Nucleolar stress with and without p53

Targeting the nucleolus for cancer intervention

(2014) Jaclyn E. Quin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Nucleolar stress in Diamond Blackfan anemia pathophysiology

(2014) Steven R. Ellis   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

How Parkinson's disease meets nucleolar stress

(2014) Rosanna Parlato et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Connecting the nucleolus to the cell cycle and human disease

(2014) Robert Y. L. Tsai et al.   FASEB JOURNAL

Diverse diseases from a ubiquitous process: The ribosomopathy paradox

(2014) Joy Armistead et al.   FEBS LETTERS

p53 and ribosome biogenesis stress: The essentials

(2014) Lior Golomb et al.   FEBS LETTERS

Ribosomal protein deficiency causes Tp53-independent erythropoiesis failure in zebrafish

(2014) Gnaneshwar V. Yadav et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Nucleostemin and GNL3L exercise distinct functions in genome protection and ribosome synthesis, respectively

(2014) Tao Lin et al.   JOURNAL OF CELL SCIENCE

Mutation of a Nopp140 gene dao-5 alters rDNA transcription and increases germ cell apoptosis in C. elegans

(2014) C-C Lee et al.   Cell Death & Disease

Stressing on the nucleolus in cardiovascular disease

(2013) Nirmala Hariharan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Roles of the nucleolus in the CAG RNA-mediated toxicity

(2013) Ho Tsoi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Human diseases of the SSU processome

(2013) Samuel B. Sondalle et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Nucleolar control of p53: a cellular Achilles’ heel and a target for cancer therapy

(2013) Nikolina Vlatković et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Expression of Expanded CAG Transcripts Triggers Nucleolar Stress in Huntington's Disease

(2013) Ho Tsoi et al.   CEREBELLUM

The nucleolus—guardian of cellular homeostasis and genome integrity

(2013) Ingrid Grummt   CHROMOSOMA

Targeting the nucleolus for cancer-specific activation of p53

(2013) Denis Drygin et al.   DRUG DISCOVERY TODAY

Ubiquitin-dependent recruitment of the Bloom Syndrome helicase upon replication stress is required to suppress homologous recombination

(2013) Shweta Tikoo et al.   EMBO JOURNAL

Clinical utility gene card for: Diamond – Blackfan Anemia – update 2013

(2013) Adrianna Vlachos et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Ribosome Biogenesis in the Yeast Saccharomyces cerevisiae

(2013) John L. Woolford et al.   GENETICS

Novel deletion of RPL15 identified by array-comparative genomic hybridization in Diamond–Blackfan anemia

(2013) Michael Landowski et al.   HUMAN GENETICS

Severity of X-linked Dyskeratosis Congenita (DKCX) Cellular Defects Is not Directly Related to Dyskerin (DKC1) Activity in Ribosomal RNA Biogenesis or mRNA Translation

(2013) Naresh R. Thumati et al.   HUMAN MUTATION

Balanced Production of Ribosome Components Is Required for Proper G1/S Transition inSaccharomyces cerevisiae

(2013) Fernando Gómez-Herreros et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Old Drug, New Target

(2013) William J. Andrews et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Treatment outcomes in patients with relapsed and refractory multiple myeloma and high-risk cytogenetics receiving single-agent carfilzomib in the PX-171-003-A1 study

(2013) A J Jakubowiak et al.   LEUKEMIA

Repressed synthesis of ribosomal proteins generates protein-specific cell cycle and morphological phenotypes

(2013) Mamata Thapa et al.   MOLECULAR BIOLOGY OF THE CELL

The Complexity of Human Ribosome Biogenesis Revealed by Systematic Nucleolar Screening of Pre-rRNA Processing Factors

(2013) Lionel Tafforeau et al.   MOLECULAR CELL

Repression of RNA Polymerase I upon Stress Is Caused by Inhibition of RNA-Dependent Deacetylation of PAF53 by SIRT7

(2013) Sifan Chen et al.   MOLECULAR CELL

Nucleostemin deletion reveals an essential mechanism that maintains the genomic stability of stem and progenitor cells

(2013) L. Meng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structures of EF-G-Ribosome Complexes Trapped in Intermediate States of Translocation

(2013) J. Zhou et al.   SCIENCE

Conserved Regulators of Nucleolar Size Revealed by Global Phenotypic Analyses

(2013) R. A. Neumuller et al.   Science Signaling

The nucleolus: an emerging target for cancer therapy

(2013) Nadine Hein et al.   TRENDS IN MOLECULAR MEDICINE

5S Ribosomal RNA Is an Essential Component of a Nascent Ribosomal Precursor Complex that Regulates the Hdm2-p53 Checkpoint

