Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity

Structure of the human κ-opioid receptor in complex with JDTic

(2012) Huixian Wu et al.   NATURE

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

(2012) Aashish Manglik et al.   NATURE

Repeated Exposure to the κ-Opioid Receptor Agonist Salvinorin A Modulates Extracellular Signal-Regulated Kinase and Reward Sensitivity

(2011) David N. Potter et al.   BIOLOGICAL PSYCHIATRY

Novel opioid cyclic tetrapeptides: Trp isomers of CJ-15,208 exhibit distinct opioid receptor agonism and short-acting κ opioid receptor antagonism

(2011) Nicolette C Ross et al.   BRITISH JOURNAL OF PHARMACOLOGY

Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET

(2011) P. Kannan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel

(2010) Yong Zhang et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Measurement of Unbound Drug Exposure in Brain: Modeling of pH Partitioning Explains Diverging Results between the Brain Slice and Brain Homogenate Methods

(2010) M. Friden et al.   DRUG METABOLISM AND DISPOSITION

Lipophilicity in drug discovery

(2010) Michael J Waring   Expert Opinion on Drug Discovery

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Ligand-directed c-Jun N-terminal kinase activation disrupts opioid receptor signaling

(2010) E. J. Melief et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of the selective kappa-opioid receptor antagonist JDTic on nicotine antinociception, reward, and withdrawal in the mouse

(2010) K. J. Jackson et al.   PSYCHOPHARMACOLOGY

Kinase cascades and ligand-directed signaling at the kappa opioid receptor

(2010) Michael R. Bruchas et al.   PSYCHOPHARMACOLOGY

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Relationship between Passive Permeability, Efflux, and Predictability of Clearance from In Vitro Metabolic Intrinsic Clearance

(2009) L. Huang et al.   DRUG METABOLISM AND DISPOSITION

Prediction of Vss from In Vitro Tissue-Binding Studies

(2009) L. M. Berry et al.   DRUG METABOLISM AND DISPOSITION

Improved Measurement of Drug Exposure in the Brain Using Drug-Specific Correction for Residual Blood

(2009) Markus Fridén et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Structure−Brain Exposure Relationships in Rat and Human Using a Novel Data Set of Unbound Drug Concentrations in Brain Interstitial and Cerebrospinal Fluids

(2009) Markus Fridén et al.   JOURNAL OF MEDICINAL CHEMISTRY

Zyklophin, a systemically active selective kappa opioid receptor peptide antagonist with short duration of action

(2009) J. V. Aldrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative modeling of selective lysosomal targeting for drug design

(2008) Stefan Trapp et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Role of active metabolites in the use of opioids

(2008) Janet K. Coller et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Kinetics of Cellular Retention during Caco-2 Permeation Experiments: Role of Lysosomal Sequestration and Impact on Permeability Estimates

(2008) A. T. Heikkinen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS