Article
Chemistry, Applied
Dabin Lee, Yeoseon Kim, Iqbal Jalaludin, Huu-Quang Nguyen, Minsun Kim, Jungju Seo, Kyoung-Soon Jang, Jeongkwon Kim
Summary: Disaccharides are sugars composed of two monosaccharides linked by a glycosidic linkage, with specific properties determined by the type of linkage and the identity of the monosaccharides. Using MALDI-MS with a graphene oxide matrix, seven disaccharide isomers were analyzed and their unique cleavage patterns were identified. The study demonstrated a strong linear correlation between the relative peak intensity of a sucrose fragment peak and the amount of sucrose in a mixture, which was successfully applied to quantify maltose and sucrose in different honey samples.
Article
Oncology
Magdalena Buszewska-Forajta, Pawel Pomastowski, Fernanda Monedeiro, Justyna Walczak-Skierska, Marcin Markuszewski, Marcin Matuszewski, Michal J. Markuszewski, Boguslaw Buszewski
Summary: Prostate cancer is a major cause of cancer death in men, often recognized late due to lack of fast diagnostic methods. This study used mass spectrometry to analyze lipid alterations in prostate tissue, aiming to develop a quick and sensitive diagnostic method and improve hormone therapies effectiveness. The results suggest that lipidomics could serve as an alternative diagnostic tool for prostate cancer diagnosis.
Article
Engineering, Environmental
Peter Shanta, Bochao Li, Daniel D. Stuart, Quan Cheng
Summary: This study uses microchip technology combined with MALDI-MS to evaluate the impact of agrochemicals on aquatic species at the single-cell level. Significant changes in lipid content were observed in C. reinhardtii cells exposed to different herbicides, demonstrating the effectiveness of microchip-based MALDI technique for high-throughput screening and single-cell analysis in ecotoxicity studies.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jenny Leopold, Patricia Prabutzki, Kathrin M. Engel, Juergen Schiller
Summary: In this update on the progress in MALDI-based lipid analysis since 2018, the selection of an appropriate matrix is found to be crucial for optimum results. The complexity of lipid classes increases from free fatty acids to cardiolipins and phosphoinositides over the last five years.
Article
Chemistry, Multidisciplinary
Christoph Bookmeyer, Ulrich Roehling, Klaus Dreisewerd, Jens Soltwisch
Summary: Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is a rapidly growing method in the life sciences. The study introduces a novel post-ionization scheme based on single-photon induced chemical ionization using pulsed RF-Kr lamps, which effectively improves the ionization efficiency for analytes. Through the interplay with chemical dopants, the signal of various lipid molecules from mammalian tissue sections was significantly boosted.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Xingyue Liu, Zhao Chen, Tao Wang, Xinrong Jiang, Xuetong Qu, Wei Duan, Fengna Xi, Zhengfu He, Jianmin Wu
Summary: The tissue imprinting technology using 2D nanoflakes-capped silicon nanowires allows for convenient and authentic revelation of molecular distribution on tissue samples, which is crucial for accurate cancer diagnosis.
Article
Chemistry, Multidisciplinary
Qiuqin Zhou, Stefano Rizzo, Janina Oetjen, Annabelle Fueloep, Miriam Rittner, Hartmut Gillandt, Carsten Hopf
Summary: Insufficient vacuum stability of matrix chemicals is a major limitation in MALDI mass spectrometry imaging of large tissue sample cohorts. A photo-cleavable caged molecule, DMNB-2,5-DHAP, was designed and synthesized for lipid MALDI-MSI of mouse brain tissue sections. DMNB-2,5-DHAP exhibited vacuum stability in a high vacuum MALDI ion source and its uncaging process resulted in the generation of 2,5-DHAP with the assistance of the built-in laser in the MALDI ion source.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Multidisciplinary
Carlo Zambonin
Summary: Extracellular vesicles (EVs) are recognized as a fundamental method for intercellular transfer of properties, containing various bioactive molecules and playing important roles in the tumor microenvironment. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can lead in analyzing and characterizing EVs due to its advantages in high throughput, low sample consumption, speed, cost-effectiveness, and ease of use.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Applied
Bin Li, Wenjing Gao, Ling Ling, Shaoning Yu
Summary: In this study, an enzyme-assisted reactive matrix-assisted laser desorption/ionization mass spectrometry (ReMALDI-MS) assay was developed for the quantification of cholesterol in food. The proposed method eliminates the need for additional derivatization/purification steps and has been successfully applied to the quantification of cholesterol in bovine milk and cream.
Review
Chemistry, Multidisciplinary
Zhi Qiao, Franziska Lissel
Summary: Researchers have overcome challenges in analyzing low molecular weight compounds using MALDI MS by adjusting sample preparation strategies and developing new matrices. These new matrices not only have high absorption and ionization efficiency, but also ensure vacuum stability and do not produce interfering signals in the low m/z region.
CHEMISTRY-AN ASIAN JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Vanna Denti, Allia Mahajneh, Giulia Capitoli, Francesca Clerici, Isabella Piga, Lisa Pagani, Clizia Chinello, Maddalena Maria Bolognesi, Giuseppe Paglia, Stefania Galimberti, Fulvio Magni, Andrew Smith
Summary: Predicting the prognosis of colorectal cancer patients is challenging, but characterizing the tumor immune environment is crucial. This study explored using spatial lipidomics by MALDI-MSI to distinguish CRC tissue based on TIL content, successfully identifying three lipid signals with the greatest impact on differentiation. Overall, the study suggests that lipidomics MALDI-MSI could be a promising tool for subtyping the diverse immune environments in CRC.
Article
Chemistry, Analytical
Zufeng Qiu, Zhiping Zheng, Zhijia Song, Yunchao Sun, Qiheng Shan, Zhiwei Lin, Zhaoxiong Xie
Summary: In this research, tricobalt tetraoxide (Co3O4) nanocrystals with rich surface hydroxyl groups were synthesized as novel matrices for the detection of small molecules by MALDI-TOF MS. These nanocrystal matrices showed little interference and high signal intensity, making them suitable for the analysis of amino acids, harmful additives, and pesticide residues.
Article
Chemistry, Applied
Ling Ling, Liyan Jiang, Qirui Chen, Bo Zhao, Yueying Li, Xinhua Guo
Summary: A rapid and highly reproducible method for profiling oligosaccharides in beer using PAPAN reactive matrix and MALDI-TOF MS was reported. Through optimization of sample dilution factor and cationization agents, successful identification of maltodextrin distributions in different brands of beers was achieved, showing potentials for analysis of oligosaccharides in other foods.
Article
Chemistry, Physical
Y. X. Ge, H. M. Zhang, X. W. Cheng, Q. B. Fan, Z. H. Zhang, X. N. Mu, L. Liu, Y. N. Liu, B. Wang
Summary: The study focused on utilizing electroless plating method to synthesize nickel coated graphene nanoflakes as reinforcements in titanium matrix composites. It was found that the nickel-plating layer played a key role in controlling the interface reaction degree and maintaining the nanostructure of graphene nanoflakes, leading to an improvement in the composite's strength.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Biochemistry & Molecular Biology
Simon Lagies, Roman Pichler, Georg Vladimirov, Jana Gawron, Fabian Bazner, Annabell Schreiner, Dajana Kadena, Dietmar A. Plattner, Soeren S. Lienkamp, Bernd Kammerer
Summary: Research has found that the concentration of vancomycin in the kidneys far exceeds plasma levels, potentially leading to nephrotoxic reactions. By studying animal models and cell lines, it was discovered that exposure to vancomycin resulted in metabolic and lipidomic alterations in kidney cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Applied
Hani Nasser Abdelhamid, Sherief A. Al Kiey, Walid Sharmoukh
Summary: Hybrid nanomaterials with dye encapsulated zeolitic imidazolate frameworks were synthesized and used as precursors for zinc oxide embedded nitrogen-doped carbon. The resulting ZnO@N-doped C exhibited high capacitance and excellent cycling stability, retaining 87.7% of the initial capacitance after 1000 galvanostatic charge-discharge cycles. The presence of a guest molecule like RhB significantly improved the capacitance of the carbonized ZIF-8 materials.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Review
Chemistry, Inorganic & Nuclear
Hani Nasser Abdelhamid, Aji P. Mathew
Summary: Cellulose-MOFs (CelloMOFs) are hybrid materials that combine cellulosic materials with metal-organic frameworks, offering a range of properties for applications in water remediation, air purification, gas storage, sensing/biosensing, and biomedicine. Their potential includes efficient adsorption for removing contaminants in water, catalytic applications for organic pollutants, air purification by removing greenhouse gases, and biomedical applications such as antibacterial and drug delivery. This review provides a synthesis, characterization, and overview of the applications of CelloMOFs materials, highlighting challenges and future prospects for researchers and scientists.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Chemistry, Applied
