Evolving toward a human-cell based and multiscale approach to drug discovery for CNS disorders
出版年份 2014 全文链接
标题
Evolving toward a human-cell based and multiscale approach to drug discovery for CNS disorders
作者
关键词
-
出版物
Frontiers in Pharmacology
Volume 5, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2014-12-02
DOI
10.3389/fphar.2014.00252
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Role of Inflammation and Tumor Microenvironment in the Development of Gastrointestinal Cancers: What Induced Pluripotent Stem Cells Can Do?
- (2015) Lei Zhang et al. Current Stem Cell Research & Therapy
- Ponatinib overcomes FGF2-mediated resistance in CML patients without kinase domain mutations
- (2014) E. Traer et al. BLOOD
- Disruption of CRAF-Mediated MEK Activation Is Required for Effective MEK Inhibition in KRAS Mutant Tumors
- (2014) Piro Lito et al. CANCER CELL
- Failure to Induce Apoptosis via BCL-2 Family Proteins Underlies Lack of Efficacy of Combined MEK and PI3K Inhibitors for KRAS-Mutant Lung Cancers
- (2014) A. N. Hata et al. CANCER RESEARCH
- Survival, Durable Tumor Remission, and Long-Term Safety in Patients With Advanced Melanoma Receiving Nivolumab
- (2014) Suzanne L. Topalian et al. JOURNAL OF CLINICAL ONCOLOGY
- Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia
- (2014) K Brennand et al. MOLECULAR PSYCHIATRY
- De novo mutations in schizophrenia implicate synaptic networks
- (2014) Menachem Fromer et al. NATURE
- A polygenic burden of rare disruptive mutations in schizophrenia
- (2014) Shaun M. Purcell et al. NATURE
- Comprehensive molecular characterization of gastric adenocarcinoma
- (2014) Adam J. Bass et al. NATURE
- Synaptic dysregulation in a human iPS cell model of mental disorders
- (2014) Zhexing Wen et al. NATURE
- In vivo discovery of immunotherapy targets in the tumour microenvironment
- (2014) Penghui Zhou et al. NATURE
- Unifying immunology with informatics and multiscale biology
- (2014) Brian A Kidd et al. NATURE IMMUNOLOGY
- Roles of Heat Shock Factor 1 in Neuronal Response to Fetal Environmental Risks and Its Relevance to Brain Disorders
- (2014) Kazue Hashimoto-Torii et al. NEURON
- PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context
- (2014) F. Schmit et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing
- (2014) J. Zhang et al. SCIENCE
- Exploiting epigenetic vulnerabilities for cancer therapeutics
- (2014) Barbara Mair et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- The ALK Inhibitor Ceritinib Overcomes Crizotinib Resistance in Non-Small Cell Lung Cancer
- (2014) L. Friboulet et al. Cancer Discovery
- A Melanoma Cell State Distinction Influences Sensitivity to MAPK Pathway Inhibitors
- (2014) D. J. Konieczkowski et al. Cancer Discovery
- Alzheimer’s disease drug-development pipeline: few candidates, frequent failures
- (2014) Jeffrey L Cummings et al. Alzheimers Research & Therapy
- Intrinsic Resistance to MEK Inhibition in KRAS Mutant Lung and Colon Cancer through Transcriptional Induction of ERBB3
- (2014) Chong Sun et al. Cell Reports
- RAF Suppression Synergizes with MEK Inhibition in KRAS Mutant Cancer Cells
- (2014) Simona Lamba et al. Cell Reports
- Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem Cells
- (2014) Diana Xuan Yu et al. Stem Cell Reports
- Antipsychotic Treatment Resistance in Schizophrenia Associated with Elevated Glutamate Levels but Normal Dopamine Function
- (2013) Arsime Demjaha et al. BIOLOGICAL PSYCHIATRY
- A long-term, phase 2, multicenter, randomized, open-label, comparative safety study of pomaglumetad methionil (LY2140023 monohydrate) versus atypical antipsychotic standard of care in patients with schizophrenia
- (2013) David H Adams et al. BMC Psychiatry
- The Evolution of Melanoma Resistance Reveals Therapeutic Opportunities
- (2013) M. D. Thakur et al. CANCER RESEARCH
- Transformed Drosophila Cells Evade Diet-Mediated Insulin Resistance through Wingless Signaling
- (2013) Susumu Hirabayashi et al. CELL
- Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease
- (2013) Bin Zhang et al. CELL
- Directed Differentiation and Functional Maturation of Cortical Interneurons from Human Embryonic Stem Cells
- (2013) Asif M. Maroof et al. Cell Stem Cell
- Functional Maturation of hPSC-Derived Forebrain Interneurons Requires an Extended Timeline and Mimics Human Neural Development
- (2013) Cory R. Nicholas et al. Cell Stem Cell
