Article
Oncology
G. E. Konecny, A. E. Wahner Hendrickson, T. M. Davidson, B. J. Winterhoff, S. Ma, S. Mahner, J. Sehouli, P. A. Fasching, G. Feisel-Schwickardi, M. Poelcher, L. D. Roman, A. Rody, B. Y. Karlan, S. A. Mullany, H. Chen, I. L. Ray-Coquard, D. M. Provencher, A. Yachnin, P. H. Cottu, J. A. Glaspy, P. Haluska, D. J. Slamon
Summary: This study investigated the efficacy and safety of adding ganitumab to CP chemotherapy in primary EOC patients, but did not show improvement in PFS. The results do not support further study of ganitumab in unselected EOC patients.
GYNECOLOGIC ONCOLOGY
(2021)
Review
Medicine, General & Internal
Natalie Y. L. Ngoi, Nicholas L. X. Syn, Robby M. Goh, Boon Cher Goh, Ruby Yun-Ju Huang, Yu Yang Soon, Elizabeth James, Adrian Cook, Andrew Clamp, David S. P. Tan
Summary: This study compared the efficacy and tolerability of weekly paclitaxel and tri-weekly paclitaxel, both in combination with carboplatin, as first-line treatment for epithelial ovarian cancer. The results showed that weekly paclitaxel may slightly improve progression-free survival (PFS), but does not affect overall survival (OS). Additionally, weekly paclitaxel is associated with an increased risk of high-grade anemia.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Oncology
Michal Mleko, Elzbieta Pluta, Kazimierz Pitynski, Maciej Bodzek, Andrzej Kalamacki, Dorota Kiprian, Tomasz Banas
Summary: Epithelial ovarian cancer is the deadliest gynaecological malignancy, and cytoreductive surgery followed by adjuvant taxane-platinum-based chemotherapy is the main therapy for this cancer. Systemic inflammatory response plays a dual role in the pathophysiology of neoplastic diseases, predicting poor survival. However, there are only few studies on changes in inflammatory markers during anti-cancer treatment. This study aimed to investigate trends in changes in inflammatory markers in women with ovarian cancer receiving standard first-line adjuvant chemotherapy.
Article
Oncology
Jiao Liu, Han Wang, Shuqin Xiao, Siyang Zhang, Ya Qi, Min Wang
Summary: In this study, circ_0000231 was found to be a vital regulator in paclitaxel-resistant ovarian cancer. The increased expression of circ_0000231 and RAP1B, as well as the decreased expression of miR-140, were observed in resistant cells. Knockdown of circ_0000231 inhibited resistance, proliferation, invasion, migration, and EMT, while promoting apoptosis in PTX-resistant OC cells.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Cell Biology
Lu Chen, Wujiang Gao, Chunli Sha, Meiling Yang, Li Lin, Taoqiong Li, Hong Wei, Qi Chen, Jie Xing, Mengxue Zhang, Shijie Zhao, Wenlin Xu, Yuefeng Li, Xiaolan Zhu
Summary: The E3 ligase SIAH1 is decreased in epithelial ovarian cancer (EOC) and negatively correlated with RPS3 levels. Overexpression of SIAH1 can suppress tumor cell growth, invasion, and cisplatin resistance by promoting RPS3 degradation and subsequent NF-kappa B inactivation.
Article
Biochemistry & Molecular Biology
Justin W. Gorski, Zhuwei Zhang, J. Robert McCorkle, Jodi M. DeJohn, Chi Wang, Rachel W. Miller, Holly H. Gallion, Charles S. Dietrich, Frederick R. Ueland, Jill M. Kolesar
Summary: The development of patient-derived tumor organoids from epithelial ovarian cancer has the potential to contribute significantly to precision medicine by testing chemotherapy sensitivity and investigating genetic drivers of drug resistance. This study identified one organoid line resistant to carboplatin, leading to a shorter progression-free survival and platinum-resistant recurrence. Gene expression analysis revealed interconnected pathways related to NF-kB, cellular differentiation, and B-cell receptor signaling in the context of carboplatin resistance.
Article
Medicine, General & Internal
Yin Tao, Xue-Ting Tang, Xing Li, An-Shan Wu, Hou-Shen Zhou, Cheng-fang Zhou
Summary: This study evaluated the role of neoadjuvant chemotherapy (NACT) with intraperitoneal perfusion of bevacizumab in advanced ovarian cancer. The results showed that treatment with the TCB regimen significantly reduced serum levels of CA125 and ascites volume, as well as intraoperative blood loss and operation time. Patients treated with the TCB regimen had a higher surgical satisfaction rate, and a lower incidence of postoperative complications compared with the TC group. No severe complications were observed between the two groups during chemotherapy.
