The Key Role of the Blood Supply to Bone

It's the Fracture that Matters –Bone Disease in COPD Patients

(2016) Elizabeth Regan et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Vasodilation to PTH (1-84) in bone arteries is dependent upon the vascular endothelium and is mediated partially via VEGF signaling

(2013) Rhonda Prisby et al.   BONE

Validated Laser Doppler protocol for measurement of mouse bone blood perfusion — Response to age or ovariectomy differs with genetic background

(2013) Bernard Roche et al.   BONE

Angiogenic factors in bone local environment

(2013) Shek Man Chim et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The effects of organic nitrates on osteoporosis: a systematic review

(2013) S. A. Jamal et al.   OSTEOPOROSIS INTERNATIONAL

HIF-1α Inhibits Wnt Signaling Pathway by Activating Sost Expression in Osteoblasts

(2013) Dafu Chen et al.   PLoS One

β1 selectivity of β-blockers and reduced risk of fractures in elderly hypertension patients

(2012) Hong Ji Song et al.   BONE

Endothelial Nitric Oxide Synthase is Not Essential for Nitric Oxide Production by Osteoblasts Subjected to Fluid Shear Stress In Vitro

(2012) Astrid D. Bakker et al.   CALCIFIED TISSUE INTERNATIONAL

Glucocorticoid-Induced Osteoporosis and Osteonecrosis

(2012) Robert S. Weinstein   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Hypoxia inhibits the differentiation of mesenchymal stem cells into osteoblasts by activation of Notch signaling

(2012) Ningru Xu et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Increased presence of capillaries next to remodeling sites in adult human cancellous bone

(2012) Helene Bjoerg Kristensen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation

(2012) Yanqiu Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Arterial calcification and bone physiology: role of the bone–vascular axis

(2012) Bithika Thompson et al.   Nature Reviews Endocrinology

Hypoxia-driven pathways in bone development, regeneration and disease

(2012) Christa Maes et al.   Nature Reviews Rheumatology

Hypoxia triggers a HIF-mediated differentiation of peripheral blood mononuclear cells into osteoclasts

(2012) T. C. Dandajena et al.   Orthodontics & Craniofacial Research

Expression of endothelial nitric oxide synthase protein is not necessary for mechanical strain-induced nitric oxide production by cultured osteoblasts

(2012) V. Das-Gupta et al.   OSTEOPOROSIS INTERNATIONAL

The effects of smoking on bone metabolism

(2012) V. Yoon et al.   OSTEOPOROSIS INTERNATIONAL

Skeletal Adaptation to Intramedullary Pressure-Induced Interstitial Fluid Flow Is Enhanced in Mice Subjected to Targeted Osteocyte Ablation

(2012) Ronald Y. Kwon et al.   PLoS One

Aging and Estrogen Status: A Possible Endothelium-Dependent Vascular Coupling Mechanism in Bone Remodeling

(2012) Rhonda D. Prisby et al.   PLoS One

Arterial Stiffness and Bone Demineralization: The Baltimore Longitudinal Study of Aging

(2011) F. Giallauria et al.   AMERICAN JOURNAL OF HYPERTENSION

Vascular Calcification Is Associated with Cortical Bone Loss in Chronic Renal Failure Rats with and without Ovariectomy: The Calcification Paradox

(2011) Tineke M. De Schutter et al.   AMERICAN JOURNAL OF NEPHROLOGY

Raloxifene Reduces Blood Pressure in Hypertensive Animals after Ovarian Hormone Deprivation

(2011) Adriana Nunes Moraes et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Krüppel-like factors KLF2 and 6 and Ki-67 are direct targets of zoledronic acid in MCF-7 cells

(2011) Regina Ebert et al.   BONE

Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading

(2011) Xiaolin Tu et al.   BONE

Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche

(2011) Toshio Suda et al.   Cell Stem Cell

Anabolic and Catabolic Regimens of Human Parathyroid Hormone 1–34 Elicit Bone- and Envelope-Specific Attenuation of Skeletal Effects inSost-Deficient Mice

(2011) Alexander G. Robling et al.   ENDOCRINOLOGY

Wnt1 is a proangiogenic molecule, enhances human endothelial progenitor function, and increases blood flow to ischemic limbs in a HGF-dependent manner

(2011) Costin M. Gherghe et al.   FASEB JOURNAL

Is Nitroglycerin a Novel and Inexpensive Treatment for Osteoporosis?

(2011) Sundeep Khosla   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effect of Nitroglycerin Ointment on Bone Density and Strength in Postmenopausal Women

(2011) Sophie A. Jamal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Difference in intraosseous blood vessel volume and number in osteoporotic model mice induced by spinal cord injury and sciatic nerve resection

(2011) Wen-Ge Ding et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Intermittent PTH(1-84) is osteoanabolic but not osteoangiogenic and relocates bone marrow blood vessels closer to bone-forming sites

(2011) Rhonda Prisby et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Sildenafil accelerates fracture healing in mice

(2011) Tina Histing et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Soft Bone – Hard Arteries: A Link?

(2011) Gérard M. London   KIDNEY & BLOOD PRESSURE RESEARCH

Hypoxia Inhibits Osteogenesis in Human Mesenchymal Stem Cells through Direct Regulation of RUNX2 by TWIST

(2011) Der-Chih Yang et al.   PLoS One

Mechanical regulation of vascular growth and tissue regeneration in vivo

(2011) J. D. Boerckel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acidosis, hypoxia and bone

(2010) Timothy R. Arnett   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Therapeutically Relevant Concentrations of Raloxifene Dilate Pressurized Rat Resistance Arteries via Calcium-Dependent Endothelial Nitric Oxide Synthase Activation

(2010) Yau Chi Chan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Does blood pressure enhance solute transport in the bone lacunar–canalicular system?

(2010) Wen Li et al.   BONE

Osteopenia and endothelin-1-mediated vasconstrictor tone in postmenopausal women

(2010) Michael L. Mestek et al.   BONE

Hypoxia stimulates osteoclast formation from human peripheral blood

(2010) Jennifer C. Utting et al.   CELL BIOCHEMISTRY AND FUNCTION

Osteoblast Precursors, but Not Mature Osteoblasts, Move into Developing and Fractured Bones along with Invading Blood Vessels

(2010) Christa Maes et al.   DEVELOPMENTAL CELL

Bone mineral loss and recovery after 17 weeks of bed rest

(2010) Adrian D. Leblanc et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Uncoupled angiogenesis and osteogenesis in nicotine-compromised bone healing

(2010) Li Ma et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Microfluidic enhancement of intramedullary pressure increases interstitial fluid flow and inhibits bone loss in hindlimb suspended mice

(2010) Ronald Y Kwon et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Reduced Bone Perfusion in Osteoporosis: Likely Causes in an Ovariectomy Rat Model

(2010) James F. Griffith et al.   RADIOLOGY

Advances in Pharmacologic Modulation of Nitric Oxide in Hypertension

(2010) Yoshiko Mizuno et al.   Current Cardiology Reports

Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in aged mice

(2009) Robert S. Weinstein et al.   AGING CELL

Diabetes Mellitus Induces Bone Marrow Microangiopathy

(2009) Atsuhiko Oikawa et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Increased nitric oxide-mediated vasodilation of bone resistance arteries is associated with increased trabecular bone volume after endurance training in rats

(2009) James M. Dominguez et al.   BONE

Prevalence and Progression of Osteoporosis in Patients With COPD

(2009) Gary T. Ferguson et al.   CHEST

Increased skeletal VEGF enhances β-catenin activity and results in excessively ossified bones

(2009) Christa Maes et al.   EMBO JOURNAL

Assessment of fracture risk

(2009) John A. Kanis et al.   EUROPEAN JOURNAL OF RADIOLOGY

Postmenopausal women with osteoporosis may be associated with high endothelin-1

(2009) Ibrahim Gulhan et al.   GYNECOLOGICAL ENDOCRINOLOGY

Regulation of Osteogenesis-Angiogenesis Coupling by HIFs and VEGF

(2009) Ernestina Schipani et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The hematopoietic stem cell niche: Low in oxygen but a nice place to be

(2009) Pernilla Eliasson et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Proximal femur bone marrow blood perfusion indices are reduced in hypertensive rats: A dynamic contrast-enhanced MRI study

(2009) Ya-Feng Zhang et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Role of hypoxia-inducible factor-1α in angiogenic–osteogenic coupling

(2009) Ryan C. Riddle et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Estradiol-induced, endothelial progenitor cell-mediated neovascularization in male mice with hind-limb ischemia

(2009) Willem-Peter T Ruifrok et al.   VASCULAR MEDICINE

The Mechanical Environment of Bone Marrow: A Review

(2008) Umut Atakan Gurkan et al.   ANNALS OF BIOMEDICAL ENGINEERING

Fluid and Solute Transport in Bone: Flow-Induced Mechanotransduction

(2008) Susannah P. Fritton et al.   Annual Review of Fluid Mechanics

Continuous PGE2 leads to net bone loss while intermittent PGE2 leads to net bone gain in lumbar vertebral bodies of adult female rats

(2008) X.Y. Tian et al.   BONE

Changes in blood perfusion and bone healing induced by nicotine during distraction osteogenesis

(2008) Li Wu Zheng et al.   BONE

Hypertension Is a Risk Factor for Fractures

(2008) Peter Vestergaard et al.   CALCIFIED TISSUE INTERNATIONAL

Relationship Between Pulmonary Emphysema and Osteoporosis Assessed by CT in Patients With COPD

(2008) Tadashi Ohara et al.   CHEST

Compromised Bone Marrow Perfusion in Osteoporosis

(2008) James F Griffith et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Skeletal muscle contractions uncoupled from gravitational loading directly increase cortical bone blood flow rates in vivo

(2008) Carrie Caulkins et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Activation of the hypoxia-inducible factor-1  pathway accelerates bone regeneration

(2008) C. Wan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA