A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice

Collaborative Meta-analysis: Associations of 150 Candidate Genes With Osteoporosis and Osteoporotic Fracture

(2013) J. Brent Richards   ANNALS OF INTERNAL MEDICINE

Variant alleles of the Wnt antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis

(2012) Julie C. Baker-LePain et al.   ARTHRITIS AND RHEUMATISM

Mechanotransduction in bone tissue: The A214V and G171V mutations in Lrp5 enhance load-induced osteogenesis in a surface-selective manner

(2012) Paul J. Niziolek et al.   BONE

Novel SOST gene mutation in a sclerosteosis patient and her parents

(2012) Sanjay Kumar Bhadada et al.   BONE

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Dominant-negative isoforms of Tcf/Lef proteins in development and disease

(2012) Tomas Vacik et al.   CELL CYCLE

Wnt9b-dependent FGF signaling is crucial for outgrowth of the nasal and maxillary processes during upper jaw and lip development

(2012) Y.-R. Jin et al.   DEVELOPMENT

Roles of N-glycosylation and lipidation in Wg secretion and signaling

(2012) Xiaofang Tang et al.   DEVELOPMENTAL BIOLOGY

Wls-mediated Wnts differentially regulate distal limb patterning and tissue morphogenesis

(2012) Xuming Zhu et al.   DEVELOPMENTAL BIOLOGY

Structural Architecture and Functional Evolution of Wnts

(2012) J. Fernando Bazan et al.   DEVELOPMENTAL CELL

A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities

(2012) Rani Najdi et al.   DIFFERENTIATION

The many faces and functions of β-catenin

(2012) Tomas Valenta et al.   EMBO JOURNAL

Sclerostin and Dickkopf-1 as Therapeutic Targets in Bone Diseases

(2012) Hua Zhu Ke et al.   ENDOCRINE REVIEWS

Osteoporosis-Pseudoglioma Syndrome: Three Novel Mutations in the LRP5 Gene and Response to Bisphosphonate Treatment

(2012) B. Tüysüz et al.   Hormone Research in Paediatrics

Precise Regulation of Porcupine Activity Is Required for Physiological Wnt Signaling

(2012) Kyle D. Proffitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GSK-3α and GSK-3β Proteins Are Involved in Early Stages of Chondrocyte Differentiation with Functional Redundancy through RelA Protein Phosphorylation

(2012) Shozo Itoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Misexpression of Dickkopf-1 in endothelial cells, but not in chondrocytes or hypertrophic chondrocytes, causes defects in endochondral ossification

(2012) Hwanhee Oh et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Loss of wnt/β-catenin signaling causes cell fate shift of preosteoblasts from osteoblasts to adipocytes

(2012) Lige Song et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Cartilage-specific β-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development

(2012) Debbie Y Dao et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Van Buchem disease: Clinical, biochemical, and densitometric features of patients and disease carriers

(2012) Antoon H van Lierop et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Association of AXIN2 with Non-syndromic Oral Clefts in Multiple Populations

(2012) A. Letra et al.   JOURNAL OF DENTAL RESEARCH

Mutations inWNT10Aare present in more than half of isolated hypodontia cases

(2012) Marie-José van den Boogaard et al.   JOURNAL OF MEDICAL GENETICS

Inhibition of sclerostin by systemic treatment with sclerostin antibody enhances healing of proximal tibial defects in ovariectomized rats

(2012) Michelle M. McDonald et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Strongly enhanced levels of sclerostin during human fracture healing

(2012) Kambiz Sarahrudi et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The E3 Ubiquitin Ligase ITCH Negatively Regulates Canonical Wnt Signaling by Targeting Dishevelled Protein

(2012) W. Wei et al.   MOLECULAR AND CELLULAR BIOLOGY

Single nucleotide polymorphisms in sFRP4 are associated with bone and body composition related parameters in Danish but not in Belgian men

(2012) Eveline Boudin et al.   MOLECULAR GENETICS AND METABOLISM

Active Wnt proteins are secreted on exosomes

(2012) Julia Christina Gross et al.   NATURE CELL BIOLOGY

The complex world of WNT receptor signalling

(2012) Christof Niehrs   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Distinct Roles of Muscle and Motoneuron LRP4 in Neuromuscular Junction Formation

(2012) Haitao Wu et al.   NEURON

Mice lacking Wnt2b are viable and display a postnatal olfactory bulb phenotype

(2012) Tadasuke Tsukiyama et al.   NEUROSCIENCE LETTERS

Deletion of Porcn in Mice Leads to Multiple Developmental Defects and Models Human Focal Dermal Hypoplasia (Goltz Syndrome)

(2012) Wei Liu et al.   PLoS One

Wntless functions in mature osteoblasts to regulate bone mass

(2012) Z. Zhong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted deletion of Sost distal enhancer increases bone formation and bone mass

(2012) N. M. Collette et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Unusual Case of Porcupine

(2012) L. Lum et al.   SCIENCE

WNT secretion and signalling in human disease

(2012) Patrick Herr et al.   TRENDS IN MOLECULAR MEDICINE

The  -Catenin Destruction Complex

(2012) J. L. Stamos et al.   Cold Spring Harbor Perspectives in Biology

WNT16 Influences Bone Mineral Density, Cortical Bone Thickness, Bone Strength, and Osteoporotic Fracture Risk

(2012) Hou-Feng Zheng et al.   PLoS Genetics

A novel homozygous missense mutation (c.610G>A, p.Gly204Ser) in the WNT7A gene causes tetra-amelia in two Saudi families

(2011) Wafaa Eyaid et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

WNT10A and isolated hypodontia

(2011) Piranit Kantaputra et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Isolated oligodontia associated with mutations in EDARADD, AXIN2, MSX1, and PAX9 genes

(2011) Birgitta Bergendal et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Postnatal Deletion of Wnt7a Inhibits Uterine Gland Morphogenesis and Compromises Adult Fertility in Mice1

(2011) Kathrin A. Dunlap et al.   BIOLOGY OF REPRODUCTION

High-bone-mass-producing mutations in the Wnt signaling pathway result in distinct skeletal phenotypes

(2011) Paul J. Niziolek et al.   BONE

Small molecule-based disruption of the Axin/β-catenin protein complex regulates mesenchymal stem cell differentiation

(2011) Jungsug Gwak et al.   CELL RESEARCH

Stringent requirement of a proper level of canonical WNT signalling activity for head formation in mouse embryo

(2011) N. Fossat et al.   DEVELOPMENT

Genetic mosaic analysis reveals a major role for frizzled 4 and frizzled 8 in controlling ureteric growth in the developing kidney

(2011) X. Ye et al.   DEVELOPMENT

 -Catenin is essential for Mullerian duct regression during male sexual differentiation

(2011) A. Kobayashi et al.   DEVELOPMENT

Secreted Wnt “inhibitors” are not just inhibitors: Regulation of extracellular Wnt by secreted Frizzled-related proteins

(2011) Yusuke Mii et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Secreted Wnt antagonist Dickkopf-1 controls kidney papilla development coordinated by Wnt-7b signalling

(2011) Ilkka Pietilä et al.   DEVELOPMENTAL BIOLOGY

Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo

(2011) Kyu Sang Joeng et al.   DEVELOPMENTAL BIOLOGY

Porcupine-mediated lipidation is required for Wnt recognition by Wls

(2011) Patrick Herr et al.   DEVELOPMENTAL BIOLOGY

Gpr177/mouse Wntless is essential for Wnt-mediated craniofacial and brain development

(2011) Jiang Fu et al.   DEVELOPMENTAL DYNAMICS

Deletion of Glycogen Synthase Kinase-3β in Cartilage Results in Up-Regulation of Glycogen Synthase Kinase-3α Protein Expression

(2011) J. R. Gillespie et al.   ENDOCRINOLOGY

Novel mutations affecting LRP5 splicing in patients with osteoporosis-pseudoglioma syndrome (OPPG)

(2011) C M Laine et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Update on Wnt signaling in bone cell biology and bone disease

(2011) David G. Monroe et al.   GENE

Identification of signal peptide domain SOST mutations in autosomal dominant craniodiaphyseal dysplasia

(2011) Su Jin Kim et al.   HUMAN GENETICS

Lef1ΔN Binds β-Catenin and Increases Osteoblast Activity and Trabecular Bone Mass

(2011) Luke H. Hoeppner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bone Overgrowth-associated Mutations in theLRP4Gene Impair Sclerostin Facilitator Function

(2011) Olivier Leupin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of bone formation by the serpentine receptor Frizzled-9

(2011) Joachim Albers et al.   JOURNAL OF CELL BIOLOGY

Relationship of sclerostin and secreted frizzled protein polymorphisms with bone mineral density

(2011) Carmen Valero et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Biphasic and Dosage-Dependent Regulation of Osteoclastogenesis by  -Catenin

(2011) W. Wei et al.   MOLECULAR AND CELLULAR BIOLOGY

SHP2 Tyrosine Phosphatase Converts Parafibromin/Cdc73 from a Tumor Suppressor to an Oncogenic Driver

(2011) Atsushi Takahashi et al.   MOLECULAR CELL

RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling

(2011) Yue Zhang et al.   NATURE CELL BIOLOGY

Lrp5 functions in bone to regulate bone mass

(2011) Yajun Cui et al.   NATURE MEDICINE

Wnt Signaling and Dupuytren's Disease

(2011) Guido H. Dolmans et al.   NEW ENGLAND JOURNAL OF MEDICINE

Methylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signaling

(2011) B Cha et al.   ONCOGENE

Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis

(2011) B.Y. Chan et al.   OSTEOARTHRITIS AND CARTILAGE

Ubiquitin Ligase RNF146 Regulates Tankyrase and Axin to Promote Wnt Signaling

(2011) Marinella G. Callow et al.   PLoS One

Role of GSK-3β in the Osteogenic Differentiation of Palatal Mesenchyme

(2011) Emily R. Nelson et al.   PLoS One

Tissue-specific roles of Axin2 in the inhibition and activation of Wnt signaling in the mouse embryo

(2011) L. Qian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-catenin

(2011) Marc Fiedler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome

(2011) J. J. Barrott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt Antagonists Bind through a Short Peptide to the First β-Propeller Domain of LRP5/6

(2011) Eric Bourhis et al.   STRUCTURE

Homozygous nonsense mutation in WNT10B and sporadic split-hand/foot malformation (SHFM) with autosomal recessive inheritance

(2010) Ariane Blattner et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Circulating levels of frizzled-related protein (FRZB) are increased in patients with early rheumatoid arthritis and decrease in response to disease-modifying antirheumatic drugs

(2010) F. Corallini et al.   ANNALS OF THE RHEUMATIC DISEASES

The Paf1 complex: Platform or player in RNA polymerase II transcription?

(2010) Judith A. Jaehning   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

WNTs in the Neonatal Mouse Uterus: Potential Regulation of Endometrial Gland Development

(2010) K. Hayashi et al.   BIOLOGY OF REPRODUCTION

β-catenin/cyclin D1 mediated development of suture mesenchyme in calvarial morphogenesis

(2010) Anthony J Mirando et al.   BMC DEVELOPMENTAL BIOLOGY

Transgenic mice overexpressing secreted frizzled-related proteins (sFRP)4 under the control of serum amyloid P promoter exhibit low bone mass but did not result in disturbed phosphate homeostasis

(2010) Hwa Young Cho et al.   BONE

DICKKOPF-4 activates the noncanonical c-Jun-NH2 kinase signaling pathway while inhibiting the Wnt-canonical pathway in human renal cell carcinoma

(2010) Hiroshi Hirata et al.   CANCER

The syndromic status of sclerosteosis and van Buchem disease

(2010) P. Beighton et al.   CLINICAL GENETICS

Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes

(2010) H. Yu et al.   DEVELOPMENT

Wnt modulators in the biotech pipeline

(2010) Jean-Philippe Rey et al.   DEVELOPMENTAL DYNAMICS

Gsk3β is required in the epithelium for palatal elevation in mice

(2010) Fenglei He et al.   DEVELOPMENTAL DYNAMICS

WNT4 is required for normal ovarian follicle development and female fertility

(2010) Alexandre Boyer et al.   FASEB JOURNAL

Abelson family kinases regulate Frizzled planar cell polarity signaling via Dsh phosphorylation

(2010) J. Singh et al.   GENES & DEVELOPMENT

Generation of mice with a conditional null allele for Wntless

(2010) April C. Carpenter et al.   GENESIS

Generation of Axin1 conditional mutant mice

(2010) Rong Xie et al.   GENESIS

Analysis of Dickkopf3 interactions with Wnt signaling receptors

(2010) Rei E. I. Nakamura et al.   GROWTH FACTORS

First missense mutation in the SOST gene causing sclerosteosis by loss of sclerostin function

(2010) Elke Piters et al.   HUMAN MUTATION

Novel LRP5 gene mutation in a patient with osteoporosis-pseudoglioma syndrome

(2010) Alice Marques-Pinheiro et al.   JOINT BONE SPINE

The Protein Stability of Axin, a Negative Regulator of Wnt Signaling, Is Regulated by Smad Ubiquitination Regulatory Factor 2 (Smurf2)

(2010) Sewoon Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Tcf7 by Runx2 in chondrocyte maturation and proliferation

(2010) Masaki Mikasa et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Targeted overexpression of Dkk1 in osteoblasts reduces bone mass but does not impair the anabolic response to intermittent PTH treatment in mice

(2010) Gang-Qing Yao et al.   JOURNAL OF BONE AND MINERAL METABOLISM

APC mutations are associated with increased bone mineral density in patients with familial adenomatous polyposis

(2010) Razvan L Miclea et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Wnt10b deficiency results in age-dependent loss of bone mass and progressive reduction of mesenchymal progenitor cells

(2010) Jennifer R Stevens et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones

(2010) Michael S Ominsky et al.   JOURNAL OF BONE AND MINERAL RESEARCH

WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification

(2010) G. S. Coombs et al.   JOURNAL OF CELL SCIENCE

Mitogen-Activated Protein Kinases Promote WNT/ -Catenin Signaling via Phosphorylation of LRP6

(2010) I. Cervenka et al.   MOLECULAR AND CELLULAR BIOLOGY

Osteocyte Wnt/ -Catenin Signaling Is Required for Normal Bone Homeostasis

(2010) I. Kramer et al.   MOLECULAR AND CELLULAR BIOLOGY

Lrp4 Regulates Initiation of Ureteric Budding and Is Crucial for Kidney Formation – A Mouse Model for Cenani-Lenz Syndrome

(2010) Courtney M. Karner et al.   PLoS One

European Bone Mineral Density Loci Are Also Associated with BMD in East-Asian Populations

(2010) Unnur Styrkarsdottir et al.   PLoS One

WNT10A Mutations Are a Frequent Cause of a Broad Spectrum of Ectodermal Dysplasias with Sex-Biased Manifestation Pattern in Heterozygotes

(2009) Axel Bohring et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Various types of LRP5 mutations in four patients with osteoporosis-pseudoglioma syndrome: Identification of a 7.2-kb microdeletion using oligonucleotide tiling microarray

(2009) Satoshi Narumi et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Large-scale analysis of association betweenGDF5andFRZBvariants and osteoarthritis of the hip, knee, and hand

(2009) Evangelos Evangelou et al.   ARTHRITIS AND RHEUMATISM

Adenomatous polyposis coli-mediated control of β-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors

(2009) Razvan L Miclea et al.   BMC DEVELOPMENTAL BIOLOGY

Effects of selective serotonin reuptake inhibitors on bone health in adults: Time for recommendations about screening, prevention and management?

(2009) Elizabeth M. Haney et al.   BONE

A Two-Step Model for Colon Adenoma Initiation and Progression Caused by APC Loss

(2009) Reid A. Phelps et al.   CELL

Norrin, Frizzled-4, and Lrp5 Signaling in Endothelial Cells Controls a Genetic Program for Retinal Vascularization

(2009) Xin Ye et al.   CELL

Dishevelled: The hub of Wnt signaling

(2009) Chan Gao et al.   CELLULAR SIGNALLING

Three novel mutations in the PORCN gene underlying focal dermal hypoplasia

(2009) P Leoyklang et al.   CLINICAL GENETICS

Secreted Frizzled-related proteins enhance the diffusion of Wnt ligands and expand their signalling range

(2009) Y. Mii et al.   DEVELOPMENT

Cell Cycle Control of Wnt Receptor Activation

(2009) Gary Davidson et al.   DEVELOPMENTAL CELL

Wnt2/2b and β-Catenin Signaling Are Necessary and Sufficient to Specify Lung Progenitors in the Foregut

(2009) Ashley M. Goss et al.   DEVELOPMENTAL CELL

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Wnt signaling as a therapeutic target for bone diseases

(2009) Luke H Hoeppner et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation

(2009) Florian Witte et al.   GENE EXPRESSION PATTERNS

Generation of an allele to inactivateWnt4gene function conditionally in the mouse

(2009) Jingdong Shan et al.   GENESIS

Both the RGS Domain and the Six C-Terminal Amino Acids of Mouse Axin Are Required for Normal Embryogenesis

(2009) I. V. Chia et al.   GENETICS

Characterization of the Structural Features and Interactions of Sclerostin

(2009) Vaclav Veverka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G Protein-coupled Receptor Kinases Phosphorylate LRP6 in the Wnt Pathway

(2009) Minyong Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-Density Association Study of 383 Candidate Genes for Volumetric BMD at the Femoral Neck and Lumbar Spine Among Older Men

(2009) Laura M Yerges et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Dishevelled-2 docks and activates Src in a Wnt-dependent manner

