Article
Chemistry, Multidisciplinary
Junggeon Park, Sanghun Lee, Mingyu Lee, Hyung-Seok Kim, Jae Young Lee
Summary: Injectable conductive hydrogels (ICHs) with tunable degradability have been developed as implantable bioelectrodes. ICHs exhibit good conductivity, tissue compatibility, and significantly improved sensitivity in electromyography signals compared to skin electrodes and nonconductive hydrogel electrodes. This study demonstrates the great potential of ICHs to develop various bioelectronic devices.
Article
Chemistry, Multidisciplinary
Jose Munoz, Edurne Redondo, Martin Pumera
Summary: 3D printing technology has enabled decentralized and customized manufacturing of 3D-printed electronic devices, particularly in the field of electrochemical (bio)sensing. This study explores the feasibility of using 3D-printed electrodes for chiral analyses, introducing a straightforward electrochemical approach for sensitive and selective analysis of enzymatic systems.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Polymer Science
Sarah Vanessa Homburg, Anant Patel
Summary: Despite the potential of microalgae as a feedstock for various industries, their production processes are currently uneconomical due to slow growth rates, expensive media, problematic downstream processes, and low cell densities. Entrapment via immobilization in silica hydrogels offers a promising solution to these challenges, allowing continuous processes with protection against shear forces and contaminations. Efforts have been made to improve biocompatibility and, through various methods, enable the proliferation of entrapped microalgae cells. This review provides an overview of entrapment methods in silica hydrogels, specifically for sensitive microalgae.
Article
Biochemistry & Molecular Biology
Seyed Saeed Mousavi, Hamid Keshvari, Hamed Daemi
Summary: This study demonstrates that partial sulfation of Gellan gum (GG) can produce a cytocompatible temperature-responsive hydrogel. The resulting hydrogel shows an interesting thermoreversibility at 42°C and a drop in mechanical properties can be compensated by further calcium-mediated ionic crosslinking.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
J. Andres Ortiz, Francesca Antonella Sepulveda, Concepcion Panadero-Medianero, Paola Murgas, Manuel Ahumada, Humberto Palza, Betty Matsuhiro, Paula A. Zapata
Summary: In this study, pH-responsive CMA/CS hydrogels were prepared and the model drug DS was successfully loaded into the PCE. The results showed that the hydrogels had high loading capacity and release efficiency. Cell viability assay demonstrated the non-toxic nature of the hydrogels. Therefore, CMA/CS PECs can be applied for dermal drug delivery.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Lukas Hahn, Matthias Beudert, Marcus Gutmann, Larissa Kessler, Philipp Stahlhut, Lena Fischer, Emine Karakaya, Thomas Lorson, Ingo Thievessen, Rainer Detsch, Tessa Luehmann, Robert Luxenhofer
Summary: In this study, a Diels-Alder click chemistry approach was introduced into thermogelling diblock copolymers to achieve printability and cell-friendliness, while functional modifications were made through acid/amine coupling and thiol-maleimide chemistry to facilitate cell adhesion. Testing showed good biocompatibility of the bioink formulations, which combined physical precursor gelation with additional chemical stabilization for versatile biomechanical adaptation.
MACROMOLECULAR BIOSCIENCE
(2021)
Review
Chemistry, Multidisciplinary
Vidushi Aggarwal, Shipra Solanki, Bansi D. Malhotra
Summary: Metal-organic frameworks (MOFs) are a promising class of porous nanomaterials with large surface area, high porosity, tunable pore size, stability, facile synthesis, and catalytic nature. Recent research has discovered their potential as ideal platforms for biomolecule immobilization, leading to the fabrication of bioelectrochemical devices with unique characteristics. MOFs-based bioelectrodes have gained interest for their applications in biosensing and biofuel cells, offering improved biomolecule immobilization, electrolyte membranes, fuel storage, biocatalysis, and biosensing.
Article
Chemistry, Multidisciplinary
Mireia Buaki-Sogo, Laura Garcia-Carmona, Mayte Gil-Agusti, Marta Garcia-Pellicer, Alfredo Quijano-Lopez
Summary: The development of flexible and biocompatible conductive bioelectrodes using chitosan-carbon black membranes has been achieved, showing potential applications in enzymatic glucose biofuel cells and glucose detection. The membranes demonstrated good electrical and mechanical properties, making them suitable for wearable sensing and energy harvesting technologies in the clinical field.
Article
Chemistry, Physical
Jae Seon Baik, Sang A. Kim, Dae-Woong Jung, Weon-Sik Chae, Changhyun Pang, Suk Ho Bhang, Laurent Corte, Gi-Ra Yi
Summary: The adsorption of polymers on the surface of mesoporous silica nanoparticles allows for versatile adhesion between hydrogels or biological tissues. However, when the number of nanoparticles deposited exceeds a critical threshold, thick multilayers form at the interface and decrease the adhesion strength. To overcome this limitation, spherical aggregates were prepared by spray drying, resulting in stronger cohesion between nanoparticles. The adhesion energy with these supraballs was significantly enhanced compared to nanoparticles, and corrugated interfaces stabilized by supraballs contributed to the largest adhesion enhancement.
CHEMISTRY OF MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Xuefeng Yang, Boguang Yang, Yingrui Deng, Xian Xie, Yanwei Qi, Guoqing Yan, Xin Peng, Pengchao Zhao, Liming Bian
Summary: In this study, a coacervate-to-hydrogel transition strategy was developed to create macroporous hydrogels (MPH) using supramolecular assemblies (SA). The SA had liquid-like rheological properties due to weak and reversible supramolecular crosslinks, which facilitated the formation of SA-derived macroporous coacervates and their transition into MPH (pore size around 100 μm). The structural dynamics of SA and the cytocompatible void-forming process of MPH made them suitable for colony growth of encapsulated multicellular spheroids, suggesting potential applications in 3D multicellular spheroid culture and other biomedical fields.
ADVANCED MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Ziyan Wang, Jieyu Gu, Difei Zhang, Yan Zhang, Jinghua Chen
Summary: In this study, a series of multiresponsive hydrogels were prepared by using biocompatible starting materials and a dynamic covalent imine/Diels-Alder network. By further crosslinking with a hyperbranched triethoxysilane reagent, the hydrogels exhibited strengthened self-healing and temperature-responsive shape memory effect. With superior stretchability, good cytocompatibility, and 3D printable properties, these multifunctional hydrogels showed great potential for broad biomedical applications.
Article
Materials Science, Paper & Wood
Mengshi Wang, Jiatai Gu, Yunna Hao, Xiaohong Qin, Yanping Yu, Hongnan Zhang
Summary: This study developed a novel hydrogel-based nanofiber membrane with adhesive, sustained-release, antibacterial, and biocompatible performance. By combining functionalized nanofiber membranes and polysaccharide hydrogels, a composite structure was created that exhibited remarkable antibacterial activity, sustained-release characteristics, and high biocompatibility.
Article
Engineering, Biomedical
Vincent Mair, Ilona Paulus, Jurgen Groll, Matthias Ryma
Summary: Conventional additive manufacturing technologies have limitations in design freedom, but freeform printing, which controls the temperature profile to print materials in true 3D space, overcomes these limitations. This study introduces the use of freeform printing for poly(2-cyclopropyl-oxazoline) (PcycloPrOx), demonstrating its significance in biofabrication.
Article
Biochemistry & Molecular Biology
Lea Andree, Pascal Bertsch, Rong Wang, Malin Becker, Jeroen Leijten, Peter Fischer, Fang Yang, Sander C. G. Leeuwenburgh
Summary: We developed a versatile hydrogel platform using modular building blocks, allowing for the design of customized hydrogels with specific physical architecture and mechanical properties. By assembling different combinations of gelatin methacryloyl (Gel-MA) and gelatin nanoparticles, we demonstrated the versatility of the platform. The incorporation of particles resulted in softer hydrogels with enhanced stress relaxation, and the stiffness of the hydrogels influenced cell behavior.
