Why Activated Protein C Was Not Successful in Severe Sepsis and Septic Shock: Are We Still Tilting at Windmills?

A REGISTRY OF PATIENTS TREATED WITH DROTRECOGIN ALFA (ACTIVATED) IN BELGIAN INTENSIVE CARE UNITS - AN OBSERVATIONAL STUDY

(2014) J.-L. Vincent et al.   ACTA CLINICA BELGICA

Recombinant Human Activated Protein C for Adults with Septic Shock. A Randomized Controlled Trial

(2013) Djillali Annane et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Microcirculatory Alterations in Patients With Severe Sepsis

(2013) Daniel De Backer et al.   CRITICAL CARE MEDICINE

Activated protein C and septic shock

(2012) Emily Rimmer et al.   CRITICAL CARE MEDICINE

Effectiveness and safety of drotrecogin alfa (activated) for severe sepsis: a meta-analysis and metaregression

(2012) Andre C Kalil et al.   LANCET INFECTIOUS DISEASES

Assessing available information on the burden of sepsis: global estimates of incidence, prevalence and mortality

(2012) Issrah Jawad et al.   Journal of Global Health

Recombinant activated protein C attenuates coagulopathy and inflammation when administered early in murine pneumococcal pneumonia

(2011) Cornelis van ’t Veer et al.   THROMBOSIS AND HAEMOSTASIS

Pandemic 2009 Influenza A in Argentina

(2010) Elisa Estenssoro et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Activated protein C and hospital mortality in septic shock: A propensity-matched analysis*

(2010) Peter K. Lindenauer et al.   CRITICAL CARE MEDICINE

The Surviving Sepsis Campaign: Results of an international guideline-based performance improvement program targeting severe sepsis*

(2010) Mitchell M. Levy et al.   CRITICAL CARE MEDICINE

Effectiveness of Treatments for Severe Sepsis

(2009) Ricard Ferrer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Extended drotrecogin alfa (activated) treatment in patients with prolonged septic shock

(2009) Jean-Francois Dhainaut et al.   INTENSIVE CARE MEDICINE

Adverse outcomes associated with the use of drotrecogin alfa (activated) in patients with severe sepsis and baseline bleeding precautions*

(2008) Chris A. Gentry et al.   CRITICAL CARE MEDICINE

Improvement in Process of Care and Outcome After a Multicenter Severe Sepsis Educational Program in Spain

(2008) Ricard Ferrer   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION