Review
Immunology
Jose Inciarte-Mundo, Beatriz Frade-Sosa, Raimon Sanmarti
Summary: S100A9/S100A8 (calprotectin), a member of the S100 protein family, plays a crucial role in innate immunity activation and is essential in the pathogenesis of rheumatoid arthritis (RA). Calprotectin levels in serum or plasma have been found to correlate better with composite inflammatory disease activity indexes compared to conventional markers like C-reactive protein (CRP) or erythrocyte sedimentation rate (ESR). It independently predicts radiographic progression and shows strong correlations with other sensitive techniques to detect inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Michael Gernert, Marc Schmalzing, Hans-Peter Tony, Patrick-Pascal Strunz, Eva Christina Schwaneck, Matthias Froehlich
Summary: Calprotectin in the serum can be a useful inflammation parameter in tocilizumab-treated rheumatoid arthritis patients, with good sensitivity and specificity for detecting disease activity.
ARTHRITIS RESEARCH & THERAPY
(2022)
Article
Multidisciplinary Sciences
Ruisheng Song, Kevin Struhl
Summary: The study reveals that the calcium-dependent cytokines S100A8 and S100A9 can act as transcriptional coactivators in breast cellular transformation, enhancing oncogenic transcription and promoting the transformation phenotype.
Review
Immunology
Pengpeng Xia, Xingduo Ji, Li Yan, Siqi Lian, Ziyue Chen, Yi Luo
Summary: S100 proteins are small proteins that are only expressed in vertebrates and play a crucial role in various biological processes. Among them, S100A8, S100A9, and S100A12 are important in resisting microbial infection and maintaining immune homeostasis. They can chelate metal nutrients of pathogens, inhibit pathogen growth, initiate inflammatory signal transduction, induce cytokine expression, and participate in immune regulation. They can also serve as disease markers for screening and detecting related diseases.
Article
Rheumatology
Celine La, Phu Quoc Le, Alina Ferster, Laurence Goffin, Delphine Spruyt, Bernard Lauwerys, Patrick Durez, Cecile Boulanger, Tatiana Sokolova, Joanne Rasschaert, Valerie Badot
Summary: The study demonstrates the potential utility of sCal as a biomarker in the diagnosis and monitoring of juvenile idiopathic arthritis (JIA), providing valuable information on disease activity, treatment response, and risk of flares.
Article
Biochemistry & Molecular Biology
Woosol Chris Hong, Da Eun Lee, Hyeon Woong Kang, Myeong Jin Kim, Minsoo Kim, Ju Hyun Kim, Sungsoon Fang, Hyo Jung Kim, Joon Seong Park
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly form of pancreatic cancer and the role of CD74 in PDAC is not well understood. Silencing CD74 in the pancreatic cancer cell line Capan-1 led to reduced cell proliferation, migration, invasion, increased apoptosis, and decreased expression and secretion of S100A8 and S100A9. The study suggests that CD74 may serve as a potential diagnostic biomarker and therapeutic target for pancreatic cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Nuria Barbarroja, Maria Dolores Lopez-Montilla, Laura Cuesta-Lopez, Carlos Perez-Sanchez, Miriam Ruiz-Ponce, Clementina Lopez-Medina, Maria Lourdes Ladehesa-Pineda, Chary Lopez-Pedrera, Alejandro Escudero-Contreras, Eduardo Collantes-Estevez, Ivan Arias-de la Rosa
Summary: This study characterized the inflammatory proteome of synovial fluid in patients with Psoriatic Arthritis (PsA) using a high-throughput proteomic platform. The results showed the presence of 79 inflammation-related proteins in the synovial fluid of PsA patients, and identified two specific phenotypes based on the levels of these proteins. Additionally, compared to patients with osteoarthritis, PsA patients had significantly altered levels of 39 proteins specifically related to cell migration and inflammatory response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Ari Polachek, Victoria Furer, Mirna Zureik, Sharon Nevo, Liran Mendel, David Levartovsky, Jonathan Wollman, Valerie Aloush, Reut Tzemach, Ofir Elalouf, Marina Anouk, Mark Berman, Ilana Kaufman, Or Carmi, Yael Lahat, Tali Eviatar, Hagit Padova, Hagit Sarbagil-Maman, Sara Borok, Adi Broyde, Lihi Eder, Daphna Paran, Ori Elkayam