Article
Chemistry, Analytical
Celeste R. Rousseau, Madeline L. Honig, Philippe Buhlmann
Summary: This study explored the stability of solid-contact ion-selective electrodes by controlling the potential variations between electrodes using different membranes and redox buffers. The reproducibility and long-term drift of the electrodes were assessed with varying results depending on the membrane type used.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Yang Song, Sandra Casale, Antoine Miche, David Montero, Christel Laberty-Robert, David Portehault
Summary: Metal silicide electrocatalysts for water oxidation were synthesized using silicon nanoparticles and molten salt solvents, resulting in nanocrystals with high electrocatalytic activity and stability exceeding 85 hours. The core-shell-shell nanostructure enables the silicides to exhibit excellent performance for oxygen evolution reaction.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Engineering, Biomedical
Sophie Maillard, Ludovic Sicard, Caroline Andrique, Coralie Torrens, Julie Lesieur, Brigitte Baroukh, Thibaud Coradin, Anne Poliard, Lotfi Slimani, Catherine Chaussain
Summary: Combining implantation of dense collagen hydrogels hosting murine dental pulp stem cells (mDPSC) with systemic injections of a sclerostin antibody leads to increased bone regeneration in large bone defects. The study also suggests that implantation of sclerostin-deficient MSC promotes new bone formation similarly to complete sclerostin deficiency.
ACTA BIOMATERIALIA
(2022)
Article
Electrochemistry
Jeremy Sum, Olivier Durupthy, Natacha Krins, Christel Laberty-Robert
Summary: This study demonstrates the interplays between hydrogen evolution reaction (HER) and lithium-ion insertion in water-in-salt electrolyte (WISE) using mesoporous TiO2 electrodes.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Kun Wang, Marie Camman, Gervaise Mosser, Bernard Haye, Lea Trichet, Thibaud Coradin
Summary: A new protocol for preparing fibrin-collagen composite gels is described, showing potential as biomaterials. The addition of collagen increases the turbidity of the gels and reduces their shrinkage, with minimal influence on the rheological properties. Collagen fibers are observed within the fibrin network. Collagen favors cell proliferation and alignment, but interferes with cell differentiation and myotube formation.
Article
Chemistry, Multidisciplinary
Estelle Palierse, Sylvie Masse, Guillaume Laurent, Patrick Le Griel, Gervaise Mosser, Thibaud Coradin, Claude Jolivalt
Summary: This study compared two methods, adsorption and in situ incorporation, for preparing hybrid polyphenol/hydroxyapatite nanoparticles. The results showed that adsorption of polyphenols on pre-formed nanoparticles did not change their properties, while in situ incorporation inhibited hydroxyapatite formation but resulted in higher loadings. Most hybrid particles exhibited a burst effect followed by slow release over time.
Article
Materials Science, Ceramics
Jeremy Sum, Natacha Krins, Christel Laberty-Robert
Summary: This study investigates how the process of electrochemically inserting or extracting lithium ions in TiO2 can initiate and direct the solar hydrogen evolution reaction. The rejuvenation of LixTiO2, which is envisioned as a photo(electro)catalyst, can be achieved by controlling the potential in situ. The research is conducted using a half-battery cell design, wherein a mesoporous, anatase TiO2 thin film is deposited onto a transparent conducting oxide substrate, with water-in-salt serving as the electrolyte. By changing the state of charge of the working electrode material, the ratio between the Li-rich phase and the Li-poor phase can be adjusted, altering the opto-electronic properties of the material and potentially impacting the light-matter interaction. The impact of light on the interplay between hydrogen evolution reaction and lithium insertion/extraction in TiO2 is analyzed through classic electrochemical characterizations inspired by battery and photoelectrode communities. Solar hydrogen is produced either at the working or counter electrode with a minimum of Li-rich phase, while lithium is photo-extracted from the Li-rich phase to regenerate TiO2.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2023)
Article
Robotics
Mouna Ben Salem, Laurent Petit, Muneeb Ullah Khan, Jeremy Terrien, Christine Prelle, Frederic Lamarque, Thibaud Coradin, Christophe Egles
Summary: In this paper, a concept of an implantable drug delivery device capable of delivering drugs in the duodenum for a long period of time is presented. The device aims to address therapeutic non-adherence, which is a major barrier to patients receiving the full benefits of their medications. The device is based on a miniature tubular linear actuator that can move at discrete positions inside a tube, and the research work primarily focuses on the actuator design and validation.
JOURNAL OF MICRO-BIO ROBOTICS
(2023)
Article
Engineering, Biomedical
Sophia Houari, Karen Derocher, Tran Thu Thuy, Thibaud Coradin, Vesna Srot, Peter A. van Aken, Helene Lecoq, Thierry Sauvage, Etienne Balan, Julie Aufort, Marco Calemme, Nicolas Roubier, Julia Bosco, Katia Jedeon, Ariane Berdal, Derk Joester, Sylvie Babajko
Summary: Developmental Defects of Enamel (DDE), such as Dental Fluorosis (DF) and Molar Incisor Hypomineralization (MIH), are a significant public health problem. This study used a combination of structural and chemical methods to compare and study MIH, DF, and healthy teeth from 89 patients. The results show that DF is characterized by a homogeneous loss of mineral content and crystallinity on the outer layer of enamel, while MIH is associated with localized defects in the depth of enamel. Minor differences in elemental composition were detected at the nanoscale. The study also proposes the use of colorimetric measurements for clinical diagnosis and improved restoration protocols. The findings contribute to a better understanding of DDE and provide insights for personalized dentistry.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Physical
Arvinder Singh, Christel Laberty-Robert, Veronique Balland, Benoit Limoges
Summary: This study investigates the charge storage mechanism of manganese oxides (MnOx) in mild aqueous Zn batteries through quantitative and comparative electrochemical analysis. The results show that the oxidation state and crystallinity of MnOx have little impact on the electrochemical reactivity, with all MnOx being fully converted into soluble Mn2+ during discharge. Additionally, the study reveals the effect of Mn3O4 dismutation in acidic electrolytes and emphasizes the importance of studying Mn3O4 under mildly acidic to neutral pH conditions to understand its thermodynamics and kinetics. Furthermore, the study confirms the phase transformation of Mn3O4 to Mn5O8 and the formation of amorphous MnO2 electrodeposits on top of Mn3O4 in Mn2+-free electrolytes. Finally, the study concludes that subsequent charge/discharge cycles rely on reversible proton-coupled electrodeposition of amorphous MnO2, regardless of the starting MnOx material.
ADVANCED ENERGY MATERIALS
(2023)
Review
Polymer Science
Enguerran Devernois, Thibaud Coradin
Summary: Type I collagen and chitosan are commonly used biological macromolecules for tissue engineering scaffolds. While collagen is biocompatible and provides biochemical cues, it has poor mechanical properties. Chitosan, on the other hand, is more versatile but not a good substrate for mammalian cells. Combining these two biomacromolecules allows for the preparation of interesting biomaterials with improved properties. However, there is a lack of understanding regarding chitosan-type I collagen interactions.
Article
Materials Science, Multidisciplinary
Anastasia Permyakova, Alshaba Kakar, Jonathan Bachir, Effrosyni Gkaniatsou, Bernard Haye, Nicolas Menguy, Farid Nouar, Christian Serre, Nathalie Steunou, Thibaud Coradin, Francisco M. Fernandes, Clemence Sicard
Summary: The mesoporous iron polycarboxylate MIL-100(Fe) was synthesized with the presence of Pseudomonas putida bacteria. The synthesis was done under green conditions, using pure aqueous media at 30 degrees C to ensure the integrity of the cell membrane. The resulting biohybrid showed a unique microstructure, with an exoskeleton encapsulating individual bacteria cell, suggesting strong interactions between the exopolysaccharides network and MOF precursors.
ACS MATERIALS LETTERS
(2023)
Article
Chemistry, Physical
Stephanie De Oliveira, Gregor Miklosic, Joelle Veziers, Sebastien Grastilleur, Thibaud Coradin, Catherine Le Visage, Jerome Guicheux, Matteo DEste, Christophe Helary
Summary: Collagen/hyaluronan composite hydrogels with physical properties suitable for biomedical applications can be synthesized by inhibiting the formation of polyionic complexes.
Article
Nanoscience & Nanotechnology
Kankan Qin, Rui F. P. Pereira, Thibaud Coradin, Veronica de Zea Bermudez, Francisco M. Fernandes
Summary: This study demonstrates the fabrication of three-dimensional porous silk foams as dermal patches for wound protection and controlled delivery of antibiotics. The silk foams exhibit good water wicking capacity, deformability, and antibacterial behavior. The method of reassembling natural materials as macroporous foams can be applicable to other multicomponent natural materials, playing a crucial role in applications involving controlled release of molecules and fluid transport.
ACS APPLIED BIO MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Kankan Qin, Rui F. P. Pereira, Thibaud Coradin, Veronica de Zea Bermudez, Francisco M. Fernandes
Summary: Silk from Bombyx mori has a unique arrangement of its two major components, which provides mechanical and surface properties for protecting the moth during its vulnerable phase. By reshaping the silk fibers into macroporous foam structures, this study demonstrates the potential of using these silk foams as dermal patches for wound protection and controlled drug delivery. This method can be extended to other natural materials and play a crucial role in applications involving controlled release and fluid transport.
ACS APPLIED BIO MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Sarah Christoph, Pierre Barre, Bernard Haye, Thibaud Coradin, Francisco M. Fernandes
Summary: We present a new class of hybrid material composed of a polysaccharide macroporous core surrounded by a thin silica layer, which can be used as adsorption platforms for organic pollutants in soil. These hybrid materials showed structural stability and sorption capacity for organic pollutants significantly higher than the surrounding soils. They possess all the necessary properties to be effective materials for soil depollution and are easy to recover.
Article
Materials Science, Biomaterials
Izabela Stupka, Artur P. Biela, Bernard Piette, Agnieszka Kowalczyk, Karolina Majsterkiewicz, Kinga Borzecka-Solarz, Antonina Naskalska, Jonathan G. Heddle
Summary: Artificial protein cages, such as TRAP-cages, have potential applications in vaccines and drug delivery. TRAP-cages have the ability to control the disassembly conditions by modifying the interface between their building blocks. By using TRAP rings with different numbers of monomers, it is possible to predict the formation of other cages.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Guo Zhang, Yu Wang, Hua Qiu, Lei Lu
Summary: This study presents a one-pot synthesis method for flower-like AMPs@EAMP particles by combining antimicrobial peptides with ellagic acid, offering enlarged surface area, excellent biocompatibility, and broad-spectrum antibacterial activity. In vivo studies indicate their potential for tissue repair and immune barrier reconstruction.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Jiamei Zhang, Lingshuang Wang, Cheng Xu, Yingui Cao, Shengsheng Liu, Rui L. Reis, Subhas C. Kundu, Xiao Yang, Bo Xiao, Lian Duan
Summary: Pluronic F127 modified silk fibroin film with different types of antibacterial agents could accelerate wound recovery by promoting fibroblast adhesion, eradicating bacteria, and facilitating angiogenesis and re-epithelialization.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Yinsheng Liu, Mingyue Wang, Yinfei Hui, Lei Sun, Yanrui Hao, Henlong Ren, Hao Guo, Wu Yang
Summary: In this study, a rare-earth hybrid luminescent material was developed for the detection of a biomarker for anthrax. The material showed excellent selectivity and high sensitivity, allowing for the determination of the biomarker in saliva and urine. Additionally, a convenient point-of-care testing method using fluorescent test paper and a smartphone was established for the initial diagnosis of anthrax.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Review
Materials Science, Biomaterials
Wenshuai Yang, Jingsi Chen, Ziqian Zhao, Meng Wu, Lu Gong, Yimei Sun, Charley Huang, Bin Yan, Hongbo Zeng
Summary: Injectable hydrogels with shear-thinning and/or in situ formation properties offer distinct advantages in bioengineering applications, as they can be directly delivered to target sites, possess self-healing abilities, and simplify the implantation process.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
