Article
Obstetrics & Gynecology
Hamdi Mbarek, Scott D. Gordon, David L. Duffy, Nikki Hubers, Sally Mortlock, Jeffrey J. Beck, Jouke-Jan Hottenga, Rene Pool, Conor Dolan, Ky'Era Actkins, Zachary F. Gerring, Jenny Van Dongen, Erik A. Ehli, William G. Iacono, Matt Mcgue, Daniel Chasman, C. Scott Gallagher, Samantha L. P. Schilit, Cynthia C. Morton, Guillaume Pare, Gonneke Willemsen, David C. Whiteman, Catherine M. Olsen, Catherine Derom, Robert Vlietinck, Daniel Gudbjartsson, Lisa Cannon-Albright, Eva Krapohl, Robert Plomin, Patrik K. E. Magnusson, Nancy L. Pedersen, Pirro Hysi, Massimo Mangino, Timothy D. Spector, Teemu Palviainen, Yuri Milaneschi, Brenda W. Penninnx, Adrian Campos, Ken K. Ong, John R. B. Perry, Cornelis B. Lambalk, Jaakko Kaprio, Isleifur Olafsson, Karine Duroure, Celine Revenu, Miguel E. Renteria, Loic Yengo, Lea Davis, Eske M. Derks, Sarah E. Medland, Hreinn Stefansson, Kari Stefansson, Filippo Del Bene, Bruno Reversade, Grant W. Montgomery, Dorret Boomsma, Nicholas G. Martin
Summary: This study identified four new loci associated with female propensity for giving birth to spontaneous dizygotic twins. The novel loci, GNRH1 and FSHR, have established roles in female reproduction, while ZFPM1 and IPO8 were not previously linked to female fertility. The study also found significant genetic correlations with multiple aspects of female reproduction and body size, suggesting important roles in human evolution.
HUMAN REPRODUCTION
(2023)
Article
Hematology
Ming Wai Yeung, Siqi Wang, Yordi J. van de Vegte, Oleg Borisov, Jessica van Setten, Harold Snieder, Niek Verweij, M. Abdullah Said, Pim van der Harst
Summary: Three genome-wide association studies were conducted in over 45,000 individuals, identifying 25 novel loci associated with cIMT. These findings provide insights into the genetic architecture underlying atherosclerosis and the shared biological mechanisms with cardiovascular diseases.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Genetics & Heredity
Ekaterina Orlova, Tom Dudding, Jonathan M. Chernus, Rasha N. Alotaibi, Simon Haworth, Richard J. Crout, Myoung Keun Lee, Nandita Mukhopadhyay, Eleanor Feingold, Steven M. Levy, Daniel W. McNeil, Betsy Foxman, Robert J. Weyant, Nicholas J. Timpson, Mary L. Marazita, John R. Shaffer
Summary: Although genetics plays a role in early childhood caries (ECC) risk, little is known about the specific genetic determinants. This study conducted genome-wide association studies (GWAS) and transcriptome-wide association studies (TWAS) to identify genes associated with ECC. The results indicated suggestive evidence for the involvement of certain genetic regions and revealed four risk genes, including TAS2R14 which is associated with innate immunity and antimicrobial defense against cariogenic bacteria. These findings provide insights into the genetic architecture of ECC and highlight the importance of host-microbial interaction in caries risk.