(2013) Giulio Donati et al.   Cell Reports

The 5S RNP Couples p53 Homeostasis to Ribosome Biogenesis and Nucleolar Stress

(2013) Katherine E. Sloan et al.   Cell Reports

Autophagy Induction Is a Tor- and Tp53-Independent Cell Survival Response in a Zebrafish Model of Disrupted Ribosome Biogenesis

(2013) Yeliz Boglev et al.   PLoS Genetics

Nucleolar stress in Drosophila melanogaster

(2013) Allison James et al.   Nucleus

CRM1 and its ribosome export adaptor NMD3 localize to the nucleolus and affect rRNA synthesis

(2013) Baoyan Bai et al.   Nucleus

Human rpL3 induces G₁/S arrest or apoptosis by modulating p21waf1/cip1levels in a p53-independent manner

(2012) Annapina Russo et al.   CELL CYCLE

Drosophila p53 isoforms differentially regulate apoptosis and apoptosis-induced proliferation

(2012) M-L Dichtel-Danjoy et al.   CELL DEATH AND DIFFERENTIATION

Suprainduction of p53 by disruption of 40S and 60S ribosome biogenesis leads to the activation of a novel G2/M checkpoint

(2012) S. Fumagalli et al.   GENES & DEVELOPMENT

Diverging gain-of-function mechanisms of two novel KRAS mutations associated with Noonan and cardio-facio-cutaneous syndromes

(2012) I. C. Cirstea et al.   HUMAN MOLECULAR GENETICS

Frameshift mutation in p53 regulatorRPL26is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia

(2012) Hanna T. Gazda et al.   HUMAN MUTATION

PHF6 Regulates Cell Cycle Progression by Suppressing Ribosomal RNA Synthesis

(2012) Jiadong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin- and MDM2 E3 Ligase-independent Proteasomal Turnover of Nucleostemin in Response to GTP Depletion

(2012) Dorothy Lo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleostemin prevents telomere damage by promoting PML-IV recruitment to SUMOylated TRF1

(2012) Joseph K. Hsu et al.   JOURNAL OF CELL BIOLOGY

Nucleolar activity in neurodegenerative diseases: a missing piece of the puzzle?

(2012) Rosanna Parlato et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Collaborating functions of BLM and DNA topoisomerase I in regulating human rDNA transcription

(2012) Patrick M. Grierson et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

TFIIS is required for the balanced expression of the genes encoding ribosomal components under transcriptional stress

(2012) Fernando Gómez-Herreros et al.   NUCLEIC ACIDS RESEARCH

Parkinson's Disease DJ-1 L166P Alters rRNA Biogenesis by Exclusion of TTRAP from the Nucleolus and Sequestration into Cytoplasmic Aggregates via TRAF6

(2012) Sandra Vilotti et al.   PLoS One

A Role for the CAL1-Partner Modulo in Centromere Integrity and Accurate Chromosome Segregation in Drosophila

(2012) Chin-Chi Chen et al.   PLoS One

Severe Heat Shock Induces Nucleolar Accumulation of mRNAs in Trypanosoma cruzi

(2012) Ezequiel Názer et al.   PLoS One

Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress

(2012) S. Bursac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atomic structures of the eukaryotic ribosome

(2012) Sebastian Klinge et al.   TRENDS IN BIOCHEMICAL SCIENCES

Emerging roles of the neuronal nucleolus

(2012) Michal Hetman et al.   TRENDS IN NEUROSCIENCES

The Structure and Function of the Eukaryotic Ribosome

(2012) D. N. Wilson et al.   Cold Spring Harbor Perspectives in Biology

A zebrafish model of dyskeratosis congenita reveals hematopoietic stem cell formation failure resulting from ribosomal protein-mediated p53 stabilization

(2011) T. C. Pereboom et al.   BLOOD

Ribosomal protein gene deletions in Diamond-Blackfan anemia

(2011) J. E. Farrar et al.   BLOOD

Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia

(2011) P. Jaako et al.   BLOOD

Erythropoiesis failure due to RPS19 deficiency is independent of an activated Tp53 response in a zebrafish model of Diamond-Blackfan anaemia

(2011) Hidetsugu Torihara et al.   BRITISH JOURNAL OF HAEMATOLOGY

RNA Helicase DDX5 Is a p53-Independent Target of ARF That Participates in Ribosome Biogenesis

(2011) A. J. Saporita et al.   CANCER RESEARCH

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

p27 as Jekyll and Hyde: Regulation of cell cycle and cell motility

(2011) Michelle D. Larrea et al.   CELL CYCLE

Biological functions of p53 isoforms through evolution: lessons from animal and cellular models

(2011) V Marcel et al.   CELL DEATH AND DIFFERENTIATION

Hematopoietic defects in rps29 mutant zebrafish depend upon p53 activation

(2011) Alison M. Taylor et al.   EXPERIMENTAL HEMATOLOGY

RNA polymerase I activity is regulated at multiple steps in the transcription cycle: Recent insights into factors that influence transcription elongation

(2011) David Alan Schneider   GENE

Of blood, bones, and ribosomes: is Swachman-Diamond syndrome a ribosomopathy?

