Review
Oncology
Rachel M. Morris, Toni O. Mortimer, Kim L. O'Neill
Summary: Cytokines play a crucial role in cancer development, influencing immune function, inflammation, and tumor cell survival. They also have a significant impact on the molecular biology and microbiology of the tumor microenvironment. Therefore, cytokines have become attractive targets for cancer treatment.
Review
Oncology
Shih-Hsuan Cheng, Hsin-Ying Clair Chiou, Jiunn-Wei Wang, Ming-Hong Lin
Summary: Gastrointestinal (GI) cancers are a major cause of cancer-related deaths worldwide. Despite advancements in current treatments, high recurrence rates still pose a challenge for patients with GI cancers. The tumor microenvironment (TME) plays a crucial role in tumor progression, metastasis, and chemotherapy resistance, particularly through the interaction of cytokines/chemokines produced by cancer-associated fibroblasts (CAFs). Understanding this crosstalk between CAFs and the TME can open new avenues for reducing therapeutic recurrence in GI cancers.
Article
Oncology
Moran Yang, Jiaqi Lu, Guodong Zhang, Yiying Wang, Mengdi He, Qing Xu, Congjian Xu, Haiou Liu
Summary: This study reveals the critical role of CXCL13 in shaping the antitumor microenvironment by facilitating the maintenance of CXCR5(+)CD8(+) T cells in TLSs, and supports a clinical investigation for a combination of CXCL13 and PD-1 blockade therapy in HGSC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Biochemistry & Molecular Biology
Nao Nagai, Yotaro Kudo, Daisuke Aki, Hayato Nakagawa, Koji Taniguchi
Summary: This article mainly discusses the effects of chronic inflammation on tumorigenesis and metastasis, as well as how it induces immune-suppressive tumor microenvironment. It also mentions the impact of chronic inflammation on age-related diseases, especially in the liver and colon.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Moloud Sooreshjani, Shashwat Tripathi, Corey Dussold, Hinda Najem, John de Groot, Rimas V. Lukas, Amy B. Heimberger
Summary: Glioblastoma, a highly infiltrative tumor, often recurs despite multi-modal treatment. Novel strategies incorporating cytokines as potential therapeutic options, including virotherapy, systemic cytokine therapy, and cellular and gene therapy, are being explored to improve treatment outcomes in glioblastoma patients.
Review
Cell Biology
Hsiang-Wei Huang, Cheng-Chih Chang, Chia-Siu Wang, Kwang-Huei Lin
Summary: Inflammatory processes play a crucial role in the tumor microenvironment, promoting tumor progression through cytokine release and cellular interactions. Immunosuppressive molecules in infiltrating immune and tumor cells inhibit cytotoxic T cells, allowing tumors to evade immune surveillance. Glycosylation and sialylation of overexpressed proteins on cancer cells enhance immune escape and metastasis.
