Article
Medicine, Research & Experimental
Seyedmousa Motavallihaghi, Amir Hossein Maghsood, Davood Nematollahi, Nastaran Barati, Sara Soleimani Asl, Abbas Farmani, Faeze Foroughi-Parvar, Mohammad Fallah
Summary: This study investigated the potential protective role of DIM nanoparticles in a toxoplasmosis animal model, and found that nano-DIM can reduce the proliferation of intracellular parasites, reduce liver cell pathology, and alleviate oxidative stress.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Multidisciplinary
Kimberly S. Butler, C. Jeffrey Brinker, Hon Sing Leong
Summary: The avian embryo and chorioallantoic membrane (CAM) model provides a valuable in vivo preclinical platform for evaluating the behavior and performance of nanoparticles. It allows for the study of nanoparticle stability, distribution, and interactions at a cellular level, and can be used to accelerate the development of nanoparticle delivery and imaging agents.
Article
Biochemistry & Molecular Biology
Dibyalochan Mohanty, Sadaf Jamal Gilani, Ameeduzzafar Zafar, Syed Sarim Imam, Ladi Alik Kumar, Mohammed Muqtader Ahmed, Mohammed Asadullah Jahangir, Vasudha Bakshi, Wasim Ahmad, Eyman Mohamed Eltayib
Summary: The present study focuses on preparing polymeric ALG nanoparticles for diabetes management. The optimized ALG-NPs show small size, high encapsulation efficiency, prolonged release pattern, improved permeation, pharmacokinetic profile, and anti-diabetic activity compared to pure ALG.
Article
Chemistry, Multidisciplinary
Jae Hoon Lee, Jun Su Im, Xuanjun Jin, Tae Min Kim, Joon Weon Choi
Summary: Kraft lignin was successfully utilized as a polymer for drug-encapsulated nanoparticle synthesis, demonstrating high biocompatibility in both in vitro and in vivo tests. This lignin-based drug delivery system shows great potential as an eco-friendly and economically sustainable option for drug delivery.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Chemistry, Applied
Atefe Sadeghi Lari, Payam Zahedi, Hedayatollah Ghourchian, Alireza Khatibi
Summary: This study successfully synthesized novel crosslinked carboxymethyl chitosan nanoparticles using microfluidics and demonstrated their potential application in diabetes therapy. In the rat experiments, it was found that metformin hydrochloride loaded in these nanoparticles significantly increased body weight and reduced blood glucose levels, with effects on pancreatic islets and beta cells similar to healthy conditions.
CARBOHYDRATE POLYMERS
(2021)
Article
Pharmacology & Pharmacy
Laura Cresti, Gemma Conte, Giovanni Cappello, Jlenia Brunetti, Chiara Falciani, Luisa Bracci, Fabiana Quaglia, Francesca Ungaro, Ivana d'Angelo, Alessandro Pini
Summary: In this study, a biocompatible nanosystem was developed to enhance the delivery of the antimicrobial peptide SET-M33 to the lungs. The encapsulated peptide showed prolonged antibacterial activity, controlled release, and lower toxicity compared to the free peptide. The nanosystem effectively killed Pseudomonas aeruginosa and exhibited no cytotoxicity to bronchial epithelial cells from healthy individuals and cystic fibrosis patients.
Article
Pharmacology & Pharmacy
Mohammad Reza Malekpour, Saereh Hosseindoost, Fatemeh Madani, Morteza Kamali, Masood Khosravani, Mahdi Adabi
Summary: This study explores the use of Poly(lactic co-glycolic acid) nanoparticles loaded with Paclitaxel (PTX) and Doxorubicin (DOX) to improve the treatment of glioblastoma tumors. The results show that these nanoparticles enhance cytotoxicity and decrease tumor size. MRI results also demonstrate a longer median survival rate for the combination therapy. Additionally, the combination therapy has a positive effect on rat movement, as indicated by behavioral tests.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Alexis Orr, Kunli Liu, Adam E. Mullick, Xuefei Huang, Stephanie W. Watts
Summary: Nanoparticles can be used to deliver drugs to targeted tissues. This study aims to investigate the contribution of chemerin produced in adipose tissue to blood pressure/hypertension, and develop an ATS drug delivery system to reduce adipose tissue-derived chemerin. In vitro experiments showed that nanoparticles containing an antisense oligonucleotide and an ATS peptide reduced chemerin mRNA expression in isolated fat adipocytes from rats. However, in vivo experiments revealed that the nanoparticles were mainly delivered to the liver instead of adipose tissue. Further research is needed to improve the delivery of the antisense oligonucleotide to adipose tissue.
