Helminths and their implication in sepsis - a new branch of their immunomodulatory behaviour?

Helminth Infection with Litomosoides sigmodontis Induces Regulatory T Cells and Inhibits Allergic Sensitization, Airway Inflammation, and Hyperreactivity in a Murine Asthma Model

(2014) A. M. Dittrich et al.   JOURNAL OF IMMUNOLOGY

Lower production of IL-17A and increased susceptibility to Mycobacterium bovis in mice coinfected with Strongyloides venezuelensis

(2014) Alyria Teixeira Dias et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Co-activation through TLR4 and TLR9 but not TLR2 skews Treg-mediated modulation of Igs and induces IL-17 secretion in Treg:B cell co-cultures

(2013) Tomabu Adjobimey et al.   Innate Immunity

Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis

(2013) Steven M. Opal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Decreased prevalence of sepsis but not mild or severe P. falciparum malaria is associated with pre-existing filarial infection

(2013) Madhumita Panda et al.   Parasites & Vectors

CD4+CD25+ Regulatory T Cells Attenuate Lipopolysaccharide-Induced Systemic Inflammatory Responses and Promotes Survival in Murine Escherichia coli Infection

(2013) Emeka B. Okeke et al.   SHOCK

Helminth-host immunological interactions: prevention and control of immune-mediated diseases

(2012) David E. Elliott et al.   Annals of the New York Academy of Sciences

Helminth infection is associated with decreased basophil responsiveness in human beings

(2012) David Larson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cutting Edge: In the Absence of TGF-  Signaling in T Cells, Fewer CD103+ Regulatory T Cells Develop, but Exuberant IFN-  Production Renders Mice More Susceptible to Helminth Infection

(2012) L. A. Reynolds et al.   JOURNAL OF IMMUNOLOGY

Helminth Infection Impairs Autophagy-Mediated Killing of Bacterial Enteropathogens by Macrophages

(2012) C.-w. Su et al.   JOURNAL OF IMMUNOLOGY

Chronic Helminth Infection Reduces Basophil Responsiveness in an IL-10-Dependent Manner

(2012) D. Larson et al.   JOURNAL OF IMMUNOLOGY

C-type lectin receptors orchestrate antifungal immunity

(2012) Sarah E Hardison et al.   NATURE IMMUNOLOGY

Fatal septicemic shock associated with Strongyloides stercoralis infection in a patient with angioimmunoblastic T-cell lymphoma: A case report and literature review

(2012) M.Z. Abdelrahman et al.   PARASITOLOGY INTERNATIONAL

Schistosomes Induce Regulatory Features in Human and Mouse CD1dhi B Cells: Inhibition of Allergic Inflammation by IL-10 and Regulatory T Cells

(2012) Luciën E. P. M. van der Vlugt et al.   PLoS One

Elevated Adaptive Immune Responses Are Associated with Latent Infections of Wuchereria bancrofti

(2012) Kathrin Arndts et al.   PLoS Neglected Tropical Diseases

Evidence of Microbial Translocation Associated with Perturbations in T Cell and Antigen-Presenting Cell Homeostasis in Hookworm Infections

(2012) Palakkal Jovvian George et al.   PLoS Neglected Tropical Diseases

Chronic Helminth Infection Does Not Exacerbate Mycobacterium tuberculosis Infection

(2012) Marc P. Hübner et al.   PLoS Neglected Tropical Diseases

Chitohexaose Activates Macrophages by Alternate Pathway through TLR4 and Blocks Endotoxemia

(2012) Santosh K. Panda et al.   PLoS Pathogens

Immunomodulatory Properties of ES-62, a Phosphorylcholine - Containing Glycoprotein Secreted by Acanthocheilonema viteae

(2012) Lamyaa Al-Riyami et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

TLRs, Treg, and B Cells, an Interplay of Regulation during Helminth Infection

(2012) Isis Ludwig-Portugall et al.   Frontiers in Immunology

Human Schistosomiasis Is Associated with Endotoxemia and Toll-Like Receptor 2- and 4-Bearing B Cells

(2011) Daniel Onguru et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

The Pathogenesis of Sepsis

(2011) Deborah J. Stearns-Kurosawa et al.   Annual Review of Pathology-Mechanisms of Disease

Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis

(2011) Timo Schwandt et al.   EMBO JOURNAL

Functional and Phenotypic Characteristics of Alternative Activation Induced in Human Monocytes by Interleukin-4 or the Parasitic Nematode Brugia malayi

(2011) Roshanak Tolouei Semnani et al.   INFECTION AND IMMUNITY

Preexisting helminth infection induces inhibition of innate pulmonary anti-tuberculosis defense by engaging the IL-4 receptor pathway

(2011) Julius A. Potian et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Endotoxin Tolerance Represents a Distinctive State of Alternative Polarization (M2) in Human Mononuclear Cells

(2011) O. M. Pena et al.   JOURNAL OF IMMUNOLOGY

Helminth Protection against Autoimmune Diabetes in Nonobese Diabetic Mice Is Independent of a Type 2 Immune Shift and Requires TGF- 

(2011) M. P. Hubner et al.   JOURNAL OF IMMUNOLOGY

The neutrophil in vascular inflammation

(2011) Mia Phillipson et al.   NATURE MEDICINE

Parasitic Infection Improves Survival from Septic Peritonitis by Enhancing Mast Cell Responses to Bacteria in Mice

(2011) Rachel E. Sutherland et al.   PLoS One

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

Influence of Severity of Illness on the Effects of Eritoran Tetrasodium (E5564) and on Other Therapies for Severe Sepsis

(2011) Andre C. Kalil et al.   SHOCK

Neutralization of interleukin-10 or transforming growth factor-β decreases the percentages of CD4+CD25+Foxp3+ regulatory T cells in septic mice, thereby leading to an improved survival

(2011) Shuhichi Hiraki et al.   SURGERY

A Family of Helminth Molecules that Modulate Innate Cell Responses via Molecular Mimicry of Host Antimicrobial Peptides

(2011) Mark W. Robinson et al.   PLoS Pathogens

Induction of immunoglobulin G4 in human filariasis: an indicator of immunoregulation

(2010) T. Adjobimey et al.   ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY

Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department*

(2010) David F. Gaieski et al.   CRITICAL CARE MEDICINE

Similarity and Diversity in Macrophage Activation by Nematodes, Trematodes, and Cestodes

(2010) Stephen J. Jenkins et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway

(2010) John R. Grainger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RORC2 Is Involved in T Cell Polarization through Interaction with the FOXP3 Promoter

(2010) S. Burgler et al.   JOURNAL OF IMMUNOLOGY

IL-7 Promotes T Cell Viability, Trafficking, and Functionality and Improves Survival in Sepsis

(2010) J. Unsinger et al.   JOURNAL OF IMMUNOLOGY

Lymphatic filariasis and onchocerciasis

(2010) Mark J Taylor et al.   LANCET

Microflora, Helminths, and the Immune System — Who Controls Whom?

(2010) Achim Hoerauf   NEW ENGLAND JOURNAL OF MEDICINE

Immunotherapy for Sepsis — A New Approach against an Ancient Foe

(2010) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

Low levels of transforming growth factor-beta (TGF-beta) and reduced suppression of Th2-mediated inflammation in hyperreactive human onchocerciasis

(2010) S. KORTEN et al.   PARASITOLOGY

Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses

(2010) M. Ritter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploitation of the Intestinal Microflora by the Parasitic Nematode Trichuris muris

(2010) K. S. Hayes et al.   SCIENCE

Granulocyte–Macrophage Colony-stimulating Factor to Reverse Sepsis-associated Immunosuppression

(2009) Christian Meisel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Multifunctional host defense peptides: Antimicrobial peptides, the small yet big players in innate and adaptive immunity

(2009) Constance Auvynet et al.   FEBS Journal

Promoting Global Research Excellence in Severe Sepsis (PROGRESS): Lessons from an International Sepsis Registry

(2009) R. Beale et al.   INFECTION

The Fasciola hepatica Tegumental Antigen Suppresses Dendritic Cell Maturation and Function

(2009) C. M. Hamilton et al.   INFECTION AND IMMUNITY

The Management of Severe Sepsis and Septic Shock

(2009) Matthew R. Morrell et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Alternatively activated macrophage-derived RELM-α is a negative regulator of type 2 inflammation in the lung

(2009) Meera G. Nair et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dying and Necrotic Neutrophils Are Anti-Inflammatory Secondary to the Release of  -Defensins

(2009) K. Miles et al.   JOURNAL OF IMMUNOLOGY

Pronounced Phenotype in Activated Regulatory T Cells during a Chronic Helminth Infection

(2009) L. E. Layland et al.   JOURNAL OF IMMUNOLOGY

IL-15 Prevents Apoptosis, Reverses Innate and Adaptive Immune Dysfunction, and Improves Survival in Sepsis

(2009) S. Inoue et al.   JOURNAL OF IMMUNOLOGY

Alternatively Activated Macrophages Elicited by Helminth Infection Can Be Reprogrammed to Enable Microbial Killing

(2009) K. J. Mylonas et al.   JOURNAL OF IMMUNOLOGY

Human Type 1 and 17 Responses in Latent Tuberculosis Are Modulated by Coincident Filarial Infection through Cytotoxic T Lymphocyte Antigen–4 and Programmed Death–1

(2009) Subash Babu et al.   JOURNAL OF INFECTIOUS DISEASES

Helminth immunoregulation: The role of parasite secreted proteins in modulating host immunity

(2009) James P. Hewitson et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The sepsis seesaw: tilting toward immunosuppression

(2009) Richard S Hotchkiss et al.   NATURE MEDICINE

Relative imbalance between T regulatory cells and activated T cells in mice with differential morbidity in chronicSchistosoma mansoniinfections

(2009) K. WATANABE et al.   PARASITE IMMUNOLOGY

Protection from lethal Gram-negative bacterial sepsis by targeting Toll-like receptor 4

(2009) T. Roger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor  B

(2009) C. Porta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis

(2009) X. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treatment ofStrongyloides stercoralishyperinfection-associated septic shock and acute respiratory distress syndrome with drotrecogin alfa (activated) in a renal transplant recipient

(2009) J.M. Huston et al.   Transplant Infectious Disease

Attenuation of Toll-Like Receptor Expression and Function in Latent Tuberculosis by Coexistent Filarial Infection with Restoration Following Antifilarial Chemotherapy

(2009) Subash Babu et al.   PLoS Neglected Tropical Diseases

Retnla (Relmα/Fizz1) Suppresses Helminth-Induced Th2-Type Immunity

(2009) John T. Pesce et al.   PLoS Pathogens

Inhibition of TLR3 and TLR4 function and expression in human dendritic cells by helminth parasites

(2008) R. T. Semnani et al.   BLOOD

Tr1 and naturally occurring regulatory T cells induce IgG4 in B cells through GITR/GITR-L interaction, IL-10 and TGF-β

(2008) Judith S. Satoguina et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Review series on helminths, immune modulation and the hygiene hypothesis: The broader implications of the hygiene hypothesis

(2008) Graham A. W. Rook   IMMUNOLOGY

Inhibition of type 1 diabetes in filaria-infected non-obese diabetic mice is associated with a T helper type 2 shift and induction of FoxP3+regulatory T cells

(2008) Marc P. Hübner et al.   IMMUNOLOGY

Microfilariae of the Filarial Nematode Litomosoides sigmodontis Exacerbate the Course of Lipopolysaccharide-Induced Sepsis in Mice

(2008) M. P. Hubner et al.   INFECTION AND IMMUNITY

Increased circulating regulatory T cells (CD4+CD25+CD127−) contribute to lymphocyte anergy in septic shock patients

(2008) Fabienne Venet et al.   INTENSIVE CARE MEDICINE

Differential impact of L-arginine deprivation on the activation and effector functions of T cells and macrophages

(2008) B.-S. Choi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Strongyloides stercoralisHyperinfection

(2008) Stephen R. Gorman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hydrocortisone Therapy for Patients with Septic Shock

(2008) Charles L. Sprung et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

(2008) H. von Bernuth et al.   SCIENCE

Natural death of adult Onchocerca volvulus and filaricidal effects of doxycycline induce local FOXP3+/CD4+ regulatory T cells and granzyme expression

(2007) Simone Korten et al.   MICROBES AND INFECTION