FRONTIERS IN MEDICINE
(2022)
Article
Obstetrics & Gynecology
Chencheng Dai, Pengfei Xu, Siyu Liu, Sujuan Xu, Juan Xu, Ziyi Fu, Jian Cao, Mingming Lv, Juan Zhou, Guangquan Liu, Huilin Zhang, Xuemei Jia
Summary: The study revealed that ZEB1-AS1 plays a pivotal role in cancer chemoresistance by regulating MMP19, providing a potential target for overcoming drug resistance in ovarian cancer cells.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Biotechnology & Applied Microbiology
Li-ying Zhang, Jia-ying Yu, Yan-long Leng, Ran-ran Zhu, Hong-xian Liu, Xin-yu Wang, Ting-ting Yang, Yi-ning Guo, Jing-ling Tang, Xin-chen Zhang
Summary: The study identified miR-181c as downregulated in PTX-resistant ovarian cancer cells and tissues, which induced apoptosis and inhibited the PI3K/Akt pathway by directly targeting GRP78. Overexpression of miR-181c sensitized resistant ovarian cancer to PTX, suggesting a potential therapeutic strategy.
CANCER GENE THERAPY
(2022)
Article
Cell & Tissue Engineering
Kun Wang, Yiyang Wang, Yuanjian Wang, Shujie Liu, Chunyan Wang, Shuo Zhang, Tianli Zhang, Xingsheng Yang
Summary: The study reveals that EIF5A2 positively regulates stemness in ovarian cancer cells through the E2F1/KLF4 pathway, indicating its potential as a target for CSCs-targeted therapy in ovarian cancer.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Oncology
Taoqiong Li, Li Lin, Qin Liu, Wujiang Gao, Lu Chen, Chunli Sha, Qi Chen, Wenlin Xu, Yuefeng Li, Xiaolan Zhu
Summary: The study revealed that exosomal transfer of miR-429 enhances chemoresistance and proliferation of epithelial ovarian cancer cells. NF-κB promotes miR-429 expression, affecting the calcium-sensing receptor pathway and leading to drug resistance in cells.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Review
Oncology
Chalaithorn Nantasupha, Chanisa Thonusin, Kittipat Charoenkwan, Siriporn Chattipakorn, Nipon Chattipakorn
Summary: Cancer cells show adaptations to their metabolism to facilitate growth, invasiveness, and metastasis. While aerobic glycolysis has been thought to be the dominant energy metabolism in cancer, recent data suggest that oxidative phosphorylation may be more likely in some cancer cells, particularly in epithelial ovarian cancer.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Yeong-In Yang, Yi-Yue Wang, Ji-Hye Ahn, Bo-Hyung Kim, Jung-Hye Choi
Summary: Tumor cells can develop resistance to paclitaxel by secreting large amounts of CCL2, which not only acts as an autocrine factor to induce chemoresistance, but also functions as a chemokine to attract macrophages, contributing to chemoresistance. Inhibiting the CCL2/CCR2 signaling axis may improve the therapeutic response of patients with ovarian cancer to paclitaxel.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Min-Ji Yoon, Hwijae Cha, Jungho Ahn, Danbi Lee, Hyun-Seok Jeong, Hwa Seon Koo, Youn-Jung Kang
Summary: Ovarian cancer is the deadliest gynecological malignancy worldwide, and resistance to genotoxic stress may be a critical cause of chemoresistance in patients.
Article
Plant Sciences
Qian-Wen Kong, Jiao Yang, Dan Li, Ya-Wei Ding, Yu-Jie Hu, Xiao-Chuan Xue, Mei-Zhi Shi, Bo Jiang, Yang-Yun Zhou, Min Zhang, Jiu-Dong Hu, Cheng Guo, Jun-Jun Chen, Yong-Long Han
Summary: This study evaluated the effects of Tongguanteng injection on reversing paclitaxel resistance in ovarian cancer and investigated the potential mechanism related to TAB1. The results showed that the combination of Tongguanteng injection and paclitaxel could reverse paclitaxel resistance in ovarian cancer cells, possibly through the activation of the TAB1/TAK1/p38 MAPK signaling pathway. These findings provide a theoretical basis for the combination of Tongguanteng injection and paclitaxel in the treatment of ovarian cancer.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Pathology
Ryosuke Ichihara, Yukihiro Shiraki, Yasuyuki Mizutani, Tadashi Iida, Yuki Miyai, Nobutoshi Esaki, Akira Kato, Shinji Mii, Ryota Ando, Masamichi Hayashi, Hideki Takami, Tsutomu Fujii, Masahide Takahashi, Atsushi Enomoto
Summary: Recent studies have shown that cancer-associated fibroblasts (CAFs) are heterogeneous and can be categorized into cancer-promoting and -restraining CAFs. This study identifies MXRA8 as a new marker for CAFs, but the biological importance of MXRA8(+)CAF is still unclear.