Article
Chemistry, Multidisciplinary
Suke Lan, Jiahao Zhang, Xin Li, Lejie Pan, Juncheng Li, Xian Wu, Sheng-Tao Yang
Summary: The study found that oral exposure to MOF-74(Co) NPs can lead to significant accumulation of Co in the liver and kidneys, but overall has low toxicity to mice. Cell viability is lost at 100 mg/L, while cell cycle arrest can occur even at 12.5 mg/L. Apart from slight inflammation, the histopathological images of the liver and kidneys after oral exposure to MOF-74(Co) NPs were normal compared to the control group.
Article
Engineering, Biomedical
Akhil Patel, Jessica Kosanovich, Sameera Sansare, Sricharani Balmuri, Vinayak Sant, Kerry M. Empey, Shilpa Sant
Summary: This study investigates the potential of cube and sphere-shaped cerium oxide nanoparticles (CNP) to modulate reactive oxygen (ROS) and nitrogen (RNS) species and immune cell phenotypes in the presence of RSV infection. The results show that cube CNP significantly reduces RSV-induced ROS levels and drives an M1 phenotype in RSV-infected macrophages. Sphere CNP increases RSV-induced RNS levels with minimal effect on ROS levels and decreases M2 marker CD206 expression. Cube CNP preferentially accumulates in murine alveolar macrophages and induces their activation, avoiding enhanced uptake and activation of other inflammatory cells.
BIOACTIVE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Eun Suh Kim, Youjin Baek, Hyun-Jae Yoo, Ji-Soo Lee, Hyeon Gyu Lee
Summary: This study demonstrated the enhanced stability, antioxidant activity, and bioavailability of astaxanthin through encapsulation within chitosan-tripolyphosphate nanoparticles. The nanoparticles prolonged the release of astaxanthin and improved its antioxidant properties. The results suggest the potential of chitosan-tripolyphosphate nanoparticles as a delivery system for astaxanthin.
Article
Pharmacology & Pharmacy
Deepak Kumar, Arti Gautam, Patit Paban Kundu
Summary: The present research aimed to synthesize capecitabine-loaded core-shell nanoparticles (Cap@AAM-g-ML/IA-g-Psy-NPs) to deliver the drug to the targeted colonic area, improving its anti-cancer activity. The drug release behavior of Cap@AAM-g-ML/IA-g-Psy-NPs was studied at different biological pH levels, and the highest drug release rate (95%) was observed at pH 7.2. Cytotoxicity experiments on HCT-15 cell line showed that Cap@AAM-g-ML/IA-g-Psy-NPs exhibited significant toxicity. In-vivo studies on a DMH-induced colon cancer rat model demonstrated that Cap@AAM-g-ML/IA-g-Psy-NPs enhanced anticancer activity compared to capecitabine. Histology studies indicated that treatment with Cap@AAM-g-ML/IA-g-Psy-NPs reduced the inflation caused by DMH-induced cancer. This study provides a valuable approach for the synthesis of Cap@AAM-g-ML/IA-g-Psy-NPs for anticancer applications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Reeju Amatya, Seungmi Hwang, Taehoon Park, Kyoung Ah Min, Meong Cheol Shin
Summary: The study prepared PEG-starch-IONPs and investigated their physical properties through various techniques, revealing that PEGylation significantly increased drug accumulation in tumors, and PEG-starch-IONPs showed significant photothermal effects at the tumor site.
