Article
Clinical Neurology
Paul A. Yushkevich, Monica Munoz Lopez, Maria Mercedes Iniguez de Onzono Martin, Ranjit Ittyerah, Sydney Lim, Sadhana Ravikumar, Madigan L. Bedard, Stephen Pickup, Weixia Liu, Jiancong Wang, Ling Yu Hung, Jade Lasserve, Nicolas Vergnet, Long Xie, Mengjin Dong, Salena Cui, Lauren McCollum, John L. Robinson, Theresa Schuck, Robin de Flores, Murray Grossman, M. Dylan Tisdall, Karthik Prabhakaran, Gabor Mizsei, Sandhitsu R. Das, Emilio Artacho-Perula, Mari'a Del Mar Arroyo Jimenez, Mari'a Pilar Marcos Raba, Francisco Javier Molina Romero, Sandra Cebada Sanchez, Jose Carlos Delgado Gonzalez, Carlos De la Rosa-Prieto, Marta Corcoles Parada, Edward B. Lee, John Q. Trojanowski, Daniel T. Ohm, Laura E. M. Wisse, David A. Wolk, David J. Irwin, Ricardo Insausti
Summary: This study utilized ex vivo MRI and dense serial histological imaging to construct three-dimensional quantitative maps of neurofibrillary tangle burden in the medial temporal lobe, revealing significant variation along different anatomical regions. The findings provide valuable insights into the distribution of this neurodegenerative pathology and may support the development and validation of neuroimaging biomarkers.
Article
Neurosciences
Robin de Flores, Sandhitsu R. Das, Long Xie, Laura E. M. Wisse, Xueying Lyu, Preya Shah, Paul A. Yushkevich, David A. Wolk
Summary: This study reveals the relationship between the medial temporal lobe and the anterior-temporal and posterior-medial networks, and explores the vulnerability of these networks to proteinopathies in Alzheimer's disease. The results show that the atrophy of distinct subregions in the medial temporal lobe propagates differently within the anterior-temporal and posterior-medial networks. Additionally, these networks are differentially associated with relative tau and amyloid burden.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Robin de Flores, Elizabeth Kuhn, Brigitte Landeau, Nicolas Delcroix, Julie Gonneaud, Denis Vivien, Solene Demeilliez-Servouin, Lea Chauveau, Gael Chetelat
Summary: Medial temporal lobe subregions, including the entorhinal cortex, perirhinal cortex, and hippocampal cornu ammonis (CA)1, are differentially affected in Alzheimer's disease (AD). This study investigated the relationship between amyloid (A beta) and APOE epsilon 4 with MTL atrophy using baseline data from 130 participants. The results showed an interaction between A beta and APOE epsilon 4 status with age on CA1, indicating their specific involvement in early AD-related atrophy.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Geriatrics & Gerontology
Etsuko Imabayashi, Kenji Ishii, Jun Toyohara, Kei Wagatsuma, Muneyuki Sakata, Tetsuro Tago, Kenji Ishibashi, Narumi Kojima, Noriyuki Kohda, Aya M. Tokumaru, Hunkyung Kim
Summary: Neurodegenerative changes in the preclinical stage of Alzheimer's disease (AD) may present treatment opportunities, and the interaction between clinical stage and amyloid PET positivity on cerebral atrophy has been observed. The study found that amyloid-positive CN participants had larger R_L-MedT-Atrophy-scores than amyloid-negative CN participants, suggesting that amyloid deposition may lead to left-right differences in the medial temporal area.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Parichita Choudhury, Jonathan Graff-Radford, Jeremiah A. Aakre, Lincoln Wurtz, David S. Knopman, Neill R. Graff-Radford, Kejal Kantarci, Leah K. Forsberg, Julie A. Fields, Otto Pedraza, Qin Chen, Toji Miyagawa, Gregory S. Day, Philip Tipton, Rodolfo Savica, Hugo Botha, Christian Lachner, Brynn Dredla, R. Ross Reichard, Ronald C. Petersen, Dennis W. Dickson, Bradley F. Boeve, Tanis J. Ferman
Summary: An earlier onset of DLB was associated with men, RBD, and Lewy body disease without neocortical tangles. Women with DLB tended to be older, more cognitively impaired, less likely to have RBD, diagnosed later, and more likely to have neocortical tangles.