- Bench to bedside with fruit flies: an interview with Ross Cagan
- (2013) Disease Models & Mechanisms
- Imaging glutamate in schizophrenia: review of findings and implications for drug discovery
- (2013) E M P Poels et al. MOLECULAR PSYCHIATRY
- Abnormal neuronal differentiation and mitochondrial dysfunction in hair follicle-derived induced pluripotent stem cells of schizophrenia patients
- (2013) O Robicsek et al. MOLECULAR PSYCHIATRY
- Integrated genomic characterization of endometrial carcinoma
- (2013) Gad Getz et al. NATURE
- Mutational landscape and significance across 12 major cancer types
- (2013) Cyriac Kandoth et al. NATURE
- Signatures of mutational processes in human cancer
- (2013) Ludmil B. Alexandrov et al. NATURE
- The Cancer Genome Atlas Pan-Cancer analysis project
- (2013) John N Weinstein et al. NATURE GENETICS
- Genome-wide association analysis identifies 13 new risk loci for schizophrenia
- (2013) Stephan Ripke et al. NATURE GENETICS
- Mechanisms of resistance to therapies targeting BRCA-mutant cancers
- (2013) Christopher J Lord et al. NATURE MEDICINE
- Alzheimer disease in the United States (2010-2050) estimated using the 2010 census
- (2013) L. E. Hebert et al. NEUROLOGY
- Pyramidal Neurons Derived from Human Pluripotent Stem Cells Integrate Efficiently into Mouse Brain Circuits In Vivo
- (2013) Ira Espuny-Camacho et al. NEURON
- Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells
- (2013) Yingsha Zhang et al. NEURON
- Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation
- (2013) S. Chanda et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Foretinib is a potent inhibitor of oncogenic ROS1 fusion proteins
- (2013) M. A. Davare et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Bypass Mechanisms of Resistance to Receptor Tyrosine Kinase Inhibition in Lung Cancer
- (2013) M. J. Niederst et al. Science Signaling
- Therapeutic Targeting of a Robust Non-Oncogene Addiction to PRKDC in ATM-Defective Tumors
- (2013) A. Riabinska et al. Science Translational Medicine
- A Drug Repositioning Approach Identifies Tricyclic Antidepressants as Inhibitors of Small Cell Lung Cancer and Other Neuroendocrine Tumors
- (2013) N. S. Jahchan et al. Cancer Discovery
- Relief of Profound Feedback Inhibition of Mitogenic Signaling by RAF Inhibitors Attenuates Their Activity in BRAFV600E Melanomas
- (2012) Piro Lito et al. CANCER CELL
- CNVs: Harbingers of a Rare Variant Revolution in Psychiatric Genetics
- (2012) Dheeraj Malhotra et al. CELL
- The GATA2 Transcriptional Network Is Requisite for RAS Oncogene-Driven Non-Small Cell Lung Cancer
- (2012) Madhu S. Kumar et al. CELL
- MED12 Controls the Response to Multiple Cancer Drugs through Regulation of TGF-β Receptor Signaling
- (2012) Sidong Huang et al. CELL
- Synthetic lethality of PARP and NAMPT inhibition in triple-negative breast cancer cells
- (2012) Ilirjana Bajrami et al. EMBO Molecular Medicine
- Reactivation of Mitogen-activated Protein Kinase (MAPK) Pathway by FGF Receptor 3 (FGFR3)/Ras Mediates Resistance to Vemurafenib in Human B-RAF V600E Mutant Melanoma
- (2012) Vipin Yadav et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Secondary mutations inBRCA2associated with clinical resistance to a PARP inhibitor
- (2012) Louise J Barber et al. JOURNAL OF PATHOLOGY
- Synthetic Lethal Screening with Small-Molecule Inhibitors Provides a Pathway to Rational Combination Therapies for Melanoma
- (2012) D. G. Roller et al. MOLECULAR CANCER THERAPEUTICS
- Common variant at 16p11.2 conferring risk of psychosis
- (2012) S Steinberg et al. MOLECULAR PSYCHIATRY
- Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers
- (2012) I.-M. Wang et al. Molecular Systems Biology
- Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
- (2012) Anirudh Prahallad et al. NATURE
- Systematic identification of genomic markers of drug sensitivity in cancer cells
- (2012) Mathew J. Garnett et al. NATURE
- Passenger deletions generate therapeutic vulnerabilities in cancer
- (2012) Florian L. Muller et al. NATURE
- Chemical genetic discovery of targets and anti-targets for cancer polypharmacology
- (2012) Arvin C. Dar et al. NATURE
- The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
- (2012) Jordi Barretina et al. NATURE
- Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
- (2012) Luke Jostins et al. NATURE
- Leveraging models of cell regulation and GWAS data in integrative network-based association studies
- (2012) Andrea Califano et al. NATURE GENETICS
- Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs
- (2012) S Hong Lee et al. NATURE GENETICS
- Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses
- (2012) Yichen Shi et al. NATURE NEUROSCIENCE
- Ponatinib in Refractory Philadelphia Chromosome–Positive Leukemias
- (2012) Jorge E. Cortes et al. NEW ENGLAND JOURNAL OF MEDICINE
- Modeling human cortical development in vitro using induced pluripotent stem cells
- (2012) J. Mariani et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Functional genomics identifies therapeutic targets for MYC-driven cancer
- (2012) M. Toyoshima et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- EGFR-Mediated Reactivation of MAPK Signaling Contributes to Insensitivity of BRAF -Mutant Colorectal Cancers to RAF Inhibition with Vemurafenib
- (2012) Ryan B. Corcoran et al. Cancer Discovery
- Stitching together Multiple Data Dimensions Reveals Interacting Metabolomic and Transcriptomic Networks That Modulate Cell Regulation
- (2012) Jun Zhu et al. PLOS BIOLOGY
- Inferring causal genomic alterations in breast cancer using gene expression data
- (2011) Linh M Tran et al. BMC Systems Biology
- LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress
- (2011) Ha Nam Nguyen et al. Cell Stem Cell
- Direct Reprogramming of Adult Human Fibroblasts to Functional Neurons under Defined Conditions
- (2011) Rajesh Ambasudhan et al. Cell Stem Cell
- Altered Oxygen Metabolism Associated to Neurogenesis of Induced Pluripotent Stem Cells Derived from a Schizophrenic Patient
- (2011) Bruna Da Silveira Paulsen et al. CELL TRANSPLANTATION
- A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort
- (2011) D. M. Greenawalt et al. GENOME RESEARCH
- Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation
- (2011) Aaron Y.L. Cheung et al. HUMAN MOLECULAR GENETICS
- Modelling schizophrenia using human induced pluripotent stem cells
- (2011) Kristen J. Brennand et al. NATURE
- MicroRNA-mediated conversion of human fibroblasts to neurons
- (2011) Andrew S. Yoo et al. NATURE
- Direct generation of functional dopaminergic neurons from mouse and human fibroblasts
- (2011) Massimiliano Caiazzo et al. NATURE
- Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease
- (2011) Sonja Kriks et al. NATURE
- Induction of human neuronal cells by defined transcription factors
- (2011) Zhiping P. Pang et al. NATURE
- A chemical-genetic screen reveals a mechanism of resistance to PI3K inhibitors in cancer
- (2011) Markus K Muellner et al. Nature Chemical Biology
- Genome-wide association study identifies five new schizophrenia loci
- (2011) NATURE GENETICS
- Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome
- (2011) Sergiu P Paşca et al. NATURE MEDICINE
- Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma
- (2011) Caroline Robert et al. NEW ENGLAND JOURNAL OF MEDICINE
- Isogenic Pairs of Wild Type and Mutant Induced Pluripotent Stem Cell (iPSC) Lines from Rett Syndrome Patients as In Vitro Disease Model
- (2011) Gene Ananiev et al. PLoS One
- Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer
- (2011) H. W. Cheung et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Exploring the Genomes of Cancer Cells: Progress and Promise
- (2011) M. R. Stratton SCIENCE
- Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease
- (2011) J. T. Dudley et al. Science Translational Medicine
- Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data
- (2011) M. Sirota et al. Science Translational Medicine
- Integrating Pathway Analysis and Genetics of Gene Expression for Genome-wide Association Studies
- (2010) Hua Zhong et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF
- (2010) Sonja J. Heidorn et al. CELL
- A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells
- (2010) Maria C.N. Marchetto et al. CELL
- Targeting the BCR-ABL Signaling Pathway in Therapy-Resistant Philadelphia Chromosome-Positive Leukemia
- (2010) T. O'Hare et al. CLINICAL CANCER RESEARCH
- Identification and validation of genes affecting aortic lesions in mice
- (2010) Xia Yang et al. JOURNAL OF CLINICAL INVESTIGATION
- Vandetanib for the Treatment of Patients With Locally Advanced or Metastatic Hereditary Medullary Thyroid Cancer
- (2010) Samuel A. Wells et al. JOURNAL OF CLINICAL ONCOLOGY
- RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
