Article
Optics
Vladislav Moshaev, Yulia Leibin, Dror Malka
Summary: This paper studied and analyzed the forward biasing of Si PIN diode PS at 1550 nm wavelength, and optimization can reduce voltage, decrease attenuation, and achieve an extremely small voltage-length product, providing the potential for designing high-speed MZMs.
OPTICS AND LASER TECHNOLOGY
(2021)
Article
Chemistry, Physical
A. A. Malafronte, A. R. Petri, J. A. C. Goncalves, S. F. Barros, C. C. Bueno, N. L. Maidana, A. Mangiarotti, M. N. Martins, A. A. Quivy, V. R. Vanin
Summary: This study explores the potential of repurposing commercial silicon PIN photodiodes as particle detectors, with the BPX 65 photodiode meeting the requirements for low-cost and high performance. The electrical characteristics of the devices were tested and it was found that they provided good energy resolution for gamma-ray spectra testing.
RADIATION PHYSICS AND CHEMISTRY
(2021)
Article
Metallurgy & Metallurgical Engineering
Yang Shuai, Zhang Xiao-dong, Cao An, Luo Wen-yu, Zhang Guang-lei, Peng Bo, Zhao Jin-jin
Summary: The novel UHV 3D-PBL MPS has outstanding device performance, with the ability to transfer the peak electric field deeper into the epitaxial layer in the reverse blocking state, enhancing the device's ability to shield high electric fields and maintaining forward conduction characteristics.
JOURNAL OF CENTRAL SOUTH UNIVERSITY
(2021)
Article
Chemistry, Physical
Ian W. Hamley, Valeria Castelletto
Summary: This review summarizes the use of small-angle scattering (SAS) in the study of the self-assembly of peptides and peptide conjugates. It discusses the methods and analysis techniques, focusing on the capabilities of small-angle x-ray scattering (SAXS) and small-angle neutron scattering (SANS). Examples are provided to illustrate the application of these techniques in studying self-assembled structures, such as micelles, fibrils, and nanotubes, as well as ordered phases, peptide gels, and hybrid materials.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
Article
Multidisciplinary Sciences
Philip Arthur, Mubarak Sani Ellis, Abdul-Rahman Ahmed, Jerry John Kponyo
Summary: This work presents a pattern-reconfigurable circularly polarized antenna for 2.45 GHz industrial, scientific, and medical (ISM) band applications. The antenna achieves stable unidirectional radiation and adjustable radiation patterns, making it suitable for body-centric wireless communication and personal wireless area networks.
Review
Chemistry, Physical
Kun Qian, Randall E. Winans, Tao Li
Summary: Understanding the nanostructures of liquid electrolytes is crucial for enhancing electrochemical energy storage capacities, but the solvation structures and molecular dynamics in electrolytes are difficult to probe. Small-angle X-ray scattering (SAXS) offers unique insights into molecular clusters and ion pairs in electrolytes, with excellent time-resolution for studying molecular dynamics. This review focuses on the microscopic understanding of liquid electrolytes by SAXS and highlights the unique capabilities of X-ray scattering for nanostructure characterization.
ADVANCED ENERGY MATERIALS
(2021)
Article
Chemistry, Physical
A. C. Josemary Gonsalves, Alessio Mangiarotti, C. Carmen Bueno
Summary: The characterization of a dosimetry system based on a commercial PIN photodiode as a routine dosimeter in a 60Co industrial facility shows that it fully adheres to standard protocols for radiation processing dosimetry. The performance of the diode as a routine dosimeter is validated by its good overall agreement with radiochromic films and alanine dosimetry.
RADIATION PHYSICS AND CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Dainius Jakubauskas, Kell Mortensen, Poul Erik Jensen, Jacob J. K. Kirkensgaard
Summary: Research on ultrastructural membrane arrangements in living cells and their dynamic remodeling in response to environmental changes is an active area with large uncertainty. Noninvasive methods like X-ray and neutron scattering offer attractive complementary information to direct imaging in studying in vivo systems under near-natural conditions, but without solid structural modeling, scattering may provide qualitative information at best and direct misinterpretations at worst.