Article
Biotechnology & Applied Microbiology
Wenrui Wang, Mengyang Zhou, Yang Xu, Wei Peng, Shiwen Zhang, Rongjie Li, Han Zhang, Hui Zhang, Shumin Cheng, Youjing Wang, Xinyu Wei, Chengxu Yue, Qingling Yang, Changjie Chen
Summary: The study successfully formulated TPGS-Res-SLNs nanoparticles to improve therapeutic efficacy against breast cancer, showing significant anti-tumor activity and promotion of cell apoptosis. It also exhibited significant inhibition of cancer cell invasion and migration. In vivo experiments showed that TPGS-Res-SLNs had higher efficacy in promoting tumor cell apoptosis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Oncology
Takumi Sato, Yasumasa Kakei, Takumi Hasegawa, Masahiko Kashin, Shun Teraoka, Akinobu Yamaguchi, Ryohei Sasaki, Masaya Akashi
Summary: This study demonstrated that gold nanoparticles can enhance the sensitivity of head and neck squamous cell carcinoma to radiotherapy and bind to cetuximab, leading to enhanced antitumor effects.
Article
Biotechnology & Applied Microbiology
Holly Holliday, Jessica Yang, Eoin Dodson, Iva Nikolic, Alvin Kamili, Madeleine Wheatley, Niantao Deng, Sarah Alexandrou, Thomas P. Davis, Maria Kavallaris, C. Elizabeth Caldon, Joshua McCarroll, Katleen De Preter, Pieter Mestdagh, Glenn M. Marshall, Kaylene J. Simpson, Jamie Fletcher, Alexander Swarbrick
Summary: This study discovered that miR-99b-5p, miR-380-3p, and miR-485-3p enhance the chemotherapeutic effects of doxorubicin in high-risk neuroblastoma. These miRNAs are often lost in patients and their low expression predicts poor survival outcomes.
Article
Multidisciplinary Sciences
Francesco De Logu, Romina Nassini, Alan Hegron, Lorenzo Landini, Dane D. Jensen, Rocco Latorre, Julia Ding, Matilde Marini, Daniel Souza Monteiro de Araujo, Paulina Ramirez-Garcia, Michael Whittaker, Jeffri Retamal, Mustafa Titiz, Alessandro Innocenti, Thomas P. Davis, Nicholas Veldhuis, Brian L. Schmidt, Nigel W. Bunnett, Pierangelo Geppetti
Summary: This study reveals that the CGRP-mediated neuronal/Schwann cell pathway mediates allodynia associated with neurogenic inflammation, contributing to the algesic action of CGRP in mice.
NATURE COMMUNICATIONS
(2022)
Article
Nanoscience & Nanotechnology
Xumin Huang, Tianhong Xu, Ao Shen, Thomas P. Davis, Ruirui Qiao, Shi-Yang Tang
Summary: This study investigates the effect of different anchoring groups on the stability of liquid metal nanoparticles (LMNPs), and finds that increasing the number of anchoring groups enhances the colloidal stability of LMNPs, while polymers bearing multidentate phosphonic acids provide the optimum chemical stability for LMNPs.
ACS APPLIED NANO MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Nicholas Andrikopoulos, Yuhuan Li, Aparna Nandakumar, John F. Quinn, Thomas P. Davis, Feng Ding, Nabanita Saikia, Pu Chun Ke
Summary: This study developed a biocompatible metal-phenolic network (MPN) consisting of epigallocatechin gallate (EGCG) and physiological Zn(II), which showed remarkable potency against amyloid aggregation in Alzheimer's disease. The MPN@AuNP nanoconstruct exhibited superior performance in inhibiting amyloid aggregation and toxicity compared to EGCG@AuNP, due to its larger surface area. The atomic coordination of Zn(II)-EGCG and the structure and dynamics of amyloid aggregation modulated by MPN were analyzed, suggesting potential applications for regulating AD pathology.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Multidisciplinary Sciences
Jennifer Cable, Barney S. Graham, Richard A. Koup, Robert A. Seder, Katalin Kariko, Norbert Pardi, Dan H. Barouch, Bhawna Sharma, Susanne Rauch, Raffael Nachbagauer, Mattias N. E. Forsell, Michael Schotsaert, Ali H. Ellebedy, Karin Lore, Darrell J. Irvine, Emily Pilkington, Siri Tahtinen, Elizabeth A. Thompson, Yanis Feraoun, Neil P. King, Kevin Saunders, Galit Alter, Syed M. Moin, Kwinten Sliepen, Gunilla B. Karlsson Hedestam, Hedda Wardemann, Bali Pulendran, Nicole A. Doria-Rose, Wan-Ting He, Jennifer A. Juno, Sila Ataca, Adam K. Wheatley, Jason S. McLellan, Laura M. Walker, Julia Lederhofer, Lisa C. Lindesmith, Holger Wille, Peter J. Hotez, Linda-Gail Bekker