ALZHEIMERS & DEMENTIA
(2022)
Article
Neurosciences
Minjae Kim, Dahyun Yi, Min Soo Byun, Hyejin Ahn, Joon Hyung Jung, Nayeong Kong, Yoonyoung Chang, Hyeji Choi, Jungmin Choi, Kyungtae Kim, Gijung Jung, Dong Young Lee
Summary: This study aimed to develop a culturally appropriate cognitive composite that can sensitively identify subtle cognitive decline in Korean older adults with preclinical Alzheimer's disease (AD). Through careful selection of tests for various cognitive functions, a final cognitive composite (CPAD) for Korean older adults was established.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Psychiatry
Hao Hu, Lan Tan, Yan-Lin Bi, Wei Xu, Lin Tan, Xue-Ning Shen, Xiao-He Hou, Ya-Hui Ma, Qiang Dong, Jin-Tai Yu
Summary: The study found that hypomethylation of the BIN1 promoter in peripheral blood is associated with early cognitive decline in late-onset Alzheimer's disease (LOAD). Additionally, changes in methylation levels are correlated with alterations in AD-related biomarkers in cerebrospinal fluid, particularly in participants with significant AD biological characteristics and subjective cognitive decline (SCD).
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Clinical Neurology
Philip S. Insel, Christina B. Young, Paul S. Aisen, Keith A. Johnson, Reisa A. Sperling, Elizabeth C. Mormino, Michael C. Donohue
Summary: The rates of tau accumulation in cognitively unimpaired older adults are subtle and vary in magnitude and spatial patterns. The degree of regional accumulation also likely depends on the amyloid-beta-dependent accumulation. Therefore, it is important to evaluate the pattern and consistency of tau accumulation across multiple cohorts and its relationship with amyloid burden to design optimal tau endpoints for clinical trials.
Article
Clinical Neurology
Yara J. Yakoub, Nicholas Ashton, Cherie Strikwerda-Brown, Laia K. Montoliu-Gaya, Thomas Karikari, Przemyslaw R. Kac, Fernando Gonzalez-Ortiz, Jonathan Gallego-Rudolf, Pierre-Francois Meyer, Frederic St-Onge, Michael Schoell, Jean-Paul Soucy, John C. S. Breitner, Henrik Zetterberg, Kaj Blennow, Judes Poirier, Sylvia Villeneuve
Summary: Plasma biomarkers can indicate changes in individuals with preclinical AD, as seen in the decreased A beta(42/40) ratio and increased NfL and GFAP values over a 4-year follow-up. Carriers of the APOE epsilon 4 allele showed a faster increase in plasma pTau181, while older individuals had a faster increase in plasma NfL and females showed a faster increase in plasma GFAP values.
ALZHEIMERS & DEMENTIA
(2023)
Article
Cell Biology
Wanting Liu, Lisa Wing Chi Au, Jill Abrigo, Yishan Luo, Adrian Wong, Bonnie Yin Ka Lam, Xiang Fan, Pauline Wing Lam Kwan, Hon Wing Ma, Anthea Yee Tung Ng, Sirong Chen, Eric Yim Lung Leung, Chi Lai Ho, Simon Ho Man Wong, Winnie C. W. Chu, Ho Ko, Alexander Yuk Lun Lau, Lin Shi, Vincent Chung Tong Mok
Summary: AD-RAI shows potential in detecting early Alzheimer's disease, particularly in the prodromal stage.