Article
Psychology, Developmental
Eshim S. Jami, Anke R. Hammerschlag, Hill F. Ip, Andrea G. Allegrini, Beben Benyamin, Richard Border, Elizabeth W. Diemer, Chang Jiang, Ville Karhunen, Yi Lu, Qing Lu, Travis T. Mallard, Pashupati P. Mishra, Ilja M. Nolte, Teemu Palviainen, Roseann E. Peterson, Hannah M. Sallis, Andrey A. Shabalin, Ashley E. Tate, Elisabeth Thiering, Natalia Vilor-Tejedor, Carol Wang, Ang Zhou, Daniel E. Adkins, Silvia Alemany, Helga Ask, Qi Chen, Robin P. Corley, Erik A. Ehli, Luke M. Evans, Alexandra Havdahl, Fiona A. Hagenbeek, Christian Hakulinen, Anjali K. Henders, Jouke Jan Hottenga, Tellervo Korhonen, Abdullah Mamun, Shelby Marrington, Alexander Neumann, Kaili Rimfeld, Fernando Rivadeneira, Judy L. Silberg, Catharina E. van Beijsterveldt, Eero Vuoksimaa, Alyce M. Whipp, Xiaoran Tong, Ole A. Andreassen, Dorret Boomsma, Sandra A. Brown, S. Alexandra Burt, William Copeland, Danielle M. Dick, K. Paige Harden, Kathleen Mullan Harris, Catharina A. Hartman, Joachim Heinrich, John K. Hewitt, Christian Hopfer, Elina Hypponen, Marjo-Riitta Jarvelin, Jaakko Kaprio, Liisa Keltikangas-Jarvinen, Kelly L. Klump, Kenneth Krauter, Ralf Kuja-Halkola, Henrik Larsson, Terho Lehtimaki, Paul Lichtenstein, Sebastian Lundstrom, Hermine H. Maes, Per Magnus, Marcus R. Munafo, Jake M. Najman, Pal R. Njolstad, Albertine J. Oldehinkel, Craig E. Pennell, Robert Plomin, Ted Reichborn-Kjennerud, Chandra Reynolds, Richard J. Rose, Andrew Smolen, Harold Snieder, Michael Stallings, Marie Standl, Jordi Sunyer, Henning Tiemeier, Sally J. Wadsworth, Tamara L. Wall, Andrew J. O. Whitehouse, Gail M. Williams, Eivind Ystrom, Michel G. Nivard, Meike Bartels, Christel M. Middeldorp
Summary: The study investigates the genetic architecture of internalizing symptoms in children and adolescents, finding rater-based heterogeneity in genetic effects and genetic correlations with adult internalizing disorders and other childhood psychiatric traits. Additionally, reducing phenotypic heterogeneity in childhood samples is crucial for future GWAS success.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Qingqin S. Li, Randall L. Morrison, Gustavo Turecki, Wayne C. Drevets
Summary: Epigenetic mechanisms play a significant role in the etiology of major depressive disorder (MDD), as indicated by a meta-analysis study. The study identified differentially methylated positions (DMPs) and differentially methylated regions (DMRs) associated with MDD, highlighting the involvement of pathways related to neuronal synaptic plasticity, calcium signaling, and inflammation.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Connor A. Emdin, Mary Haas, Veeral Ajmera, Tracey G. Simon, Julian Homburger, Cynthia Neben, Lan Jiang, Wei-Qi Wei, Qiping Feng, Alicia Zhou, Joshua Denny, Kathleen Corey, Rohit Loomba, Sekar Kathiresan, Amit Khera
Summary: This study identified 12 independent genetic variants, including 7 newly identified ones, that confer risk for cirrhosis. A polygenic score based on these variants can identify a subset of the population at substantially increased risk, particularly those susceptible to the hepatotoxic effects of excess alcohol consumption or obesity.
Article
Gastroenterology & Hepatology
Leticia Camargo Tavares, Tenghao Zheng, Madeline Kwicklis, Emily Mitchell, Anita Pandit, Suraj Pullapantula, Cheryl Bernard, Maris Teder-Laving, Francine Z. Marques, Tonu Esko, Braden Kuo, Robert J. Shulman, Bruno P. Chumpitazi, Kenneth L. Koch, Irene Sarosiek, Thomas L. Abell, Richard W. Mccallum, Henry P. Parkman, Pankaj J. Pasricha, Frank A. Hamilton, James Tonascia, Matthew Zawistowski, Gianrico Farrugia, Madhusudan Grover, Mauro D'Amato
Summary: This study conducted a genome-wide association study (GWAS) on gastroparesis (GP), identifying candidate genes and pathways related to immune and sensory-motor dysregulation. Larger studies are needed to validate and expand these findings.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Urology & Nephrology
Cassianne Robinson-Cohen, Jefferson L. Triozzi, Bryce Rowan, Jing He, Hua C. Chen, Neil S. Zheng, Wei-Qi Wei, Otis D. Wilson, Jacklyn N. Hellwege, Philip S. Tsao, J. Michael Gaziano, Alexander Bick, Michael E. Matheny, Cecilia P. Chung, Loren Lipworth, Edward D. Siew, T. Alp Ikizler, Ran Tao, Adriana M. Hung
Summary: By conducting a meta-analysis of genome-wide association studies, three genetic loci associated with longitudinal eGFR change have been identified, shedding light on the molecular mechanisms of eGFR decline and potentially contributing to the development of new therapeutic approaches for progressive CKD.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Cassianne Robinson-Cohen, Jefferson L. Triozzi, Bryce Rowan, Jing He, Hua C. Chen, Neil S. Zheng, Wei-Qi Wei, Otis D. Wilson, Jacklyn N. Hellwege, Philip S. Tsao, J. Michael Gaziano, Alexander Bick, Michael E. Matheny, Cecilia P. Chung, Loren Lipworth, Edward D. Siew, T. Alp Ikizler, Ran Tao, Adriana M. Hung
Summary: The study identified three significant loci associated with longitudinal decline in eGFR, providing insights into the molecular mechanisms of eGFR decline and potential therapeutic approaches for progressive CKD.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jorim J. Tielbeek, Emil Uffelmann, Benjamin S. Williams, Lucia Colodro-Conde, Eloi Gagnon, Travis T. Mallard, Brandt E. Levitt, Philip R. Jansen, Ada Johansson, Hannah M. Sallis, Giorgio Pistis, Gretchen R. B. Saunders, Andrea G. Allegrini, Kaili Rimfeld, Bettina Konte, Marieke Klein, Annette M. Hartmann, Jessica E. Salvatore, Ilja M. Nolte, Ditte Demontis, Anni L. K. Malmberg, S. Alexandra Burt, Jeanne E. Savage, Karen Sugden, Richie Poulton, Kathleen Mullan Harris, Scott Vrieze, Matt McGue, William G. Iacono, Nina Roth Mota, Jonathan Mill, Joana F. Viana, Brittany L. Mitchell, Jose J. Morosoli, Till F. M. Andlauer, Isabelle Ouellet-Morin, Richard E. Tremblay, Sylvana M. Cote, Jean-Philippe Gouin, Mara R. Brendgen, Ginette Dionne, Frank Vitaro, Michelle K. Lupton, Nicholas G. Martin, Enrique Castelao, Katri Raikkonen, Johan G. Eriksson, Jari Lahti, Catharina A. Hartman, Albertine J. Oldehinkel, Harold Snieder, Hexuan Liu, Martin Preisig, Alyce Whipp, Eero Vuoksimaa, Yi Lu, Patrick Jern, Dan Rujescu, Ina Giegling, Teemu Palviainen, Jaakko Kaprio, Kathryn Paige Harden, Marcus R. Munafo, Genevieve Morneau-Vaillancourt, Robert Plomin, Essi Viding, Brian B. Boutwell, Fazil Aliev, Danielle M. Dick, Arne Popma, Stephen Faraone, Anders D. Borglum, Sarah E. Medland, Barbara Franke, Michel Boivin, Jean-Baptiste Pingault, Jeffrey C. Glennon, J. C. Barnes, Simon E. Fisher, Terrie E. Moffitt, Avshalom Caspi, Tinca J. C. Polderman, Danielle Posthuma
Summary: This study identified significant genetic associations with broad antisocial behavior (ASB) and found that these genetic risks are associated with various antisocial outcomes, as well as mental health, physical health, smoking, cognitive ability, educational attainment, and reproductive traits.
MOLECULAR PSYCHIATRY
(2022)
Article
Endocrinology & Metabolism
Niina Sandholm, Joanne B. Cole, Viji Nair, Xin Sheng, Hongbo Liu, Emma Ahlqvist, Natalie van Zuydam, Emma H. Dahlstrom, Damian Fermin, Laura J. Smyth, Rany M. Salem, Carol Forsblom, Erkka Valo, Valma Harjutsalo, Eoin P. Brennan, Gareth J. McKay, Darrell Andrews, Ross Doyle, Helen C. Looker, Robert G. Nelson, Colin Palmer, Amy Jayne McKnight, Catherine Godson, Alexander P. Maxwell, Leif Groop, Mark I. McCarthy, Matthias Kretzler, Katalin Susztak, Joel N. Hirschhorn, Jose C. Florez, Per-Henrik Groop
Summary: By performing meta-analysis of previous genome-wide association studies (GWAS) on diabetic kidney disease (DKD) and integrating the results with renal transcriptomics datasets, novel genetic factors and genes contributing to DKD have been identified.
Article
Clinical Neurology
Elena Scumaci, Enrica Marzola, Giovanni Abbate-Daga, Marianna Pellegrini, Valentina Ponzo, Ilaria Goitre, Andrea Benso, Fabio Broglio, Sara Belcastro, Chiara Crespi, Chiara D'Eusebio, Franco De Michieli, Ezio Ghigo, Simona Bo
Summary: The study found that many outpatient with obesity reported symptoms of anxiety and depression even without a formal psychiatric diagnosis. Cyclothymic temperament was positively associated with binge eating, while hyperthymic temperament showed a protective effect on both binge eating and multiple weight cycling.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Medicine, General & Internal
Zhengbo Xue, Jian Yuan, Fukun Chen, Yinghao Yao, Shilai Xing, Xiangyi Yu, Kai Li, Chenxiao Wang, Jinhua Bao, Jia Qu, Jianzhong Su, Hao Chen
Summary: This study aimed to investigate the shared genetic etiology among age-related macular degeneration (AMD), diabetic retinopathy (DR), glaucoma, retinal detachment (RD), and myopia. The analysis of genome-wide association identified meaningful genetic correlations between these ocular diseases. Cross-trait meta-analysis revealed 23 shared loci associated with at least two ocular diseases and 14 loci unique to individual disorders.
Article
Biochemistry & Molecular Biology
Monika Mokrzycka, Stefan Stojalowski, Miroslaw Tyrka, Przemyslaw Matysik, Barbara Zmijewska, Rafal Marcinkowski, Urszula Wozna-Pawlak, Roza Martofel, Michal Rokicki, Monika Rakoczy-Trojanowska, Pawel Krajewski
Summary: This study identified markers associated with wheat agronomic traits using genome-wide association analysis. The study also investigated the effects of markers on heterosis and their linkage disequilibrium grouping. The results revealed a large number of single nucleotide polymorphisms with significant effects, predominantly influencing protein translation modification. These findings provide valuable insights for developing new wheat varieties with desirable properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Zhiyu Hao, Jin Gao, Yuxin Song, Runqing Yang, Di Liu
Summary: In this study, a hierarchical mixed model (Hi-LMM) was proposed to estimate genomic breeding values and infer the association between genotypes and phenotypes, effectively correcting confounding factors and improving the statistical power of association analysis.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Gastroenterology & Hepatology
Sally Mortlock, Anton Lord, Grant Montgomery, Martha Zakrzewski, Lisa A. Simms, Krupa Krishnaprasad, Katherine Hanigan, James D. Doecke, Alissa Walsh, Ian C. Lawrance, Peter A. Bampton, Jane M. Andrews, Gillian Mahy, Susan J. Connor, Miles P. Sparrow, Sally Bell, Timothy H. Florin, Jakob Begun, Richard B. Gearry, Graham L. Radford-Smith
Summary: This study identified genetic loci associated with medically refractory ulcerative colitis (UC) through a genome wide association analysis. The findings suggest different genetic risk factors for medically refractory UC compared to non-medically refractory UC. Further research may uncover additional loci related to disease severity.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Pediatrics
Suvi Alenius, Eero Kajantie, Reijo Sund, Markku Nurhonen, Peija Haaramo, Pieta Nasanen-Gilmore, Marja Vaarasmaki, Sakari Lemola, Katri Raikkonen, Daniel D. Schnitzlein, Dieter Wolke, Mika Gissler, Petteri Hovi
Summary: This population-based study found that individuals born preterm have a lower risk of sexually transmitted infections and teenage pregnancies, but a higher risk of payment defaults. Extremely preterm individuals have a lower risk of criminal offending, whereas very preterm individuals have a higher risk of payment defaults.
