Interplay Between Genomic Alterations and Androgen Receptor Signaling During Prostate Cancer Development and Progression

Cancer statistics for Hispanics/Latinos, 2012

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Distinct Transcriptional Programs Mediated by the Ligand-Dependent Full-Length Androgen Receptor and Its Splice Variants in Castration-Resistant Prostate Cancer

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Androgen Receptor Splice Variants Mediate Enzalutamide Resistance in Castration-Resistant Prostate Cancer Cell Lines

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A transcriptional repressor co-regulatory network governing androgen response in prostate cancers

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Interactions and relationships of PTEN, ERG, SPINK1 and AR in castration-resistant prostate cancer

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The androgen receptor gene mutations database: 2012 update

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Androgen Receptor Splice Variants Activate Androgen Receptor Target Genes and Support Aberrant Prostate Cancer Cell Growth Independent of Canonical Androgen Receptor Nuclear Localization Signal

(2012) Siu Chiu Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mutational landscape of lethal castration-resistant prostate cancer

(2012) Catherine S. Grasso et al.   NATURE

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

(2012) Christopher E Barbieri et al.   NATURE GENETICS

Increased Survival with Enzalutamide in Prostate Cancer after Chemotherapy

(2012) Howard I. Scher et al.   NEW ENGLAND JOURNAL OF MEDICINE

AR intragenic deletions linked to androgen receptor splice variant expression and activity in models of prostate cancer progression

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Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways

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Disruptive Events in the Life of Prostate Cancer

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Common Structural and Epigenetic Changes in the Genome of Castration-Resistant Prostate Cancer

(2011) T. W. Friedlander et al.   CANCER RESEARCH

Intragenic Rearrangement and Altered RNA Splicing of the Androgen Receptor in a Cell-Based Model of Prostate Cancer Progression

(2011) Y. Li et al.   CANCER RESEARCH

Resistance to CYP17A1 Inhibition with Abiraterone in Castration-Resistant Prostate Cancer: Induction of Steroidogenesis and Androgen Receptor Splice Variants

(2011) Elahe A. Mostaghel et al.   CLINICAL CANCER RESEARCH

Molecular Alterations during Progression of Prostate Cancer to Androgen Independence

(2011) P. Saraon et al.   CLINICAL CHEMISTRY

Intratumoral androgen biosynthesis in prostate cancer pathogenesis and response to therapy

(2011) Changmeng Cai et al.   ENDOCRINE-RELATED CANCER

Alternatively spliced androgen receptor variants

(2011) Scott M Dehm et al.   ENDOCRINE-RELATED CANCER

Common Gene Rearrangements in Prostate Cancer

(2011) Mark A. Rubin et al.   JOURNAL OF CLINICAL ONCOLOGY

The genomic complexity of primary human prostate cancer

(2011) Michael F. Berger et al.   NATURE

Abiraterone and Increased Survival in Metastatic Prostate Cancer

(2011) Johann S. de Bono et al.   NEW ENGLAND JOURNAL OF MEDICINE

Recurrent deletion of CHD1 in prostate cancer with relevance to cell invasiveness

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Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1

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Expression of Androgen Receptor Splice Variants in Prostate Cancer Bone Metastases is Associated with Castration-Resistance and Short Survival

(2011) Emma Hörnberg et al.   PLoS One

Androgen Receptor Variants Occur Frequently in Castration Resistant Prostate Cancer Metastases

(2011) Xiaotun Zhang et al.   PLoS One

Advancing a clinically relevant perspective of the clonal nature of cancer

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Therapeutic Targeting of SPINK1-Positive Prostate Cancer

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Roles of the Polycomb group proteins in stem cells and cancer

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Regression of Castrate-Recurrent Prostate Cancer by a Small-Molecule Inhibitor of the Amino-Terminus Domain of the Androgen Receptor

(2010) Raymond J. Andersen et al.   CANCER CELL

An Integrated Network of Androgen Receptor, Polycomb, and TMPRSS2-ERG Gene Fusions in Prostate Cancer Progression

(2010) Jindan Yu et al.   CANCER CELL

Integrative Genomic Profiling of Human Prostate Cancer

(2010) Barry S. Taylor et al.   CANCER CELL

Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant

(2010) Shihua Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements

(2010) Michael C Haffner et al.   NATURE GENETICS

Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor

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Induction of Prostatic Intraepithelial Neoplasia and Modulation of Androgen Receptor by ETS Variant 1/ETS-Related Protein 81

(2009) S. Shin et al.   CANCER RESEARCH

Treatment-Dependent Androgen Receptor Mutations in Prostate Cancer Exploit Multiple Mechanisms to Evade Therapy

(2009) M. P. Steinkamp et al.   CANCER RESEARCH

A Novel Androgen Receptor Splice Variant Is Up-regulated during Prostate Cancer Progression and Promotes Androgen Depletion-Resistant Growth

(2009) Z. Guo et al.   CANCER RESEARCH

Nuclear Receptor-Induced Chromosomal Proximity and DNA Breaks Underlie Specific Translocations in Cancer

(2009) Chunru Lin et al.   CELL

The Role of Androgen Receptor Mutations in Prostate Cancer Progression

(2009) G. Brooke et al.   CURRENT GENOMICS

Cistromics of hormone-dependent cancer

(2009) Mathieu Lupien et al.   ENDOCRINE-RELATED CANCER

Induced Chromosomal Proximity and Gene Fusions in Prostate Cancer

(2009) R.-S. Mani et al.   SCIENCE

Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy

(2008) W Weichert et al.   BRITISH JOURNAL OF CANCER

The Role of SPINK1 in ETS Rearrangement-Negative Prostate Cancers

(2008) Scott A. Tomlins et al.   CANCER CELL

Splicing of a Novel Androgen Receptor Exon Generates a Constitutively Active Androgen Receptor that Mediates Prostate Cancer Therapy Resistance

(2008) S. M. Dehm et al.   CANCER RESEARCH

Ligand-Independent Androgen Receptor Variants Derived from Splicing of Cryptic Exons Signify Hormone-Refractory Prostate Cancer

(2008) R. Hu et al.   CANCER RESEARCH

FoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription

(2008) Mathieu Lupien et al.   CELL