Article
Immunology
Winston E. Anthony, Carey-Ann D. Burnham, Gautam Dantas, Jennie H. Kwon
Summary: This review discusses the gut as a reservoir for antimicrobial resistance and pathogen colonization, with a focus on beta-lactam and plasmid-mediated quinolone resistance. It also explores the use of functional metagenomics and long-read sequencing technologies to detect and understand antimicrobial resistance genes within the gut microbiome, as well as the potential for future microbiome-directed methods for detecting and preventing infections.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Chemistry, Medicinal
Liqiang Hu, Huixin Yang, Tao Yu, Fangfang Chen, Runqiu Liu, Shuyuan Xue, Shuangzhan Zhang, Wuyu Mao, Changge Ji, Hao Wang, Hexin Xie
Summary: This study demonstrates the effectiveness of stereochemically altered cephalosporins as potent inhibitors against NDM-1, a major cause of antibiotic resistance. The findings provide a new approach to combat antibiotic resistance.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Katariina M. M. Parnanen, Jenni Hultman, Melina Markkanen, Reetta Satokari, Samuli Rautava, Regina Lamendella, Justin Wright, Christopher J. McLimans, Shannon L. Kelleher, Marko P. Virta
Summary: The study found that early exposure to formula is correlated with a higher neonatal ARG burden, suggesting that feeding mode should be considered by clinicians to minimize the proliferation of antibiotic-resistant gut bacteria in infants, in addition to antibiotic use during the first months of life.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Microbiology
Zhiyuan He, Yulin Ma, Sirui Yang, Shuyuan Zhang, Shuai Liu, Jianxin Xiao, Yajing Wang, Wei Wang, Hongjian Yang, Shengli Li, Zhijun Cao
Summary: This study provides evidence that UDCA can confer diarrhea resistance in newborn dairy calves infected with ESBL-EAEC. UDCA blocks bacterial growth and invasion, alleviates commensal bacterial dysbiosis in neonatal mouse models of sepsis and colitis via the TGR5-NF-kappa B axis, and upregulates SCFA production in the hindgut digesta.
Article
Microbiology
Kevin S. Blake, Drew J. Schwartz, Srinand Paruthiyil, Bin Wang, Jie Ning, Sandra D. Isidean, Daniel S. Burns, Harris Whiteson, Tahaniyat Lalani, Jamie A. Fraser, Patrick Connor, Tom Troth, Chad K. Porter, David R. Tribble, Mark S. Riddle, Ramiro L. Gutierrez, Mark P. Simons, Gautam Dantas
Summary: This study found that antibiotics used for treatment or prophylaxis of travelers’ diarrhea have minimal impact on the gut microbiome and carriage of antibiotic resistance genes.
Article
Multidisciplinary Sciences
Andrea Laconi, Roberta Tolosi, Lapo Mughini-Gras, Matteo Cuccato, Francesca Tiziana Cannizzo, Alessandra Piccirillo
Summary: This study aimed to assess the dynamics of microbial communities and antimicrobial resistance genes (ARGs) in the chicken gut following amoxicillin and thiamphenicol treatments and potential co-selection of ARGs. Results showed that the administered antimicrobials changed the composition of the gut microbiome, with certain bacteria being enriched after treatment. The abundance of ARGs also increased, possibly due to interaction between the two antimicrobials.
