Molecular mechanism of the intramembrane cleavage of the β-carboxyl terminal fragment of amyloid precursor protein by γ-secretase

Perturbations of the Straight Transmembrane α-Helical Structure of the Amyloid Precursor Protein Affect Its Processing by γ-Secretase

(2014) Thomas Lemmin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer Presenilin-1 Mutations Dramatically Reduce Trimming of Long Amyloid β-Peptides (Aβ) by γ-Secretase to Increase 42-to-40-Residue Aβ

(2014) Marty A. Fernandez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Three-dimensional structure of human γ-secretase

(2014) Peilong Lu et al.   NATURE

γ-Secretase Associated with Lipid Rafts

(2013) Nobutaka Matsumura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Intermediate Steps in Amyloid Beta (Aβ) Production under Near-native Conditions

(2013) Fredrik Olsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of Intramembrane Cleavage of Alcadeins by γ-Secretase

(2013) Yi Piao et al.   PLoS One

Alzheimer’s disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production

(2013) Mitko Dimitrov et al.   Nature Communications

γ-Secretase Modulators and Presenilin 1 Mutants Act Differently on Presenilin/γ-Secretase Function to Cleave Aβ42 and Aβ43

(2013) Masayasu Okochi et al.   Cell Reports

Presenilins and  -Secretase: Structure, Function, and Role in Alzheimer Disease

(2013) B. De Strooper et al.   Cold Spring Harbor Perspectives in Medicine

The Backbone Dynamics of the Amyloid Precursor Protein Transmembrane Helix Provides a Rationale for the Sequential Cleavage Mechanism of γ-Secretase

(2012) Oxana Pester et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of a presenilin family intramembrane aspartate protease

(2012) Xiaochun Li et al.   NATURE

Dissociation between the Processivity and Total Activity of γ-Secretase: Implications for the Mechanism of Alzheimer's Disease-Causing Presenilin Mutations

(2011) Omar Quintero-Monzon et al.   BIOCHEMISTRY

Evidence from Solid-State NMR for Nonhelical Conformations in the Transmembrane Domain of the Amyloid Precursor Protein

(2011) Jun-Xia Lu et al.   BIOPHYSICAL JOURNAL

The crystal structure of GXGD membrane protease FlaK

(2011) Jian Hu et al.   NATURE

Potent amyloidogenicity and pathogenicity of Aβ43

(2011) Takashi Saito et al.   NATURE NEUROSCIENCE

Alzheimer's Disease

(2011) D. J. Selkoe   Cold Spring Harbor Perspectives in Biology

Novel Research Horizons for Presenilins and γ-Secretases in Cell Biology and Disease

(2010) Bart De Strooper et al.   Annual Review of Cell and Developmental Biology

Membrane rafts in Alzheimer's disease beta-amyloid production

(2010) Kulandaivelu S. Vetrivel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

(2010) Inna Kuperstein et al.   EMBO JOURNAL

Three-Amino Acid Spacing of Presenilin Endoproteolysis Suggests a General Stepwise Cleavage of  -Secretase-Mediated Intramembrane Proteolysis

(2010) A. Fukumori et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's failure raises questions about disease-modifying strategies

(2010) Andy Extance   NATURE REVIEWS DRUG DISCOVERY

The 28-amino acid form of an APLP1-derived Aβ-like peptide is a surrogate marker for Aβ42 production in the central nervous system

(2009) Kanta Yanagida et al.   EMBO Molecular Medicine

Alcadein Cleavages by Amyloid β-Precursor Protein (APP) α- and γ-Secretases Generate Small Peptides, p3-Alcs, Indicating Alzheimer Disease-related γ-Secretase Dysfunction

(2009) Saori Hata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of  -Carboxyl Terminal Fragment

(2009) M. Takami et al.   JOURNAL OF NEUROSCIENCE

A helix-to-coil transition at the  -cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis

(2009) T. Sato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active γ-secretase is localized to detergent-resistant membranes in human brain

(2008) Ji-Yeun Hur et al.   FEBS Journal

Enzymatic Characteristics of I213T Mutant Presenilin-1/γ-Secretase in Cell Models and Knock-in Mouse Brains

(2008) Masafumi Shimojo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct and Potent Regulation of γ-Secretase by Its Lipid Microenvironment

(2008) Pamela Osenkowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY