Review
Endocrinology & Metabolism
Taylor M. Triolo, Melena D. Bellin
Summary: Diabetes mellitus is characterized by the dysfunction of beta cells, and cell transplantation offers a potential treatment option but faces challenges. Research on generating synthetic beta cells and islets has progressed, providing opportunities for future therapies.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Judith Derdelinckx, Tatjana Reynders, Inez Wens, Nathalie Cools, Barbara Willekens
Summary: Cell-based therapies show promise for rare neurological autoimmune diseases, but face challenges such as lack of suitable animal models and rarity of diseases. Various cell treatments have entered clinical trials or been used in refractory cases, but the development of antigen-specific immunotherapies for autoimmune diseases is hindered by several factors that may be addressed through future research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Ji Sun, Jingbo Li, Zhikun Huan, Stephen J. Pandol, Dechen Liu, Luoran Shang, Ling Li
Summary: Type 1 diabetes mellitus is characterized by autoimmune damage of pancreatic beta cells. This study develops mesenchymal stem cell (MSC)-laden composite beta cell porous microgels (MGs) to address sustainability for the treatment of diabetes. The results demonstrate that the MGs have great potential for the treatment of diabetes providing a promising platform for clinical beta cell transplantation.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Sarah I. Othman, Asma M. Alturki, Gasem Mohammad Abu-Taweel, Naif Ghazi Altoom, Ahmed A. Allam, Rehab Abdelmonem
Summary: Chitosan, with its excellent pharmacokinetic and chemical properties, is an attractive and promising carbohydrate biopolymer in biomedical applications, particularly in the treatment of diabetes mellitus. Its potential benefits lie in delivering antidiabetic drugs through nanocarriers to reduce blood glucose levels.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Endocrinology & Metabolism
Jiachao Xiong, Hao Hu, Rong Guo, Hui Wang, Hua Jiang
Summary: Diabetes mellitus is a metabolic disease characterized by high blood sugar levels, often accompanied by various complications. Mesenchymal stem cell exosomes possess repair functions, low immunogenicity, and ease of storage and transportation, making them a potentially effective treatment for diabetes and its complications.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell & Tissue Engineering
Phillip L. Lewis, James M. Wells
Summary: Strategies to mitigate diabetes pathologies range from insulin administration to complex drug regimens with lifestyle changes. Understanding beta-cell physiology is crucial for developing improved therapies, and advancements in various fields have led to new experimental systems for studying diabetes and beta-cell biology. The use of different insulin-secreting cell types and engineered platforms is showing promise in developing novel diabetes therapeutics.
Review
Medicine, Research & Experimental
Robin Augustine, Pan Dan, Anwarul Hasan, Israa Magdi Khalaf, Parvathy Prasad, Kajal Ghosal, Carmine Gentile, Lana McClements, Pablo Maureira
Summary: Cardiovascular disease is a major cause of death globally, with promising cardiac tissue engineering strategies using biomaterial scaffolds and stem cells. Differentiated stem cells from various sources have the potential to repair damaged heart tissue. The stem cell microenvironment plays a crucial role in maintaining stemness and directing differentiation into cardiac-specific cell lineages within tissue engineering platforms.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Chemistry, Multidisciplinary
Debkalpa Goswami, Daniel A. Domingo-Lopez, Niamh A. Ward, Jeffrey R. Millman, Garry P. Duffy, Eimear B. Dolan, Ellen T. Roche
Summary: Stem cell derived insulin producing cells or islets show promise in reversing Type 1 Diabetes (T1D), but successful transplantation currently requires long-term modulation with immunosuppressant drugs. An alternative approach to avoid immune response is to use an islet macroencapsulation device. These systems must meet stringent design criteria to achieve the ultimate goal of reversing T1D.
