Correction
Materials Science, Biomaterials
HyeongJin Lee, YongBok Kim, GeunHyung Kim
Summary: The author corrected a study on the fabrication, characterization, and in vitro cellular activities of mineralized biomimetic collagen/alginate/silica composite scaffolds for hard tissue regeneration using a low-temperature bio-plotting process.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Engineering, Biomedical
Elia Marin, Orion Yoshikawa, Francesco Boschetto, Taigi Honma, Tetsuya Adachi, Wenliang Zhu, Huaizhong Xu, Narisato Kanamura, Toshiro Yamamoto, Giuseppe Pezzotti
Summary: Poly-caprolactone is a promising biocompatible polymer for temporary devices, but lacks biological support for tissue regeneration. By combining l-dopa and fibroin with electrospun poly-caprolactone fibers, bioactive effects can be induced, promoting proliferation, adhesion, and osteoconduction. The synergistic effects of these substances lead to improved mechanical properties and increased mineralized deposits in vitro.
BIOMEDICAL MATERIALS
(2022)
Article
Engineering, Biomedical
Iulian Antoniac, Aurora Antoniac, Eugeniu Vasile, Camelia Tecu, Marco Fosca, Viktoriya G. Yankova, Julietta Rau
Summary: Novel composite scaffolds composed of collagen-hydroxyapatite and collagen-hydroxyapatite-magnesium were developed, showing promising potential for bone tissue engineering applications. The nanostructural properties and degradation behavior of the scaffolds were thoroughly investigated through advanced microscopy techniques.
BIOACTIVE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Caroline S. Taylor, Joseph Barnes, Manohar Prasad Koduri, Shamsal Haq, David A. Gregory, Ipsita Roy, Raechelle A. D'Sa, Judith Curran, John W. Haycock
Summary: Silane modification is a cost-effective method to modify existing biomaterials for tissue engineering. This study reports the deposition of CL11 onto PCL scaffolds for peripheral nerve regeneration. The modified fibers significantly support cell viability and differentiation, indicating their potential for improving nerve regeneration.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Engineering, Biomedical
Yubo Shi, Lei Wang, Liguo Sun, Zhennan Qiu, Xiaoli Qu, Jingyi Dang, Zhao Zhang, Jiankang He, Hongbin Fan
Summary: Melt electrospinning writing (MEW) is a promising 3D printing technology for scaffold fabrication. This study investigated the use of NaOH treatment to enhance the cytocompatibility and osteoinductive properties of polycaprolactone (PCL) scaffolds. The NaOH-treated PCL scaffold exhibited nanopits and nanogrooves on the surface, which increased surface roughness and wettability, leading to improved cell proliferation and adhesion. In vitro experiments demonstrated that the NaOH-treated surface could induce osteogenic differentiation of bone marrow mesenchymal stem cells via the integrin alpha 2/beta 1-PI3K-Akt signaling pathway. Animal studies showed that the NaOH-treated PCL scaffold promoted new bone formation. The study concluded that NaOH treatment is a simple and effective method to enhance the cellular affinity and osteoinductive property of MEW PCL scaffolds.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Article
Polymer Science
Julia Venturini Helaehil, Carina Basqueira Lourenco, Boyang Huang, Luiza Venturini Helaehil, Isaque Xavier de Camargo, Gabriela Bortolanca Chiarotto, Milton Santamaria-Jr, Paulo Bartolo, Guilherme Ferreira Caetano
Summary: Composite scaffolds made of polycaprolactone (PCL) mixed with bioceramics, such as hydroxyapatite (HA) and tricalcium phosphate (TCP), showed improved biological recognition and bioactivity. Electrical stimulation (ES) enhanced cell proliferation and differentiation. The study revealed that the combined use of PCL with HA or TCP scaffolds and ES improved bone regeneration.
Review
Chemistry, Multidisciplinary
Peng Yu, Fanyuan Yu, Jie Xiang, Kai Zhou, Ling Zhou, Zhengmin Zhang, Xiao Rong, Zichuan Ding, Jiayi Wu, Wudi Li, Zongke Zhou, Ling Ye, Wei Yang
Summary: Rebuilding mineralized tissues in skeletal and dental systems is costly and challenging. Artificial scaffolds have emerged as efficient alternatives to autografts, allografts, and xenografts, which have limited sources and carry significant risks. This article systematically summarizes the strategies of cell-free biomimetic mineralization (BM) and cell-dependent scaffolds in regenerative dentistry and orthopedics, focusing on their mechanisms. By understanding the mechanisms, researchers can make better clinical choices and approach research directions for rebuilding hard tissues.
ADVANCED MATERIALS
(2022)
Article
Engineering, Biomedical
Feilong Wang, Dandan Xia, Siyi Wang, Ranli Gu, Fan Yang, Xiao Zhao, Xuenan Liu, Yuan Zhu, Hao Liu, Yongxiang Xu, Yunsong Liu, Yongsheng Zhou
Summary: In this study, a photocrosslinkable composite membrane containing collagen and polycaprolactone methacryloyl was developed, and the addition of magnesium particles improved its mechanical properties and degradation rate. The composite membrane demonstrated spatial support and enhanced osteogenic capability, making it suitable for oral implant repair.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Fritz Koch, Ole Thaden, Stefan Conrad, Kevin Troendle, Gunter Finkenzeller, Roland Zengerle, Sabrina Kartmann, Stefan Zimmermann, Peter Koltay
Summary: The generation of artificial human tissue using 3D bioprinting has become an important research topic in recent years. In this study, the authors evaluate the process parameters relevant to a hybrid bioprinting process, involving the printing of thermoplastic material and a cell-laden hydrogel. Through their experiments, they determine the optimal printing temperature and filament bonding strength for successful tissue generation. They also examine the mechanical strength of the printed structures and observe that scaffolds made using the hybrid bioprinting technique show promising mechanical properties.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Elham Bagherzadeh, Zahra Sherafat, Seyed Mojtaba Zebarjad, Azin Khodaei, Saber Amin Yavari
Summary: Polymeric scaffolds play a crucial role in tissue engineering due to their diversity, adaptability, and processability. Piezoelectric PVDF/PCL blend fibers are developed to promote bone regeneration by converting mechanical impulses to electrical signals. These fibers show improved wettability, controlled biodegradability, and piezoelectric behavior, and they are found to be biocompatible, supporting cell attachment, proliferation, and stem cell differentiation into osteoblasts. The potential of these blend fibers for bone scaffolds is undeniable.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2023)
Article
Biotechnology & Applied Microbiology
Armin Hassanzadeh, Javad Ashrafihelan, Roya Salehi, Reza Rahbarghazi, Masomeh Firouzamandi, Mahdi Ahmadi, Majid Khaksar, Mahdieh Alipour, Marziyeh Aghazadeh
Summary: The injectable PCL-PEG-PCL-Col/nHA hydrogels demonstrated good biocompatibility, suitable for further research in hard tissue regeneration, with no significant pro-inflammatory response and a delayed biodegradation rate.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Xuefeng Zhou, Xi Cheng, Danlei Xing, Qi Ge, Yan Li, Xianghong Luan, Ning Gu, Yunzhu Qian
Summary: This study aimed to enhance the osteogenic potential of bioactive synthetic scaffolds through the development of a novel PP/COL I-pDA-Ca scaffold, which showed increased cell adhesion and osteogenic differentiation in cell culture experiments. The incorporation of polydopamine-based Ca chelation, COL I, and 3D bionic structure in the scaffold promoted osteogenesis and cell adhesion, making it an attractive alternative for guided bone regeneration.
MATERIALS & DESIGN
(2021)
Article
Biotechnology & Applied Microbiology
Paola Nitti, Sanosh Kunjalukkal Padmanabhan, Serena Cortazzi, Eleonora Stanca, Luisa Siculella, Antonio Licciulli, Christian Demitri
Summary: In this study, composite structures made of hydroxyapatite scaffold impregnated with a collagen slurry were designed to mimic bone tissue structure, with the addition of magnesium and silicon ions enhancing mechanical and biological properties. An innovative freeze-drying approach was developed to create open-pore structures for tissue regeneration. The biodegradation behavior of the scaffolds, particularly HA-Mg_Coll scaffolds, showed moderate weight loss and mechanical performance reduction due to collagen dissolution, while also protecting the ceramic structure until degradation, making them suitable candidates for bone remodeling.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Xiaotang He, Wen Li, Siyang Liu, Yi Li, Yining Chen, Nianhua Dan, Weihua Dan, Meifeng Zhu
Summary: In this study, high-strength, flexible, and porous collagen-based scaffolds were successfully prepared using a novel strategy. Compared to regular collagen scaffolds, these scaffolds demonstrated superior mechanical properties and cell compatibility. Animal experiments showed that the scaffolds promoted cell infiltration, vascularization, and tissue regeneration. This study provides a new solution for tissue repair and broadens the application range in regenerative medicine.
MATERIALS TODAY BIO
(2022)
Article
Engineering, Environmental
Jing-Han Song, Jun-Ting Gu, Gao-Peng Dang, Zhi-Ting Li, Chen Lei, Ling Li, Zhao Mu, Franklin R. Tay, Kai Jiao, Li-na Niu
Summary: Unmodified collagen scaffolds are limited in bone tissue engineering due to their mechanical and osteoinductive properties. A DNA-crosslinked collagen scaffold (DNA-Col) is fabricated to enhance bone healing. The improved osteogenic performance of DNA-Col is attributed to its interaction with T cells, specifically regulatory T cells (Tregs). Mechanistic experiments show that DNA-Col triggers recruitment of Tregs in vivo, and depletion of Tregs reverses DNA-Col-induced bone regeneration. Further investigations reveal that DNA-Col promotes Treg differentiation through metabolic reprogramming. These findings establish the role of DNA-Col as a bioactive bone regeneration scaffold via its interaction with Tregs.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Materials Science, Biomaterials
Izabela Stupka, Artur P. Biela, Bernard Piette, Agnieszka Kowalczyk, Karolina Majsterkiewicz, Kinga Borzecka-Solarz, Antonina Naskalska, Jonathan G. Heddle
Summary: Artificial protein cages, such as TRAP-cages, have potential applications in vaccines and drug delivery. TRAP-cages have the ability to control the disassembly conditions by modifying the interface between their building blocks. By using TRAP rings with different numbers of monomers, it is possible to predict the formation of other cages.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Guo Zhang, Yu Wang, Hua Qiu, Lei Lu
Summary: This study presents a one-pot synthesis method for flower-like AMPs@EAMP particles by combining antimicrobial peptides with ellagic acid, offering enlarged surface area, excellent biocompatibility, and broad-spectrum antibacterial activity. In vivo studies indicate their potential for tissue repair and immune barrier reconstruction.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Jiamei Zhang, Lingshuang Wang, Cheng Xu, Yingui Cao, Shengsheng Liu, Rui L. Reis, Subhas C. Kundu, Xiao Yang, Bo Xiao, Lian Duan
Summary: Pluronic F127 modified silk fibroin film with different types of antibacterial agents could accelerate wound recovery by promoting fibroblast adhesion, eradicating bacteria, and facilitating angiogenesis and re-epithelialization.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Yinsheng Liu, Mingyue Wang, Yinfei Hui, Lei Sun, Yanrui Hao, Henlong Ren, Hao Guo, Wu Yang
Summary: In this study, a rare-earth hybrid luminescent material was developed for the detection of a biomarker for anthrax. The material showed excellent selectivity and high sensitivity, allowing for the determination of the biomarker in saliva and urine. Additionally, a convenient point-of-care testing method using fluorescent test paper and a smartphone was established for the initial diagnosis of anthrax.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Review
Materials Science, Biomaterials
Wenshuai Yang, Jingsi Chen, Ziqian Zhao, Meng Wu, Lu Gong, Yimei Sun, Charley Huang, Bin Yan, Hongbo Zeng
Summary: Injectable hydrogels with shear-thinning and/or in situ formation properties offer distinct advantages in bioengineering applications, as they can be directly delivered to target sites, possess self-healing abilities, and simplify the implantation process.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)