Summary: The COVID-19 pandemic has highlighted the importance of vaccines in public health and advancements in vaccine technology are vital for preventing infectious diseases. While many diseases still lack effective vaccines, recent developments in fields like immunology and structural biology may lead to breakthroughs in vaccination and enhance preparedness for future pandemics.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Multidisciplinary Sciences
Xuejing Cui, Xiaoyu Wang, Xueling Chang, Lin Bao, Junguang Wu, Zhiqiang Tan, Jinmei Chen, Jiayang Li, Xingfa Gao, Pu Chun Ke, Chunying Chen, Catherine Murphy
Summary: Carbon-based nanomaterials (CNMs) have been found in humans, and their integration into the endogenous carbon flow through the gut microbiota has been uncovered. The gut microbiota ferments CNMs, incorporating inorganic carbon into organic butyrate. Butyrate-producing bacteria prefer CNMs as their carbon source, and excessive butyrate derived from microbial CNMs fermentation affects the function of intestinal stem cells. This study highlights the need to assess the transformation of CNMs and their health risk via the gut-centric physiological and anatomical pathways.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Engineering, Biomedical
Mai N. Vu, Emily H. Pilkington, Wen Shi Lee, Hyon-Xhi Tan, Thomas P. Davis, Nghia P. Truong, Stephen J. Kent, Adam K. Wheatley
Summary: Using monoclonal antibodies to target vaccine antigens to specific immune cells within lymph nodes can enhance immune responses. The authors developed a system using self-assembling ferritin nanoparticles to attach antibodies to the nanoparticles, allowing for rapid screening of different targeting antibodies. By targeting Clec9a, the authors observed higher antibody titers and increased germinal center formation, leading to robust antibody responses. However, the effectiveness of immune cell targeting depends on the antigen, with variation observed for different immunogens.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Sujian Cao, Zhiyuan Song, Jinyu Rong, Nicholas Andrikopoulos, Xiufang Liang, Yue Wang, Guotao Peng, Feng Ding, Pu Chun Ke
Summary: Alzheimer's disease is a major cause of cognitive decline, memory loss, and mortality among the elderly, and viral infection may play a role in its pathogenesis.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Biochemical Research Methods
Subina Mehta, Matthias Bernt, Matthew Chambers, Matthias Fahrner, Melanie Christine Foell, Bjoern Gruening, Carlos Horro, James E. Johnson, Valentin Loux, Andrew T. Rajczewski, Oliver Schilling, Yves Vandenbrouck, Ove Johan Ragnar Gustafsson, W. C. Mike Thang, Cameron Hyde, Gareth Price, Pratik D. Jagtap, Timothy J. Griffin
Summary: The Galaxy ecosystem offers a range of open-source tools for MS-based proteomics analyses, providing an adaptable, scalable, and accessible computing environment. This community-supported resource is crucial for basic biological and clinical studies, and ongoing developments are underway to meet emerging challenges in MS-based proteomic informatics.
EXPERT REVIEW OF PROTEOMICS
(2023)
Article
Chemistry, Medicinal
Gangtong Huang, Huayuan Tang, Yuying Liu, Chi Zhang, Pu Chun Ke, Yunxiang Sun, Feng Ding
Summary: Through computational investigations, we found that the growth of amyloid fibrils is influenced by their morphologies, resulting in different elongation rates and populations. We also observed asymmetric fibril growth, which is attributed to differences in surface curvatures and exposed hydrogen-bond donors and acceptors at the fibril ends. These mechanistic findings provide a theoretical basis for understanding disease progression in different amyloid strains.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Multidisciplinary Sciences
Magdiel Inggrid Setyawati, Qin Wang, Nengyi Ni, Jie Kai Tee, Katsuhiko Ariga, Pu Chun Ke, Han Kiat Ho, Yucai Wang, David Tai Leong
Summary: Traditional nanomedicine relies on tumor induced EPR effect for drug delivery. Here the authors show that gold nanoparticles are independently able to induce leakiness at tumor vasculature to enhance the tumor killing effect.