SCIENTIFIC REPORTS
(2022)
Review
Chemistry, Multidisciplinary
Yang Ding, Zheng Li, Chenchen Xu, Wenjing Qin, Qiong Wu, Xuchun Wang, Xiamin Cheng, Lin Li, Wei Huang
Summary: Beta-lactam antibiotics are important inventions in treating infections, but the emergence of beta-lactamase in bacteria leads to drug resistance. Various detection methods and inhibitors are available, and designing improved probes may help overcome bacterial resistance.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Microbiology
Yueyang Yan, Hao Li, Amna Fayyaz, Yunpeng Gai
Summary: The study investigated the diversity and abundance of antibiotic resistance genes in the gut microbiota of cynomolgus monkeys using metagenomic analysis. It was found that dietary changes significantly affect the composition and abundance of ARGs in the gut microbiota of cynomolgus monkeys. Furthermore, all ARG types carried by humans were also present in cynomolgus monkeys, indicating potential conservation and homology in tetracycline resistance genes.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Peixin Fan, Zhengxin Ma, Arianna J. Partow, Miju Kim, Grace M. Shoemaker, Ruwen Tan, Zhaohui Tong, Corwin D. Nelson, Yeongseon Jang, Kwangcheol C. Jeong
Summary: Antimicrobial resistance poses a major global threat, especially multidrug resistant ESBL-producing pathogens. Researchers developed a novel therapy combining cephalosporin antibiotics and beta-lactamase inhibitors encapsulated in chitosan nanoparticles, effectively combating drug-resistant Enterobacteriaceae and showing promising potential for treating critically important infections.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Microbiology
Carola Venturini, Bethany Bowring, Alicia Fajardo-Lubian, Carol Devine, Jonathan Iredell
Summary: The study found that different antibiotics have a significant impact on the gut microbiota of mice, with third-generation cephalosporins causing more severe dysbiosis. Even after the antibiotics are stopped, the gut of mice remains highly susceptible to colonization by antibiotic-resistant enterobacterial pathogens. Co-habitation of untreated mice with treated mice can mitigate the dysbiosis caused by treatment.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Gastroenterology & Hepatology
Matthew Davies, Gianluca Galazzo, Jarne M. van Hattem, Maris S. Arcilla, Damian C. Melles, Menno D. de Jong, Constance Schultsz, Petra Wolffs, Alan McNally, Willem van Schaik, John Penders
Summary: Previous studies have shown a high risk of ESBL-producing Enterobacteriaceae acquisition among international travelers visiting AMR hotspots. This study investigated whether successful colonization of ESBL-E during travel is associated with the composition, functional capacity, and resilience of the traveler's microbiome. The results suggest that changes in the microbial composition and abundance of certain bacteria may play a role in preventing ESBL-E acquisition.
Article
Biochemistry & Molecular Biology
Bernhard Kienesberger, Beate Obermueller, Georg Singer, Barbara Mittl, Reingard Grabherr, Sigrid Mayrhofer, Stefan Heinl, Vanessa Stadlbauer, Angela Horvath, Wolfram Miekisch, Patricia Fuchs, Ingeborg Klymiuk, Holger Till, Christoph Castellani
Summary: The study assessed the antimicrobial activity of (S)-reutericyclin against various bacteria in vitro and its effects on the fecal microbiome and VOC profile in murine models in vivo. Results showed that (S)-reutericyclin only inhibited the growth of S. epidermidis, leading to shifts in microbiome composition and alterations in fecal VOC profile. This differs from previous reports on (R)-reutericyclin and highlights the potential dysbiotic effects of (S)-reutericyclin in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Masood Ur Rehman Kayani, Kan Yu, Yushu Qiu, Yao Shen, Caixia Gao, Ru Feng, Xinxin Zeng, Weiye Wang, Lei Chen, Huang Li Su
Summary: Long-term exposure to environmental concentrations of oxytetracycline and sulfamethoxazole significantly affects the taxonomic composition and metabolic pathways of the zebrafish gut microbiome, leading to an increase in abundance of pathogenic bacteria, antibiotic resistance genes, and associated pathways.
ENVIRONMENTAL POLLUTION
(2021)
Article
Microbiology
Jieun Kim, Erin Kim, Bongyoung Kim, Jinsup Kim, Hyun Ju Lee, Jun-Sun Park, Sehee Hwang, Mina Rho, Hyunjoo Pai
Summary: The study examines the bacterial composition of the gut microbiota in different age groups in Korea. The results indicate that bacterial diversity of the gut microbiota increases with age, and there are significant differences between different age groups.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Microbiology
Silvia Saturio, Alejandra Rey, Anna Samarra, Maria Carmen Collado, Marta Suarez, Laura Mantecon, Gonzalo Solis, Miguel Gueimonde, Silvia Arboleya
Summary: The development of the neonate's intestinal microbiome begins at birth when the mother provides the initial microbial inoculum. This microbiome contains antibiotic resistance genes, which are affected by different perinatal factors. Antibiotics, commonly used in pediatrics, can disrupt the early microbiota and increase the levels of antibiotic resistance genes. Understanding the factors influencing the development of the resistome in early life is crucial due to the emergence of antibiotic-resistant microorganisms.