Article
Medicine, Research & Experimental
Hongquan Qin, Jiali Chen, Katia Bouchekioua-Bouzaghou, Ya-Ming Meng, Jordi Bach Griera, Xue Jiang, Xiangzhan Kong, Minghui Wang, Qiuping Xu, Ping-Pui Wong
Summary: The study found that MAGEA regulates tumor-stromal crosstalk in PDAC, with high expression correlating with poor chemotherapeutic response and prognosis in multiple cancers. The mechanism includes inhibition of gemcitabine-induced cancer cell apoptosis and activation of GDF15 secretion to enhance gemcitabine resistance. Targeting MAGEA-mediated paracrine regulation of chemoresistance by immunotherapy could be a promising strategy for pancreatic cancer treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Carlo Sorrentino, Stefania Livia Ciummo, Luigi D'Antonio, Cristiano Fieni, Paola Lanuti, Alice Turdo, Matilde Todaro, Emma Di Carlo
Summary: IL30 plays a crucial role in regulating the viability and growth of breast cancer stem cells (BCSC) through juxtacrine signals and mediators such as CXCL10 and IL23. Targeting IL30 could potentially restrain the BCSC compartment and counteract breast cancer progression by disrupting its autocrine loops and immune subversion pathways.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Saisai Chen, Kai Lu, Yue Hou, Zonghao You, Chuanjun Shu, Xiaoying Wei, Tiange Wu, Naipeng Shi, Guangyuan Zhang, Jianping Wu, Shuqiu Chen, Lihua Zhang, Wenchao Li, Dingxiao Zhang, Shenghong Ju, Ming Chen, Bin Xu
Summary: The study found that high expression of YY1 is closely associated with M2 macrophages in prostate cancer, promoting tumor development. The study also revealed that treatment targeting YY1 can suppress tumor metastasis and generate synergistic anti-tumor effects. Furthermore, the study revealed that YY1 upregulates IL-6 expression by regulating enhancer-promoter interactions, thereby promoting tumor progression.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Leonie K. de Klerk, Anuj K. Patel, Sarah Derks, Eirini Pectasides, Jeremy Augustin, Mohamed Uduman, Nihal Raman, Fahire G. Akarca, Nadine J. McCleary, James M. Cleary, Douglas A. Rubinson, Jeffrey W. Clark, Bridget Fitzpatrick, Lauren K. Brais, Megan E. Cavanaugh, Amanda J. Rode, Melissa G. Jean, Patrick H. Lizotte, Matthew J. Nazzaro, Mariano Severgnini, Hui Zheng, Charles S. Fuchs, Peter C. Enzinger, Adam J. Bass
Summary: This study indicates that single-agent pembrolizumab has limited efficacy in patients with esophageal cancer, but circulating CXCL10 at baseline appears to be a robust predictor of response. Upregulation of other T cell exhaustion markers in PD-L1-positive patients suggests that immunotherapy combinations may hold promise in refractory esophageal cancer treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Chemistry, Multidisciplinary
Lin Jia, Fei Gao, Guiming Hu, Yan Fang, Liming Tang, Qiang Wen, Na Gao, Haiwei Xu, Hailing Qiao
Summary: Lung cancer, the leading cause of cancer-related deaths, is closely associated with persistent chronic inflammatory microenvironment. This study demonstrates that the novel CYP2E1 inhibitor Q11 is effective in treating lung cancer in mice, mainly by changing macrophage polarization. The findings suggest that CYP2E1 may serve as a promising inflammatory target for lung cancer therapy.
Review
Cell Biology
Zhengshuo Li, Xiaoyue Zhang, Can Liu, Jian Ma
Summary: Genetic susceptibility factors, immune microenvironment, and microbial factors interact to contribute to gastrointestinal tumorigenesis. The suppressive immune microenvironment reshaped by tumors directly leads to T-cell depletion in tumor immunotherapy. Soluble factors secreted by tumor or stromal cells collectively shape the suppressive immune environment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Federica Papaccio, Daniela Kovacs, Barbara Bellei, Silvia Caputo, Emilia Migliano, Carlo Cota, Mauro Picardo
Summary: Research indicates that cancer-associated fibroblasts play significant roles in tumor growth, extracellular matrix remodeling, and inflammatory response. A thorough understanding of the melanoma-fibroblast relationship can expand treatment options.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Mohd Mughees, Jyoti Bala Kaushal, Gunjan Sharma, Saima Wajid, Surinder Kumar Batra, Jawed Akhtar Siddiqui
Summary: Chemokines play a crucial role in tumorigenesis and cancer progression, particularly in prostate cancer. Inflammatory processes and the secretion of chemokines and cytokines in the tumor microenvironment play a key role in cancer development and treatment resistance.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Oncology
Apriliana E. R. Kartikasari, Cesar S. Huertas, Arnan Mitchell, Magdalena Plebanski
Summary: Chronic inflammation induced by the tumor microenvironment plays a vital role in cancer initiation, progression, and therapy resistance, with cytokines potentially serving as biomarkers. Analyzing circulating cytokines in conjunction with cancer-specific biomarkers could potentially enhance cancer detection, prognosis, and treatment decisions.
FRONTIERS IN ONCOLOGY
(2021)