NATURE COMMUNICATIONS
(2023)
Article
Materials Science, Biomaterials
Paulina D. Ramirez-Garcia, Nicholas A. Veldhuis, Nigel W. Bunnett, Thomas P. Davis
Summary: In this article, we propose a new opportunity to target intracellular compartments by delivering antagonists via nanoparticles to G-protein coupled receptors. We specifically discuss the application of this approach in antagonizing endosomal receptors involved in pain for developing long-lasting analgesics, and also highlight the potential broader applications. We also discuss the materials used and provide design requirements for future successful applications.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Xiufang Liang, Nicholas Andrikopoulos, Huayuan Tang, Yue Wang, Feng Ding, Pu Chun Ke
Summary: Plastic wastes in the environment pose potential health hazards and their interactions with amyloid proteins relevant to neurological diseases remain unknown. This study reveals the impact of nanoplastics on the aggregation pathway and toxicity of amyloid proteins, providing new insights into the neurological burden of plastic pollution.
Review
Chemistry, Multidisciplinary
Nicholas Andrikopoulos, Huayuan Tang, Yue Wang, Xiufang Liang, Yuhuan Li, Thomas P. Davis, Pu Chun Ke
Summary: Therapeutic peptides are important drugs that specifically target abnormal protein-protein interactions associated with amyloid diseases. The use of nanoparticles in combination with peptide drugs has emerged as a promising strategy for enhancing their efficacy against amyloid aggregation and cellular inflammation. However, there is still a lack of understanding of the chemistry and function of peptido-nanocomposites, and a systematic analysis of their application against a range of amyloid pathogeneses is missing.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Materials Science, Biomaterials
Izabela Stupka, Artur P. Biela, Bernard Piette, Agnieszka Kowalczyk, Karolina Majsterkiewicz, Kinga Borzecka-Solarz, Antonina Naskalska, Jonathan G. Heddle
Summary: Artificial protein cages, such as TRAP-cages, have potential applications in vaccines and drug delivery. TRAP-cages have the ability to control the disassembly conditions by modifying the interface between their building blocks. By using TRAP rings with different numbers of monomers, it is possible to predict the formation of other cages.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Guo Zhang, Yu Wang, Hua Qiu, Lei Lu
Summary: This study presents a one-pot synthesis method for flower-like AMPs@EAMP particles by combining antimicrobial peptides with ellagic acid, offering enlarged surface area, excellent biocompatibility, and broad-spectrum antibacterial activity. In vivo studies indicate their potential for tissue repair and immune barrier reconstruction.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Jiamei Zhang, Lingshuang Wang, Cheng Xu, Yingui Cao, Shengsheng Liu, Rui L. Reis, Subhas C. Kundu, Xiao Yang, Bo Xiao, Lian Duan
Summary: Pluronic F127 modified silk fibroin film with different types of antibacterial agents could accelerate wound recovery by promoting fibroblast adhesion, eradicating bacteria, and facilitating angiogenesis and re-epithelialization.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Yinsheng Liu, Mingyue Wang, Yinfei Hui, Lei Sun, Yanrui Hao, Henlong Ren, Hao Guo, Wu Yang
Summary: In this study, a rare-earth hybrid luminescent material was developed for the detection of a biomarker for anthrax. The material showed excellent selectivity and high sensitivity, allowing for the determination of the biomarker in saliva and urine. Additionally, a convenient point-of-care testing method using fluorescent test paper and a smartphone was established for the initial diagnosis of anthrax.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Review
Materials Science, Biomaterials
Wenshuai Yang, Jingsi Chen, Ziqian Zhao, Meng Wu, Lu Gong, Yimei Sun, Charley Huang, Bin Yan, Hongbo Zeng
Summary: Injectable hydrogels with shear-thinning and/or in situ formation properties offer distinct advantages in bioengineering applications, as they can be directly delivered to target sites, possess self-healing abilities, and simplify the implantation process.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