(2011) A. W. Johnson et al.   GENES & DEVELOPMENT

Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome

(2011) A. J. Finch et al.   GENES & DEVELOPMENT

Compensation for differences in gene copy number among yeast ribosomal proteins is encoded within their promoters

(2011) D. Zeevi et al.   GENOME RESEARCH

BLM helicase facilitates RNA polymerase I-mediated ribosomal RNA transcription

(2011) Patrick M. Grierson et al.   HUMAN MOLECULAR GENETICS

Selective inhibition of rRNA transcription downregulates E2F-1: a new p53-independent mechanism linking cell growth to cell proliferation

(2011) Giulio Donati et al.   JOURNAL OF CELL SCIENCE

Nucleolar Disruption in Dopaminergic Neurons Leads to Oxidative Damage and Parkinsonism through Repression of Mammalian Target of Rapamycin Signaling

(2011) C. Rieker et al.   JOURNAL OF NEUROSCIENCE

Autoregulatory circuit of human rpL3 expression requires hnRNP H1, NPM and KHSRP

(2011) Annapina Russo et al.   NUCLEIC ACIDS RESEARCH

Nucleophosmin and its complex network: a possible therapeutic target in hematological diseases

(2011) E Colombo et al.   ONCOGENE

Epigenetic Silencing of Nucleolar rRNA Genes in Alzheimer's Disease

(2011) Maciej Pietrzak et al.   PLoS One

Nucleolar stress is an early response to myocardial damage involving nucleolar proteins nucleostemin and nucleophosmin

(2011) D. Avitabile et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of release factor RF3 trapped in the GTP state on a rotated conformation of the ribosome

(2011) J. Zhou et al.   RNA

Crystal Structure of the Eukaryotic 60S Ribosomal Subunit in Complex with Initiation Factor 6

(2011) S. Klinge et al.   SCIENCE

The Structure of the Eukaryotic Ribosome at 3.0 A Resolution

(2011) A. Ben-Shem et al.   SCIENCE

WDR55 Is a Nucleolar Modulator of Ribosomal RNA Synthesis, Cell Cycle Progression, and Teleost Organ Development

(2011) Norimasa Iwanami et al.   PLoS Genetics

Assembly and disassembly of the nucleolus during the cell cycle

(2011) Danièle Hernandez-Verdun   Nucleus

Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells

(2010) S. Dutt et al.   BLOOD

Ribosomopathies: human disorders of ribosome dysfunction

(2010) A. Narla et al.   BLOOD

Ribosomal protein L11 mutation in zebrafish leads to haematopoietic and metabolic defects

(2010) Nadia Danilova et al.   BRITISH JOURNAL OF HAEMATOLOGY

Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth

(2010) Denis Drygin et al.   CANCER RESEARCH

Nucleostemin

(2010) Dorothy Lo et al.   CELL CYCLE

The winged-helix transcription factor JUMU regulates development, nucleolus morphology and function, and chromatin organization of Drosophila melanogaster

(2010) Annemarie Hofmann et al.   CHROMOSOME RESEARCH

The Drosophila Nol12 homologue viriato is a dMyc target that regulates nucleolar architecture and is required for dMyc-stimulated cell growth

(2010) J. Marinho et al.   DEVELOPMENT

Roles of Werner syndrome protein in protection of genome integrity

(2010) Marie L. Rossi et al.   DNA REPAIR

Linking pseudouridine synthases to growth, development and cell competition

(2010) Giuseppe Tortoriello et al.   FEBS Journal

Chemotherapeutic Drugs Inhibit Ribosome Biogenesis at Various Levels

(2010) Kaspar Burger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of the nuclear export adaptor protein Nmd3 in association with the 60S ribosomal subunit

(2010) Jayati Sengupta et al.   JOURNAL OF CELL BIOLOGY

The Nucleolus under Stress

(2010) Séverine Boulon et al.   MOLECULAR CELL

Mutations in genes encoding subunits of RNA polymerases I and III cause Treacher Collins syndrome

(2010) Johannes G Dauwerse et al.   NATURE GENETICS

PIM1 kinase is destabilized by ribosomal stress causing inhibition of cell cycle progression

(2010) V Iadevaia et al.   ONCOGENE

Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution

(2010) J.-P. Armache et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Localization of eukaryote-specific ribosomal proteins in a 5.5-A cryo-EM map of the 80S eukaryotic ribosome

(2010) J.-P. Armache et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the Eukaryotic 40S Ribosomal Subunit in Complex with Initiation Factor 1

