Review
Fisheries
Alehegne Yirsaw, Cynthia L. Baldwin
Summary: Goats are significant food animals with high adaptability. Infectious diseases can impact their productivity, while gamma delta T cells play important roles in immune responses. These cells respond to various infections and may have altered representation and function due to infection.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Oncology
Wenjing He, Yi Hu, Dan Chen, Yijia Li, Dongmei Ye, Qiang Zhao, Li Lin, Xiaomin Shi, Ligong Lu, Zhinan Yin, Xiaoshun He, Yifang Gao, Yangzhe Wu
Summary: This study reported the dysfunctional features of γδ T cells in hepatocellular carcinoma (HCC) within the tumor microenvironment, providing scientific support for the use of allogeneic V delta 2(+) γδ T cells in HCC immunotherapy.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Review
Microbiology
Pedro H. Papotto, Bahtiyar Yilmaz, Bruno Silva-Santos
Summary: The interactions between microbiota and gamma delta T cells impact tissue homeostasis and disease pathology, with microbiota-induced IL-17-producing gamma delta T cells playing a role in various immunological processes. However, the reciprocal interactions between gamma delta T cells and microbiota remain to be fully elucidated.
NATURE MICROBIOLOGY
(2021)
Review
Immunology
Thomas Herrmann, Mohindar M. Karunakaran
Summary: This article discusses the role of BTNs, related molecules, and SKINT1 in the development, activation, and homeostasis of γδT cells, as well as their potential as interesting targets for therapeutic intervention.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Lea Rimailho, Carla Faria, Marcin Domagala, Camille Laurent, Christine Bezombes, Mary Poupot
Summary: Despite advancements in therapy and increased survival rates, B cell malignancies often lead to relapse. Immune cell-based therapies, particularly γδ T cells, show promising results for cancer immunotherapy. Manipulating γδ T cells through immunotherapeutic approaches provides potential treatment strategies for B cell malignancies.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Mousumi Mahapatro, Lena Erkert, Christoph Becker
Summary: Cytokines play a crucial role in the gut by regulating immune responses and disease susceptibility loci, influencing gut health. Intestinal epithelial cells act as translators between the microbiota and the immune system, maintaining gut homeostasis.
Article
Pharmacology & Pharmacy
Shihong Zhong, Qiong Li, Chunhua Wen, Yifan Li, Yang Zhou, Zihan Jin, Guofu Ye, Yanda Zhao, Jinlin Hou, Yongyin Li, Libo Tang
Summary: The objective of this study was to investigate the role of B cells in IFN-alpha-mediated anti-HBV cellular immunity. The results showed that B cell depletion impaired the function of T cells and delayed HBV clearance. IFN-alpha treatment enhanced the response of HBV-specific CD8+ T cells, but this effect was lost in B cell-deficient models. These findings suggest that IFN-alpha orchestrates protective HBV-specific cellular immunity in a B cell-dependent manner.
ANTIVIRAL RESEARCH
(2022)
Editorial Material
Immunology
Mitchell N. Lefebvre, John T. Harty
Summary: The new research shows that gamma delta T cells recognize Plasmodium-infected erythrocytes through the interaction of the T cell antigen receptor with the phosphoantigen sensor BTN3A1 and subsequently destroy infected cells either by secreting cytotoxic molecules or through antibody-dependent phagocytosis.
Article
Oncology
Dongli Song, Furong Yan, Huirong Fu, Liyang Li, Jie Hao, Zhenhua Zhu, Ling Ye, Yong Zhang, Meiling Jin, Lihua Dai, Hao Fang, Zhenju Song, Duojiao Wu, Xiangdong Wang
Summary: Increasing evidence indicates the central role of the immune system in lung diseases, providing opportunities for immunotherapy. Studying immunological alterations between lung diseases through proteomic and transcriptomic profiles offers new insights into immune cell function and interactions.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Immunology
Yang Li, Gen Li, Jian Zhang, Xiaoli Wu, Xi Chen
Summary: Gamma delta T cells, a unique subgroup of T cells, can promote anti-tumor immune response but also potentially contribute to tumor progression. Studies have summarized and discussed their functions and effects in cancer, as well as reviewed recent anti-tumor immunotherapy based on gamma delta T cells, and identified existing problems and future prospects of this immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Defne Bayik, Justin D. Lathia
Summary: The development of tumors is affected by cellular heterogeneity and an immunosuppressive tumor microenvironment, which interact with each other and lead to therapeutic resistance. The interaction between cancer stem cells and infiltrating immune cell populations in the tumor microenvironment promotes tumor development and immune evasion.
NATURE REVIEWS CANCER
(2021)
Review
Immunology
Byunghyuk Lee, Seung-Hyo Lee, Kihyuk Shin
Summary: Fibroblasts play a crucial role in supporting organ structures and regulating immune responses. They have diverse origins and functions, leading to distinct phenotypes and functions in different organs. Fibroblasts can interact with T cells to modulate immune responses, influencing the development and progression of inflammatory diseases. Understanding the mechanisms of fibroblast-T cell interactions could provide new insights into therapeutic targets for various diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Virology
Eleonora Cimini, Chiara Agrati
Summary: New emerging viruses pose serious threats to public health and are a global concern. Monitoring the emergence and transmission of these viruses is crucial for public health authorities. γδ T cells, as part of the innate immune system, play a vital role in protecting the host from viral infections. They have the ability to directly combat a wide range of viruses and orchestrate the interaction between innate and acquired immunity.
Article
Immunology
Alexandra L. Morrison, Sally Sharpe, Andrew D. White, Mark Bodman-Smith
Summary: Research suggests that the BCG vaccine could be a valuable tool in combating new SARS-CoV-2 variants by providing broad protection, including against respiratory viruses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Bing Liu, Xu He, Yong Wang, Jian-Wen Huang, You-Bing Zheng, Yong Li, Li-Gong Lu
Summary: Gamma delta T cells are unique immune cells that play a role in cancer progression, particularly in gastric and breast cancers. China has shown the highest productivity and citations in international research collaboration. The cytokines IL-17 and IL-2 are most commonly associated with gamma delta T cells and have different roles in various malignancies.
FRONTIERS IN IMMUNOLOGY
(2022)