PATHOLOGY INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Keiko Nakanishi, Kyohei Higashi, Toshihiko Toida, Masato Asai
Summary: Chondroitin sulfate and its isomeric variant, dermatan sulfate, play important roles in umbilical cord blood cells and may be involved in stem cell proliferation and differentiation.
Article
Pathology
Kai Adachi, Yasutaka Sakurai, Masaaki Ichinoe, Masayoshi Tadehara, Akihiro Tamaki, Yurika Kesen, Takuya Kato, Shinji Mii, Atsushi Enomoto, Masahide Takahashi, Wasaburo Koizumi, Yoshiki Murakumo
Summary: CD109 expression in both tumor cells and stroma is significantly associated with the progression and prognosis of pancreatic ductal adenocarcinoma (PDAC), and may serve as a valuable prognostic marker.
Article
Oncology
Yasuyuki Mizutani, Tadashi Iida, Eizaburo Ohno, Takuya Ishikawa, Fumie Kinoshita, Yachiyo Kuwatsuka, Miwa Imai, Shinobu Shimizu, Toshihisa Tsuruta, Atsushi Enomoto, Hiroki Kawashima, Mitsuhiro Fujishiro
Summary: Cancer-associated fibroblasts (CAFs) are an important component of the tumor microenvironment. Recent studies have identified a subset of CAFs, called cancer-restraining CAFs (rCAFs), which can suppress cancer progression. This study aims to investigate the efficacy of a combination of the synthetic retinoid AM80 and chemotherapy drugs gemcitabine (GEM) and nab-paclitaxel (nab-PTX) in patients with advanced pancreatic cancer.
Article
Gastroenterology & Hepatology
Hiroki Kobayashi, Krystyna A. Gieniec, Tamsin R. M. Lannagan, Tongtong Wang, Naoya Asai, Yasuyuki Mizutani, Tadashi Iida, Ryota Ando, Elaine M. Thomas, Akihiro Sakai, Nobumi Suzuki, Mari Ichinose, Josephine A. Wright, Laura Vrbanac, Jia Q. Ng, Jarrad Goyne, Georgette Radford, Matthew J. Lawrence, Tarik Sammour, Yoku Hayakawa, Sonja Klebe, Alice E. Shin, Samuel Asfaha, Mark L. Bettington, Florian Rieder, Nicholas Arpaia, Tal Danino, Lisa M. Butler, Alastair D. Burt, Simon J. Leedham, Anil K. Rustgi, Siddhartha Mukherjee, Masahide Takahashi, Timothy C. Wang, Atsushi Enomoto, Susan L. Woods, Daniel L. Worthley
Summary: In colorectal cancer, ACTA2(+) cancer-associated fibroblasts (CAFs) emerge through proliferation from intestinal pericryptal leptin receptor (Lepr)(+) cells. These Lepr-lineage CAFs express melanoma cell adhesion molecule (MCAM), which is inversely associated with patient survival. Knockout of stromal Mcam attenuates orthotopically injected colorectal tumoroid growth and improves survival through decreased tumor-associated macrophage recruitment. The fibroblast MCAM interacts with interleukin-1 receptor 1 to promote macrophage chemotaxis.