Article
Medicine, General & Internal
Min Jeong Kwon, Subin Lee, Jieun Park, Sungman Jo, Ji Won Han, Dae Jong Oh, Jun-Young Lee, Joon Hyuk Park, Jae Hyoung Kim, Ki Woong Kim
Summary: Texture analysis may be an important neuroimaging marker for early detection of svPPA and differentiation from AD.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Clinical Neurology
Clara Vila-Castelar, Pierre N. Tariot, Kaycee M. Sink, David Clayton, Jessica B. Langbaum, Ronald G. Thomas, Yinghua Chen, Yi Su, Kewei Chen, Nan Hu, Margarita Giraldo-Chica, Carlos Tobon, Natalia Acosta-Baena, Ernesto Luna, Marisol Londono, Paula Ospina, Victoria Tirado, Claudia Munoz, Eliana Henao, Yamile Bocanegra, Sergio Alvarez, Silvia Rios-Romenets, Valentina Ghisays, Dhruman Goradia, Wendy Lee, Ji Luo, Michael H. Malek-Ahmadi, Hillary D. Protas, Francisco Lopera, Eric M. Reiman, Yakeel T. Quiroz
Summary: This study examined the effect of sex on pathology, neurodegeneration, and memory in cognitively-unimpaired individuals with and without the Presenilin-1 (PSEN1) E280A mutation. The results suggest that females may have greater cognitive resilience to AD pathology and neurodegeneration than males.
ALZHEIMERS & DEMENTIA
(2022)
Article
Pharmacology & Pharmacy
Peter Bloomingdale, Daniela Bumbaca-Yadav, Jonathan Sugam, Steve Grauer, Brad Smith, Svetlana Antonenko, Michael Judo, Glareh Azadi, Ka Lai Yee
Summary: The objective of this study was to develop a mechanistic mathematical model to enhance our understanding of tau antibody pharmacokinetics and pharmacodynamics in animals and humans, supporting the preclinical development and clinical translation of therapeutic antibodies for the treatment of Alzheimer's disease.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Mohammad Rafi Khezri, Keyvan Yousefi, Negin Mahboubi, Darya Hodaei, Morteza Ghasemnejad-Berenji
Summary: Alzheimer's disease (AD) is a common neurodegenerative disorder worldwide, and its association with diseases like diabetes has been well-studied. Metformin, a medication commonly used for type 2 diabetes, has shown potential disease-modifying effects on various aspects of AD pathophysiology.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Health Care Sciences & Services
Thomas F. Tropea, Alice Chen-Plotkin
Summary: There is a significant overlap between Alzheimer's Disease (AD) and Parkinson's Disease (PD) in terms of neuropathology, biomarkers, and mechanisms. AD biomarkers are associated with cognitive decline and dementia in PD patients. Precision medicine approaches may successfully identify PD patients most likely to develop concomitant AD, providing an ideal cohort for trials of AD-directed therapies in PD patients.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Multidisciplinary Sciences
Kamel Lahouel, Laurent Younes, Ludmila Danilova, Francis M. Giardiello, Ralph H. Hruban, John Groopman, Kenneth W. Kinzler, Bert Vogelstein, Donald Geman, Cristian Tomasetti
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Neurosciences
Amith Umesh, Kwame S. Kutten, Patrick S. Hogan, J. Tilak Ratnanather, Vikram S. Chib
JOURNAL OF NEUROPHYSIOLOGY
(2020)
Article
Clinical Neurology
S. Bryn Dhir, Kwame S. Kutten, Muwei Li, Andreia Faris, Laurent Younes, J. Tilak Ratnanather
Article
Neurosciences
Sue Kulason, Eileen Xu, Daniel J. Tward, Arnold Bakker, Marilyn Albert, Laurent Younes, Michael I. Miller
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Psychiatry
Yoichiro Takayanagi, Sue Kulason, Daiki Sasabayashi, Tsutomu Takahashi, Naoyuki Katagiri, Atsushi Sakuma, Noriyuki Ohmuro, Masahiro Katsura, Shimako Nishiyama, Mihoko Nakamura, Mikio Kido, Atsushi Furuichi, Kyo Noguchi, Kazunori Matsumoto, Masafumi Mizuno, J. Tilak Ratnanather, Michio Suzuki
FRONTIERS IN PSYCHIATRY
(2020)
Editorial Material
Neurosciences
Athina Tzovara, Ishmael Amarreh, Valentina Borghesani, M. Mallar Chakravarty, Elizabeth DuPre, Christian Grefkes, Amelie Haugg, Lee Jollans, Hyang Woon Lee, Sharlene D. Newman, Rosanna K. Olsen, J. Tilak Ratnanather, Gina Rippon, Lucina Q. Uddin, Maria L. Bringas Vega, Michele Veldsman, Tonya White, AmanPreet Badhwar
Summary: Diversity in scientific research is crucial for promoting innovation and productivity, but discrimination against women, ethnic minorities, and individuals with disabilities still exists. Scientific organizations should actively promote diversity and inclusivity to foster a more inclusive environment.