JOURNAL OF PEDIATRICS
(2023)
Article
Biochemistry & Molecular Biology
Qingqin S. Li, Andrey A. Shabalin, Emily DiBlasi, Srihari Gopal, Carla M. Canuso, Aarno Palotie, Wayne C. Drevets, Anna R. Docherty, Hilary Coon
Summary: This study aimed to identify genetic risk variants associated with suicide death and suicidal behavior. The results showed that a locus in the neuroligin 1 (NLGN1) gene was associated with suicide death, while ROBO2 and ZNF28 genes were associated with suicidal behavior. Additionally, variants near SOX5 and LOC101928519 were found to be associated with suicidal attempts. Suicide death and suicidal behavior showed positive correlations with depression, schizophrenia, pain, and suicidal attempt, and negative correlation with educational attainment.
MOLECULAR PSYCHIATRY
(2023)
Article
Endocrinology & Metabolism
Mika Ala-Korpela, Terho Lehtimaki, Mika Kahonen, Jorma Viikari, Markus Perola, Veikko Salomaa, Johannes Kettunen, Olli T. Raitakari, Ville-Petteri Makinen
Summary: This study tested whether cross-sectional modeling can distinguish slow vs accelerated aging in a human population. A machine learning model was trained to predict age and tested against longitudinal data. The results showed that the cross-sectional proxy failed to predict longitudinal observations, suggesting that differences in starting points may explain diverging aging rates.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biology
Pyry Helkkula, Shabbeer Hassan, Elmo Saarentaus, Emilia Vartiainen, Sanni T. Ruotsalainen, Jaakko Leinonen, Aarno Palotie, Juha Karjalainen, Mitja Kurki, Samuli Ripatti, Taru Tukiainen
Summary: A genome-wide association study conducted in a Finnish cohort identified new genetic loci associated with varicose veins, including the connexin gene family member, GJD3, which could be a potential drug target. These findings provide insights into the etiology of varicose veins and emphasize the ability of isolated populations, such as Finns, to discover genetic variants relevant to therapeutic development.
COMMUNICATIONS BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Qile Dai, Geyu Zhou, Hongyu Zhao, Urmo Vosa, Lude Franke, Alexis Battle, Alexander Teumer, Terho Lehtimaki, Olli T. Raitakari, Tonu Esko, Michael P. Epstein, Jingjing Yang
Summary: Most TWAS tools require individual-level eQTL reference data, making them not suitable for summary-level reference eQTL datasets. Hence, the development of TWAS methods that can utilize summary-level reference data is valuable. In this study, a TWAS framework called OTTERS is introduced, which adapts multiple polygenic risk score methods to estimate eQTL weights from summary-level data and performs omnibus TWAS. Both simulations and application studies demonstrate the practicality and power of OTTERS as a TWAS tool.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Havard Aanes, Oyvind Bleka, Pal Skage Dahlberg, Kristina Totland Carm, Terho Lehtimaki, Olli Raitakari, Mika Kahonen, Mikko Hurme, Veslemoy Rolseth
Summary: More than 1/4 of children globally lack documentation of their date of birth, emphasizing the need for biological methods to predict age. DNA methylation is the most promising biomarker for age assessment, but there is currently no epigenetic clock specifically designed for adolescents and young adults. A novel age predictor called PAYA, using 267 CpG methylation sites, shows potential for age assessment in this population, but further research is needed to test its robustness across different populations and environments.