(2009) Noriko Yokoyama et al.   JOURNAL OF CELL SCIENCE

Axin2 controls bone remodeling through the  -catenin-BMP signaling pathway in adult mice

(2009) Y. Yan et al.   JOURNAL OF CELL SCIENCE

Runx2 and bone morphogenic protein 2 regulate the expression of an alternative Lef1 transcript during osteoblast maturation

(2009) Luke H. Hoeppner et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Regulation of GSK-3 beta in the proliferation and apoptosis of human thyrocytes investigated using a GSK-3 beta-targeting RNAi adenovirus expression vector: involvement the Wnt/beta-catenin pathway

(2009) Gang Chen et al.   MOLECULAR BIOLOGY REPORTS

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies

(2009) Fernando Rivadeneira et al.   NATURE GENETICS

β-Catenin hits chromatin: regulation of Wnt target gene activation

(2009) Christian Mosimann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Motor Neurons with Axial Muscle Projections Specified by Wnt4/5 Signaling

(2009) Dritan Agalliu et al.   NEURON

Lef1 Haploinsufficient Mice Display a Low Turnover and Low Bone Mass Phenotype in a Gender- and Age-Specific Manner

(2009) Tommy Noh et al.   PLoS One

Lrp4, a Novel Receptor for Dickkopf 1 and Sclerostin, Is Expressed by Osteoblasts and Regulates Bone Growth and Turnover In Vivo

(2009) Hong Y. Choi et al.   PLoS One

Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation

(2009) J. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential effects of secreted frizzled-related proteins (sFRPs) on osteoblastic differentiation of mouse mesenchymal cells and apoptosis of osteoblasts

(2008) Sun Wook Cho et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AXIN2andCDH1polymorphisms, tooth agenesis, and oral clefts

(2008) Ariadne Letra et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Rac1 Activation Controls Nuclear Localization of β-catenin during Canonical Wnt Signaling

(2008) Ximei Wu et al.   CELL

Lrp5 Controls Bone Formation by Inhibiting Serotonin Synthesis in the Duodenum

(2008) Vijay K. Yadav et al.   CELL

Wnt Signaling and Prostate Cancer

(2008) Daniel Robinson et al.   CURRENT DRUG TARGETS

WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth

(2008) Mary Anne Potok et al.   DEVELOPMENTAL DYNAMICS

SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability

(2008) Min Jung Kim et al.   FASEB JOURNAL

Parathyroid hormone signaling through low-density lipoprotein-related protein 6

(2008) M. Wan et al.   GENES & DEVELOPMENT

Homozygous WNT10b mutation and complex inheritance in Split-Hand/Foot Malformation

(2008) Sibel Aylin Ugur et al.   HUMAN MOLECULAR GENETICS

A model for familial exudative vitreoretinopathy caused by LPR5 mutations

(2008) C.-H. Xia et al.   HUMAN MOLECULAR GENETICS

β-Catenin Levels Influence Rapid Mechanical Responses in Osteoblasts

(2008) Natasha Case et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lrp6 Hypomorphic Mutation Affects Bone Mass Through Bone Resorption in Mice and Impairs Interaction With Mesd

(2008) Takuo Kubota et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength

(2008) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Activation of β-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult β-Catenin Conditional Activation Mice

(2008) Mei Zhu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Brachy-syndactyly caused by loss ofSfrp2function

(2008) Roy Morello et al.   JOURNAL OF CELLULAR PHYSIOLOGY

An Essential Role for Frizzled5 in Neuronal Survival in the Parafascicular Nucleus of the Thalamus

(2008) C. Liu et al.   JOURNAL OF NEUROSCIENCE

Tissue-Specific Role of Glycogen Synthase Kinase 3  in Glucose Homeostasis and Insulin Action

(2008) S. Patel et al.   MOLECULAR AND CELLULAR BIOLOGY

Decoding of Methylated Histone H3 Tail by the Pygo-BCL9 Wnt Signaling Complex

(2008) Marc Fiedler et al.   MOLECULAR CELL

Radiographic osteoarthritis at three joint sites and FRZB, LRP5, and LRP6 polymorphisms in two population-based cohorts

(2008) J.M. Kerkhof et al.   OSTEOARTHRITIS AND CARTILAGE

Murine Dishevelled 3 Functions in Redundant Pathways with Dishevelled 1 and 2 in Normal Cardiac Outflow Tract, Cochlea, and Neural Tube Development

(2008) S. Leah Etheridge et al.   PLoS Genetics

Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3

(2007) Yi-Nan Lee et al.   CELLULAR SIGNALLING