The NOTCH signaling pathway in normal and malignant blood cell production

NOTCH2 and FLT3 gene mis-splicings are common events in patients with acute myeloid leukemia (AML): new potential targets in AML

(2014) S. Adamia et al.   BLOOD

Notch signals are required for in vitro but not in vivo maintenance of human hematopoietic stem cells and delay the appearance of multipotent progenitors

(2013) P. Benveniste et al.   BLOOD

Blockade of individual Notch ligands and receptors controls graft-versus-host disease

(2013) Ivy T. Tran et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch pathway activation targets AML-initiating cell homeostasis and differentiation

(2013) Camille Lobry et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Notch activation inhibits AML growth and survival: a potential therapeutic approach

(2013) Sankaranarayanan Kannan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The matricellular protein CCN3 regulates NOTCH1 signalling in chronic myeloid leukaemia

(2013) Sukanya Suresh et al.   JOURNAL OF PATHOLOGY

Targeting Notch signaling pathway in cancer: Clinical development advances and challenges

(2013) Naoko Takebe et al.   PHARMACOLOGY & THERAPEUTICS

Cross-talk between leukemic and endothelial cells promotes angiogenesis by VEGF activation of the Notch/Dll4 pathway

(2012) Jingru Zhang et al.   CARCINOGENESIS

Non-canonical Notch signaling: emerging role and mechanism

(2012) Peter Andersen et al.   TRENDS IN CELL BIOLOGY

Constitutive Notch pathway activation in murine ZMYM2-FGFR1-induced T-cell lymphomas associated with atypical myeloproliferative disease

(2011) M. Ren et al.   BLOOD

Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia

(2011) D. Rossi et al.   BLOOD

In vitro effects of stromal cells expressing different levels of Jagged-1 and Delta-1 on the growth of primitive and intermediate CD34+ cell subsets from human cord blood

(2011) Verónica Fernández-Sánchez et al.   BLOOD CELLS MOLECULES AND DISEASES

Notch signaling: simplicity in design, versatility in function

(2011) E. R. Andersson et al.   DEVELOPMENT

The Notch signaling pathway in hematopoiesis and hematologic malignancies

(2011) R. Schwanbeck et al.   HAEMATOLOGICA

Notch2 governs the rate of generation of mouse long- and short-term repopulating stem cells

(2011) Barbara Varnum-Finney et al.   JOURNAL OF CLINICAL INVESTIGATION

Analysis of the chronic lymphocytic leukemia coding genome: role ofNOTCH1mutational activation

(2011) Giulia Fabbri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Notch3-mediated regulation of MKP-1 levels promotes survival of T acute lymphoblastic leukemia cells

(2011) M Masiero et al.   LEUKEMIA

A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia

(2011) Apostolos Klinakis et al.   NATURE

Endothelial Cells Are Essential for the Self-Renewal and Repopulation of Notch-Dependent Hematopoietic Stem Cells

(2010) Jason M. Butler et al.   Cell Stem Cell

The Notch pathway in the developing hematopoietic system

(2010) Anna Bigas et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Direct Comparison of Dll1- and Dll4-Mediated Notch Activation Levels Shows Differential Lymphomyeloid Lineage Commitment Outcomes

(2010) M. Mohtashami et al.   JOURNAL OF IMMUNOLOGY

Therapeutic antibody targeting of individual Notch receptors

(2010) Yan Wu et al.   NATURE

Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution

(2010) Colleen Delaney et al.   NATURE MEDICINE

Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia

(2009) F. Nakahara et al.   BLOOD

Cyclin D1 is a direct target of JAG1-mediated Notch signaling in breast cancer

(2009) Brenda Cohen et al.   BREAST CANCER RESEARCH AND TREATMENT

Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma

(2009) Suk-young Lee et al.   CANCER SCIENCE

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

DrosophilaHey is a target of Notch in asymmetric divisions during embryonic and larval neurogenesis

(2009) Maria Monastirioti et al.   DEVELOPMENT

A Notch updated

(2009) An-Chi Tien et al.   JOURNAL OF CELL BIOLOGY

Direct inhibition of the NOTCH transcription factor complex

(2009) Raymond E. Moellering et al.   NATURE

In Vivo Analysis of the Notch Receptor S1 Cleavage

(2009) Robert J. Lake et al.   PLoS One

Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells

(2008) E. Rosati et al.   BLOOD

Canonical Notch Signaling Is Dispensable for the Maintenance of Adult Hematopoietic Stem Cells

(2008) Ivan Maillard et al.   Cell Stem Cell

Notch signaling is necessary for GATA3 function in the initiation of T cell development

(2008) Katsuto Hozumi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

NOTCH2 mutations in marginal zone lymphoma

(2008) G. Troen et al.   HAEMATOLOGICA

Signaling pathways involved in the development of T-cell acute lymphoblastic leukemia

(2008) F. J.T. Staal et al.   HAEMATOLOGICA

The molecular logic of Notch signaling - a structural and biochemical perspective

(2008) W. R. Gordon et al.   JOURNAL OF CELL SCIENCE

Notch-1 regulates Akt signaling pathway and the expression of cell cycle regulatory proteins cyclin D1, CDK2 and p21 in T-ALL cell lines

(2008) Dongmei Guo et al.   LEUKEMIA RESEARCH

Overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notch1 induced acute leukemia in p210BCR/ABL transgenic mice

(2008) T Mizuno et al.   ONCOGENE

The many facets of Notch ligands

(2008) B D'Souza et al.   ONCOGENE