SCIENTIFIC REPORTS
(2023)
Article
Pediatrics
Ingrid Marie Husby Hollund, Kristina Anna Djupvik Aakvik, Silje Dahl Benum, Sigrid Hegna Ingvaldsen, Stian Lydersen, Marjaana Tikanmaki, Petteri Hovi, Katri Raikkonen, Eero Kajantie, Samantha Johnson, Neil Marlow, Nicole Baumann, Dieter Wolke, Marit S. Indredavik, Kari Anne I. Evensen
Summary: The associations between mental health, pain, and tiredness in adults are independent of gestation or birthweight. Further research should explore other potential mechanisms to explain the increased risk of mental health problems in the preterm population.
Article
Genetics & Heredity
Xiaotong Wang, Alicia Walker, Joana A. Revez, Guiyan Ni, Mark J. Adams, Andrew M. McIntosh, Peter M. Psychiatric Genomics Consortium, Peter M. Visscher, Naomi R. Wray
Summary: In polygenic score (PGS) analysis, the coefficient of determination (R-2) is used to evaluate efficacy. However, in real data analyses, R-2 has been found to exceed the theoretical upper limit of the out-of-sample prediction calculated by SNP-based heritability (h(SNP)(2)). This is likely due to heterogeneities in cohort-specific h(SNP)(2) and genetic correlations between cohorts. We provide simulated and real data evidence to support these observations and emphasize the need for a better approach to address between-cohort heterogeneity.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Psychiatry
Jan Scott, Jacob J. Crouse, Sarah Medland, Enda Byrne, Frank Iorfino, Brittany Mitchell, Nathan A. Gillespie, Nicholas Martin, Naomi Wray, Ian B. Hickie
Summary: The study found that combining polygenic risk scores (PRS) with other risk factors may improve outcome prediction in youth. Adding PRS improved prediction of mood and/or psychotic disorder cases, as shown in receiver operating curve and logistic regression analyses.
EARLY INTERVENTION IN PSYCHIATRY
(2023)
Article
Gastroenterology & Hepatology
Anil K. Giri, Mervi Aavikko, Linnea Wartiovaara, Toni Lemmetyinen, Juha Karjalainen, Juha Mehtonen, Kimmo Palin, Niko Valimaki, Max Tamlander, Riikka Saikkonen, Auli Karhu, Ekaterina Morgunova, Benjamin Sun, Heiko Runz, Priit Palta, Shuang Luo, Heikki Joensuu, Tomi P. Makela, Iiro Kostiainen, Camilla Schalin-Jantti, Aarno FinnGen, Aarno Palotie, Lauri A. Aaltonen, Saara Ollila, Mark J. Daly
Summary: This study is the largest genome-wide association study on small intestinal neuroendocrine tumors (SI-NETs) to date, and it identified 6 significant loci associated with SI-NET risk. Four of these loci are novel, and one of the top hits is a missense variant in the LGR5 gene, a marker of adult intestinal stem cells.
Article
Biology
Matti A. Vuori, Tuomo Kiiskinen, Niina Pitkanen, Samu Kurki, Hannele Laivuori, Tarja Laitinen, Sampo Mantylahti, Aarno Palotie, FinnGen, Teemu J. Niiranen
Summary: This study aims to assess whether electronic health record data text mining can be used to improve register-based heart failure subtyping. The results show that quantitative ejection fraction data can be efficiently extracted from electronic health records and used with laboratory data to subtype heart failure with reasonable accuracy, especially for heart failure with reduced ejection fraction.
BMC RESEARCH NOTES
(2023)
Article
Biotechnology & Applied Microbiology
Pashupati P. Mishra, Binisha H. Mishra, Emma Raitoharju, Nina Mononen, Jorma Viikari, Markus Juonala, Nina Hutri-Kahonen, Mika Kahonen, Olli T. Raitakari, Terho Lehtimaki
Summary: Advanced integrative analysis of DNA methylation and transcriptomics data reveals the effects of smoke-induced epigenetic alterations on gene expression and biological processes, linking smoking and related diseases.