(2010) J. Rabl et al.   SCIENCE

Maturation of eukaryotic ribosomes: acquisition of functionality

(2010) Vikram Govind Panse et al.   TRENDS IN BIOCHEMICAL SCIENCES

Treacle recruits RNA polymerase I complex to the nucleolus that is independent of UBF

(2009) Chen-I Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bone marrow cells from patients with Shwachman-Diamond syndrome abnormally express genes involved in ribosome biogenesis and RNA processing

(2009) Piya Rujkijyanont et al.   BRITISH JOURNAL OF HAEMATOLOGY

Signaling to p53: Ribosomal Proteins Find Their Way

(2009) Yanping Zhang et al.   CANCER CELL

Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis

(2009) D. Drygin et al.   CANCER RESEARCH

Down-regulation of pescadillo inhibits proliferation and tumorigenicity of breast cancer cells

(2009) Jun Li et al.   CANCER SCIENCE

The cleaved-Caspase-3 antibody is a marker of Caspase-9-like DRONC activity in Drosophila

(2009) Y Fan et al.   CELL DEATH AND DIFFERENTIATION

Coordination of Ribosomal Protein and Ribosomal RNA Gene Expression in Response to TOR Signaling

(2009) LiJuan Xiao et al.   CURRENT GENOMICS

Assembly of ribosomes and spliceosomes: complex ribonucleoprotein machines

(2009) Jonathan P Staley et al.   CURRENT OPINION IN CELL BIOLOGY

Ribosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domain

(2009) Sridevi Yadavilli et al.   DNA REPAIR

p53-Independent Apoptosis Limits DNA Damage-Induced Aneuploidy

(2009) L. M. McNamee et al.   GENETICS

Diamond-Blackfan Anemia: Diagnosis, Treatment, and Molecular Pathogenesis

(2009) Jeffrey M. Lipton et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Deletion 5q in myelodysplastic syndrome: a paradigm for the study of hemizygous deletions in cancer

(2009) B L Ebert   LEUKEMIA

Knockdown of the Drosophila GTPase Nucleostemin 1 Impairs Large Ribosomal Subunit Biogenesis, Cell Growth, and Midgut Precursor Cell Maintenance

(2009) Raphyel Rosby et al.   MOLECULAR BIOLOGY OF THE CELL

How Common Are Extraribosomal Functions of Ribosomal Proteins?

(2009) Jonathan R. Warner et al.   MOLECULAR CELL

Cyclin-dependent kinases: a family portrait

(2009) Marcos Malumbres et al.   NATURE CELL BIOLOGY

Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction

(2009) Stefano Fumagalli et al.   NATURE CELL BIOLOGY

Loss of Ribosomal Protein L11 Affects Zebrafish Embryonic Development through a p53-Dependent Apoptotic Response

(2009) Anirban Chakraborty et al.   PLoS One

Wip1 Regulates the Generation of New Neural Cells in the Adult Olfactory Bulb through p53-Dependent Cell Cycle Control

(2009) Yun-Hua Zhu et al.   STEM CELLS

Nucleolar Proteins Suppress Caenorhabditis elegans Innate Immunity by Inhibiting p53/CEP-1

(2009) Laura E. Fuhrman et al.   PLoS Genetics

Telomere Loss Provokes Multiple Pathways to Apoptosis and Produces Genomic Instability in Drosophila melanogaster

(2008) S. W. A. Titen et al.   GENETICS

Treacher Collins syndrome: Unmasking the role of Tcof1/treacle

(2008) Daisuke Sakai et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mycophenolic Acid Activation of p53 Requires Ribosomal Proteins L5 and L11

(2008) Xiao-Xin Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical Role of Nucleostemin in Pre-rRNA Processing

(2008) Liudmila Romanova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Visual Analysis of the Yeast 5S rRNA Gene Transcriptome: Regulation and Role of La Protein

(2008) S. L. French et al.   MOLECULAR AND CELLULAR BIOLOGY

Aberrant Expression of Nucleostemin Activates p53 and Induces Cell Cycle Arrest via Inhibition of MDM2

(2008) M.-S. Dai et al.   MOLECULAR AND CELLULAR BIOLOGY

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

(2008) Benjamin L. Ebert et al.   NATURE

Positive feedback of G1 cyclins ensures coherent cell cycle entry

(2008) Jan M. Skotheim et al.   NATURE

Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function

(2008) Natalie C Jones et al.   NATURE MEDICINE

Reconstitution of Mdm2-Dependent Post-Translational Modifications of p53 in Yeast

(2008) Barbara Di Ventura et al.   PLoS One

Nucleostemin: a multiplex regulator of cell-cycle progression

(2008) Hanhui Ma et al.   TRENDS IN CELL BIOLOGY

C. elegans Nucleostemin Is Required for Larval Growth and Germline Stem Cell Division

(2008) Michelle M. Kudron et al.   PLoS Genetics