FRONTIERS IN CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Sungjae Hong, Chang-Ui Hong, Sol Lee, Myeongjin Jang, Chorom Jang, Yangjin Lee, Livia Janice Widiapradja, Sam Park, Kwanpyo Kim, Young-Woo Son, Jong-Gwan Yook, Seongil Im
Summary: Graphene has been widely used as an insertion layer in vertically stacked devices due to its excellent electrical tunabilities. However, its implications at ultrahigh frequencies have been rarely explored. In this study, diode operation of vertical Pt/n-MoSe2/graphene/Au assemblies at a cutoff frequency of about 200 GHz was demonstrated. The electric charge modulation by the inserted graphene becomes essentially frozen above a few GHz frequencies, transforming the Ohmic graphene/MoSe2 junction into a pinning-free Schottky junction. The diodes with graphene insertion exhibit much lower total capacitance and an order of magnitude higher cutoff frequency compared to devices without graphene, highlighting the significance of graphene at high frequencies.
Article
Biochemistry & Molecular Biology
Harald Rennhofer, Janea Kohnke, Jozef Keckes, Johannes Tintner, Christoph Unterweger, Thomas Zinn, Karl Deix, Helga Lichtenegger, Wolfgang Gindl-Altmutter
Summary: The utilization of low-cost carbon black from lignin relies heavily on the materials properties, such as pore structure and inner surfaces, which evolve with heat treatment temperature. The development of pore structure and graphitization increases with heat treatment temperature, leading to a shift in chemistry and bonding nature towards pure graphite. Heat treatment at 1600 degrees C may be sufficient for various applications, reducing production energy consumption while maintaining material properties.
Article
Engineering, Electrical & Electronic
John W. Murphy, Clint D. Frye, Roger A. Henderson, Mark A. Stoyer, Lars F. Voss, Rebecca J. Nikolic
Summary: The study demonstrates a high-aspect ratio, three-dimensionally structured betavoltaic device using high-aspect ratio silicon PIN diodes as the semiconductor absorber and (PmCl3)-Pm-147 as the beta emitter. The devices with different Pm-147 activities showed small deviations in output current, primarily attributed to humidity in the experimental room.
JOURNAL OF ELECTRONIC MATERIALS
(2021)
Article
Engineering, Electrical & Electronic
J. O. Bodunrin, D. A. Oeba, S. J. Moloi
Summary: Through current-voltage measurements on Fe doped n-Si, it was found that Fe doping can change the electrical properties of diodes, transforming their behavior from exponential to ohmic. In addition, the density of defect levels increased with Fe implantation fluence, leading to changes in the diode conduction mechanism.
MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING
(2021)
Article
Chemistry, Physical
A. Mangiarotti, A. R. Petri, A. A. Malafronte, J. A. C. Goncalves, S. F. Barros, C. C. Bueno, J. M. Fernandez-Varea, N. L. Maidana, M. N. Martins, V. R. Vanin
Summary: Commercial PIN photodiodes repurposed as particle detectors have gained significant attention for their low-cost solution suitability. In this study, the BPX-65 photodiode was used to measure electrons near an accelerator beam, and the response function was investigated through empirical expressions with 7 free parameters. The study also included experiments to estimate the thickness of the partially dead layer on the device.
RADIATION PHYSICS AND CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Jill Trewhella
Summary: Applications of small-angle scattering (SAS) in structural biology have been enhanced by advancements in instrumentation, data analysis tools, modeling capabilities, data presentation standards, and data archiving. These capabilities have allowed SAS to contribute to breakthroughs in the study of biomolecular complexes and assemblies, including whole cells, membrane proteins in lipid environments, and dynamic systems across various time scales.
Article
Chemistry, Physical
D. F. Coral, P. A. Soto, E. de Sousa, M. E. F. Brollo, J. A. Mera-Cordoba, P. Mendoza Zelis, C. P. Setton-Avruj, A. Roig, M. B. Fernandez van Raap
Summary: SAXS is a valuable tool for providing high-resolution information on the disposition and size distribution of nanoparticles inside cells, as well as quantifying nanoparticle uptake. Experiments using various iron oxide nanostructures as carriers demonstrate the potential of SAXS for analyzing MNP in cells and tissues.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Oncology
Elisabeth Schuetke, Sam Bayat, Stefan Bartzsch, Elke Brauer-Krisch, Valentin Djonov, Stefan Fiedler, Cristian Fernandez-Palomo, Felix Jaekel, Paolo Pellicioli, Verdiana Trappetti, Guido Hildebrandt
Summary: The mouse model study shows that microbeam irradiation in lung tissue has low acute adverse effects up to peak doses of 400 Gy. This model is well suited for exploring the potential of microbeam radiation therapy in the treatment of lung cancer.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Instruments & Instrumentation
Elisabeth Schueltke, Stefan Fiedler, Ralf Hendrik Menk, Felix Jaekel, Diego Dreossi, Katia Casarin, Giuliana Tromba, Stefan Bartzsch, Stephan Kriesen, Guido Hildebrandt, Fulvia Arfelli
Summary: Research has shown that microbeam irradiation can effectively control malignant tumor cells, with a reduction of approximately 80% observed in melanoma cells after MBI. While high energy is essential for achieving high dose rates, lower energy spectra may be equally suitable or even advantageous for in vitro studies and superficial tumor treatments.