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2023)
Correction
Multidisciplinary Sciences
Mitja I. Kurki, Juha Karjalainen, Priit Palta, Timo P. Sipila, Kati Kristiansson, Kati M. Donner, Mary P. Reeve, Hannele Laivuori, Mervi Aavikko, Mari A. Kaunisto, Anu Loukola, Elisa Lahtela, Hannele Mattsson, Paivi Laiho, Pietro Della Briotta Parolo, Arto A. Lehisto, Masahiro Kanai, Nina Mars, Joel Ramo, Tuomo Kiiskinen, Henrike O. Heyne, Kumar Veerapen, Sina Rueger, Susanna Lemmela, Wei Zhou, Sanni Ruotsalainen, Kalle Parn, Tero Hiekkalinna, Sami Koskelainen, Teemu Paajanen, Vincent Llorens, Javier Gracia-Tabuenca, Harri Siirtola, Kadri Reis, Abdelrahman G. Elnahas, Benjamin Sun, Christopher N. Foley, Katriina Aalto-Setala, Kaur Alasoo, Mikko Arvas, Kirsi Auro, Shameek Biswas, Argyro Bizaki-Vallaskangas, Olli Carpen, Chia-Yen Chen, Oluwaseun A. Dada, Zhihao Ding, Margaret G. Ehm, Kari Eklund, Martti Farkkila, Hilary Finucane, Andrea Ganna, Awaisa Ghazal, Robert R. Graham, Eric M. Green, Antti Hakanen, Marco Hautalahti, Asa K. Hedman, Mikko Hiltunen, Reetta Hinttala, Iiris Hovatta, Xinli Hu, Adriana Huertas-Vazquez, Laura Huilaja, Julie Hunkapiller, Howard Jacob, Jan-Nygaard Jensen, Heikki Joensuu, Sally John, Valtteri Julkunen, Marc Jung, Juhani Junttila, Kai Kaarniranta, Mika Kahonen, Risto Kajanne, Lila Kallio, Reetta Kalviainen, Jaakko Kaprio, Nurlan Kerimov, Johannes Kettunen, Elina Kilpelainen, Terhi Kilpi, Katherine Klinger, Veli-Matti Kosma, Teijo Kuopio, Venla Kurra, Triin Laisk, Jari Laukkanen, Nathan Lawless, Aoxing Liu, Simonne Longerich, Reedik Magi, Johanna Makela, Antti Makitie, Anders Malarstig, Arto Mannermaa, Joseph Maranville, Athena Matakidou, Tuomo Meretoja, Sahar V. Mozaffari, Mari E. K. Niemi, Marianna Niemi, Teemu Niiranen, Christopher J. O'Donnell, Ma'En Obeidat, George Okafo, Hanna M. Ollila, Antti Palomaki, Tuula Palotie, Jukka Partanen, Dirk S. Paul, Margit Pelkonen, Rion K. Pendergrass, Slave Petrovski, Anne Pitkaranta, Adam Platt, David Pulford, Eero Punkka, Pirkko Pussinen, Neha Raghavan, Fedik Rahimov, Deepak Rajpal, Nicole A. Renaud, Bridget Riley-Gillis, Rodosthenis Rodosthenous, Elmo Saarentaus, Aino Salminen, Eveliina Salminen, Veikko Salomaa, Johanna Schleutker, Raisa Serpi, Huei-yi Shen, Richard Siegel, Kaisa Silander, Sanna Siltanen, Sirpa Soini, Hilkka Soininen, Jae Hoon Sul, Ioanna Tachmazidou, Kaisa Tasanen, Pentti Tienari, Sanna Toppila-Salmi, Taru Tukiainen, Tiinamaija Tuomi, Joni A. Turunen, Jacob C. Ulirsch, Felix Vaura, Petri Virolainen, Jeffrey Waring, Dawn Waterworth, Robert Yang, Mari Nelis, Anu Reigo, Andres Metspalu, Lili Milani, Tonu Esko, Caroline Fox, Aki S. Havulinna, Markus Perola, Samuli Ripatti, Anu Jalanko, Tarja Laitinen, Tomi P. Makela, Robert Plenge, Mark McCarthy, Heiko Runz, Mark J. Daly, Aarno Palotie