Allergic airway inflammation: unravelling the relationship between IL-37, IL-18Rα and Tir8/SIGIRR

IL-37 requires IL-18Rα and SIGIRR/IL-1R8 to diminish allergic airway inflammation in mice

(2015) L. Lunding et al.   ALLERGY

Helicobacter urease–induced activation of the TLR2/NLRP3/IL-18 axis protects against asthma

(2015) Katrin N. Koch et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction

(2015) Claudia A Nold-Petry et al.   NATURE IMMUNOLOGY

Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8

(2015) Suzhao Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-37 ameliorates myocardial ischaemia/reperfusion injury in mice

(2014) B. Wu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

RETRACTED: IL-37 reduces inflammatory response after cerebral ischemia and reperfusion injury through down-regulation of pro-inflammatory cytokines

(2014) Faye J. Patel et al.   CYTOKINE

IL-37 inhibits the production of inflammatory cytokines in peripheral blood mononuclear cells of patients with systemic lupus erythematosus: its correlation with disease activity

(2014) Liang Ye et al.   Journal of Translational Medicine

Increased Expression of IL-37 in Patients with Graves' Disease and Its Contribution to Suppression of Proinflammatory Cytokines Production in Peripheral Blood Mononuclear Cells

(2014) Yanqun Li et al.   PLoS One

Suppression of antigen-specific adaptive immunity by IL-37 via induction of tolerogenic dendritic cells

(2014) Yuchun Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses

(2014) A.-M. Bulau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate immunity but not NLRP3 inflammasome activation correlates with severity of stable COPD

(2014) Antonino Di Stefano et al.   THORAX

IL-37 Inhibits Inflammasome Activation and Disease Severity in Murine Aspergillosis

(2014) Silvia Moretti et al.   PLoS Pathogens

Absence of Toll–IL-1 Receptor 8/Single Immunoglobulin IL-1 Receptor–Related Molecule Reduces House Dust Mite–Induced Allergic Airway Inflammation in Mice

(2013) Jessica Barry et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Epithelial expression of interleukin-37b in inflammatory bowel disease

(2013) H. Imaeda et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

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(2013) Dov B. Ballak et al.   CYTOKINE

IL-18 Induces Airway Hyperresponsiveness and Pulmonary Inflammation via CD4+ T Cell and IL-13

(2013) Masanori Sawada et al.   PLoS One

Increased Serum Levels of Soluble IL-18 Receptor Complex in Patients with Allergic Asthma

(2013) Haruki Imaoka et al.   ALLERGOLOGY INTERNATIONAL

DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori–specific immune tolerance, and asthma protection

(2012) Mathias Oertli et al.   JOURNAL OF CLINICAL INVESTIGATION

Interleukin-37 reduces liver inflammatory injury via effects on hepatocytes and non-parenchymal cells

(2012) Nozomu Sakai et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

TIR8/SIGIRR is an Interleukin-1 Receptor/Toll Like Receptor Family Member with Regulatory Functions in Inflammation and Immunity

(2012) Federica Riva et al.   Frontiers in Immunology

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

(2011) C. A. Dinarello   BLOOD

Interleukin-18 system plays an important role in keloid pathogenesis via epithelial-mesenchymal interactions

(2011) D.V. Do et al.   BRITISH JOURNAL OF DERMATOLOGY

Interleukin 37 expression protects mice from colitis

(2011) E. N. McNamee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo Expression of Interleukin-37 Reduces Local and Systemic Inflammation in Concanavalin A-Induced Hepatitis

(2011) Ana-Maria Bulau et al.   TheScientificWorldJOURNAL

IL-37 is a fundamental inhibitor of innate immunity

(2010) Marcel F Nold et al.   NATURE IMMUNOLOGY

Neurotrophins in lung health and disease

(2010) YS Prakash et al.   Expert Review of Respiratory Medicine

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress

(2009) Luke A. J. O'Neill   IMMUNOLOGICAL REVIEWS

Interleukin 18 receptor 1 gene polymorphisms are associated with asthma

(2008) Guohua Zhu et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

IL-1, IL-18, and IL-33 families of cytokines

(2008) William P. Arend et al.   IMMUNOLOGICAL REVIEWS

Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system

(2008) Y. Kondo et al.   INTERNATIONAL IMMUNOLOGY

Immunologic and inflammatory mechanisms that drive asthma progression to remodeling

(2008) David H. Broide   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The cytokine network in asthma and chronic obstructive pulmonary disease

(2008) Peter J. Barnes   JOURNAL OF CLINICAL INVESTIGATION

Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease

(2008) Gary P Anderson   LANCET

T Cells and NKT Cells in the Pathogenesis of Asthma

(2007) Everett H. Meyer et al.   Annual Review of Medicine