Review
Neurosciences
Francis A. M. Manno, Raul Rodriguez-Cruces, Rachit Kumar, J. Tilak Ratnanather, Condon Lau
Summary: Hearing loss, a heterogeneous disorder, is found to impact grey and white matter in nearly every brain region according to MRI studies. Congenital loss decreases grey matter in frontal lobe most, while acquired loss shows significant decreases in both frontal and insula grey matter. Different impacts on hemispheres are observed between congenital and acquired hearing loss.
Article
Health Care Sciences & Services
J. Tilak Ratnanather, Rohit Bhattacharya, Margo B. Heston, Joanne Song, Lindsey R. Fernandez, Hong Seo Lim, Seung-Wook Lee, Edric Tam, Sungho Yoo, Seung-Ho Bae, Inez Lam, Hyoung Won Jeon, Son A. Chang, Ja-Won Koo
Summary: This study developed a mobile health app called "Speech Banana" in English and Korean languages for auditory training, offering users a cost-effective and portable method. The app provides a training model focusing on modern techniques and tracks users' progress, providing a more continuous experience for users.
JMIR MHEALTH AND UHEALTH
(2021)
Article
Biochemical Research Methods
Qian Ke, Wikum Dinalankara, Laurent Younes, Donald Geman, Luigi Marchionni
Summary: This study introduces a representation of multi-omics profiles to account for heterogeneity of DNA and RNA molecular profiles in cancer cells, and uses integer programming to identify a small set of paired DNA-RNA aberrations in cancer populations, resulting in the discovery of novel molecular alterations signatures. The results suggest that cancer heterogeneity increases with disease severity. This framework is well-suited for the expanding complexity of cancer genomes and epigenomes.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Mathematics, Applied
Dai-Ni Hsieh, Sylvain Arguillere, Nicolas Charon, Laurent Younes
Summary: This paper examines a model for the longitudinal shape evolution, where a three-dimensional volume evolves through the time-derivative of an internal force and includes a regularization to ensure reversible transformations. The existence and uniqueness of solutions are discussed for two different models, and sufficient conditions for the optimal response are derived. This study is important for understanding the growth and atrophy processes in anatomical structures.
SIAM JOURNAL ON APPLIED DYNAMICAL SYSTEMS
(2022)
Article
Mathematics, Applied
Dai-Ni Hsieh, Sylvain Arguillere, Nicolas Charon, Laurent Younes
Summary: This paper studies a longitudinal shape transformation model that deforms shapes in response to an evolving internal growth potential. The mathematical study of this model proves the uniqueness and long time existence of solutions. Additionally, simulations in 2D isotropic elastic materials are provided to demonstrate the application of this model.
QUARTERLY OF APPLIED MATHEMATICS
(2022)
Article
Multidisciplinary Sciences
Athira Jacob, Daniel J. Tward, Susan Resnick, Paul F. Smith, Christophe Lopez, Elliott Rebello, Eric X. Wei, J. Tilak Ratnanather, Yuri Agrawal
Review
Medicine, Research & Experimental
J. Tilak Ratnanather
WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE
(2020)
Proceedings Paper
Computer Science, Information Systems
Dai-Ni Hsieh, Sylvain Arguillere, Nicolas Charon, Michael I. Miller, Laurent Younes
INFORMATION PROCESSING IN MEDICAL IMAGING, IPMI 2019
(2019)