Quercetin-3-glucoside increases low-density lipoprotein receptor (LDLR) expression, attenuates proprotein convertase subtilisin/kexin 9 (PCSK9) secretion, and stimulates LDL uptake by Huh7 human hepatocytes in culture

Sortilin

(2014) Adarsh M. Thaker et al.   Cardiology in Review

The Hypercholesterolemia-Risk Gene SORT1 Facilitates PCSK9 Secretion

(2014) Camilla Gustafsen et al.   Cell Metabolism

Isoquercitrin: Pharmacology, toxicology, and metabolism

(2014) Kateřina Valentová et al.   FOOD AND CHEMICAL TOXICOLOGY

Proprotein Convertase Subtilisin Kexin 9 (PCSK9) Inhibitors in the Treatment of Hypercholesterolemia and other Pathologies

(2013) Nabil G. Seidah   CURRENT PHARMACEUTICAL DESIGN

Novel Insights into the Pharmacology of Flavonoids

(2013) Barbara Romano et al.   PHYTOTHERAPY RESEARCH

Proprotein Convertases Subtilisin/Kexin Type 9, an enzyme turned escort protein: Hepatic and extra hepatic functions (第9型前蛋白转换酶-枯草溶菌素/蛋白酶K，一种酶转变的护送蛋白：在肝脏与肝外的功能)

(2013) Majambu Mbikay et al.   Journal of Diabetes

SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion

(2013) Xiao-Wei Chen et al.   eLife

Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia

(2012) Marianne Abifadel et al.   ATHEROSCLEROSIS

The novel function of HINFP as a co-activator in sterol-regulated transcription ofPCSK9in HepG2 cells

(2012) Hai Li et al.   BIOCHEMICAL JOURNAL

My road to Damascus: how I converted to the prohormone theory and the proprotein convertases

(2012) Michel Chrétien   Biochemistry and Cell Biology

Anti-PCSK9 therapies for the treatment of hypercholesterolemia

(2012) Amanda J Hooper et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism

(2012) Alanna Strong et al.   JOURNAL OF CLINICAL INVESTIGATION

Quercetin Up-regulates LDL Receptor Expression in HepG2 Cells

(2012) Jiyoung Moon et al.   PHYTOTHERAPY RESEARCH

Novel Loss-of-Function PCSK9 Variant Is Associated with Low Plasma LDL Cholesterol in a French-Canadian Family and with Impaired Processing and Secretion in Cell Culture

(2011) J. Mayne et al.   CLINICAL CHEMISTRY

Leucine 10 allelic variant in signal peptide of PCSK9 increases the LDL cholesterol-lowering effect of statins in patients with familial hypercholesterolaemia

(2011) L. Pisciotta et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Oral bioavailability of quercetin from different quercetin glycosides in dogs

(2010) Marianne Reinboth et al.   BRITISH JOURNAL OF NUTRITION

Sort1, Encoded by the Cardiovascular Risk Locus 1p13.3, Is a Regulator of Hepatic Lipoprotein Export

(2010) Mads Kjolby et al.   Cell Metabolism

Strong induction of PCSK9 gene expression through HNF1α and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters

(2010) Bin Dong et al.   JOURNAL OF LIPID RESEARCH

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

(2010) Kiran Musunuru et al.   NATURE

Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease

(2009) Patrick Linsel-Nitschke et al.   ATHEROSCLEROSIS

The relationship between reduction in low-density lipoprotein cholesterol by statins and reduction in risk of cardiovascular outcomes: An updated meta-analysis

(2009) Philippa J. Delahoy et al.   CLINICAL THERAPEUTICS

Hepatocyte Nuclear Factor 1α Plays a Critical Role inPCSK9Gene Transcription and Regulation by the Natural Hypocholesterolemic Compound Berberine

(2009) Hai Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proprotein convertases as therapeutic targets

(2008) Michel Chrétien et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

PCSK9: a convertase that coordinates LDL catabolism

(2008) Jay D. Horton et al.   JOURNAL OF LIPID RESEARCH

Plasma PCSK9 levels are significantly modified by statins and fibrates in humans

(2008) Janice Mayne et al.   Lipids in Health and Disease

Quercetin Ameliorates Metabolic Syndrome and Improves the Inflammatory Status in Obese Zucker Rats

(2008) Leonor Rivera et al.   Obesity

Effects of ezetimibe and/or simvastatin on LDL receptor protein expression and on LDL receptor and HMG-CoA reductase gene expression: A randomized trial in healthy men

(2007) Ioanna Gouni-Berthold et al.   ATHEROSCLEROSIS