JOURNAL OF SYNCHROTRON RADIATION
(2021)
Article
Multidisciplinary Sciences
Boris Krichel, Ganesh Bylapudi, Christina Schmidt, Clement Blanchet, Robin Schubert, Lea Brings, Martin Koehler, Renato Zenobi, Dmitri Svergun, Kristina Lorenzen, Ramakanth Madhugiri, John Ziebuhr, Charlotte Uetrecht
Summary: This study presents the framework of nsp7+8 complex stoichiometry and topology based on native mass spectrometry and complementary biophysical techniques. The complexes of seven coronaviruses cluster into three groups, forming either heterotrimers or heterotetramers with distinct topologies. SARS-CoV-2 nsp7+8 primarily consists of heterotetramers even at high protein concentrations.
Article
Chemistry, Multidisciplinary
Neda Iranpour Anaraki, Marianne Liebi, Quy Ong, Clement Blanchet, Anjani K. Maurya, Francesco Stellacci, Stefan Salentinig, Peter Wick, Antonia Neels
Summary: This study investigates the influence of nanoparticles properties on colloidal stability in NaCl and protein solutions, revealing that PEG coating provides high stability for nanoparticles. Different mechanisms are observed for citrate-capped nanoparticles, with proteins attaching to the nanoparticle surfaces. Findings pave the way for designing and synthesizing nanoparticles with controlled behaviors in biomedical applications.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Joao P. L. Guerra, Clement E. Blanchet, Bruno J. C. Vieira, Ana V. Almeida, Joao C. Waerenborgh, Nykola C. Jones, Soren V. Hoffmann, Pedro Tavares, Alice S. Pereira
Summary: DNA-binding proteins (Dps) are nanocages that bind and compact DNA to protect it from oxidative stress. The N-terminal tail extensions are crucial for DNA binding. However, the structure of Dps can be influenced by ionic strength, which may affect its DNA-binding properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Falko Lange, Timo Kirschstein, Jeremy Davis, Jason Paino, Micah Barnes, Mitzi Klein, Katrin Porath, Paula Stoehlmacher, Stefan Fiedler, Marcus Frank, Rudiger Koehling, Guido Hildebrandt, Daniel Hausermann, Michael Lerch, Elisabeth Schueltke
Summary: Microbeam radiation therapy (MRT) with a peak dose up to 400 Gy did not result in severe changes in cardiac electrophysiology or mechanics, indicating a potential for minimal acute and subacute toxicity.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Instruments & Instrumentation
Elisabeth Schueltke, Michael Lerch, Timo Kirschstein, Falko Lange, Katrin Porath, Stefan Fiedler, Jeremy Davis, Jason Paino, Elette Engels, Micah Barnes, Mitzi Klein, Christopher Hall, Daniel Haeusermann, Guido Hildebrandt
Summary: Microbeam radiotherapy has the potential to cure therapy-resistant malignant tumors. Researchers have developed a powerful ex vivo tool to assess the adverse effects of microbeam irradiation on the heart. In a pilot experiment, they found that the cardiac function was preserved despite temporary arrhythmias.