- (2010) Poulikos I. Poulikakos et al. NATURE
- RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
- (2010) Georgia Hatzivassiliou et al. NATURE
- Direct conversion of fibroblasts to functional neurons by defined factors
- (2010) Thomas Vierbuchen et al. NATURE
- Synthetic lethal approaches to breast cancer therapy
- (2010) Farah L. Rehman et al. Nature Reviews Clinical Oncology
- The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner
- (2010) E. W. Joseph et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Synthetic Lethal Screen of an EGFR-Centered Network to Improve Targeted Therapies
- (2010) I. Astsaturov et al. Science Signaling
- Characterizing Dynamic Changes in the Human Blood Transcriptional Network
- (2010) Jun Zhu et al. PLoS Computational Biology
- Liver and Adipose Expression Associated SNPs Are Enriched for Association to Type 2 Diabetes
- (2010) Hua Zhong et al. PLoS Genetics
- Dopamine D2 Receptor Levels in Striatum, Thalamus, Substantia Nigra, Limbic Regions, and Cortex in Schizophrenic Subjects
- (2009) Robert M. Kessler et al. BIOLOGICAL PSYCHIATRY
- Disentangling molecular relationships with a causal inference test
- (2009) Joshua Millstein et al. BMC GENETICS
- Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
- (2009) Ji Luo et al. CELL
- Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors
- (2009) Frank Soldner et al. CELL
- A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene
- (2009) Ji Luo et al. CELL
- Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1
- (2009) Kwan-Hyuck Baek et al. NATURE
- Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs
- (2009) Gabsang Lee et al. NATURE
- Common variants on chromosome 6p22.1 are associated with schizophrenia
- (2009) Jianxin Shi et al. NATURE
- Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
- (2009) Shaun M. Purcell et al. NATURE
- Common variants conferring risk of schizophrenia
- (2009) Hreinn Stefansson et al. NATURE
- Molecular networks as sensors and drivers of common human diseases
- (2009) Eric E. Schadt NATURE
- Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
- (2009) Stuart M Chambers et al. NATURE BIOTECHNOLOGY
- Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks
- (2009) Xia Yang et al. NATURE GENETICS
- EOS lentiviral vector selection system for human induced pluripotent stem cells
- (2009) Akitsu Hotta et al. Nature Protocols
- A network view of disease and compound screening
- (2009) Eric E. Schadt et al. NATURE REVIEWS DRUG DISCOVERY
- Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers
- (2009) Peter C. Fong et al. NEW ENGLAND JOURNAL OF MEDICINE
- Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449
- (2009) Charles M. Rudin et al. NEW ENGLAND JOURNAL OF MEDICINE
- Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma
- (2009) Daniel D. Von Hoff et al. NEW ENGLAND JOURNAL OF MEDICINE
- Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons
- (2009) L. Wen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma
- (2009) R. L. Yauch et al. SCIENCE
- Translation of the Philadelphia chromosome into therapy for CML
- (2008) B. J. Druker BLOOD
- Genomic Alterations of Anaplastic Lymphoma Kinase May Sensitize Tumors to Anaplastic Lymphoma Kinase Inhibitors
- (2008) U. McDermott et al. CANCER RESEARCH
- Disease-Specific Induced Pluripotent Stem Cells
- (2008) In-Hyun Park et al. CELL
- A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor
- (2008) Nicholas C Turner et al. EMBO JOURNAL
- Meta-analysis of 32 genome-wide linkage studies of schizophrenia
- (2008) M Y M Ng et al. MOLECULAR PSYCHIATRY
- Induced pluripotent stem cells from a spinal muscular atrophy patient
- (2008) Allison D. Ebert et al. NATURE
- Variations in DNA elucidate molecular networks that cause disease
- (2008) Yanqing Chen et al. NATURE
- Genetics of gene expression and its effect on disease
- (2008) Valur Emilsson et al. NATURE
- Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks
- (2008) Jun Zhu et al. NATURE GENETICS
- Integrated detection and population-genetic analysis of SNPs and copy number variation
- (2008) Steven A McCarroll et al. NATURE GENETICS
- Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons
- (2008) J. T. Dimos et al. SCIENCE
- Mapping the Genetic Architecture of Gene Expression in Human Liver
- (2008) Eric E Schadt et al. PLOS BIOLOGY
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