Article
Chemistry, Physical
Myriam Neumann, Thierry Arnould, Bao-Lian Su
Summary: Type 1 diabetes mellitus is an autoimmune disease characterized by the destruction of insulin-producing β-cells, leading to chronic hyperglycemia. Current treatments have limitations, and this review discusses the potential solution of using stem cell-derived β-cells encapsulated within a protective matrix. The article provides an extensive overview of different stem cell sources and encapsulation methods, aiming to overcome the limitations and improve glycemic control in diabetes.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Review
Endocrinology & Metabolism
Eleonora de Klerk, Matthias Hebrok
Summary: Intraportal allogeneic cadaveric islet transplantation shows promise for Type I Diabetes patients, but is limited by issues like cadaveric islet availability and immunosuppressive drug dependence. Mesenchymal stem cell and human embryonic stem cell approaches are explored as alternatives, but still face challenges such as immune rejection. Protective immune strategies and innovative technologies are being developed to address these challenges.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Immunology
Maryam Zare Moghaddam, Mohammad Javad Mousavi, Somayeh Ghotloo
Summary: Cell-based therapy, including stem cells and non-stem cells, is considered as a therapeutic option for treating autoimmune diseases. The unique properties of stem cells, such as differentiation ability, can influence diseases caused by immunological abnormalities. The efficacy and related issues of cell-based therapy are evaluated and discussed through the assessment of different types of stem cells and non-stem cells.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Carmine Liberatore, Mauro Di Ianni
Summary: The management of relapsed acute myeloid leukemia (AML) post allogeneic hematopoietic stem cell transplantation (HSCT) remains a clinical challenge. Hypomethylating agents (HMAs) have become the standard therapeutic approach due to favorable tolerability and their ability to be combined with other anti-leukemic agents. The addition of donor lymphocytes infusions (DLI) generally leads to improved outcomes, while the introduction of novel targeted drugs offers new possibilities in salvage regimens.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Mahdi Zavvar, Aisan Yahyapoor, Hamed Baghdadi, Sina Zargaran, Sara Assadiasl, Kamal Abdolmohammadi, Amir Hossein Abooei, Mohammad Reza Sattarian, Melina JalaliFarahani, Negar Zarei, Amirali Farahvash, Yousef Fatahi, Gunnur Deniz, Mitra Zarebavani, Mohammad Hossein Nicknam
Summary: Efforts are being made to control and treat COVID-19 worldwide. Adoptive immune cell therapy is an innovative approach that offers promising prophylactic or therapeutic options, but it may result in excessive inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
Fritz Cayabyab, Lina R. Nih, Eiji Yoshihara
Summary: Diabetes is a complex global disease affecting over 400 million people, with pancreatic islet transplantation showing promise in treating type 1 diabetes but facing challenges such as immune rejection. Current research focuses on finding optimal transplantation sites and methods to improve islet graft survival, with the aim of translating these studies into successful clinical therapies.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Xin-Xing Wan, Dan-Yi Zhang, Md. Asaduzzaman Khan, Sheng-Yuan Zheng, Xi-Min Hu, Qi Zhang, Rong-Hua Yang, Kun Xiong
Summary: This review article discusses the application of stem cell transplantation in the treatment of type 1 diabetes mellitus (T1DM). Stem cells have the potential to reestablish immunotolerance and preserve islet beta-cell function, providing a promising alternative for T1DM treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Fiona N. Manderson Koivula, Neville H. McClenaghan, Alan G. S. Harper, Catriona Kelly
Article
Physiology
Catriona Kelly, Paul Canning, Paul J. Buchanan, Mark T. Williams, Vanessa Brown, Dieter C. Gruenert, J. Stuart Elborn, Madeleine Ennis, Bettina C. Schock
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2013)
Review
Biochemistry & Molecular Biology
Catriona Kelly, Michael D. Shields, J. Stuart Elborn, Bettina C. Schock
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2011)
Article
Biochemistry & Molecular Biology
Catriona Kelly, Peter R. Flatt, Neville H. McClenaghan
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2010)
Article
Endocrinology & Metabolism
Catriona Kelly, Hong Guo Parke, Jane T. McCluskey, Peter R. Flatt, Neville H. McClenaghan
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2010)
Article
Respiratory System
Catriona Kelly, Mark T. Williams, Kathryn Mitchell, J. Stuart Elborn, Madeleine Ennis, Bettina C. Schock
EUROPEAN RESPIRATORY JOURNAL
(2013)
Article
Respiratory System
Catriona Kelly, Mark T. Williams, J. Stuart Elbom, Madeleine Ennis, Bettina C. Schock
JOURNAL OF CYSTIC FIBROSIS
(2013)
Article
Endocrinology & Metabolism
Hong Guo-Parke, Jane T. McCluskey, Catriona Kelly, Muhajir Hamid, Neville H. McClenaghan, Peter R. Flatt
JOURNAL OF ENDOCRINOLOGY
(2012)
Article
Gastroenterology & Hepatology
Catriona Kelly, Hong Guo, Jane T. McCluskey, Peter R. Flatt, Neville H. McClenaghan
Article
Endocrinology & Metabolism
Shanta J. Persaud, Catherine Arden, Peter Bergsten, Adrian J. Bone, James Brown, Simon Dunmore, Moria Harrison, Astrid Hauge-Evans, Catriona Kelly, Aileen King, Tania Maffucci, Claire E. Marriott, Neville McClenaghan, Noel G. Morgan, Christina Reers, Mark A. Russell, Mark D. Turner, Emma Willoughby, Mustafa Y. G. Younis, Z. L. Zhi, Peter M. Jones
Review
Endocrinology & Metabolism
Catriona Kelly, Neville H. McClenaghan, Peter R. Flatt
Article
Endocrinology & Metabolism
Wiktoria Ratajczak, Sarah D. Atkinson, Catriona Kelly
Summary: TWEAK, a member of the TNF superfamily, controls various cellular events through different signaling pathways. It has a dual role in protecting healthy tissues and becoming detrimental in chronic inflammatory states. Fn14 and CD163 are the receptors for TWEAK, and the effects of TWEAK vary depending on the receptor it binds to.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Meeting Abstract
Medicine, General & Internal
F. Manderson-Koivula, J. Robinson, R. Yates, N. McClenaghan, A. Harper, C. Kelly
IRISH JOURNAL OF MEDICAL SCIENCE
(2014)
Meeting Abstract
Pediatrics
C. Kelly, M. T. Williams, J. S. Elborn, M. Ennis, B. C. Schock
PEDIATRIC PULMONOLOGY
(2010)