Article
Immunology
Chihiro Kurematsu, Masato Sawada, Masaki Ohmuraya, Motoki Tanaka, Kazuya Kuboyama, Takashi Ogino, Mami Matsumoto, Hisashi Oishi, Hiroyuki Inada, Yuri Ishido, Yukina Sakakibara, Huy Bang Nguyen, Truc Quynh Thai, Shinichi Kohsaka, Nobuhiko Ohno, Maki K. Yamada, Masato Asai, Masahiro Sokabe, Junichi Nabekura, Kenichi Asano, Masato Tanaka, Kazunobu Sawamoto
Summary: This study demonstrates the involvement of phosphatidylserine (PS) in the synaptic pruning and functional maturation of adult-born neurons in the olfactory bulb and hippocampus. Using an inducible transgenic mouse model, the researchers found that impaired microglial spine pruning and altered electrophysiological properties of adult-born neurons occurred when PS exposure was masked by a dominant-negative form of milk fat globule-EGF-factor 8 (MFG-E8). These findings highlight the significance of PS in microglial pruning and the maturation of adult-born neurons.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Oncology
Masaya Yamanaka, Masamichi Hayashi, Fuminori Sonohara, Suguru Yamada, Haruyoshi Tanaka, Akihiro Sakai, Shinji Mii, Daigo Kobayashi, Keisuke Kurimoto, Nobutake Tanaka, Yoshikuni Inokawa, Hideki Takami, Norifumi Hattori, Mitsuro Kanda, Chie Tanaka, Goro Nakayama, Masahiko Koike, Yasuhiro Kodera
Summary: Decreased ROBO4 expression is associated with malignant phenotypes and poor survival outcomes in pancreatic cancer.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuya Aono, Yuzo Suzuki, Ryo Horiguchi, Yusuke Inoue, Masato Karayama, Hironao Hozumi, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Naoki Inui, Shinji Mii, Masahide Takahashi, Takafumi Suda
Summary: CD109 plays an important role in the development of asthma. Its deficiency reduces airway hyperreactivity and eosinophilic inflammation, as well as Th2 cytokine expression. Therefore, CD109 may be a novel therapeutic target for asthma.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Katsuya Onishi, Seiichiro Ishihara, Masayuki Takahashi, Akihiro Sakai, Atsushi Enomoto, Kentaro Suzuki, Hisashi Haga
Summary: Stiffness of the extracellular matrix plays a vital role in regulating biological responses, and this study identifies nuclear diphosphorylated myosin regulatory light chain (2P-MRLC) as a critical mediator in suppressing apoptosis in response to substrate stiffness. The kinase ZIPK and actin fiber formation are involved in promoting the nuclear localization of 2P-MRLC in response to stiff substrates. 2P-MRLC, in turn, regulates the expression of MafB and inhibits apoptosis in response to substrate stiffness, revealing a new mechanism in mechanotransduction.
Article
Nutrition & Dietetics
Takayuki Inoue, Bin Fu, Miwako Nishio, Miyako Tanaka, Hisashi Kato, Masashi Tanaka, Michiko Itoh, Hajime Yamakage, Kozue Ochi, Ayaka Ito, Yukihiro Shiraki, Satoshi Saito, Masafumi Ihara, Hideo Nishimura, Atsuhiko Kawamoto, Shian Inoue, Kumiko Saeki, Atsushi Enomoto, Takayoshi Suganami, Noriko Satoh-Asahara
Summary: The molecular pathogenesis of nonalcoholic steatohepatitis (NASH) involves metabolic stress and inflammatory stimuli. In this study, we found that Taxifolin treatment effectively prevented hepatic steatosis, chronic inflammation, and liver fibrosis in a NASH murine model. Taxifolin inhibited lipid accumulation in hepatocytes and increased brown adipose tissue activity. Furthermore, Taxifolin treatment after NASH development could prevent the development of liver tumors. These findings indicate the pleiotropic effects of Taxifolin for NASH treatment.
Review
Oncology
Hiroyoshi Y. Tanaka, Takuya Nakazawa, Atsushi Enomoto, Atsushi Masamune, Mitsunobu R. Kano
Summary: Pancreatic cancer is difficult to treat and novel treatment strategies are urgently needed. The use of nanomedicines is being explored as a potential solution, but the fibrotic barrier in pancreatic cancer hinders their delivery. This review discusses strategies to overcome this barrier and highlights gaps in our understanding.
Article
Pathology
Natsumi Mori, Nobutoshi Esaki, Yoshie Shimoyama, Yukihiro Shiraki, Naoya Asai, Tomohisa Sakai, Yoshihiro Nishida, Masahide Takahashi, Atsushi Enomoto, Shinji Mii
Summary: CD109 is highly expressed in osteosarcoma and is associated with poor prognosis. It affects tumor cell migration through the BMP signaling pathway.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
Hidenori Tabata, Daisuke Mori, Tohru Matsuki, Kaichi Yoshizaki, Masato Asai, Atsuo Nakayama, Norio Ozaki, Koh-ichi Nagata
Summary: 22q11.2 deletion syndrome (22q11.2DS) is associated with a high risk of psychiatric and developmental disorders. A mouse model of this disease, Del(3.0Mb)/+, was generated and its behavior was extensively studied. The histological features of the brains of Del(3.0Mb)/+ mice were investigated and changes were observed in the morphology of individual neurons in specific brain regions. These changes in the dopamine system may explain the abnormal behaviors of the mice and the psychiatric symptoms of 22q11.2DS.
Meeting Abstract
Critical Care Medicine
A. Suzuki, K. Sakamoto, Y. Nakahara, A. Enomoto, J. Hino, A. Ando, M. Inoue, N. Omote, M. Kusaka, J. Fukihara, N. Hashimoto
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
N. Hashimoto, K. Sakamoto, Y. Nakahara, N. Omote, A. Ando, M. Inoue, A. Suzuki, J. Fukihara, M. Kusaka, K. Wakahara, A. Enomoto
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