JOURNAL OF SYNCHROTRON RADIATION
(2022)
Article
Biochemistry & Molecular Biology
Munir A. Al-Zeer, Franziska Prehn, Stefan Fiedler, Ulrich Lienert, Michael Krisch, Johanna Berg, Jens Kurreck, Guido Hildebrandt, Elisabeth Schueltke
Summary: Radiotherapy is crucial in the treatment of lung cancer, but standardized samples are needed to evaluate new therapeutic approaches. 3D bioprinting techniques provide a sophisticated solution to this challenge. A pilot project using 3D printed standardized samples evaluated the effectiveness of radiotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Jill Trewhella, Patrice Vachette, Jan Bierma, Clement Blanchet, Emre Brookes, Srinivas Chakravarthy, Leonie Chatzimagas, Thomas E. Cleveland, Nathan Cowieson, Ben Crossett, Anthony P. Duff, Daniel Franke, Frank Gabel, Richard E. Gillilan, Melissa Graewert, Alexander Grishaev, J. Mitchell Guss, Michal Hammel, Jesse Hopkins, Qingqui Huang, Jochen S. Hub, Greg L. Hura, Thomas C. Irving, Cy Michael Jeffries, Cheol Jeong, Nigel Kirby, Susan Krueger, Anne Martel, Tsutomu Matsui, Na Li, Javier Perezt, Lionel Porcar, Thierry Prange, Ivan Rajkovic, Mattia Rocco, Daniel J. Rosenberg, Timothy M. Ryan, Soenke Seifert, Hiroshi Sekiguchi, Dmitri Svergun, Susana Teixeira, Aurelien Thureaut, Thomas M. Weiss, Andrew E. Whitten, Kathleen Wood, Xiaobing Zuo
Summary: By collecting SAXS and SANS measurements, consensus scattering profiles for proteins were obtained, which were consistent with theoretical predictions. Optimization of sample purification methods and measurement conditions can improve the quality and precision of the data.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY
(2022)
Article
Oncology
Elisabeth Schultke, Stefan Fiedler, Catharina Mewes, Elisabetta Gargioni, Johannes Klingenberg, Guilherme Abreu Faria, Michael Lerch, Marco Petasecca, Franziska Prehn, Marie Wegner, Marten Scholz, Felix Jaekel, Guido Hildebrandt
Summary: High dose rate radiotherapy has shown excellent preservation of normal tissue function and a new research tool has been developed to speed up the translation of experimental radiotherapy techniques. The tool enables delivery of dose rates of several hundred Gy/s, supporting efforts to improve radiotherapy concepts for radioresistant tumors.
Article
Biochemistry & Molecular Biology
Rita Del Giudice, Nicolo Paracini, Tomas Laursen, Clement Blanchet, Felix Roosen-Runge, Marite Cardenas
Summary: This study expands the toolkit of lipid and detergent combinations that allow the formation of stable bicelles. Systematic sample characterization using various techniques provides a set of conditions under which bicelles can be successfully formed.
Article
Biochemistry & Molecular Biology
Joao P. L. Guerra, Clement E. Blanchet, Bruno J. C. Vieira, Joao C. Waerenborgh, Nykola C. Jones, Soren Vronning Hoffmann, Alice S. Pereira, Pedro Tavares
Summary: DNA-binding proteins from starved cells (Dps) are small multifunctional nanocages expressed by prokaryotes as a bacterial defense mechanism. They protect bacterial DNA from damage by binding directly or removing precursors of reactive oxygen species. The conformation of the N-terminal tails of Dps proteins is altered upon metal binding in a reversible and specific manner, indicating a potential regulatory process for their DNA-binding properties through metal binding to their N- and/or C-terminal extensions.
Article
Cell Biology
Bernd Frerker, Stefan Fiedler, Timo Kirschstein, Falko Lange, Katrin Porath, Tina Sellmann, Leonie Kutzner, Fabian Wilde, Julian Moosmann, Ruediger Koehling, Guido Hildebrandt, Elisabeth Schueltke
Summary: In an ex vivo model of rodent esophageal smooth muscle, high-dose-rate radiotherapy did not affect the function of the contractile apparatus, but a significant increase in peak latency and a decrease in maximal force change were observed in the middle and distal esophageal segments, indicating delayed esophageal function.
Article
Nanoscience & Nanotechnology
Neda Iranpour Anaraki, Marianne Liebi, Kamran Iranshahi, Clement Blanchet, Peter Wick, Antonia Neels
Summary: The combination of microfluidic approach and SAXS measurements allows for the evaluation of nanoparticle systems in nanomedicine. The study shows that 5nm PEGylated gold nanoparticles can self-assemble into 3D ordered domains in different media and maintain this ordering in the presence of human serum albumin molecules.
ACS APPLIED NANO MATERIALS
(2022)
Article
Multidisciplinary Sciences
Melissa A. Graewert, Christoph Wilhelmy, Tijana Bacic, Jens Schumacher, Clement Blanchet, Florian Meier, Roland Drexel, Roland Welz, Bastian Kolb, Kim Bartels, Thomas Nawroth, Thorsten Klein, Dmitri Svergun, Peter Langguth, Heinrich Haas
Summary: This study presents a generic approach to determine size-dependent critical quality attributes in nanoparticulate pharmaceutical products, using a combination of AF4 and SAXS techniques. The method provides valuable information for the study and development of drug formulations.
SCIENTIFIC REPORTS
(2023)