Summary: This study found that ultrasound has a significantly greater value than composite clinical scores in the assessment of disease activity in PsA patients with FMS. Patients with both PsA and FMS had significantly higher clinical composite indices scores, while their ultrasound scores were similar to those without FMS.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Liliana F. Mellor, Nuria Gago-Lopez, Latifa Bakiri, Felix N. Schmidt, Bjorn Busse, Simon Rauber, Maria Jimenez, Diego Megias, Sergio Oterino-Soto, Ricardo Sanchez-Prieto, Sergei Grivennikov, Xinzhu Pu, Julia Oxford, Andreas Ramming, Georg Schett, Erwin F. Wagner
Summary: Keratinocyte-derived S100A9 plays a regulatory role in psoriatic skin and joint disease. In addition, S100A9 and CP have the potential to serve as biomarkers for identifying Ps patients at risk of developing PsA.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Medicine, General & Internal
Isaac T. Cheng, Huan Meng, Martin Li, Edmund K. Li, Priscilla C. Wong, Jack Lee, Bryan P. Yan, Alex P. W. Lee, Ho So, Lai-Shan Tam
Summary: This study found an association between serum calprotectin level and the presence of carotid plaque in patients with PsA. The levels of Ln-calprotectin and PsA disease duration were identified as predictors for CP presence. Further studies are needed to confirm the connection between this pathway and CV events in PsA.
FRONTIERS IN MEDICINE
(2022)
Article
Rheumatology
M. Romano, V Gerloni, O. De Lucia, D. Piskin, T. Giani, M. Gattinara, M. O. Borghi, C. Bodio, M. Mahler, P. L. Meroni, R. Cimaz
Summary: This study explored the association between serum calprotectin levels, clinical, and ultrasound assessment in JIA patients. Results showed moderate correlation between calprotectin levels and CRP, but no association with disease status in patients with low number of active joints. Further studies with a larger number of patients are needed.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Article
Rheumatology
Milena L. Pachowsky, Maria Gabriella Raimondo, Cong Xu, Simon Rauber, Koray Tascilar, Hannah Labinsky, Mario Vogg, Mina Saad Aziz Saad, David Simon, Juergen Rech, Alina Soare, Lars Braeuer, Arnd Kleyer, Georg Schett, Andreas Ramming
Summary: A minimally invasive biopsy technique was established to retrieve entheseal tissue in patients with psoriatic arthritis. Label-free second harmonic generation microscopy was used to analyze the biopsies, which showed high fraction of entheseal tissue and immune cell infiltration. The technique provides a reliable way to study entheseal tissue in psoriatic arthritis.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Gavriel Balulu, Victoria Furer, Jonathan Wollman, David Levartovsky, Valerie Aloush, Ofir Elalouf, Hagit Sarbagil-Maman, Liran Mendel, Sara Borok, Daphna Paran, Ori Elkayam, Ari Polachek
Summary: This study aims to examine the association between sonographic enthesitis and sonographic synovitis and tenosynovitis in PsA patients, as well as the association between sonographic enthesitis and clinical characteristics. The results showed a significant association between sonographic enthesitis and sonographic synovitis and tenosynovitis, and the severity of sonographic enthesitis may be a marker for inflammatory activity in other musculoskeletal domains.
Review
Biochemistry & Molecular Biology
Julie Mondet, Simon Chevalier, Pascal Mossuz
Summary: Deregulations of S100A8 and S100A9 genes/proteins in acute leukemias impact prognosis by affecting leukemic cell viability through various mechanisms. Therapeutic targeting of S100A8 and S100A9 shows promise in improving treatment efficiency.
Article
Immunology
Karen F. Johnstone, Yuping Wei, Peter D. Bittner-Eddy, Gerrit W. Vreeman, Ian A. Stone, Jonathan B. Clayton, Cavan S. Reilly, Travis B. Walbon, Elisa N. Wright, Susan L. Hoops, William S. Boyle, Massimo Costalonga, Mark C. Herzberg
Summary: The study suggests that calprotectin can suppress the emergence of a dysbiotic oral microbial community in periodontitis, reducing immune effector activity and protecting against alveolar bone loss.
INFECTION AND IMMUNITY
(2021)