Hani Nasser Abdelhamid
Summary: In this article, the authors review the application of ZIF-based materials for CO2 removal via adsorption and catalysis. Various reaction types and recent membrane technologies are highlighted. The prospects for industrial applications and commercialization of ZIF-based materials are also briefly discussed.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Applied
Mahmoud R. Saleh, Haitham M. El-Bery, Hani Nasser Abdelhamid
Summary: A wet-incipient impregnation method was used to synthesize hierarchical porous bimetallic (Co, Zn)-zeolitic imidazolate frameworks (ZIF-8)/TiO2 for efficient photocatalytic water splitting. Co@ZIF-8/TiO2 exhibited significantly higher photocatalytic efficiency than TiO2, with a hydrogen generation rate of 13 mmol·h(-1)·g(-1) and a 151-fold increase in catalytic performance. The hierarchical porous structure of Co@ZIF-8 facilitated charge transfer and provided efficient transport channels. This study demonstrates the potential of hierarchical porous metal-organic frameworks (MOFs) as support and promoter in photocatalytic applications of TiO2.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Applied
Hani Nasser Abdelhamid, Ghada Abd-Elmonsef Mahmoud
Summary: In this study, copper-based metal-organic frameworks (MOFs) were used to synthesize copper oxide (CuO) embedded into carbon (CuO@C), which displayed high antifungal activity against four economic postharvest plant pathogens. The CuO@C nanoparticles inhibited the growth of the fungal species and decreased their enzyme activity, reducing the potentiality of fruit disease. The successful formation of CuO@C nanoparticles was confirmed using various characterization techniques.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Hani Nasser Abdelhamid
Summary: One-pot co-precipitation method for synthesizing microporous-mesoporous zeolitic imidazolate frameworks-8 (ZIF-8) crystals, using organic dyes as target molecules, was reported. The crystal growth involves an intermediate phase of zinc hydroxyl nitrate nanosheets, allowing the adsorption of the dyes. The materials showed potential for CO2 adsorption and ATP biosensing.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Walid Sharmoukh, Hani Nasser Abdelhamid
Summary: A metal-organic framework (MOF) of cerium (Ce) ions and 4,4 ',4 ''-nitrilotribenzoic acid linker was synthesized via a hydro thermal method. The Ce-MOF showed Fenton-like properties and displayed excellent catalytic oxidation activity for various organic compounds and water pollutants. It exhibited high efficiency in the oxidative degradation of dyes and could be recycled multiple times without significant loss of catalytic performance.
JOURNAL OF CLUSTER SCIENCE
(2023)
Article
Chemistry, Applied
Hani Nasser Abdelhamid
Summary: Metal-organic frameworks (MOFs) have shown great potential for industrial applications but current synthesis processes limit their use due to the powder form. A solvothermal method was used to grow copper-based MOFs onto a cotton textile, creating a material called CuBDC@Textile. CuBDC@Textile demonstrated excellent vapor sensing properties and high adsorption capacity for pyridine. This dual-functional material holds promise for further research on MOFs in textile applications.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Materials Science, Ceramics
Numa A. A. Althubiti, T. A. Taha, A. A. Azab, Hani Nasser Abdelhamid
Summary: The use of solid-state materials such as sodium borohydride for hydrogen storage and release can meet the requirements of the "Hydrogen Economy". This study investigated ZnO-based materials as catalysts for hydrogen release through the hydrolysis of NaBH4. The synthesis method produced nanocomposites consisting of ZnO-xTiO(2) and ZnO-xCeO(2) (x = 5 wt.% or 10 wt.%). Characterization techniques confirmed the phase purity and optical properties of the materials. The materials exhibited a high hydrogen generation rate and different activation energies.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Physical
Hani Nasser Abdelhamid, Islam M. A. Mekhemer, Abdel-Aal M. Gaber
Summary: In this study, benzimidazole derivatives were successfully synthesized through photocatalytic synthesis using a solid-state acid catalyst ZrOSO4@C. The reaction, which allowed for condensation and cyclization in a single vessel, resulted in high yield (77-98%) and high purity of the benzimidazoles. The catalyst showed improvement in the synthesis of various benzimidazole derivatives using a wide range of aromatic aldehydes and heterocycles.
MOLECULAR CATALYSIS
(2023)
Article
Energy & Fuels
Moushira Saleh, Hani Nasser Abdelhamid, Dina M. Fouad, Haitham M. El-Bery
Summary: The use of light radiation to split water into hydrogen gas has great potential for green hydrogen production. A comparative study was conducted on the photocatalytic activity of TiO2 nanocomposites with two co-catalysts, Pt or Cu nanocrystals, using different synthesis methods. The study found that the deposition technique of the co-catalyst has a significant influence on the efficiency of photocatalysis for hydrogen production.
Article
Chemistry, Inorganic & Nuclear
Hani Nasser Abdelhamid, Sahar Sultan, Aji P. Mathew
Summary: 3D printing of cellulose/leaf-like zeolitic imidazolate frameworks (CelloZIF-L) allows for the creation of structures with high adsorption efficiency, capable of adsorbing carbon dioxide and heavy metals.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Dimitrios Georgouvelas, Hani Nasser Abdelhamid, Ulrica Edlund, Aji P. Mathew
Summary: In this study, nanocellulose/alginate composite hydrogel beads were successfully prepared and modified with in situ TEMPO-mediated oxidation. The modified beads exhibited improved adsorption efficiency and water flux, making them promising candidates for large-volume, high flux water treatment.
NANOSCALE ADVANCES
(2023)
Article
Engineering, Environmental
Ahmed F. Abdel-Magied, Radwa M. Ashour, Le Fu, Moataz Dowaidar, Wei Xia, Kerstin Forsberg, Hani Nasser Abdelhamid
Summary: The study synthesized two magnetic metal-organic frameworks and investigated their adsorption capacities for Cd(II) and Pb(II). The adsorption efficiency is strongly dependent on the pH of the solution, and the process follows a pseudo-second-order model and fits the Langmuir isotherm model.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Ahmed I. A. Soliman, Aboel-Magd A. Abdel-Wahab, Hani Nasser Abdelhamid
Summary: This study reports the use of zeolitic imidazolate framework-8 (ZIF-8) and ZnO@N-doped C as effective adsorbents and photocatalysts for the removal of organic dyes from water. ZnO@N-doped C shows high degradation efficiency under UV exposure.
Article
Materials Science, Biomaterials
Izabela Stupka, Artur P. Biela, Bernard Piette, Agnieszka Kowalczyk, Karolina Majsterkiewicz, Kinga Borzecka-Solarz, Antonina Naskalska, Jonathan G. Heddle
Summary: Artificial protein cages, such as TRAP-cages, have potential applications in vaccines and drug delivery. TRAP-cages have the ability to control the disassembly conditions by modifying the interface between their building blocks. By using TRAP rings with different numbers of monomers, it is possible to predict the formation of other cages.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Guo Zhang, Yu Wang, Hua Qiu, Lei Lu
Summary: This study presents a one-pot synthesis method for flower-like AMPs@EAMP particles by combining antimicrobial peptides with ellagic acid, offering enlarged surface area, excellent biocompatibility, and broad-spectrum antibacterial activity. In vivo studies indicate their potential for tissue repair and immune barrier reconstruction.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Jiamei Zhang, Lingshuang Wang, Cheng Xu, Yingui Cao, Shengsheng Liu, Rui L. Reis, Subhas C. Kundu, Xiao Yang, Bo Xiao, Lian Duan
Summary: Pluronic F127 modified silk fibroin film with different types of antibacterial agents could accelerate wound recovery by promoting fibroblast adhesion, eradicating bacteria, and facilitating angiogenesis and re-epithelialization.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Yinsheng Liu, Mingyue Wang, Yinfei Hui, Lei Sun, Yanrui Hao, Henlong Ren, Hao Guo, Wu Yang
Summary: In this study, a rare-earth hybrid luminescent material was developed for the detection of a biomarker for anthrax. The material showed excellent selectivity and high sensitivity, allowing for the determination of the biomarker in saliva and urine. Additionally, a convenient point-of-care testing method using fluorescent test paper and a smartphone was established for the initial diagnosis of anthrax.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Review
Materials Science, Biomaterials
Wenshuai Yang, Jingsi Chen, Ziqian Zhao, Meng Wu, Lu Gong, Yimei Sun, Charley Huang, Bin Yan, Hongbo Zeng
Summary: Injectable hydrogels with shear-thinning and/or in situ formation properties offer distinct advantages in bioengineering applications, as they can be directly delivered to target sites, possess self-healing abilities, and simplify the implantation process.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
