BLOOD

Mixed lineage leukemia: roles in human malignancies and potential therapy

(2010) Rolf Marschalek   FEBS Journal

Molecular Mechanism of MLL PHD3 and RNA Recognition by the Cyp33 RRM Domain

(2010) Robert A. Hom et al.   JOURNAL OF MOLECULAR BIOLOGY

The leukemogenic AF4–MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures

(2010) A Benedikt et al.   LEUKEMIA

Selective Inhibition of Histone Deacetylases Sensitizes Malignant Cells to Death Receptor Ligands

(2010) T. E. Wood et al.   MOLECULAR CANCER THERAPEUTICS

Calcitriol Upregulates Open Chromatin and Elongation Markers at Functional Vitamin D Response Elements in the Distal Part of the 5-Lipoxygenase Gene

(2009) Kirsten L. Stoffers et al.   JOURNAL OF MOLECULAR BIOLOGY

Global Analysis of H3K4 Methylation Defines MLL Family Member Targets and Points to a Role for MLL1-Mediated H3K4 Methylation in the Regulation of Transcriptional Initiation by RNA Polymerase II

(2009) P. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

(2008) Nagma Khan et al.   BIOCHEMICAL JOURNAL

A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas

(2008) S Balasubramanian et al.   LEUKEMIA

MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo

(2008) M. Fournel et al.   MOLECULAR CANCER THERAPEUTICS

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

(2008) Xiang-Jiao Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY