Article
Gastroenterology & Hepatology
Yu-Jie Zhou, Xiao-Fan Lu, Huimin Chen, Xin-Yuan Wang, Wenxuan Cheng, Qing-Wei Zhang, Jin-Nan Chen, Xiao-Yi Wang, Jing-Zheng Jin, Fang-Rong Yan, Haoyan Chen, Xiao-Bo Li
Summary: This study used single-cell transcriptomics to investigate serrated lesions in the colon and found that there were redox imbalances in the epithelial cell clusters, which were tumor-promoting. Additionally, specific epithelial cell clusters in serrated lesions displayed distinct molecular features, and the immune environment underwent alterations.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Carla Satorres, Maria Garcia-Campos, Marco Bustamante-Balen
Summary: Serrated lesions are precursor lesions of colorectal cancer, with the serrated pathway likely responsible for up to 30% of cases. Multiple molecular mechanisms are involved, including MAPK pathway alterations, CpG island methylation, and microsatellite instability. Further research is needed to clarify the precise roles of alterations in the serrated pathway and develop specific prevention and therapeutic strategies.
Article
Gastroenterology & Hepatology
Fumika Nakamura, Yasushi Sato, Koichi Okamoto, Yasuteru Fujino, Yasuhiro Mitsui, Kaizo Kagemoto, Tomoyuki Kawaguchi, Hiroshi Miyamoto, Naoki Muguruma, Tomoko Sonoda, Koichi Tsuneyama, Tetsuji Takayama
Summary: This study found that more than half of colorectal cancers (CRCs), particularly those in the left-side colorectum, in serrated polyposis syndrome (SPS) patients develop through the adenoma-carcinoma pathway. Adenoma was identified as a significant risk factor for CRCs, highlighting its importance in colorectal carcinogenesis.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Dan Li, Amanda R. Doherty, Menaka Raju, Liyan Liu, Nan Ye Lei, Laura B. Amsden, Jeffrey K. Lee, Theodore R. Levin, Douglas A. Corley, Lisa J. Herrinton
Summary: This community-based, case-control study found a close association between serrated polyps (SPs) and the risk of colorectal cancer (CRC), especially large proximal serrated lesions or those with dysplasia. Close endoscopic surveillance of serrated polyps can help reduce the risk of CRC. Proximal unspecified SPs are also associated with an increased risk of CRC and should be managed as serrated lesions.
Article
Oncology
Xin-Yuan Wang, Yu-Jie Zhou, Hai-Ying Chen, Jin-Nan Chen, Shan-Shan Chen, Hui-Min Chen, Xiao-Bo Li
Summary: tsRNAs, specifically tiRNA-1:33-Pro-TGG-1, play a crucial role in the development of sessile serrated lesions (SSLs) and BRAF-mutant CRC. They promote the progression of CRC through metabolic and immune pathways by interacting with HPSE2 and regulating its expression. tsRNAs have the potential to become novel biomarkers for early diagnosis and therapeutic targets for CRC.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2023)
Article
Oncology
Fabio Catalano, Roberto Borea, Silvia Puglisi, Andrea Boutros, Annalice Gandini, Malvina Cremante, Valentino Martelli, Stefania Sciallero, Alberto Puccini
Summary: Defective DNA damage response (DDR) is a characteristic of cancer, with a significant number of colorectal cancer patients having DDR alterations. However, the role of DDR alterations in prognosis and therapeutic targets requires further investigation. Current clinical trials have not yielded satisfactory results, mainly due to inadequate patient selection based on molecular characteristics. Before DDR alterations can be effectively targeted, challenges such as selecting appropriate patients and identifying reliable clinical or molecular biomarkers need to be overcome. Moreover, different DDR alterations may not have equal sensitivity to platinum-based chemotherapy. Therefore, additional efforts are needed in both preclinical and clinical settings to discover DDR inhibitors with potential clinical benefits for colorectal cancer patients.
Article
Gastroenterology & Hepatology
Aisling Murphy, Joyce Solomons, Peter Risby, Jessica Gabriel, Tina Bedenham, Michael Johnson, Nathan Atkinson, Adam A. Bailey, Elizabeth Bird-Lieberman, Simon J. Leedham, James E. East, Sujata Biswas
Summary: This study found that 20.5% of SPS patients tested had heterozygous germline variants, including previously unreported associations with CHEK2 and POLD1. Current recommendations may miss SPS associated with germline variants.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
David E. F. W. M. van Toledo, Joep E. G. Ijspeert, Arne G. C. Bleijenberg, Barbara A. J. Bastiaansen, Carel J. M. van Noesel, Evelien Dekker
Summary: This study assessed the prevalence and clinical relevance of appendiceal lesions in a large cohort of Serrated polyposis syndrome (SPS) patients. The results showed that although appendiceal lesions were common in SPS patients, the proportion of advanced lesions was low, indicating limited clinical significance.
Article
Cell Biology
Jin-Feng Zhu, Yi Liu, Wen-Ting Li, Ming-Hui Li, Chao-Hui Zhen, Pei-Wei Sun, Ji-Xin Chen, Wen-Hao Wu, Wei Zeng
Summary: This study aimed to investigate the effect of Ibrutinib and ferroptosis inducers on colorectal cancer treatment and its underlying mechanism. The upregulation of Nrf2 was found to be correlated with CRC progression and antioxidant proteins. Ibrutinib increased the sensitivity of CRC cells to ferroptosis inducers by inhibiting Nrf2.
CELL DEATH & DISEASE
(2023)
Article
Gastroenterology & Hepatology
Charles Muller, Akihiro Yamada, Sachie Ikegami, Haider Haider, Yuga Komaki, Fukiko Komaki, Dejan Micic, Atsushi Sakuraba
Summary: Serrated polyposis syndrome (SPS) is an underrecognized CRC predisposition syndrome with a higher risk of colorectal cancer, especially at the time of diagnosis. Early recognition, screening, and enhanced surveillance protocols are crucial in managing the elevated CRC risk in SPS patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Marina Hanna, Neelendu Dey, William M. Grady
Summary: Colorectal cancer is a common cancer globally and is a leading cause of cancer-related deaths. Current screening methods for colorectal cancer have limitations and many people are not compliant with screening recommendations. Novel screening tests based on advances in molecular biology, genetics, and epigenetics, as well as sequencing technologies and computational analytic methods, have been developed to improve early detection of colorectal cancer.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Dong Hang, Xiaosheng He, Ane Sorlie Kvaerner, Andrew T. Chan, Kana Wu, Shuji Ogino, Zhibin Hu, Hongbing Shen, Edward L. Giovannucci, Mingyang Song
Summary: The study found that sex hormones, particularly sex hormone-binding globulin (SHBG), may play a role in early colorectal carcinogenesis. High SHBG levels were associated with a lower risk of conventional adenomas, while high levels of free estradiol and free testosterone were associated with a higher risk of conventional adenomas.
Review
Genetics & Heredity
Irati Romero-Garmendia, Koldo Garcia-Etxebarria
Summary: Colorectal cancer is a highly diagnosed cancer and the second leading cause of cancer-related death. Studying biomarkers for its diagnosis, prognosis, and treatment is essential for improving and personalizing colorectal cancer prevention and clinical management. Omic techniques provide an opportunity to better understand CRC and make personalized medicine possible, but also present challenges.
Review
Biochemistry & Molecular Biology
Antonios N. Gargalionis, Kostas A. Papavassiliou, Athanasios G. Papavassiliou
Summary: STAT3 plays a critical role in the development of colorectal cancer by enhancing tumor cell proliferation and growth through inflammatory mechanisms. However, the mechanisms underlying the role of STAT3 in tumor immunity are not fully understood, and STAT3 inhibitors have not yet been widely used in clinical practice.
Article
Surgery
Roupen Djinbachian, Marie-Lyssa Lafontaine, Talia Dufault, Edgard Medawar, Michel Boivin, Mickael Bouin, Daniel von Renteln
Summary: This study aimed to evaluate the rate of synchronous advanced neoplasia (S-AN) and synchronous CRC (S-CRC) in colonoscopies where serrated lesions (SL) were detected. The study included 1262 patients with 1649 SLs. The results showed that patients with SLs are at high-risk of S-AN and S-CRC, with SSPs >= 10 mm and SSP dysplasia being high-risk factors for S-AN.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
