Alzheimer Presenilin-1 Mutations Dramatically Reduce Trimming of Long Amyloid β-Peptides (Aβ) by γ-Secretase to Increase 42-to-40-Residue Aβ
出版年份 2014 全文链接
标题
Alzheimer Presenilin-1 Mutations Dramatically Reduce Trimming of Long Amyloid β-Peptides (Aβ) by γ-Secretase to Increase 42-to-40-Residue Aβ
作者
关键词
-
出版物
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 289, Issue 45, Pages 31043-31052
出版商
American Society for Biochemistry & Molecular Biology (ASBMB)
发表日期
2014-09-20
DOI
10.1074/jbc.m114.581165
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The Many Substrates of Presenilin/γ-Secretase
- (2018) Annakaisa Haapasalo et al. JOURNAL OF ALZHEIMERS DISEASE
- γ-Secretase inhibitors and modulators
- (2013) Todd E. Golde et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Trans-Dominant Negative Effects of Pathogenic PSEN1 Mutations on -Secretase Activity and A Production
- (2013) E. A. Heilig et al. JOURNAL OF NEUROSCIENCE
- γ-Secretase Modulators and Presenilin 1 Mutants Act Differently on Presenilin/γ-Secretase Function to Cleave Aβ42 and Aβ43
- (2013) Masayasu Okochi et al. Cell Reports
- The mechanism of γ-Secretase dysfunction in familial Alzheimer disease
- (2012) Lucía Chávez-Gutiérrez et al. EMBO JOURNAL
- Dissociation between the Processivity and Total Activity of γ-Secretase: Implications for the Mechanism of Alzheimer's Disease-Causing Presenilin Mutations
- (2011) Omar Quintero-Monzon et al. BIOCHEMISTRY
- Purine derivatives as potent γ-secretase modulators
- (2010) Alexey Rivkin et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio
- (2010) Inna Kuperstein et al. EMBO JOURNAL
- Three-Amino Acid Spacing of Presenilin Endoproteolysis Suggests a General Stepwise Cleavage of -Secretase-Mediated Intramembrane Proteolysis
- (2010) A. Fukumori et al. JOURNAL OF NEUROSCIENCE
- Gamma-secretase activating protein is a therapeutic target for Alzheimer’s disease
- (2010) Gen He et al. NATURE
- The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel
- (2010) Kohji MORI et al. Psychogeriatrics
- -Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of -Carboxyl Terminal Fragment
- (2009) M. Takami et al. JOURNAL OF NEUROSCIENCE
- Enzymatic Characteristics of I213T Mutant Presenilin-1/γ-Secretase in Cell Models and Knock-in Mouse Brains
- (2008) Masafumi Shimojo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Independent Generation of Aβ42 and Aβ38 Peptide Species by γ-Secretase
- (2008) Eva Czirr et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Direct and Potent Regulation of γ-Secretase by Its Lipid Microenvironment
- (2008) Pamela Osenkowski et al. JOURNAL OF BIOLOGICAL CHEMISTRY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now